Investigation of treatment of Alzheimer's disease with EP2 receptor inhibitors.
| Project/Area Number |
18K07574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Kyushu University of Health and Welfare (2019-2021)
Hyogo Medical University (2018) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ミクログリア / プロスタグランジンE2 / プロスタグランジン / アルツハイマー病 |
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| Outline of Final Research Achievements |
Prostaglandin E2 (PGE2) increased microglial cyclooxygease (COX)-2 mRNA and protein expression. These results suggest that microglial production of PGE2, which may contribute to the increase in Alzheimer's disease brains. On the other hand, PGE2 suppresses phagocytosis and other processes of microglia. Therefore, suppression of PGE2 signaling may be a potential amelioration of Alzheimer's disease.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究成果は、PGE2のミクログリアに対する作用について、詳細に検討されたところに学術的意義があると考えられる。これまでの過去の報告などもあわせて考えると、ミクログリアにおけるPGE2シグナルが抑制されることはアルツハイマー病の改善につながる可能性が示唆され、社会的意義もあると考えられる。
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Report
(5 results)
Research Products
(3 results)
