| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We immunohistochemically examined the frontal cortex, caudate nucleus, putamen, and amygdala in 105 cases including argyrophilic grain disease cases (AGD, N=26), progressive supranuclear palsy (PSP, N=10), Alzheimer's disease (AD, N=20), primary age-related tauopathy cases (PART, N=18) to clarify the distribution patterns of GFAs and the impacts of major pathological factors and age on GFA formation. Amygdala-predominant distribution of GFA was found in AGD and PART cases, frontal and striatum-predominant pattern was found in PSP, and striatum-predominant pattern was noted in AD cases. Ordered logistic regression analyses using all cases demonstrated that the strongest independent factor of GFA formation in the frontal cortex and striatum was the diagnosis of PSP, while that in the amygdala was AGD. Given these findings, AGD, PSP, AD, and PART cases may show distinct distributions of GFAs, which may provide clues to predict the underlying processes of primary tauopathies.
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