| Project/Area Number |
18K07598
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 52030:Psychiatry-related
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
森 康治 大阪大学, 医学系研究科, 助教 (40775318)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | タウ / 認知症 / 炎症 / TDP-43 / ジペプチドリピート蛋白 |
|---|
| Outline of Final Research Achievements |
Interaction between intrinsic inhibitor to apoptosis proteins (IAPs) and aggregative proteins usually accumulated in demented brain, was investigated. Both proteins were shown to be bound, and the complex was also shown to bind with caspase-1, in vitro. in addition, caspase-1 was activated by the binding, therefore, intracellular inflammatory processes might be induced by the whole aggregative protein products through activation of caspase-1.
|
| Academic Significance and Societal Importance of the Research Achievements |
認知症性疾患はその神経変性の過程に慢性の炎症反応があるという報告が多いが、どのような機序で炎症が惹起されるかに関しては、不明な点が多い。そして、認知症脳に認められる細胞内蛋白凝集体形成は、凝集性蛋白のオリゴマー状態での毒性を抑制するために集積されるという生体の防衛反応的意味で理解されることが多い。本研究は、細胞内蛋白凝集体がIAPsやCaspaseとの結合を介して、炎症性反応を誘導する可能性を示唆したものである。
|
