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Crosstalk between neutral glycolipids and inflammatory molecules in cerebral infarction

Research Project

Project/Area Number 18K07538
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionFujita Health University

Principal Investigator

Ito Shinji  藤田医科大学, 医学部, 教授 (40572079)

Co-Investigator(Kenkyū-buntansha) 武藤 多津郎  藤田医科大学, 医学部, 教授 (60190857)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳梗塞 / 脳血管障害 / 炎症 / 糖脂質 / 炎症関連分子 / 血管内皮 / ライソゾーム水解酵素 / Trousseau症候群
Outline of Final Research Achievements

In recent years, the involvement of inflammatory mechanisms in the development of arteriosclerosis has attracted attention. We focused on the multifunction of neutral glycolipids and tried to elucidate their action as proinflammatory factors in the pathophysiology of atherothrombotic infarction. We compared the expression of inflammatory molecules and neutral glycolipids, and the activity of lysosome hydrolytic enzymes involved in glycolipid metabolism between atherothrombotic infarction and cardiogenic embolism whose pathogenic mechanism is remarkably different, but could not demonstrate the involvement of these factors in the pathogenesis. The expression of inflammatory molecules and glycolipid metabolism were influenced by the clinical background of each case, such as the time after onset, underlying diseases, and the presence of infectious diseases and malignancies. In the future, it will be necessary to further analyze many more cases for which multivariate analysis is possible.

Academic Significance and Societal Importance of the Research Achievements

学術的には炎症と糖脂質代謝という、各々生体におけるきわめて普遍的なプロセス間のクロストークを、脳梗塞発症における動脈硬化の機序からできるだけ広範に捉えることで、さらに虚血性心疾患や種々の血管炎症候群などへの展開を意図したが、成果が得られなかった。社会的意義としては、血中の糖脂質と関連分子の発現パターンの解析や、ライソゾーム水解酵素活性測定など、血液検査のみで簡便に脳梗塞の病型診断を行い、早期治療・再発予防の精度向上や、急性期における積極的な免疫療法や糖脂質を利用した新たな治療法の開発につながることを目指した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Altered regulation of serum lysosomal acid hydrolase activities in Parkinson's disease: A potential peripheral biomarker?2019

    • Author(s)
      Niimi Yoshiki、Ito Shinji、Mizutani Yasuaki、Murate Kenichiro、Shima Sayuri、Ueda Akihiro、Satake Wataru、Hattori Nobutaka、Toda Tatsushi、Mutoh Tatsuro
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 61 Pages: 132-137

    • DOI

      10.1016/j.parkreldis.2018.10.032

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in Serial D-Dimer Levels Predict the Prognoses of Trousseau's Syndrome Patients2018

    • Author(s)
      Ito Shinji、Kikuchi Koichi、Ueda Akihiro、Nagao Ryunosuke、Maeda Toshiki、Murate Kenichiro、Shima Sayuri、Mizutani Yasuaki、Niimi Yoshiki、Mutoh Tatsuro
    • Journal Title

      Frontiers in Neurology

      Volume: 9 Pages: 1083-1083

    • DOI

      10.3389/fneur.2018.00528

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Altered regulation of serum lysosomal hydrolase activity in Parkinson's disease.2018

    • Author(s)
      Yoshiki Niimi, Toshiki Maeda, Kouichi Kikuchi, Ryunosuke Nagao, Kenichiro Murate, Seiko Hirota, Chika Hikichi, Tomomasa Ishikawa, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Shinji Ito, Wataru Satake, Nobutaka Hattori, Tatsushi Toda and Tatsuro Mutoh.
    • Organizer
      第59回日本神経学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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