| Project/Area Number |
18K07572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
YAMAMOTO Ryo 金沢医科大学, 医学部, 准教授 (30447974)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 哲史 富山大学, 学術研究部医学系, 教授 (90334812)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 攻撃性 / 視床下部 / 分界条床核 / 扁桃体 / ストレス / CRF / 威嚇音声 / 視床下部内腹側核 / CRFニューロン |
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| Outline of Final Research Achievements |
While stress induces depressive states, stress also enhances aggression of the individuals. To elucidate how the neural circuits control the aggressive behavior and how the stress alter activities of those circuits, we conducted current study. First, we confirmed that the anterior BNST enhances the activity of core neurons in VMH via poly-synaptic dis-inhibition. Second, we confirmed the BMA also enhances the activity of core neurons in VMH via mono-synaptic excitation. These results indicate that the different structures exert different mechanisms to control the activity of VMH which plays pivotal role in aggressive behaviors.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は攻撃行動を司る視床下部内腹側核に投射を持つことが知られていた分界条床核と扁桃体外側基底核に注目し、それぞれの領域からの視床下部内腹側核へのシナプス入力の特徴を明らかにした。この結果は視床下部内腹側核への多様な調節機構を明らかにするものであり、攻撃行動の調節の複雑な機構の一部を解明することにつながる。攻撃行動調節の神経機構を明らかにすることは、様々な社会的衝突の解決方法の創出につながる。
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