Involvement of abnormal protein aggregation and inflammation in neurodegenerative processes of dementia
| Project/Area Number |
18K07598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森 康治 大阪大学, 医学系研究科, 助教 (40775318)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | タウ / 認知症 / 炎症 / TDP-43 / ジペプチドリピート蛋白 |
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| Outline of Final Research Achievements |
Interaction between intrinsic inhibitor to apoptosis proteins (IAPs) and aggregative proteins usually accumulated in demented brain, was investigated. Both proteins were shown to be bound, and the complex was also shown to bind with caspase-1, in vitro. in addition, caspase-1 was activated by the binding, therefore, intracellular inflammatory processes might be induced by the whole aggregative protein products through activation of caspase-1.
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| Academic Significance and Societal Importance of the Research Achievements |
認知症性疾患はその神経変性の過程に慢性の炎症反応があるという報告が多いが、どのような機序で炎症が惹起されるかに関しては、不明な点が多い。そして、認知症脳に認められる細胞内蛋白凝集体形成は、凝集性蛋白のオリゴマー状態での毒性を抑制するために集積されるという生体の防衛反応的意味で理解されることが多い。本研究は、細胞内蛋白凝集体がIAPsやCaspaseとの結合を介して、炎症性反応を誘導する可能性を示唆したものである。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Efficacy, Safety, and Tolerability of Switching from Oral Cholinesterase Inhibitors to Rivastigmine Transdermal Patch with 1-Step Titration in Patients with Mild to Moderate Alzheimer's Disease: A 24-Week, Open-Label, Multicenter Study in Japan.2019
Author(s)
Ueda K, Katayama S, Arai T, Furuta N, Ikebe S, Ishida Y, Kanaya K, Ouma S, Sakurai H, Sugitani M, Takahashi M, Tanaka T, Tsuno N, Wakutani Y, Shekhawat A, Das Gupta A, Kiyose K, Toriyama K, Nakamura Y.
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Journal Title
Dement Geriatr Cogn Dis Extra.
Volume: 15
Issue: 2
Pages: 302-318
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cerebral blood flow and Alzheimer's disease-related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus.2019
Author(s)
Azuma S, Kazui H, Kanemoto H, Suzuki Y, Sato S, Suehiro T, Matsumoto T, Yoshiyama K, Kishima H, Shimosegawa E, Tanaka T, Ikeda M.
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Journal Title
Psychogeriatrics.
Volume: 印刷中
Issue: 6
Pages: 527-538
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Apathy and right caudate perfusion in idiopathic normal pressure hydrocephalus: a case-control study.2018
Author(s)
Kanemoto H, Kazui H, Suehiro T, Kishima H, Suzuki Y, Sato S, Azuma S, Matsumoto T, Yoshiyama K, Shimosegawa E, Tanaka T, Ikeda M.
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Journal Title
Int J Geriatr Psychiatry.
Volume: 26
Issue: 3
Pages: 453-462
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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