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Cross-sectional and prospective studies of the elucidation of actual status of dementia in a Japanese older residents.

Research Project

Project/Area Number 18K07565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionKyushu University

Principal Investigator

Ohara Tomoyuki  九州大学, 大学病院, 講師 (20623630)

Co-Investigator(Kenkyū-buntansha) 吉田 大悟  九州大学, 医学研究院, 助教 (10596828)
神庭 重信  九州大学, 医学研究院, 教授 (50195187)
二宮 利治  九州大学, 医学研究院, 教授 (30571765)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords認知症 / 有病率 / 横断調査 / 縦断調査 / 危険因子 / 介護保険 / 脳部位 / 孤独感 / 血糖変動 / 海馬萎縮 / NT-proBNP / バイオマーカー / 睡眠時間 / sTREM2 / 認知症発症 / アルツハイマー型認知症 / 軽度認知障害 / 発症率
Outline of Final Research Achievements

In 2017, a total of 2,202 Japanese older residents participated in the dementia survey in a Hisayama town (participation rate: 94.1%). Among these, 346 participants were diagnosed as having dementia (crude prevalence:e 15.7%), and 69.7% of subjects with dementia obtained a certification of long-term care insurance. The cross-sectional study using brain magnetic resonance imaging demonstrated that higher serum glycated albumin and higher glycated albumin/hemoglobin A1c ratio are significantly associated with hippocampal atrophy.
In a prospective study of dementia, increased serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels, higher serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and short and long duration of sleep are significant risk factors for the development of dementia.

Academic Significance and Societal Importance of the Research Achievements

2012年の全国調査以降にわが国の地域高齢住民における認知症の有病率を調査した研究はなく、本研究で得られた認知症の有病率や介護保険の認定状況は今後の認知症施策に貢献するものと考えられる。また、横断調査や縦断調査の成績から認知症の発症には、適切な睡眠時間の確保という生活習慣だけでなく、脳内炎症や心機能の維持が重要であることを明らかにした。これらの知見は認知症の予防法の確立に寄与するだけでなく、ひいては国民の健康寿命の延伸につながるものと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (43 results)

All 2021 2020 2019 2018 Other

All Journal Article (18 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 18 results,  Open Access: 12 results) Presentation (24 results) (of which Int'l Joint Research: 1 results,  Invited: 10 results) Remarks (1 results)

  • [Journal Article] Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: The Hisayama Study2021

    • Author(s)
      Ohara, Tomoyuki; Yoshida, Daigo; Hata, Jun; Shibata, Mao; Honda, Takanori; Furuta, Yoshihiko; Hirabayashi, Naoki; Kitazono, Takanari; Nakao, Tomohiro; Ninomiya, Toshiharu;
    • Journal Title

      Psychiatry and clinical neurosciences

      Volume: - Issue: 5 Pages: 182-182

    • DOI

      10.1111/pcn.13204

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese ― The Hisayama Study ―2020

    • Author(s)
      Yamasaki Keisuke、Hata Jun、Furuta Yoshihiko、Hirabayashi Naoki、Ohara Tomoyuki、Yoshida Daigo、Hirakawa Yoichiro、Nakano Toshiaki、Kitazono Takanari、Ninomiya Toshiharu
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 6 Pages: 935-942

    • DOI

      10.1253/circj.CJ-19-1069

    • NAID

      130007846238

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2020-05-25
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decline in Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study2020

    • Author(s)
      Hatabe Y, Shibata M, Ohara T, Oishi E, Yoshida D, Honda T, Hata J, Kanba S, Kitazono T, Ninomiya T.
    • Journal Title

      Journal of Epidemiology

      Volume: 30 Issue: 1 Pages: 15-23

    • DOI

      10.2188/jea.JE20180137

    • NAID

      130007782493

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2020-01-05
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study2020

    • Author(s)
      Shibata M, Ohara T, Hosoi M, Jun H, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T
    • Journal Title

      The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

      Volume: - Issue: 9 Pages: 1756-1766

    • DOI

      10.1093/geronb/gbaa196

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan2020

    • Author(s)
      Yoshida, Daigo; Ohara, Tomoyuki; Hata, Jun; Shibata, Mao; Hirakawa, Yoichiro; Honda, Takanori; Furuta, Yoshihiko; Oishi, Emi; Sakata, Satoko; Kanba, Shigenobu;
    • Journal Title

      Neurology

      Volume: 95 Issue: 5

    • DOI

      10.1212/wnl.0000000000009917

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia2020

    • Author(s)
      Lee Crystal ManYing、Woodward Mark、Batty G, et al.
    • Journal Title

      Obesity Reviews

      Volume: 21 Issue: 4

    • DOI

      10.1111/obr.12989

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association Between Blood Pressure Variability and Cerebral Small-Vessel Disease: A Systematic Review and Meta-Analysis2020

    • Author(s)
      Tully Phillip J.、Yano Yuichiro、Launer Lenore J, et al.
    • Journal Title

      Journal of the American Heart Association

      Volume: 9 Issue: 1

    • DOI

      10.1161/jaha.119.013841

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Growth Differentiation Factor 15 and NT‐proBNP as Blood‐Based Markers of Vascular Brain Injury and Dementia2020

    • Author(s)
      McGrath Emer R.、Himali Jayandra J.、Levy Daniel、Conner Sarah C.、DeCarli Charles、Pase Matthew P.、Ninomiya Toshiharu、Ohara Tomoyuki、Courchesne Paul、Satizabal Claudia L.、Vasan Ramachandran S.、Beiser Alexa S.、Seshadri Sudha
    • Journal Title

      Journal of the American Heart Association

      Volume: 9 Issue: 19

    • DOI

      10.1161/jaha.119.014659

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elevated serum glycated albumin and glycated albumin to hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study.2020

    • Author(s)
      Ohara Tomoyuki、Furuta Yoshihiko、Hirabayashi Naoki、Hata Jun、Hirakawa Yoichiro、Honda Takanori、Yoshida Daigo、Shibata Mao、Kitazono Takanari、Ninomiya Toshiharu
    • Journal Title

      Journal of Diabetes Investigation

      Volume: - Issue: 4 Pages: 971-979

    • DOI

      10.1111/jdi.13220

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] NT‐proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study2019

    • Author(s)
      Nagata Takuya、Ohara Tomoyuki、Hata Jun、Sakata Satoko、Furuta Yoshihiko、Yoshida Daigo、Honda Takanori、Hirakawa Yoichiro、Ide Tomomi、Kanba Shigenobu、Kitazono Takanari、Tsutsui Hiroyuki、Ninomiya Toshiharu
    • Journal Title

      Journal of the American Heart Association

      Volume: 8 Issue: 17

    • DOI

      10.1161/jaha.118.011652

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between Serum β-Alanine and Risk of Dementia2019

    • Author(s)
      Hata Jun、Ohara Tomoyuki、Katakura Yoshinori、Shimizu Kuniyoshi、Yamashita Shuntaro、Yoshida Daigo、Honda Takanori、Hirakawa Yoichiro、Shibata Mao、Sakata Satoko、Kitazono Takanari、Kuhara Satoru、Ninomiya Toshiharu
    • Journal Title

      American Journal of Epidemiology

      Volume: 188 Issue: 9 Pages: 1637-1645

    • DOI

      10.1093/aje/kwz116

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum elaidic acid concentration and risk of dementia2019

    • Author(s)
      Honda Takanori、Ohara Tomoyuki、Shinohara Masakazu、Hata Jun、Toh Ryuji、Yoshida Daigo、Shibata Mao、Ishida Tatsuro、Hirakawa Yoichiro、Irino Yasuhiro、Sakata Satoko、Uchida Kazuhiro、Kitazono Takanari、Kanba Shigenobu、Hirata Ken-Ichi、Ninomiya Toshiharu
    • Journal Title

      Neurology

      Volume: 93 Issue: 22

    • DOI

      10.1212/wnl.0000000000008464

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study2019

    • Author(s)
      Yoshida Daigo、Ohara Tomoyuki、Hata Jun、Shibata Mao、Hirakawa Yoichiro、Honda Takanori、Uchida Kazuhiro、Takasugi Satoshi、Kitazono Takanari、Kiyohara Yutaka、Ninomiya Toshiharu
    • Journal Title

      The American Journal of Clinical Nutrition

      Volume: 109 Issue: 6 Pages: 1664-1671

    • DOI

      10.1093/ajcn/nqz040

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study2019

    • Author(s)
      Hamasaki Hideomi、Honda Hiroyuki、Suzuki Satoshi O.、Shijo Masahiro、Ohara Tomoyuki、Hatabe Yozo、Okamoto Tsuyoshi、Ninomiya Toshiharu、Iwaki Toru
    • Journal Title

      Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

      Volume: 11 Issue: 1 Pages: 415-423

    • DOI

      10.1016/j.dadm.2019.04.008

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study2018

    • Author(s)
      Ohara Tomoyuki、Hata Jun、Tanaka Masashi、Honda Takanori、Yamakage Hajime、Yoshida Daigo、Inoue Takayuki、Hirakawa Yoichiro、Kusakabe Toru、Shibata Mao、Teraoka Tadashi、Kitazono Takanari、Kanba Shigenobu、Satoh-Asahara Noriko、Ninomiya Toshiharu
    • Journal Title

      Annals of Neurology

      Volume: 85 Issue: 1 Pages: 47-58

    • DOI

      10.1002/ana.25385

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of daily sleep duration with the risk of dementia and mortality in a Japanese community2018

    • Author(s)
      Tomoyuki Ohara, Takanori Honda, Jun Hata, Daigo Yoshida, Naoko Mukai, Yoichiro Hirakawa, Mao Shibata, Hiro Kishimoto, Takanari Kitazono, Shigenobu Kanba, Toshiharu Ninomiya
    • Journal Title

      Journal of the American Geriatrics Society

      Volume: in press Issue: 10 Pages: 1911-1918

    • DOI

      10.1111/jgs.15446

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reply to “Long sleep duration: An epiphenomenon or risk for dementia?”2018

    • Author(s)
      Ohara T, Ninomiya T.
    • Journal Title

      J Am Geriatr Soc

      Volume: 66 Issue: 11 Pages: 2225-2226

    • DOI

      10.1111/jgs.15558

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.2018

    • Author(s)
      Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T.
    • Journal Title

      Hum Genet.

      Volume: 37(6-7) Issue: 6-7 Pages: 521-533

    • DOI

      10.1007/s00439-018-1906-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] アルツハイマー型認知症の血管性危険因子の検討:久山町研究2021

    • Author(s)
      小原知之、二宮利治
    • Organizer
      第46回日本脳卒中学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 認知症にどう立ち向かうか:久山町研究2020

    • Author(s)
      小原知之、二宮利治
    • Organizer
      第26回日本心臓リハビリテーション学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] WHOの予防ガイドラインについて2020

    • Author(s)
      小原知之
    • Organizer
      第62回日本老年医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 久山町研究の知見からみた認知症予防の可能性2020

    • Author(s)
      小原知之、二宮利治
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 安全性を重視した不眠症の治療戦略-高齢者の不眠を中心に-2020

    • Author(s)
      小原知之
    • Organizer
      第41回日本臨床薬理学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] WHOガイドライン「認知機能低下および認知症のリスク軽減」について2020

    • Author(s)
      小原知之
    • Organizer
      第35回日本老年精神医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 認知症コホート研究から (1) : 久山町研究2019

    • Author(s)
      小原 知之, 二宮 利治
    • Organizer
      第116回日本内科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 血清sTREM2と認知症発症の関係:久山町研究2019

    • Author(s)
      小原 知之, 二宮 利治
    • Organizer
      第34回日本老年精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 地域高齢住民における認知症の実態とその危険因子:久山町研究2019

    • Author(s)
      小原 知之, 二宮 利治
    • Organizer
      第9回認知症予防学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 疫学の視点からみた睡眠障害と認知症発症2019

    • Author(s)
      小原 知之
    • Organizer
      第38回日本認知症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 久山町研究からみたアルツハイマー型認知症の血管性危険因子2019

    • Author(s)
      小原 知之, 二宮 利治
    • Organizer
      第38回日本認知症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 久山町における認知症コホート研究2019

    • Author(s)
      小原 知之, 二宮 利治
    • Organizer
      第38回日本認知症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 血清sTREM2と認知症発症:久山町研究2019

    • Author(s)
      小原 知之, 二宮 利治
    • Organizer
      第26回日本未病システム学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 生活習慣病や生活習慣との関連:久山町研究2018

    • Author(s)
      小原知之,二宮利治
    • Organizer
      第114回日本精神神経学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Serum soluble TREM2 and risk of dementia: the Hisayama Study.2018

    • Author(s)
      Tomoyuki Ohara, Sigenobu kanba, Masashi Tanaka, Hajime Yamakage, Toru Iwaki, Takayuki Inoue, Noriko Sato-Asahara, Toshiharu Ninomiya.
    • Organizer
      第40回日本生物学的精神医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 久山町研究から考える血糖変動と認知症の関連2018

    • Author(s)
      小原知之
    • Organizer
      第8回日本認知症予防学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Epidemiology of clinically-diagnosed dementia in a Japanese community: the Hisayama Study2018

    • Author(s)
      Tomoyuki Ohara, Toshiharu Ninomiya
    • Organizer
      The 19th International Congress of Neuropathology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖代謝異常と認知症:久山町研究2018

    • Author(s)
      小原知之,二宮利治
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 認知症の危険因子・防御因子:久山町研究2018

    • Author(s)
      小原知之,二宮利治
    • Organizer
      第37回日本認知症学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 食事と認知症の関係:久山町研究2018

    • Author(s)
      二宮利治
    • Organizer
      第15回日本口腔ケア学会総会・学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 血圧日間変動と認知症発症との関連:久山町研究2018

    • Author(s)
      二宮利治
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 健康寿命延伸に必要な認知症予防対策2018

    • Author(s)
      二宮利治
    • Organizer
      第54回日本循環器病予防学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 地域住民における認知症コホート研究:久山町研究2018

    • Author(s)
      二宮利治
    • Organizer
      第8回日本認知症予防学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 血糖指標とアルツハイマー型認知症:久山町研究の成績より2018

    • Author(s)
      二宮利治
    • Organizer
      第25回日本未病システム学会学術総会
    • Related Report
      2018 Research-status Report
  • [Remarks] 九州大学大学院医学研究院 衛生・公衆衛生学分野

    • URL

      http://www.eph.med.kyushu-u.ac.jp/

    • Related Report
      2020 Annual Research Report 2019 Research-status Report 2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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