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Pathophysiology of schizophrenia and abnormalities of the hippocampal glutamatergic nervous system: an MRS analysis based on the affective pathway hypothesis.

Research Project

Project/Area Number 18K07586
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionTohoku University

Principal Investigator

Ito Fumiaki  東北大学, 医学系研究科, 大学院非常勤講師 (10535157)

Co-Investigator(Kenkyū-buntansha) 麦倉 俊司  東北大学, 東北メディカル・メガバンク機構, 教授 (20375017)
松本 和紀  東北大学, 医学系研究科, 准教授 (40301056)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳構造MRI / 幻覚 / 統合失調症 / 早期精神症 / Voxel-Based Morphometry / 拡散テンソル画像解析 / MRS / グルタミン酸 / 海馬 / トラウマ
Outline of Final Research Achievements

The purpose of this study was to examine the association between brain region (hippocampus), neurological function (glutamate), risk factors (psychological trauma), and clinical stage to provide useful indicators for the pathophysiology and treatment of schizophrenia. However, due to changes in the study members, the study plan needed to be reconsidered. Brain structural imaging analysis was conducted based on data on early psychosis obtained in the past. Abnormalities in brain structures (gray matter volume, white matter volume, and white matter microstructure) related to hallucinations in early psychosis were examined. The results indicated that abnormalities in white matter microstructure of language-related brain networks may be related to hallucinations in early psychosis. These results have implications for the process of hallucinations.

Academic Significance and Societal Importance of the Research Achievements

これまで、統合失調症を主な対象とした神経画像研究により幻覚と脳構造の関係が示されてきたが、研究の結果は必ずしも一致しておらず、幻覚の神経基盤は明らかではなかった。早期精神症を対象とした本研究により、脳内ネットワークの変化が幻覚の発症に関わることを示唆された。今後、神経画像研究による幻覚の病態解明をさらに進めることで、病態理解に基づいた治療戦略の選択や、幻覚に対する新たな治療法の開発につながる可能性がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2021 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] White matter volume not associated with hallucinations in clinical high risk and first‐episode psychosis: A voxel‐based morphometry study2021

    • Author(s)
      Sato Yutaro、Sakuma Atsushi、Ohmuro Noriyuki、Katsura Masahiro、Abe Koichi、Tomimoto Kazuho、Iizuka Kunio、Ito Fumiaki、Tomita Hiroaki、Matsumoto Kazunori
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 75 Issue: 9 Pages: 299-301

    • DOI

      10.1111/pcn.13284

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship Between White Matter Microstructure and Hallucination Severity in the Early Stages of Psychosis: A Diffusion Tensor Imaging Study2021

    • Author(s)
      Sato Yutaro、Sakuma Atsushi、Ohmuro Noriyuki、Katsura Masahiro、Abe Koichi、Tomimoto Kazuho、Iizuka Kunio、Ito Fumiaki、Tomita Hiroaki、Matsumoto Kazunori
    • Journal Title

      Schizophrenia Bulletin Open

      Volume: 2 Issue: 1

    • DOI

      10.1093/schizbullopen/sgab015

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 早期精神症における大脳白質微細構造と幻覚との関連2019

    • Author(s)
      佐藤 祐太朗
    • Organizer
      第115回日本精神神経学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] The relationship between white matter radial diffusivity and hallucination severity in the early stage of psychosis: a diffusion tensor imaging study2019

    • Author(s)
      佐藤 祐太朗
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学会大会合同大会(NEURO2019)
    • Related Report
      2019 Research-status Report
  • [Presentation] 早期精神症における大脳白質微細構造と幻覚の関係: 性別による違いの検討2019

    • Author(s)
      佐藤 祐太朗
    • Organizer
      第23回日本精神保健・予防学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 幻覚の脳構造画像研究の発展と今後の展望2019

    • Author(s)
      佐藤 祐太朗
    • Organizer
      第23回日本精神保健・予防学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Association of reduced regional white matter volume with hallucination in the early stage of psychosis: a MRI volumetric study2018

    • Author(s)
      佐藤 祐太朗
    • Organizer
      International Consortium on Hallucination Research 2018 Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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