The impact of frailty on the cardiovascular diseases
Project/Area Number |
18K07471
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52010:General internal medicine-related
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Research Institution | Kagoshima University |
Principal Investigator |
Okui Hideki 鹿児島大学, 医歯学総合研究科, 客員研究員 (70815620)
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Co-Investigator(Kenkyū-buntansha) |
池田 義之 鹿児島大学, 医歯学域医学系, 准教授 (00573023)
窪薗 琢郎 鹿児島大学, 医歯学域医学系, 講師 (00598013)
大石 充 鹿児島大学, 医歯学域医学系, 教授 (50335345)
二宮 雄一 鹿児島大学, 医歯学総合研究科, 特任助教 (40722575)
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Project Period (FY) |
2018-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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Keywords | フレイル / 栄養 / 肥満 / 心房細動 / 心血管疾患 / 動脈硬化 / 生活習慣病 / サルコペニア / 低栄養 |
Outline of Final Research Achievements |
Retrospective study was conducted using the annual health checkup data of 67,379 adults without baseline AF. Participants were grouped according to waist circumference (WC): large-WC group and normal-WC group. During a median follow-up of 5 years, 280 (0.4%) new cases of AF were recorded. Univariate analysis revealed a significant increase in new-onset AF in males but not in females in the large-WC group. After adjusting for clinical variables, multivariate analysis revealed that a large WC was significantly associated with new-onset AF in males but not in females. We also evaluated the effect of malnutrition on prognosis in patients with either coronary artery or peripheral artery diseases who underwent optimal percutaneous coronary intervention or endovascular treatment, respectively. Compared to the patients with normal nutritional status, those with malnutrition assessed by Geriatric Nutritional Risk Index (GNRI) had higher incidence of cardiovascular event and mortality.
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Academic Significance and Societal Importance of the Research Achievements |
栄養はフレイル進展における主たる要因である。我々の研究により、栄養過多や栄養バランス異常の存在が示唆される腹部肥満や、逆に低栄養を有することは、新規心房細動発症や、様々な心血管疾患のイベント発症および生命予後不良のリスク因子となることが明らかとなった。栄養を軸とした適切な治療介入を行うことは幅広く心血管疾患およびフレイルの有効な予防・治療となり、超高齢社会を迎え急増している心血管疾患やフレイル・サルコペニア、そしてこれに伴う医療費・医療資源の高騰という現在本邦が直面している社会的問題に対する有効な解決方法に繋がる、社会的意義の高い成果を得ることができた。
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Report
(6 results)
Research Products
(48 results)
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[Journal Article] Association of blood pressure and dietary intake of Sunomono, Japanese vinegared side dishes, in community-dwelling Japanese: A cross-sectional study.2022
Author(s)
Kanouchi H, Yamashita M, Kaimoto K, Kuwabara A, Kawakami Y, Takenaka S, Koriyama C, Kuwahata S, Takenaka T, Akasaki Y, Kubozono T, Miyata M, Ohishi M.
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Journal Title
Heliyon
Volume: 8
Issue: 5
Pages: e09505-e09505
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Absence of first-pass isolation is associated with poor pulmonary vein isolation durability and atrial fibrillation ablation outcomes.2021
Author(s)
Ninomiya Y, Inoue K, Tanaka N, Okada M, Tanaka K, Onishi T, Hirao Y, Oka T, Inoue H, Takayasu K, Nakamaru R, Kitagaki R, Koyama Y, Okamura A, Iwakura K, Ohishi M, Fujii K.
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Journal Title
J Arrhythm 2021
Volume: 37
Issue: 6
Pages: 1468-1476
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: Insight from the kids registry2020
Author(s)
Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M.
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Journal Title
Eur J Intern Med
Volume: 72
Issue: 4
Pages: 79-87
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Association between weight gain after smoking cessation and future hypertension.2023
Author(s)
Ninomiya Y, Kawasoe S, Kubozono T, Tokushige A, Ichiki H, Kamada H, Yoshimoto I, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
Organizer
第87回 日本循環器学会学術集会
Related Report
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[Presentation] Development of a score and an equation to predict 5-year chronic kidney disease using Japanese health checkup data.2022
Author(s)
Kawasoe S, Kubozono T, Salim Anwar Ahmed, Ojima S, Kawabata T, Yoshimine H, Mawatari S, Ikeda Y, Miyahara H, Tokushige K, Ido A, Ohishi M.
Organizer
ESC Congress 2022
Related Report
Int'l Joint Research
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[Presentation] Incidence of asymptomatic stroke or hemopericardium in catheter ablation for atrial fibrillation with uninterrupted use of Edoxaban, Rivaroxaban, or Warfarin.2019
Author(s)
Yoshimoto I, Oketani N, Iriki Y, Ichiki H, Okui H, Maenosono R, Namino F, Miyata M, Ohishi M.
Organizer
第83回 日本循環器学会学術集会
Related Report
Int'l Joint Research
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[Presentation] The tearing of the fossa ovalis floor in the chronicity period after repeated catheter ablation of atrial fibrillation.2019
Author(s)
Tagata K, Iriki Y, Ichiki H, Okui H, Hamamoto H, Horizoe Y, Nagatomi S, Matsumoto K, Namino F, Maenosono R, Ohishi M.
Organizer
第66回 日本不整脈心電学会学術集会
Related Report
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