| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In order to understand mechanism of treatment effects of repetitive transcranial magnetic stimulation (rTMS) in Parkinson disease, we performed series of experiments in which plasticity induction indeed affected motor learning in healthy volunteers. Furthermore, we found that reducing stimulus intensity of TBS protocol reversed non-responder to responder. These finding indicated that clinical effects of rTMS in Parkinson disease may be produced by plasticity modulation and that stimulus intensity may be very important to effectively induce plasticity in human cortex.
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