Blood biomarker for differentiating geriatric depression from Alzheimer's disease
Project/Area Number |
18K07564
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52030:Psychiatry-related
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Research Institution | Ehime University |
Principal Investigator |
Iga Junichi 愛媛大学, 医学系研究科, 准教授 (70363140)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | うつ病 / 高齢者 / アルツハイマー型認知症 / レビー小体型認知症 / パーキンソン病 / バイオマーカー / 血液 / 遺伝子発現 / 老年期うつ病 / 統合失調症 / 認知症 / 鑑別 |
Outline of Final Research Achievements |
To search for blood biomarkers to differentiate between geriatric depression (GD) and Alzheimer's disease (AD), we analyzed human blood, hippocampus and blood of AD model mice. We identified altered gene expression of MEF2C, Ghrelin, and PICALM in the blood of AD patients. On the other hand, PICALM was not altered in GD, which may be a useful marker for differentiation. In the microarray study using model mice, the human blood biomarkers that we have identified were also confirmed in mouse blood. We found that CDKN2A, which is involved in cellular senescence, was significantly altered in both blood and hippocampal tissues, and CDKN2A was also not altered in GD, which may be useful for differentiating AD from GD (submitted).
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Academic Significance and Societal Importance of the Research Achievements |
老年期うつ病とアルツハイマー型認知症は治療法も予後も異なる鑑別すべき疾患であるが、実臨床においては症状から鑑別は困難であり、早期に適切な治療が行えないことが多い。またGDからADに移行する症例も多く、両疾患の鑑別に役立つバイオマーカーの確立が望まれている。本研究からヒト血液の遺伝子発現やDNAメチル化率が各疾患の診断および鑑別のマーカーになりうることを証明した。モデルマウスの結果からは免疫や炎症に関わる遺伝子がマーカーとして特に有望であることが考察された。今後は大規模なサンプルで本研究結果の妥当性を検討する必要がある。
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Prescription patterns in patients with schizophrenia in Japan: First-quality indicator data from the survey of "Effectiveness of Guidelines for Dissemination and Education in psychiatric treatment (EGUIDE)" project2020
Author(s)
Ichihashi K, Hori H, Hasegawa N, Yasuda Y, Yamamoto T, Tsuboi T, Iwamoto K, Kishimoto T, Horai T, Yamada H, Sugiyama N, Nakamura T, Tsujino N, Nemoto K, Oishi S, Usami M, Katsumoto E, Yamamori H, Tomita H, Suwa T, Furihata R, Inagaki T, Fujita J, Onitsuka T, Miura K, Matsumoto J, Ohi K, Matsui Y, Takaesu Y, et al.
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Journal Title
Neuropsychopharmacol Rep.
Volume: 40
Issue: 3
Pages: 281-286
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 高齢者の薬物動態と治療反応性2020
Author(s)
伊賀 淳一 , 熊ノ郷 頼之 , 辻川 真緒 , 岡山 さくら , 野津 佑真 , 上野 修一
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Journal Title
Depression strategy : うつ病治療の新たなストラテジー
Volume: 10
Pages: 4-6
NAID
Related Report
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