Cross-sectional and prospective studies of the elucidation of actual status of dementia in a Japanese older residents.
| Project/Area Number |
18K07565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉田 大悟 九州大学, 医学研究院, 助教 (10596828)
神庭 重信 九州大学, 医学研究院, 教授 (50195187)
二宮 利治 九州大学, 医学研究院, 教授 (30571765)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 認知症 / 有病率 / 横断調査 / 縦断調査 / 危険因子 / 介護保険 / 脳部位 / 孤独感 / 血糖変動 / 海馬萎縮 / NT-proBNP / バイオマーカー / 睡眠時間 / sTREM2 / 認知症発症 / アルツハイマー型認知症 / 軽度認知障害 / 発症率 |
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| Outline of Final Research Achievements |
In 2017, a total of 2,202 Japanese older residents participated in the dementia survey in a Hisayama town (participation rate: 94.1%). Among these, 346 participants were diagnosed as having dementia (crude prevalence:e 15.7%), and 69.7% of subjects with dementia obtained a certification of long-term care insurance. The cross-sectional study using brain magnetic resonance imaging demonstrated that higher serum glycated albumin and higher glycated albumin/hemoglobin A1c ratio are significantly associated with hippocampal atrophy.
In a prospective study of dementia, increased serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels, higher serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and short and long duration of sleep are significant risk factors for the development of dementia.
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| Academic Significance and Societal Importance of the Research Achievements |
2012年の全国調査以降にわが国の地域高齢住民における認知症の有病率を調査した研究はなく、本研究で得られた認知症の有病率や介護保険の認定状況は今後の認知症施策に貢献するものと考えられる。また、横断調査や縦断調査の成績から認知症の発症には、適切な睡眠時間の確保という生活習慣だけでなく、脳内炎症や心機能の維持が重要であることを明らかにした。これらの知見は認知症の予防法の確立に寄与するだけでなく、ひいては国民の健康寿命の延伸につながるものと考えられる。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: The Hisayama Study2021
Author(s)
Ohara, Tomoyuki; Yoshida, Daigo; Hata, Jun; Shibata, Mao; Honda, Takanori; Furuta, Yoshihiko; Hirabayashi, Naoki; Kitazono, Takanari; Nakao, Tomohiro; Ninomiya, Toshiharu;
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Journal Title
Psychiatry and clinical neurosciences
Volume: -
Issue: 5
Pages: 182-182
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decline in Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study2020
Author(s)
Hatabe Y, Shibata M, Ohara T, Oishi E, Yoshida D, Honda T, Hata J, Kanba S, Kitazono T, Ninomiya T.
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Journal Title
Journal of Epidemiology
Volume: 30
Issue: 1
Pages: 15-23
DOI
NAID
ISSN
0917-5040, 1349-9092
Year and Date
2020-01-05
Related Report
Peer Reviewed / Open Access
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[Journal Article] Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study2020
Author(s)
Shibata M, Ohara T, Hosoi M, Jun H, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T
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Journal Title
The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences
Volume: -
Issue: 9
Pages: 1756-1766
DOI
Related Report
Peer Reviewed
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[Journal Article] Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan2020
Author(s)
Yoshida, Daigo; Ohara, Tomoyuki; Hata, Jun; Shibata, Mao; Hirakawa, Yoichiro; Honda, Takanori; Furuta, Yoshihiko; Oishi, Emi; Sakata, Satoko; Kanba, Shigenobu;
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Journal Title
Neurology
Volume: 95
Issue: 5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of daily sleep duration with the risk of dementia and mortality in a Japanese community2018
Author(s)
Tomoyuki Ohara, Takanori Honda, Jun Hata, Daigo Yoshida, Naoko Mukai, Yoichiro Hirakawa, Mao Shibata, Hiro Kishimoto, Takanari Kitazono, Shigenobu Kanba, Toshiharu Ninomiya
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Journal Title
Journal of the American Geriatrics Society
Volume: in press
Issue: 10
Pages: 1911-1918
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.2018
Author(s)
Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T.
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Journal Title
Hum Genet.
Volume: 37(6-7)
Issue: 6-7
Pages: 521-533
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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