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Relationship between brain connectivity and omega 3 fatty acid in patients with schizophrenia and mood disorders

Research Project

Project/Area Number 18K07570
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionWakayama Medical University

Principal Investigator

Takahashi Shun  和歌山県立医科大学, 医学部, 非常勤講師 (10508021)

Co-Investigator(Kenkyū-buntansha) 鵜飼 聡  和歌山県立医科大学, 医学部, 教授 (80324763)
辻 富基美  和歌山県立医科大学, 医学部, 准教授 (10347586)
石田 卓也  和歌山県立医科大学, 医学部, 博士研究員 (10549728)
山田 信一  和歌山県立医科大学, 医学部, 助教 (70549716)
山本 眞弘  和歌山県立医科大学, 医学部, 助教 (80423937)
坂本 裕司  和歌山県立医科大学, 医学部, 助教 (20535497)
上西 優介  和歌山県立医科大学, 医学部, 助教 (20648464)
奥平 和也  和歌山県立医科大学, 医学部, 助教 (70644087)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Discontinued (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords脳部位間結合性 / オメガ3脂肪酸 / 統合失調症 / 気分障害 / 認知機能 / 社会機能 / オメガ3脂肪酸 / 脳画像
Outline of Final Research Achievements

In this study, we focused on the relationship between omega 3 fatty acids and brain connectivity to elucidate the pathophysiology of cognitive dysfunction in schizophrenia and mood disorders, and further clarify the relationship between cognitive dysfunction and social function and QOL. At the end of March 2021, recruitment and data collection for about 160 subjects have been completed, and the research period for this project has ended with the adoption of the other research project submitted in the previous year of the final year. As a result of the imaging research, we published the manuscript on change in brain cortical thickness due to exercise therapy in schizophrenia, microstructural white matter abnormalities and cognitive impairment in schizophrenia, bipolar disorder, and major depressive disorder, and brain functional dysconnectivity and their relationship with cognitive function in schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

統合失調症と気分障害(うつ病、躁うつ病)は、有病率が高く、社会活動の障害の大きな要因となる重要な疾患であるが、その病態生理はいまだに解明されていない。精神疾患において認知機能障害は社会機能予後と大きく関連するとされているが、薬物療法を中心としたこれまでの治療法は主に幻覚妄想や気分症状を標的としており、認知機能障害に対する有効な治療は確立していない。本研究で統合失調症と気分障害における認知機能障害の生物学的基盤が明らかになれば、脳部位間結合性に着目した脳刺激療法などの新たな治療法の開発につながることが期待される。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (33 results)

All 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 9 results,  Open Access: 4 results) Presentation (23 results) (of which Int'l Joint Research: 12 results,  Invited: 5 results)

  • [Journal Article] Effect of aerobic exercise combined with cognitive remediation on cortical thickness and prediction of social adaptation in patients with schizophrenia2020

    • Author(s)
      Takahashi Shun、Keeser Daniel、Rauchmann Boris-Stephan、Schneider-Axmann Thomas、Keller-Varady Katriona、Maurus Isabel、Dechent Peter、Wobrock Thomas、Hasan Alkomiet、Schmitt Andrea、Ertl-Wagner Birgit、Malchow Berend、Falkai Peter
    • Journal Title

      Schizophrenia Research

      Volume: 216 Pages: 397-407

    • DOI

      10.1016/j.schres.2019.11.004

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of aerobic exercise on cortical thickness in patients with schizophrenia -a dataset2020

    • Author(s)
      Takahashi S, Keeser D, Rauchmann BS, Schneider-Axmann T, Keller-Varady K, Maurus I, Dechent P, Wobrock T, Hasan A, Schmitt A, Ertl-Wagner B, Malchow B, Falkai P.
    • Journal Title

      Data in Brief

      Volume: 30 Pages: 105517-105517

    • DOI

      10.1016/j.dib.2020.105517

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Widespread white matter microstructural abnormalities and cognitive impairment in schizophrenia, bipolar disorder, and major depressive disorder: Tract-based spatial statistics study2020

    • Author(s)
      Yamada S, Takahashi S, Ohoshi Y, Ishida T, Tsuji T, Shinosaki K, Terada M, Ukai S
    • Journal Title

      Psychiatry Res Neuroimaging

      Volume: 298 Pages: 111045-111045

    • DOI

      10.1016/j.pscychresns.2020.111045

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cognitive functions relating to aberrant interactions between task-positive and task-negative networks: Resting fMRI study of patients with schizophrenia2020

    • Author(s)
      Yamashita Madoka、Shimokawa Tetsuya、Takahashi Shun、Yamada Shinichi、Terada Masaki、Ukai Satoshi、Tanemura Rumi
    • Journal Title

      Applied Neuropsychology: Adult

      Volume: - Issue: 5 Pages: 1122-1130

    • DOI

      10.1080/23279095.2020.1852565

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of endurance training and table soccer on brain metabolites in schizophrenia2020

    • Author(s)
      Rauchmann B, Ghaseminejad F, Keeser D, Keller-Varady K, Schneider-Axmann T, Takahashi S, Karali T, Helms G, Dechent P, Maurus I, Hasan A, Wobrock T, Ertl-Wagner B, Schmitt A, Malchow B, Falkai P.
    • Journal Title

      Brain Imaging and Behavior

      Volume: 14 Issue: 2 Pages: 515-526

    • DOI

      10.1007/s11682-019-00198-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: a tract-specific analysis study2019

    • Author(s)
      Ohoshi Y, Takahashi S, Yamada S, Ishida T, Tsuda K, Tsuji T, Terada M, Shinosaki K, Ukai S.
    • Journal Title

      Brain and Behavior

      Volume: 9 Issue: 8

    • DOI

      10.1002/brb3.1357

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurobiological effects of aerobic exercise, with a focus on patients with schizophrenia2019

    • Author(s)
      Maurus I, Hasan A, Roh A, Takahashi S, Rauchmann B, Keeser D, Malchow B, Schmitt A, Falkai P.
    • Journal Title

      European Archives of Psychiatry and Clinical Neuroscience

      Volume: 269 Issue: 5 Pages: 499-515

    • DOI

      10.1007/s00406-019-01025-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 統合失調症のオメガ3脂肪酸仮説2019

    • Author(s)
      髙橋隼, 里神和美, 鵜飼聡.
    • Journal Title

      精神科治療学

      Volume: 34 Pages: 1007-1012

    • Related Report
      2019 Research-status Report
  • [Journal Article] Relationship between polyunsaturated fatty acid and eating disorders: Systematic review and meta-analysis2019

    • Author(s)
      Satogami Kazumi、Tseng Ping-Tao、Su Kuan-Pin、Takahashi Shun、Ukai Satoshi、Li Dian-Jeng、Chen Tien-Yu、Lin Pao-Yen、Chen Yen-Wen、Matsuoka Yutaka J.
    • Journal Title

      Prostaglandins, Leukotrienes and Essential Fatty Acids

      Volume: 142 Pages: 11-19

    • DOI

      10.1016/j.plefa.2019.01.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of aerobic exercise on metabolic syndrome, cardiorespiratory fitness, and symptoms in schizophrenia include decreased mortality2018

    • Author(s)
      Schmitt Andrea、Maurus Isabel、Rossner Moritz J.、Roh Astrid、Lembeck Moritz、von Wilmsdorff Martina、Takahashi Shun、Rauchmann Boris、Keeser Daniel、Hasan Alkomiet、Malchow Berend、Falkai Peter
    • Journal Title

      Frontiers in Psychiatry

      Volume: 9 Pages: 690-690

    • DOI

      10.3389/fpsyt.2018.00690

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Current evidence of rTMS treatment for depression: efficacy and cost-effectiveness.2021

    • Author(s)
      Takahashi Shun
    • Organizer
      International Symposium on rTMS Treatments 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] COPDにおける海馬体積とフレイル、抑うつ、社会適応、QOLの関連2021

    • Author(s)
      髙橋隼、平野綱彦、安田香澄、堂西倫弘、土井恵子、松永和人
    • Organizer
      International Joint Meeting 2020 in Kansai
    • Related Report
      2020 Annual Research Report
  • [Presentation] Hippocampal subfields volume and cognitive function in schizophrenia and mood disorders.2020

    • Author(s)
      Takahashi Shun, Yasuda Kasumi, Uenishi Shinya, Yamada Shinichi, Ukai Satoshi
    • Organizer
      OHBM Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simulated electric field during prefrontal tDCS in mood disorders and schizophrenia.2020

    • Author(s)
      Takahashi Shun, Uenishi Shinya, Tamaki Atsushi, Yasuda Kasumi, Keeser Daniel, Mizutani-Tiebel Yuki, Padberg Frank, Ukai Satoshi.
    • Organizer
      OHBM Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuroimaging effect of aerobic exercise on white matter abnormality in patients with schizophrenia2020

    • Author(s)
      Takahashi Shun, Keeser Daniel, Karali Temmuz, Rauchmann Boris-Stephan, Schneider-Axmann Thomas, Keller-Varady Katriona, Maurus Isabel, Dechent Peter, Wobrock Thomas, Hasan Alkomiet, Schmitt Andrea, Padberg Frank, Ertl-Wagner Birgit, Malchow Berend, Falkai Peter
    • Organizer
      OHBM Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 気分障害と統合失調症における両側前頭部のtDCSで生じる電界シミュレーション2020

    • Author(s)
      髙橋隼
    • Organizer
      第50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経精神疾患におけるTMSを用いた臨床研究2020

    • Author(s)
      髙橋隼
    • Organizer
      第50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 気分障害と統合失調症における認知機能障害の脳病態への脳構造画像的アプローチ.2020

    • Author(s)
      髙橋隼
    • Organizer
      第50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 和歌山県立医科大学附属病院におけるrTMS臨床研究の現状と課題.2020

    • Author(s)
      髙橋隼
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 気分障害と統合失調症における両側前頭部の経頭蓋直流刺激(tDCS)による電界シミュレーション値の検討.2020

    • Author(s)
      髙橋隼
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reduced efields show up in schizophrenia and major depression - A prefrontal tDCS simulation study2019

    • Author(s)
      Takahashi S, Mizutani Y, Karali T, Dechantsreiter E, Papazova I, Mezger E, Bulubas L, Stoecklein S, Thielscher A, Padberg F, Keeser D.
    • Organizer
      OHBM Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neuroimaging effect of aerobic exercise on cortical thickness in patients with schizophrenia2019

    • Author(s)
      Takahashi S, Keeser D, Rauchmann B, Schneider-Axmann T, Keller-Varady K, Maurus I, Dechent P, Wobrock T, Hasan A, Schmitt A, Ertl-Wagner B, Malchow B, Falkai P
    • Organizer
      OHBM Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] WM abnormalities and their relationship with cognitive impairment in SZ, BD, and MDD2019

    • Author(s)
      Yamada S, Takahashi S, Ishida T, Ohoshi Y, Tsuji T, Shinosaki K, Terada M, Ukai S.
    • Organizer
      OHBM Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Assessment of cortical excitability using TMS techniques in neuropsychiatric disorders2019

    • Author(s)
      Takahashi S.
    • Organizer
      6th Congress of Asian College of Neuropsychopharmacology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Reduction of simulated e-fields in schizophrenia and major depression during prefrontal tDCS2019

    • Author(s)
      Takahashi S.
    • Organizer
      13th International Conference on Complex Medical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] SIMNIBS simulations in schizophrenic, depressive patients and healthy subjects - how to better individualize neuromodulation?2019

    • Author(s)
      Takahashi S, Mizutani Y.
    • Organizer
      BrainSTIM 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 統合失調症における運動療法による脳画像変化2019

    • Author(s)
      高橋隼
    • Organizer
      第41回Fmシータ研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 安静時機能的結合を用いたうつ病への反復経磁気刺激法の遠隔作用機序の推定2019

    • Author(s)
      石田卓也、森島陽介
    • Organizer
      第41回Fmシータ研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症と双極性障害におけるtask-positive networksとtask-negative networkの安静時機能的分離と注意機能との関係2019

    • Author(s)
      山下円香、種村留美、下川哲也、山田信一、高橋隼、辻富基美、鵜飼聡
    • Organizer
      第41回Fmシータ研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Widespread white matter microstructural abnormalities related to cognitive impairment in schizophrenia, bipolar disorder, and major depressive disorder: A tract-based spatial statistics study2018

    • Author(s)
      Shinichi Yamada、Shun Takahashi、Takuya Ishida、Yuji Ohoshi、Tomikimi Tsuji、Masaki Terada、Satoshi Ukai
    • Organizer
      The 11th Annual Scientific Meeting Hong Kong Society of Biological Psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation and optimization of a cortical area parcellation using the resting-state fMRI data2018

    • Author(s)
      Takuya Ishida、Yosuke Morishima
    • Organizer
      13th Annual Meeting Clinical Neuroscience Bern
    • Related Report
      2018 Research-status Report
  • [Presentation] Widespread white matter microstructural abnormalities and their relationship with age in schizophrenia, bipolar disorder, and major depressive disorder2018

    • Author(s)
      Shinichi Yamada、Shun Takahashi、Takuya Ishida、Yuji Ohoshi、Tomikimi Tsuji、Masaki Terada、Satoshi Ukai
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症における安静時task-positive networksとtask-negative networkの機能的分離の低下と認知機能との関係2018

    • Author(s)
      山下円香、下川哲也、鵜飼聡、辻富基美、高橋隼、山田信一
    • Organizer
      第42回 日本神経心理学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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