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Exploratory research on treatments for Diabetes-related dementia

Research Project

Project/Area Number 18K07479
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionTokyo Medical University

Principal Investigator

KANETAKA HIDEKAZU  東京医科大学, 医学部, 准教授 (90385021)

Co-Investigator(Kenkyū-buntansha) 羽生 春夫  東京医科大学, 医学部, 特任教授 (10228520)
清水 聰一郎  東京医科大学, 医学部, 主任教授 (10385031)
高田 祐輔  東京医科大学, 医学部, 助教 (20449193)
平尾 健太郎  東京医科大学, 医学部, 講師 (40516639)
櫻井 博文  東京医科大学, 医学部, 兼任教授 (60235223)
馬原 孝彦  東京医科大学, 医学部, 客員教授 (70266477)
佐藤 友彦  東京医科大学, 医学部, 講師 (70421071)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsレビー小体型認知症 / アルツハイマー病 / 脳血流SPECT / Cingulate Island Sign / IMP-SPECT / Alzheimer / DLB / Lewy / 糖尿病性認知症 / cingulate island sign / Alzheimer病 / Sarcopenia / 糖尿病 / フレイル
Outline of Final Research Achievements

The CIScore using SPECT in the AD group was significantly higher than that in the DLB groups.
This suggests that the CIScore can discriminate DLB from AD, if the decrease in rCBF in the PCG is similar between them. The diagnostic accuracy of the CIScore may be low as it often shows an increase in elderly DLB patients,in whom the pathologically common form is most prevalent. Further study should include assessment of multiple components such as symptom classification and age.

Academic Significance and Societal Importance of the Research Achievements

アルツハイマー病(AD)とレビー小体型認知症(DLB)の鑑別をより容易に行うことが可能となった。認知症診断の効率化は、患者側の利益だけでなく、医療従事者にも効率的で有益な情報をもたらすことが可能となった。適切な医療と介護の提供に結びつくため、本研究によって得られる成果の社会的意義は極めて大きいといえる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2021 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Differentiating Mild Cognitive Impairment, Alzheimer's Disease, and Dementia With Lewy Bodies Using Cingulate Island Sign on Perfusion IMP-SPECT2020

    • Author(s)
      HIDEKAZU KANETAKA
    • Journal Title

      Front Neurol .

      Volume: 19 Pages: 11-11

    • DOI

      10.3389/fneur.2020.568438

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results.2019

    • Author(s)
      Takenoshita N, Shimizu S, Kanetaka H, Sakurai H, Suzuki R, Miwa T, Odawara M, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H
    • Journal Title

      J Alzheimers Dis.

      Volume: 71 Issue: 1 Pages: 261-271

    • DOI

      10.3233/jad-190620

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sarcopenia and Muscle Functions at Various Stages of Alzheimer Disease.2018

    • Author(s)
      Ogawa Y, Kaneko Y, Sato T, Shimizu S, Kanetaka H, Hanyu H
    • Journal Title

      Front Neurol.

      Volume: 9 Pages: 7-10

    • DOI

      10.3389/fneur.2018.00710

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] レビー小体型認知症のCingulate Island Signと関連する臨床症候2021

    • Author(s)
      金高 秀和、芹澤俊太郎、竹野下 尚仁、 小川 裕介、深澤雷太、高田祐輔、佐藤 友彦、 平尾 健太郎、清水 聰一郎
    • Organizer
      日本老年病学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Cingulate Island Signを示すDLBの特徴2021

    • Author(s)
      金高 秀和、稲川雄太、櫻井 周 芹澤俊太郎、金子 義嗣、小川 裕介、竹野下 尚仁、 佐藤 友彦、平尾 健太郎、清水 聰一郎
    • Organizer
      日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Differentiating mild cognitive impairment, Alzheimer’s disease, and dementia with Lewy bodies using Cingulate island sign and perfusion IMP-SPECT2019

    • Author(s)
      Hidekazu Kanetaka, Naoto Takenoshita, Daisuke Hirose, Soichiro Shimizu, Hirofumi Sakurai, Haruo Hanyu
    • Organizer
      The International Association of Gerontology and Geriatrics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] IMP-脳血流SPECTにおけるCingulate Island Signの適正VOI検討2019

    • Author(s)
      金高 秀和、稲川雄太、芹澤俊太郎、竹野下 尚仁、深澤雷太、佐藤 友彦、平尾 健太郎、清水聰一郎、櫻井 博文、羽生 春夫
    • Organizer
      日本認知症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] SEEを用いたIMP-脳血流SPECTのCingulate Island Sign2019

    • Author(s)
      金高 秀和、清水 聰一郎、竹野下 尚仁、 小川 裕介、 深澤雷太、高田祐輔、佐藤 友彦、 平尾 健太郎、櫻井 博文、羽生 春夫
    • Organizer
      日本老年医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] SarcopeniaとAlzheimer病の関連2018

    • Author(s)
      金高秀和
    • Organizer
      日本老年病学会
    • Related Report
      2018 Research-status Report
  • [Presentation] IMP-脳血流SPECTにおけるCingulate Island Signの有用性2018

    • Author(s)
      金高秀和
    • Organizer
      日本核医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] IMP-脳血流SPECTにおけるCingulate Island Signの有用性2018

    • Author(s)
      金高秀和
    • Organizer
      日本認知症学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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