The effect of Immune checkpoints in myasthenia gravis and application of its to new therapeutic medications
| Project/Area Number |
18K07494
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | Ishikawa Prefectural Nursing University (2020-2021)
Kanazawa University (2018-2019) |
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Principal Investigator |
Iwasa Kazuo 石川県立看護大学, 看護学部, 教授 (10345613)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 重症筋無力症 / 骨格筋 / 免疫チェックポイント分子 / PD-L1 / 可能性免疫チェックポイント分子 / 可溶性免疫チェックポイント分子 / 胸腺 / 血清 |
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| Outline of Final Research Achievements |
We clarified that the muscle expression of PD-L1 was involved in the pathogenesis of myasthenia gravis (MG).
The association between PD-L1 expression and clinical parameter was analyzed in a generalized additive model. It showed that MG symptoms were more severe when PD-L1 expression was inadequate. Consequently, we concluded that PD-L1 expression of MG muscle may be important factor for the pathogenesis of MG. In addition, we focused on the concentration of soluble PD-L1 (sPD-L1) in serum of MG and indicated that MG symptoms may be improved in cases with higher sPD-L1 concentrations.
These results were suggested that PD-L1 may have the possibility of a new therapeutic agent in the future.
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| Academic Significance and Societal Importance of the Research Achievements |
免疫チェックポイント分子（PD-L1）は免疫機能を調整する重要な因子であるが、重症筋無力症（MG）の病態における関与は明らかでなかった。
今回、MGの骨格筋におけるPD-L1の発現がMGの病態に関与するのみでなく、血液中の可溶化PD-L1も病態に関与することが明らかとなった。このことは、PD-L1を利用したMGの新たな治療薬の可能性が示されたと考えることができる。
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Report
(5 results)
Research Products
(10 results)
