Plasticity induction and Parkinson disease
| Project/Area Number |
18K07521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hamada Masashi 東京大学, 医学部附属病院, 講師 (40708054)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 経頭蓋磁気刺激 / パーキンソン病 / 可塑性 |
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| Outline of Final Research Achievements |
In order to understand mechanism of treatment effects of repetitive transcranial magnetic stimulation (rTMS) in Parkinson disease, we performed series of experiments in which plasticity induction indeed affected motor learning in healthy volunteers. Furthermore, we found that reducing stimulus intensity of TBS protocol reversed non-responder to responder. These finding indicated that clinical effects of rTMS in Parkinson disease may be produced by plasticity modulation and that stimulus intensity may be very important to effectively induce plasticity in human cortex.
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| Academic Significance and Societal Importance of the Research Achievements |
パーキンソン病において薬物治療のみならず非薬物療法の開発は喫緊の課題である。本研究ではその一つになりえる磁気刺激による可塑性について、効果発現機序の神経基盤の一部を解明でき、今後の応用が十分期待できる点で学術的・社会的意義があると考えた。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] The intensity of continuous theta burst stimulation, but not the waveform used to elicit motor evoked potentials, influences its outcome in the human motor cortex.2018
Author(s)
Sasaki T, Kodama S, Togashi N, Shirota Y, Sugiyama Y, Tokushikge S, Inomata-Terada S, Terao Y, Ugawa Y, Hamada M
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Journal Title
Brain stimulation
Volume: 11
Issue: 2
Pages: 400-410
DOI
Related Report
Peer Reviewed
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