Imaging analysis of myelin pathologies in multiple sclerosis using q-Space Myelin Map method
| Project/Area Number |
18K07508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | Keio University |
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Principal Investigator |
Nakahara Jin 慶應義塾大学, 医学部(信濃町), 教授 (60537950)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 多発性硬化症 / ミエリンマップ |
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| Outline of Final Research Achievements |
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, and the number of patients in Japan is on a rise. An inflammatory demyelination is the key pathology of MS, however, the ordinal MRI was only able to visualize a part of those lesions and hidden histological myelin pathologies had been reported in "normal-appearing" white matters (NAWM). In the present study, we utilized a novel MRI sequence called "Myelin Map" or q-Space Myelin Map (qMM), specific to myelin signals, to analyze myelin dynamics in NAWM. We found that qMM values were correlated with progression of, and physical and cognitive disabilities of MS.
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| Academic Significance and Societal Importance of the Research Achievements |
多発性硬化症（MS）は中枢神経系の脱髄疾患である。MRIにより脱髄病変（T2病変）を検出することが、その診断と治療効果モニタリングにおいて中心的な役割を担っているが、他方で微細な髄鞘傷害は通常のMRIでは検出できない。我々の研究グループでは髄鞘特異的なMRI撮像法（q-Space Myelin Map（qMM）法）を開発し、MS患者の髄鞘動態の解析を行った。その結果、一見正常に見えるnormal-appearing white matters（NAWM）において髄鞘傷害が生じていることが確認され、神経学的障害することを確認し、qMMがMSの個別化医療に寄与する可能性が示唆された。
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Report
(6 results)
Research Products
(53 results)
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[Presentation] q-Space Myelin Map法を用いたナタリズマブ投与下多発性硬化症の髄鞘動態解析2020
Author(s)
関口耕史, 久冨木原健二, 浅倉颯人, 北川賢, 谷川万里子, 畑純一, 鈴木重明, 藤吉兼弘, 藤原広和, 陣崎雅弘, 中村雅也, 岡野栄之, 中原仁
Organizer
日本神経免疫学会
Related Report
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[Presentation] q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with glatiramer acetate2019
Author(s)
Kufukihara K, Tanikawa M, Hata J, Suzuki S, Fujiyoshi K, Fujiwara H, Jinzaki M, Nakamura M, Okano H, Takahashi S, Nakahara J
Organizer
PACTRIMS 2019
Related Report
Int'l Joint Research
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[Presentation] q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with glatiramer acetate2018
Author(s)
K. Kufukihara, M. Tanikawa, J. Hata, S. Suzuki, K. Fujiyoshi, H. Fujiwara, M. Jinzaki, M. Nakamura, H. Okano, S. Takahashi, J. Nakahara
Organizer
Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS 2018)
Related Report
Int'l Joint Research
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[Presentation] q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with natalizumab2018
Author(s)
K. Kufukihara, M. Tanikawa, J. Hata, S. Suzuki, K. Fujiyoshi, H. Fujiwara, M. Jinzaki, M. Nakamura, H. Okano, S. Takahashi, J. Nakahara
Organizer
European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2018)
Related Report
Int'l Joint Research
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