An attempt to predict prognosis of psychotic disorders by a combination of biomarkers

• Project/Area Number: 18K07550
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: University of Toyama
• Principal Investigator: Takahashi Tsutomu 富山大学, 学術研究部医学系, 准教授 (60345577)
• Co-Investigator(Kenkyū-buntansha): 樋口 悠子 富山大学, 学術研究部医学系, 講師 (60401840) ; 笹林 大樹 富山大学, 学術研究部医学系, 助教 (80801414)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 統合失調症 / 精神病発症危険状態 / 磁気共鳴画像 / 嗅覚機能 / 事象関連電位

Outline of Final Research Achievements

The later onset of psychotic disorders in individuals at clinical high-risk state and the later clinical course of first-episode schizophrenia patients could be predicted with a certain degree of accuracy by biomarkers obtained by magnetic resonance imaging and event-related potentials, and a combination of findings was particularly useful in improving the prediction accuracy.

Academic Significance and Societal Importance of the Research Achievements

精神疾患に対する早期介入の臨床的有用性が広く認識されつつあるが、精神科早期介入における客観的検査所見の役割はわかっていない。今回の研究により、脳画像検査や脳波検査が精神疾患の経過予測に有用である可能性が示された。

Research Products

• [Int'l Joint Research] University of Melbourne(オーストラリア)
• [Int'l Joint Research] Johns Hopkins University(米国)
• [Int'l Joint Research] Johns Hopkins University(米国)
• [Int'l Joint Research] University of Melbourne/Monash University/University of Sydney(オーストラリア)
• [Int'l Joint Research] University of Melbourne(オーストラリア)
• [Journal Article] Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders (2022)
  • Author(s): Takahashi Tsutomu、Wood Stephen J.、Yung Alison R.、Nelson Barnaby、Lin Ashleigh、Yuen Hok Pan、Phillips Lisa J.、Suzuki Michio、McGorry Patrick D.、Velakoulis Dennis、Pantelis Christos
  • Journal Title: Schizophrenia Research Volume: 244 Pages: 1-7
  • DOI: 10.1016/j.schres.2022.04.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Different Heschl’s Gyrus Duplication Patterns in Deficit and Non-deficit Subtypes of Schizophrenia (2022)
  • Author(s): Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Furuichi Atsushi、Kobayashi Haruko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 867461-867461
  • DOI: 10.3389/fpsyt.2022.867461
  • Peer Reviewed / Open Access
• [Journal Article] Gross anatomical features of the insular cortex in schizophrenia and schizotypal personality disorder: Potential relationships with vulnerability, illness stages, and clinical subtypes (2022)
  • Author(s): Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Furuichi Atsushi、Kobayashi Haruko、Yuasa Yusuke、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 1050712-1050712
  • DOI: 10.3389/fpsyt.2022.1050712
  • Peer Reviewed / Open Access
• [Journal Article] Volume reduction of the dorsal lateral prefrontal cortex prior to the onset of frank psychosis in individuals with an at-risk mental state. (2022)
  • Author(s): Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Ohmuro N, Katsura M, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M
  • Journal Title: Cerebral Cortex Volume: in press Issue: 10 Pages: 2245-2253
  • DOI: 10.1093/cercor/bhab353
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Increased brain gyrification and subsequent relapse in patients with first-episode schizophrenia (2022)
  • Author(s): Sasabayashi Daiki、Takayanagi Yoichiro、Takahashi Tsutomu、Furuichi Atsushi、Kobayashi Haruko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 937605-937605
  • DOI: 10.3389/fpsyt.2022.937605
  • Peer Reviewed / Open Access
• [Journal Article] Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 1 Pages: 40-40
  • DOI: 10.3390/jpm11010040
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Altered Heschl’s gyrus duplication pattern in first-episode schizophrenia. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Schizophrenia Research Volume: 237 Pages: 174-181
  • DOI: 10.1016/j.schres.2021.09.011
  • Peer Reviewed
• [Journal Article] Potential contribution of pineal atropy and pineal cysts toward vulnerability and clinical characteristics of psychosis. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: NeuroImage: Clinical Volume: 32 Pages: 102805-102805
  • DOI: 10.1016/j.nicl.2021.102805
  • Peer Reviewed / Open Access
• [Journal Article] Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration (2021)
  • Author(s): Sasabayashi D, Takahashi T, Takayanagi Y, Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Issue: 1 Pages: 176-176
  • DOI: 10.1038/s41398-021-01297-8
  • Peer Reviewed / Open Access
• [Journal Article] Reduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor 1-year functional outcomes (2021)
  • Author(s): Sasabayashi D, Takayanagi Y、Takahashi T、Nishiyama S、Mizukami Y、Katagiri N、Tsujino N、Nemoto T、Sakuma A、Katsura M、Ohmuro N、Okada N、Tada M、Suga M、Maikusa N、Koike S、Furuichi A、Kido M、Noguchi K、Yamasue H、Matsumoto K、Mizuno M、Kasai K、Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Issue: 1 Pages: 396-396
  • DOI: 10.1038/s41398-021-01516-2
  • Peer Reviewed / Open Access
• [Journal Article] Reduced Hippocampal Subfield Volume in Schizophrenia and Clinical High-Risk State for Psychosis (2021)
  • Author(s): Sasabayashi D, Yoshimura R, Takahashi T, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Nakamura M, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 642048-642048
  • DOI: 10.3389/fpsyt.2021.642048
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal changes in brain gyrification in schizophrenia spectrum disorders. (2021)
  • Author(s): Pham TV, Sasabayashi D, Takahashi T, Takayanagi Y, Kubota M, Furuichi A, Kido M, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Aging Neuroscience Volume: 13 Pages: 752575-752575
  • DOI: 10.3389/fnagi.2021.752575
  • Peer Reviewed / Open Access
• [Journal Article] Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia. (2021)
  • Author(s): Higuchi Y, Sumiyoshi T, Tateno T, Nakajima S, Sasabayashi D, Nishiyama S, Mizukami Y, Takahashi T, Suzuki M
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 5 Pages: 327-327
  • DOI: 10.3390/jpm11050327
  • Peer Reviewed / Open Access
• [Journal Article] Duration mismatch negativity predicts remission in first-episode schizophrenia patients. (2021)
  • Author(s): Nakajima S, Higuchi Y, Tateno T, Sasabayashi D, Mizukami Y, Nishiyama S, Takahashi T, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 777378-777378
  • DOI: 10.3389/fpsyt.2021.777378
  • Peer Reviewed / Open Access
• [Journal Article] Heschl's gyrus duplication pattern in individuals at risk of developing psychosis and patients with schizophrenia. (2020)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Nishiyama S, Furuichi A, Kido M, Pham T, Kobayashi H, Noguchi K, Suzuki M.
  • Journal Title: Front Behav Neurosci. Volume: 15 Pages: 647069-647069
  • DOI: 10.3389/fnbeh.2021.647069
  • Peer Reviewed / Open Access
• [Journal Article] Features of Duration Mismatch Negativity Around the Onset of Overt Psychotic Disorders: A Longitudinal Study (2020)
  • Author(s): Tateno T, Higuchi Y, Nakajima S, Sasabayashi D, Nakamura M, Ueno M, Mizukami Y, Nishiyama S, Takahashi T, Sumiyoshi T, Suzuki M
  • Journal Title: Cerebral Cortex Volume: 31 Issue: 5 Pages: 2416-2424
  • DOI: 10.1093/cercor/bhaa364
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pineal Gland Volume in Major Depressive and Bipolar Disorders (2020)
  • Author(s): Takahashi Tsutomu、Sasabayashi Daiki、Yucel Murat、Whittle Sarah、Lorenzetti Valentina、Walterfang Mark、Suzuki Michio、Pantelis Christos、Malhi Gin S.、Allen Nicholas B.
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 450-450
  • DOI: 10.3389/fpsyt.2020.00450
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gray Matter Changes in the Insular Cortex During the Course of the Schizophrenia Spectrum (2020)
  • Author(s): Takahashi Tsutomu、Kido Mikio、Sasabayashi Daiki、Nakamura Mihoko、Furuichi Atsushi、Takayanagi Yoichiro、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 659-659
  • DOI: 10.3389/fpsyt.2020.00659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State (2020)
  • Author(s): Sasabayashi Daiki、Takayanagi Yoichiro、Takahashi Tsutomu、Katagiri Naoyuki、Sakuma Atsushi、Obara Chika、Katsura Masahiro、Okada Naohiro、Koike Shinsuke、Yamasue Hidenori、Nakamura Mihoko、Furuichi Atsushi、Kido Mikio、Nishikawa Yumiko、Noguchi Kyo、Matsumoto Kazunori、Mizuno Masafumi、Kasai Kiyoto、Suzuki Michio
  • Journal Title: Schizophrenia Bulletin Volume: - Issue: 4 Pages: 547-553
  • DOI: 10.1093/schbul/sbaa011
  • Peer Reviewed / Open Access
• [Journal Article] Structural MRI Study of the Planum Temporale in Individuals With an At-Risk Mental State Using Labeled Cortical Distance Mapping (2020)
  • Author(s): Takayanagi Yoichiro、Kulason Sue、Sasabayashi Daiki、Takahashi Tsutomu、Katagiri Naoyuki、Sakuma Atsushi、Ohmuro Noriyuki、Katsura Masahiro、Nishiyama Shimako、Nakamura Mihoko、Kido Mikio、Furuichi Atsushi、Noguchi Kyo、Matsumoto Kazunori、Mizuno Masafumi、Ratnanather J. Tilak、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 593952-593952
  • DOI: 10.3389/fpsyt.2020.593952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study. (2020)
  • Author(s): Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 74(1) Issue: 1 Pages: 56-63
  • DOI: 10.1111/pcn.12934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites (2020)
  • Author(s): Yamamoto Maeri、Bagarinao Epifanio、Kushima Itaru、Takahashi Tsutomu、Sasabayashi Daiki、Inada Toshiya、Suzuki Michio、Iidaka Tetsuya、Ozaki Norio
  • Journal Title: PLOS ONE Volume: 15 Issue: 11 Pages: 0239615-0239615
  • DOI: 10.1371/journal.pone.0239615
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between olfactory sulcus morphology and olfactory functioning in schizophrenia and psychosis high-risk status. (2019)
  • Author(s): Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Furuichi A, Kido M, Mizukami Y, Nishiyama S, Higuchi Y, Tateno T, Itoh H, Noguchi K, Masaoka Y, Suzuki M.
  • Journal Title: Heliyon Volume: 5 Issue: 10 Pages: e02642-e02642
  • DOI: 10.1016/j.heliyon.2019.e02642
  • Peer Reviewed / Open Access
• [Journal Article] Olfactory sulcus morphology in teenagers with first-presentation borderline personality disorder (2019)
  • Author(s): Takahashi Tsutomu、Nishikawa Yumiko、Velakoulis Dennis、Suzuki Michio、McGorry Patrick D.、Pantelis Christos、Chanen Andrew M.
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 292 Pages: 1-4
  • DOI: 10.1016/j.pscychresns.2019.08.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Potential role of orbitofrontal surface morphology on social and cognitive functions in high-risk subjects for psychosis and schizophrenia patients (2019)
  • Author(s): Takahashi Tsutomu、Nakamura Mihoko、Nishikawa Yumiko、Komori Yuko、Nishiyama Shimako、Takayanagi Yoichiro、Furuichi Atsushi、Kido Mikio、Sasabayashi Daiki、Higuchi Yuko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 283 Pages: 92-95
  • DOI: 10.1016/j.pscychresns.2018.12.002
  • Peer Reviewed
• [Journal Article] Reduced pineal gland volume across the stages of schizophrenia. (2018)
  • Author(s): Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Furuichi A, Kido M, Noguchi K, Suzuki M.
  • Journal Title: Schizophrenia Research Volume: in press Pages: 163-170
  • DOI: 10.1016/j.schres.2018.11.032
  • Peer Reviewed
• [Journal Article] Pituitary Volume and Socio-Cognitive Functions in Individuals at Risk of Psychosis and Patients With Schizophrenia (2018)
  • Author(s): Takahashi Tsutomu、Higuchi Yuko、Komori Yuko、Nishiyama Shimako、Takayanagi Yoichiro、Sasabayashi Daiki、Kido Mikio、Furuichi Atsushi、Nishikawa Yumiko、Nakamura Mihoko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 9 Pages: 1-9
  • DOI: 10.3389/fpsyt.2018.00574
  • Peer Reviewed / Open Access
• [Presentation] 初回エピソード統合失調症における島回の粗大形態特徴 (2023)
  • Author(s): 高橋 努, 笹林大樹, 高柳陽一郎, 古市厚志, 小林春子, 湯浅悠介, 野口 京, 鈴木道雄
  • Organizer: 第17回日本統合失調症学会
• [Presentation] 複数のモダリティを用いた精神病性障害の発症予測に関する研究 (2023)
  • Author(s): 高柳陽一郎, 笹林大樹, 高橋 努, 樋口悠子, 西山志満子, 立野貴大, 水上祐子, 古市厚志, 小林春子, 高柳みずほ, 湯浅悠介, 野口 京, 辻井農亜, 鈴木道雄
  • Organizer: 第17回日本統合失調症学会
• [Presentation] 閾値下サイコーシスにおける認知機能 -5年間の縦断的検討 (2023)
  • Author(s): 樋口悠子, 住吉太幹, 西山志満子, 水上祐子, 赤﨑有紀子, 高橋 努, 鈴木道雄
  • Organizer: 第17回日本統合失調症学会
• [Presentation] 統合失調症およびARMSにおける海馬亜領域体積変化の縦断的検討 (2023)
  • Author(s): 笹林大樹, 石井麗華, 高橋 努, 高柳陽一郎, 古市厚志, 小林春子, 湯浅悠介, 野口 京, 鈴木道雄
  • Organizer: 第17回日本統合失調症学会
• [Presentation] 早期サイコーシスにおけるミスマッチ陰性電位の特徴とアウトカムの検討. シンポジウム「統合失調症におけるミスマッチ陰性電位（MMN）」 (2022)
  • Author(s): 樋口悠子, 立野貴大, 中島 英, 水上祐子, 赤﨑有紀子, 住吉太幹, 高橋 努, 鈴木道雄
  • Organizer: 第118回日本精神神経学会学術総会
  • Invited
• [Presentation] 早期精神病の脳形態特徴と臨床応用への課題. シンポジウム「脳画像研究により精神疾患はどこまでわかったか、そして今何をやるべきなのか」 (2022)
  • Author(s): 高橋 努
  • Organizer: BPCNPNPPP4学会合同年会
  • Invited
• [Presentation] The role of neurophysiological findings as bionarkers for psychotic disporders. In Symposium "Use of electrophysiological methods in management of psychotic states" (2021)
  • Author(s): Higuchi Y, Sumiyoshi Y, Tateno T, Nakajima S, Nishiyama S, Takahashi T, Suzuki M
  • Organizer: 21st WPA World Congress of Psychitry
  • Int'l Joint Research / Invited
• [Presentation] Gray matter changes in the insular cortex during the course of schizophrenia spectrum (2021)
  • Author(s): Takahahsi T, Kido M, Sasabayashi D, Nakamura M, Furuichi A, Takayanagi Y, Noguchi K, Suzuki M
  • Organizer: 20th WPA World Congress of Psychiatry
  • Int'l Joint Research
• [Presentation] Altered Heschl’s gyrus duplication pattern in first-episode schizophrenia (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Organizer: 2021 Congress of the Schizophrenia Internatinal Research Society
  • Int'l Joint Research
• [Presentation] 精神病発症危険状態における脳形態変化. シンポジウム「統合失調症の脳画像研究最新知見 －病態解明および臨床応用に向けて－」 (2021)
  • Author(s): 高橋 努
  • Organizer: 第15回日本統合失調症学会
  • Invited
• [Presentation] 早期精神病における脳形態変化―臨床応用に向けた展望と課題―. シンポジウム「早期介入の港をより深くしていくために～早期精神病における各種生物学的指標の立場からのクロストーク～」 (2021)
  • Author(s): 高橋 努
  • Organizer: 第24回日本精神保健・予防学会
  • Invited
• [Presentation] 統合失調症圏における島回体積の縦断変化 (2020)
  • Author(s): 高橋 努, 木戸幹雄, 笹林大樹, 中村美保子, 古市厚志, 高柳陽一郎, 野口 京, 鈴木道雄
  • Organizer: 第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第４回日本精神薬学会総会・学術集会（NPBPPP2020）合同年会
• [Presentation] 早期精神病研究におけるMMNの役割. シンポジウム「Mismatch negativity (MMN): 統合失調症バイオマーカー」 (2020)
  • Author(s): 樋口悠子, 高橋 努, 立野貴大, 中島 英, 水上祐子, 西山志満子, 住吉太幹, 鈴木道雄
  • Organizer: 第116回日本精神神経学会
  • Invited
• [Presentation] 精神病性障害におけるバイオマーカーとしてのミスマッチ陰性電位の役割. シンポジウム「ミスマッチ陰性電位の精神科臨床応用」 (2020)
  • Author(s): 樋口悠子, 立野貴大, 中島 英, 水上祐子, 西山志満子, 高橋 努, 住吉太幹, 鈴木道雄
  • Organizer: 第50回日本臨床神経生理学会
• [Presentation] 統合失調症はいつから診断できるのか：バイオマーカーから (2019)
  • Author(s): 高橋 努, 樋口悠子, 鈴木道雄
  • Organizer: 第39回日本診断学会
  • Invited
• [Presentation] 統合失調症および精神病発症リスク状態における嗅覚機能 (2019)
  • Author(s): 樋口悠子, 高橋 努, 笹林大樹, 中村美保子, 立野貴大, 鈴木道雄
  • Organizer: 第49回日本臨床神経生理学会
  • Invited
• [Presentation] 統合失調症および精神病発症リスク状態に対するミスマッチ陰性電位の臨床的有用性 (2019)
  • Author(s): 樋口悠子, 住吉太幹, 西山志満子, 立野貴大, 中島 英, 高橋 努, 鈴木道雄
  • Organizer: 第49回日本臨床神経生理学会
  • Invited
• [Presentation] At-risk mental stateおよび統合失調症における眼窩前頭皮質の脳溝数減少と社会-認知機能の関連 (2019)
  • Author(s): 高橋 努, 中村美保子, 西川祐美子, 小森祐子, 西山志満子, 高柳陽一郎, 古市厚志, 木戸幹雄, 笹林大樹, 樋口悠子, 野口京, 鈴木道雄
  • Organizer: 第14回日本統合失調症学会
• [Presentation] At-risk mental stateにおける脳梁体積の減少: 多施設共同研究 (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋 努, 片桐直之, 佐久間 篤, 小原千佳, 小池進介,中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口 京, 山末英典, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄
  • Organizer: 第14回日本統合失調症学会
• [Presentation] Labeled cortical distance mappingを用いたARMS群における側頭平面の形態研究 (2019)
  • Author(s): 高柳陽一郎, Sue Kulason, 笹林大樹, 高橋 努, 古市厚志, 木戸幹雄, 西川祐美子, 中村美保子, 片桐直之, 佐久間 篤, 小原千佳, 野口 京, Tilak Ratnanather, 鈴木道雄
  • Organizer: 第14回日本統合失調症学会
• [Presentation] At-risk mental stateおよび統合失調症における嗅覚機能障害 (2019)
  • Author(s): 高橋 努, 中村美保子, 笹林大樹, 小森祐子, 樋口悠子, 西川祐美子, 西山志満子, 伊藤博子, 政岡 ゆり, 鈴木道雄
  • Organizer: 第115回日本精神神経学会
• [Presentation] At-risk mental stateおよび統合失調症における眼窩前頭皮質の脳溝脳回パターンと社会-認知機能の関連 (2019)
  • Author(s): 高橋 努, 中村美保子, 西川祐美子, 小森祐子, 西山志満子, 高柳陽一郎, 古市厚志, 木戸幹雄, 笹林大樹, 樋口悠子, 野口京, 鈴木道雄
  • Organizer: 第115回日本精神神経学会
• [Presentation] At-risk mental stateおよび統合失調症における透明中隔腔と臨床特徴の関連 (2019)
  • Author(s): 高橋 努, 中村美保子, 西川祐美子, 小森祐子, 西山志満子, 高柳陽一郎, 古市厚志, 木戸幹雄, 笹林大樹, 樋口悠子, 野口京, 鈴木道雄
  • Organizer: 第115回日本精神神経学会
• [Presentation] 精神病発症危険状態における脳回形成の偏倚-多施設共同研究- (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋 努, 小池進介, 山末英典, 片桐直之, 佐久間 篤, 小原千佳,中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口 京, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄
  • Organizer: 第115回日本精神神経学会
• [Presentation] At-risk mental state および統合失調症における嗅溝形態と嗅覚機能の関連 (2019)
  • Author(s): 高橋 努, 中村美保子, 笹林大樹, 高柳陽一郎, 古市厚志, 木戸幹雄, 西川祐美子, 小森祐子, 西山志満子, 樋口悠子, 立野貴大, 伊藤博子, 野口京, 鈴木道雄
  • Organizer: 第41回日本生物学的精神医学会
• [Presentation] 統合失調症発症前後でdMMNの低下と灰白質減少がみられた一例 (2019)
  • Author(s): 立野貴大, 樋口悠子, 笹林大樹, 高橋 努, 鈴木道雄
  • Organizer: 第49回日本臨床神経生理学会
• [Presentation] At risk mental stateにおける大脳皮質厚の変化と認知機能障害との関連 (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋 努, 西山志満子, 水上祐子, 片桐直之, 辻野尚久, 根本隆洋, 佐久間篤, 桂雅宏, 大室則幸, 岡田直大, 多田真理子, 管心, 小池進介, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口 京, 山末英典, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄
  • Organizer: 第23回日本精神保健・予防学会学
• [Presentation] MMN as Electrophysiological markers of transition to psychosis (2018)
  • Author(s): Higuchi Y, Sumiyoshi Y, Nishiyama S, Takahashi T, Suzuki M
  • Organizer: WFSBP Asia Pacific Regional Congress of Biological Psychiatry
  • Int'l Joint Research / Invited
• [Presentation] Olfactory deficits in individuals at risk for psychosis and patients with schizophrenia: Relationship with social and cognitive functions and symptom severity (2018)
  • Author(s): Takahashi T, Nakamura M, Sasabayashi D, Komori Y, Higuchi Y, Nishikawa Y, Nishiyama S, Itoh H, Masaoka Y, Suzuki M
  • Organizer: IEPA 11 Early Intervention in Mental Health
  • Int'l Joint Research
• [Presentation] ARMSおよび統合失調症における下垂体体積と社会-認知機能の関連 (2018)
  • Author(s): 高橋 努, 樋口悠子, 小森祐子, 西山志満子, 高柳陽一郎, 笹林大樹, 木戸幹雄, 古市厚志, 西川祐美子, 中村美保子, 野口 京, 鈴木道雄
  • Organizer: 第22回日本精神保健・予防学会
• [Presentation] ARMS群における大脳皮質厚の変化と機能的転帰との関連 (2018)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋 努, 小森祐子, 片桐直之, 佐久間 篤, 小原千佳, 小池進介, 山末英典, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口 京, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄
  • Organizer: 第22回日本精神保健・予防学会