| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Prostaglandin E2 (PGE2) increased microglial cyclooxygease (COX)-2 mRNA and protein expression. These results suggest that microglial production of PGE2, which may contribute to the increase in Alzheimer's disease brains. On the other hand, PGE2 suppresses phagocytosis and other processes of microglia. Therefore, suppression of PGE2 signaling may be a potential amelioration of Alzheimer's disease.
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