| Project/Area Number |
18K07562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | PTSDの発症機序 / PTSDの予防法 / PTSDの新規治療法 / PTSDの異常な神経回路 / PTSD / グルココルチコイド / 神経活動操作 |
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| Outline of Final Research Achievements |
Although the relationship between PTSD and corticosteroids is widely recognized, the present study is the first study indicated that activation of hippocampal glucocorticoid receptor (GR) in response to severe stress triggers the pathophysiological cascade that leads to impaired fear extinction, and the inhibition of hippocampal GR immediately after stress could be useful for preventing the development of PTSD.
In addition, neuromodulation approaches such as deep brain stimulation, may represent a promising treatment option for patients with PTSD who remain symptomatic even after conventional psychotherapy and/or medications, and the combined approach of neuromodulation with exposure-based therapy may lead to better therapeutic responses in PTSD. Our results indicated that neuronal activation with an adjunctive combination of exposure therapy could be useful for treating the impaired fear extinction characteristic of patients with PTSD.
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| Academic Significance and Societal Importance of the Research Achievements |
外傷的ストレスによってストレスホルモンが放出され、PTSDの発症に至る分子生物学的機序の一端を明らかにする一方で、形成されたPTSDの神経回路異常を神経活動操作によって修正する方法を提唱するなど、基礎神経科学、臨床精神医学の双方の発展に寄与する重要な知見が得られたと考えられる。
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