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Prevalence and Future Risk of REM Sleep Behavior Disorder-What Can Define Non-converters?

Research Project

Project/Area Number 18K07512
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionTeikyo University

Principal Investigator

Sakuma Taeko  帝京大学, 医療技術学部, 准教授 (70419026)

Co-Investigator(Kenkyū-buntansha) 竹内 暢  公益財団法人神経研究所, 研究部, 研究員 (80360296)
井上 雄一  公益財団法人神経研究所, 研究部, 研究員 (50213179)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsレム睡眠行動障害 / REM sleep without atonia / 軽度認知機能障害 / パーキンソン病 / 一般高齢者 / αシヌクレイノパチー / 認知機能 / 有病率 / 嗅覚機能 / 錯視 / レビー小体型認知症 / community-based RBD / idiopathic RBD / 疫学 / 高齢者
Outline of Final Research Achievements

A large-scale elderly survey was conducted in Yuzawa Town, Niigata Prefecture, to investigate the prevalence and outcome of REM sleep behavior disorder (RBD) in the general elderly population. The prevalence in the general elderly population in Japan was 1.23%. This study revealed that the proportion of women is higher in the general elderly population than in clinical cases, with a male to female ratio of 2:1, and there are latent female RBD cases in the general elderly population compared to patients with a motivation for consultation. As for neurophysiological findings, olfactory function and cognitive funtion were higher in community-based iRBD than in clinical iRBD.

Academic Significance and Societal Importance of the Research Achievements

これまで明らかにされてこなかった日本人一般高齢者でのレム睡眠行動障害の有病率が明らかになった。また、その男女比が臨床例と異なり女性患者の割合が多いことから、症状が軽度で受診にいたらないが明らかなレム睡眠行動障害である女性が一般高齢者に潜在することも明らかになった。レム睡眠行動障害の臨床例に比して、罹病期間に差はないものの嗅覚機能や認知機能は高く保たれており、一般高齢者から抽出されたレム睡眠行動障害の患者には低リスクの患者が含まれる可能性が示唆された。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (26 results)

All 2024 2023 2022 2021 2020 2019 2018 Other

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 13 results) Book (5 results) Remarks (1 results)

  • [Journal Article] ネックミオクローヌス- 生理現象か、疾患か-2023

    • Author(s)
      咲間妙子
    • Journal Title

      睡眠医療

      Volume: 4 Pages: 379-383

    • Related Report
      2023 Annual Research Report
  • [Journal Article] ネックミオクローヌス- 生理現象か、疾患か2022

    • Author(s)
      咲間妙子
    • Journal Title

      睡眠医療

      Volume: 4 Pages: 379-383

    • Related Report
      2022 Research-status Report
  • [Journal Article] Prevalence, clinical symptoms and polysomnographic findings of REM-related sleep disordered breathing in Japanese population2021

    • Author(s)
      Taeko Sasai-Sakuma, Momoko Kayaba, Yuichi Inoue, Hideaki Nakayama
    • Journal Title

      Sleep Medicine

      Volume: 80 Pages: 52

    • DOI

      10.1016/j.sleep.2021.01.009

    • URL

      https://localhost/en/publications/993adf18-19bf-4151-b4c8-218c6f829a48

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence and clinical characteristics of REM sleep behavior disorder in Japanese elderly people2020

    • Author(s)
      Taeko Sasai-Sakuma, Noboru Takeuchi, Yasuhiro Asai, Yuichi Inoue, Yosuke Inoue
    • Journal Title

      SLEEP

      Volume: 43 Issue: 8

    • DOI

      10.1093/sleep/zsaa024

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of yokukansan for the treatment of idiopathic rapid eye movement sleep behavior disorder: A retrospective analysis of consecutive patients2019

    • Author(s)
      K. Matsui, T. Sasai-Sakuma, J. Ishigooka, K. Nishimura, Y. Inoue.
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 15 Issue: 8 Pages: 1173

    • DOI

      10.5664/jcsm.7816

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ethnic differences in periodic limb movements during sleep in patients with restless legs syndrome: a preliminary cross-sectional study of Austrian and Japanese clinical population2018

    • Author(s)
      Taeko Sasai-Sakuma, Ambra Stefani, Moeko Ochi, Birgit Hogl, Yuichi Inoue
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 16 Issue: 3 Pages: 345

    • DOI

      10.1007/s41105-018-0159-5

    • NAID

      40021589228

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] αシヌクレイノパチーとレム睡眠行動障害2018

    • Author(s)
      咲間(笹井)妙子
    • Journal Title

      睡眠医療

      Volume: 12 Pages: 539-545

    • Related Report
      2018 Research-status Report
  • [Presentation] レム睡眠行動障害における 錯視所見の臨床的意義2023

    • Author(s)
      咲間妙子
    • Organizer
      第45回日本睡眠学会定期学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Longitudinal study of REM sleep behavior disorder2023

    • Author(s)
      Taeko Sakuma
    • Organizer
      4th congress of Asian Society of Sleep Medicine
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Electromyographic finding of narcolepsy2023

    • Author(s)
      Taeko Sakuma
    • Organizer
      3rd narcolepsy & hypersomnolence society meeting
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] レム睡眠行動障害における自律神経障害2022

    • Author(s)
      咲間妙子
    • Organizer
      第75回日本自律神経学会総会基礎と臨床の融合シンポジウム2
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Prodromal DLBとしてのレム睡眠行動障害 ―進展予測因子とその多様性2021

    • Author(s)
      咲間妙子
    • Organizer
      日本精神神経学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Epidemiology of RBD in population-based studies2021

    • Author(s)
      Taeko Sasai-Sakuma
    • Organizer
      3rd Asian Society of Sleep Medicine
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] パーキンソン病の前駆段階としてのRBD2019

    • Author(s)
      笹井(咲間) 妙子
    • Organizer
      第22回日本薬物脳波学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] PLMSの病態生理と臨床的意義2019

    • Author(s)
      笹井(咲間) 妙子
    • Organizer
      第49回 日本臨床神経生理学会 学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] レム関連OSAの日中機能とPSG所見2019

    • Author(s)
      笹井(咲間) 妙子,中山 秀章,井上 雄一
    • Organizer
      第44回日本睡眠学会定期学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 睡眠関連運動イベントにおける自律神経変化2018

    • Author(s)
      笹井(咲間) 妙子
    • Organizer
      第71回日本自律神経学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 筋電図の神経生理学-睡眠障害の電気生理学的所見とその意義2018

    • Author(s)
      笹井(咲間) 妙子
    • Organizer
      第13回日本睡眠学会生涯教育セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] OSASと中枢性過眠症2018

    • Author(s)
      笹井(咲間) 妙子
    • Organizer
      第19回臨床CPAP研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] RBDの診断 -臨床症状と生理・神経心理学的指標2018

    • Author(s)
      笹井(咲間) 妙子
    • Organizer
      第43回日本睡眠学会定期学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 脳神経内科診断ハンドブック第2版2024

    • Author(s)
      鈴木圭輔、咲間妙子
    • Total Pages
      616
    • Publisher
      中外医学社
    • ISBN
      9784498328792
    • Related Report
      2023 Annual Research Report
  • [Book] 睡眠学の百科事典2024

    • Author(s)
      咲間妙子
    • Total Pages
      768
    • Publisher
      丸善出版
    • ISBN
      9784621309216
    • Related Report
      2023 Annual Research Report
  • [Book] 脳神経内科診断ハンドブック2022

    • Author(s)
      鈴木圭輔、咲間妙子
    • Total Pages
      603
    • Publisher
      中外医学社
    • Related Report
      2022 Research-status Report
  • [Book] 脳神経内科診断ハンドブック2021

    • Author(s)
      下畑亨良
    • Total Pages
      604
    • Publisher
      中外医学社
    • ISBN
      9784498328785
    • Related Report
      2021 Research-status Report
  • [Book] Rapid Eye Movement Sleep Behavior Disorder2018

    • Author(s)
      Yuichi Inoue and Taeko Sasai-Sakuma
    • Total Pages
      678
    • Publisher
      Springer International Publishing
    • ISBN
      9783319901527
    • Related Report
      2018 Research-status Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/taeko

    • Related Report
      2020 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2025-01-30  

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