| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, and the number of patients in Japan is on a rise. An inflammatory demyelination is the key pathology of MS, however, the ordinal MRI was only able to visualize a part of those lesions and hidden histological myelin pathologies had been reported in "normal-appearing" white matters (NAWM). In the present study, we utilized a novel MRI sequence called "Myelin Map" or q-Space Myelin Map (qMM), specific to myelin signals, to analyze myelin dynamics in NAWM. We found that qMM values were correlated with progression of, and physical and cognitive disabilities of MS.
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