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Integrated research on dementia in older people with intellectual disability

Research Project

Project/Area Number 18K07560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionOkayama University

Principal Investigator

Terada Seishi  岡山大学, 医歯薬学総合研究科, 准教授 (20332794)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords知的障害 / 認知症 / 高齢者 / 疫学 / スクリーニング
Outline of Final Research Achievements

The survey included 493 adults with ID at 28 facilities in Japan. Dementia was diagnosed according to ICD-10, DC-LD, and DSM-5 criteria. The prevalence of dementia was 0.8% for the 45 to 54 years old group, 3.5% for the 55 to 64 years old group, and 13.9% for the 65 to 74 years old group in people with ID without DS. DSM-5 was the most inclusive in diagnosing dementia and MCI in people with ID.
People with ID without DS may develop dementia and MCI at an earlier age and higher rate than the general population.
We also verified the screening accuracy of the DSQIID (Dementia Screening Questionnaire for Individuals with Intellectual Disabilities) for Japanese people with ID. The suitable cut‐off score of the DSQIID‐J was 10/11 (sensitivity 100% and specificity 96.8%) for screening dementia. Regarding key items, the best two‐item combination was the pair of ‘Cannot dress without help’ and ‘Walks slower’ (sensitivity 100% and specificity 93.5%).

Academic Significance and Societal Importance of the Research Achievements

本研究は、ダウン症以外の知的障害者における認知症有病率を本邦で初めて明らかにした。ダウン症以外の知的障害者でも、一般集団より認知症有病率が高い傾向を示しており、今後の調査により、その理由あるいは原因を探ることが重要である。また、知的障害者での認知症診断には、DSM-5が最も有用であることを初めて明らかにした。これは、実際の診療現場において非常に有益な情報である。
さらに、知的障害者における認知症スクリーニングに役立つ具体的な項目を初めて明らかにした。高齢者が激増している知的障害者福祉施設において、より早期に認知症を疑い、適切な治療や療養環境に結びつけることが可能となる成果である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2021 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Validation of the Japanese Version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID).2020

    • Author(s)
      Takenoshita S, Terada S, Kuwano R, Inoue T, Thoju A, Suemitsu S, Yamada N.
    • Journal Title

      J Intellect Disabil Res.

      Volume: 64 Issue: 12 Pages: 970-979

    • DOI

      10.1111/jir.12788

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of dementia in people with intellectual disabilities: cross-sectional study2020

    • Author(s)
      Takenoshita S, Terada S, Kuwano R, Inoue T, Cyoju A, Suemitsu S
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 35 Issue: 4 Pages: 414-422

    • DOI

      10.1002/gps.5258

    • NAID

      120006951269

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 知的障害者における認知症の疫学研究2021

    • Author(s)
      竹之下慎太郎,寺田整司,桑野良三,井上友和,長壽厚志,末光茂,山田了士.
    • Organizer
      第46回 岡山脳研究セミナー
    • Related Report
      2020 Annual Research Report
  • [Presentation] 知的障害者における認知症の疫学研究,全国調査2020

    • Author(s)
      竹之下慎太郎,寺田整司,桑野良三,井上友和,黒住卓,末光茂,林聡,三木知子,横田修,山田了士.
    • Organizer
      第39回 日本認知症学会 学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 知的障害者における認知症のスクリーニング方法(Dementia Screening Questionnaire for Individuals with Intellectual Disabilities:DSQIID)の検討2020

    • Author(s)
      竹之下慎太郎,寺田整司,桑野良三,井上友和,長壽厚志,末光茂,林聡,三木知子,横田修,山田了士.
    • Organizer
      第35回 日本老年精神医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 全国の知的障害者入所施設における認知症の実態調査2020

    • Author(s)
      竹之下慎太郎,桑野良三,井上友和,黒住卓,寺田整司,山田了士,末光茂.
    • Organizer
      第55回日本発達障害学会研究大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 知的障害者の認知症に出現しやすい症状~全国の知的障害者入所施設における認知症の実態調査より~2020

    • Author(s)
      井上友和,桑野良三,黒住卓,寺田整司,竹之下慎太郎,山田了士,末光茂.
    • Organizer
      第55回日本発達障害学会研究大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Screening for dementia in adults with Down syndrome2019

    • Author(s)
      Kuwano R, Terada S, Takenoshita S, Inoue T, Choju A, Suemitsu S
    • Organizer
      IASSIDD 2019 (World Congress of the International Association for Scientific Study of Intellectual and Developmental Disability)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 知的障害者施設における認知症の有病率調査2019

    • Author(s)
      竹之下慎太郎,寺田整司,桑野良三,井上友和,長壽厚志,末光茂,林聡,三木知子,横田修,山田了士
    • Organizer
      第34回 日本老年精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 知的障害者における認知症の疫学研究,スクリーニング検査の作成2019

    • Author(s)
      竹之下慎太郎,寺田整司,桑野良三,井上友和,長壽厚志,末光茂,林聡,河野 禎子,住友佳代,三木知子,横田修,山田了士
    • Organizer
      第38回 日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Prevalence of dementia in people with Intellectual disabilities in Japan2019

    • Author(s)
      Takenoshita S, Terada S, Kuwano R, Inoue T, Cyoju A, Suemitsu S
    • Organizer
      14th Annual Meeting of Taiwanese Society of Geriatric Psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prevalence of dementia in old person with Down syndrome and other intellectual disability2018

    • Author(s)
      Kuwano R, Terada S, Takenoshita S, Inoue T, Choju A, Suemitsu S
    • Organizer
      5th IASSIDD Europe Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 岡山県の知的障害者施設における認知症の有病率調査2018

    • Author(s)
      竹之下慎太郎,寺田整司
    • Organizer
      第53回 日本発達障害学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 知的障害者における認知症の有病率2018

    • Author(s)
      竹之下慎太郎,寺田整司,桑野良三,井上友和,長壽厚志,末光茂,林聡,三木知子,横田修,山田了士
    • Organizer
      第37回 日本認知症学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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