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A metagenomic approach to unveil the association between gut microbiota and molecular pathophysiology of schizophrenia

Research Project

Project/Area Number 18K07601
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionOkayama University

Principal Investigator

OKAHISA YUKO  岡山大学, 大学病院, 講師 (90583097)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords統合失調症 / 腸内細菌叢 / メタゲノム / 次世代シーケンサー
Outline of Final Research Achievements

The purpose of this study is to reveal the molecular pathophysiology of schizophrenia. The microbiota in stool samples obtained from 30 patients with schizophrenia and 30 healthy control were determined by 16S rRNA gene sequencing but failed to identify pathogenesis of schizophrenia. We intend to metabologenomic analysis in further study.

Academic Significance and Societal Importance of the Research Achievements

日本人統合失調症患者で網羅的な腸内細菌叢解析を行い基礎的なデータの構築ができたことは、病態解明に向けた有意義な取り組みであったと考える。今回の解析では病態の解明につながる結果は得られなかったが、この研究を手掛かりにより多くのサンプルでの解析やメタボローム解析を行い、病態解明につなげたい。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (24 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 14 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Comparison between olanzapine and aripiprazole treatment for 104?weeks after hospital discharge in schizophrenia spectrum disorders: a multicenter retrospective cohort study in a real-world setting2023

    • Author(s)
      Hosokawa T, Miyaji C, Yoshimura Y, Washida K, Yada Y,Sakamoto S, Okahisa Y, Takao S, Nomura A, Kishi Y, Harada T, Takaki M, Takeda T, Yamada N
    • Journal Title

      Psychopharmacology

      Volume: 240(9) Issue: 9 Pages: 1911-1920

    • DOI

      10.1007/s00213-023-06407-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Initial Outcomes of the Safe and Sound Protocol on Patients with Adult Autism Spectrum Disorder: Exploratory Pilot Study.2023

    • Author(s)
      Kawai H, Kishimoto M, Okahisa Y, Sakamoto S, Terada S, Takaki M
    • Journal Title

      International journal of environmental research and public health

      Volume: 20(6) Issue: 6 Pages: 4862-4862

    • DOI

      10.3390/ijerph20064862

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The validity of atypical psychosis diagnostic criteria to detect anti-NMDA receptor encephalitis with psychiatric symptoms2022

    • Author(s)
      Hinotsu K, Miyaji C, Yada Y, Kawai H, Sakamoto S, Okahisa Y, Tsutsui K, Kanbayashi T, Tanaka K, Takao S, Kishi Y, Takaki M, Yamada N.
    • Journal Title

      Schizophr Res .

      Volume: 248 Pages: 292-299

    • DOI

      10.1016/j.schres.2022.08.024

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study2022

    • Author(s)
      Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Matsumoto J, Miura K, Hashimoto N, Makinodan M, Takahashi T, Nemoto K, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R.
    • Journal Title

      BJPsych Open .

      Volume: 8(4) Issue: 4 Pages: 1-10

    • DOI

      10.1192/bjo.2022.50

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical moderators of response to nalmefene in a randomized-controlled trial for alcohol dependence: An exploratory analysis.2022

    • Author(s)
      Hashimoto N, Habu H, Takao S, Sakamoto S, Okahisa Y, Matsuo K, Takaki M, Kishi Y, Yamada N.
    • Journal Title

      Drug Alcohol Depend.

      Volume: in press Pages: 109365-109365

    • DOI

      10.1016/j.drugalcdep.2022.109365

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between depression in chronic phase and future clinical outcome of patients with schizophrenia.2022

    • Author(s)
      Yamada Y, Yamauchi Y, Sakamoto S, Fujiwara M, Okahisa Y, Takao S, Takaki M, Yamada N.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 239 Issue: 3 Pages: 965-975

    • DOI

      10.1007/s00213-022-06099-4

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Decrease of Neutrophils After COVID-19 Vaccination in a Treatment-Resistant Patient With Schizophrenia Taking Clozapine.2022

    • Author(s)
      Takaki M, Yada Y, Sakamoto S, Fujiwara M, Okahisa Y, Yamada N.
    • Journal Title

      J Clin Psychopharmacol.

      Volume: in press Issue: 3 Pages: 324-325

    • DOI

      10.1097/jcp.0000000000001527

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mirtazapine Was Effective for a Patient With Benzodiazepine Dependence.2022

    • Author(s)
      Takaki M, Ishikawa R, Sakamoto S, Hashimoto N, Okahisa Y, Yamada N.
    • Journal Title

      Clin Neuropharmacol.

      Volume: 45 Issue: 1 Pages: 11-12

    • DOI

      10.1097/wnf.0000000000000488

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis.2022

    • Author(s)
      Okamoto S, Takaki M, Hinotsu K, Kawai H, Sakamoto S, Okahisa Y, Takao S, Tsutsui K, Kanbayashi T, Tanaka K, Yamada N.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 239 Issue: 2 Pages: 525-531

    • DOI

      10.1007/s00213-021-06036-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] The relationship between plasma clozapine concentration and clinical outcome: a cross-sectional study.2021

    • Author(s)
      Yada Y, Kitagawa K, Sakamoto S, Ozawa A, Nakada A, Kashiwagi H, Okahisa Y, Takao S, Takaki M, Kishi Y, Yamada N.
    • Journal Title

      Acta Psychiatr Scand.

      Volume: 143 Issue: 3 Pages: 227-237

    • DOI

      10.1111/acps.13264

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms Underlying the Comorbidity of Schizophrenia and Type 2 Diabetes Mellitus2020

    • Author(s)
      Mizuki Yutaka、Sakamoto Shinji、Okahisa Yuko、Yada Yuji、Hashimoto Nozomu、Takaki Manabu、Yamada Norihito
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: in press Issue: 5 Pages: 000-000

    • DOI

      10.1093/ijnp/pyaa097

    • NAID

      120007045004

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia2020

    • Author(s)
      Ishizuka Kanako、Yoshida Tomoyuki、Kawabata Takeshi、Imai Ayako、Mori Hisashi、Kimura Hiroki、Inada Toshiya、Okahisa Yuko、Egawa Jun、Usami Masahide、Kushima Itaru、Morikawa Mako、Okada Takashi、Ikeda Masashi、Branko Aleksic、Mori Daisuke、Someya Toshiyuki、Iwata Nakao、Ozaki Norio
    • Journal Title

      Journal of Neurodevelopmental Disorders

      Volume: 12 Issue: 1 Pages: 25-25

    • DOI

      10.1186/s11689-020-09325-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility2020

    • Author(s)
      Nawa Yoshihiro、Kimura Hiroki、Mori Daisuke、Kato Hidekazu、Toyama Miho、Furuta Sho、Yu Yanjie、Ishizuka Kanako、Kushima Itaru、Aleksic Branko、Arioka Yuko、Morikawa Mako、Okada Takashi、Inada Toshiya、Kaibuchi Kozo、Ikeda Masashi、Iwata Nakao、Suzuki Michio、Okahisa Yuko、Egawa Jun et al
    • Journal Title

      Human Genome Variation

      Volume: 7 Issue: 1 Pages: 37-37

    • DOI

      10.1038/s41439-020-00125-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder2020

    • Author(s)
      Kato Hidekazu、Kushima Itaru、Mori Daisuke、Yoshimi Akira、Aleksic Branko、Nawa Yoshihiro、Toyama Miho、Furuta Sho、Yu Yanjie、Ishizuka Kanako、Kimura Hiroki、Arioka Yuko、Tsujimura Keita、Morikawa Mako、Okada Takashi、Inada Toshiya、Nakatochi Masahiro、Shinjo Keiko、Kondo Yutaka、Kaibuchi Kozo、Egawa Jun et al
    • Journal Title

      Translational Psychiatry

      Volume: 10 Issue: 1 Pages: 421-421

    • DOI

      10.1038/s41398-020-01107-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Switching strategies for antipsychotic monotherapy in schizophrenia: a multi-center cohort study of aripiprazole2020

    • Author(s)
      Obayashi Y, Mitsui S, Sakamoto S, Minao N, Yoshimura B, Kono T, Yada Y, Okahisa Y, Takao S, Kishi Y, Takeda T, Takaki M, Yamada N.
    • Journal Title

      Psychopharmacology

      Volume: 237(1) Issue: 1 Pages: 167-175

    • DOI

      10.1007/s00213-019-05352-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-NMDA-receptor antibody in initial diagnosis of mood disorder.2019

    • Author(s)
      Kawai H, Takaki M, Sakamoto S, Shibata T, Tsuchida A, Yoshimura B, Yada Y, Matsumoto N, Sato K, Abe K, Okahisa Y, Kishi Y, Takao S, Tsutsui K, Kanbayashi T, Tanaka K, Yamada N.
    • Journal Title

      Eur Neuropsychopharmacol.

      Volume: 29(9) Issue: 9 Pages: 1041-1050

    • DOI

      10.1016/j.euroneuro.2019.07.137

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Psychiatry2019

    • Author(s)
      Sakamoto S, Kawai H, Okahisa Y, Tsutsui K, Kanbayashi T, Tanaka K, Mizuki Y, Takaki M, Yamada N.
    • Journal Title

      Acta Medica Okayama

      Volume: 73 Issue: 3 Pages: 189-195

    • DOI

      10.18926/AMO/56860

    • NAID

      120006647996

    • URL

      https://ousar.lib.okayama-u.ac.jp/56860

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect2018

    • Author(s)
      Ikeda M,Takahashi A,Kamatani Y,Momozawa Y,Saito T,Kondo K,Shimasaki A,Kawase K,Sakusabe T,Iwayama Y,Toyota T,Wakuda T,Kikuchi M,Kanahara N,Yamamori H,Yasuda Y,Watanabe Y,Hoya S,Aleksic B,Kushima I,Arai H,Takaki M,Hattori K,Kunugi H,Okahisa Y,Ohnuma T,Ozaki N,Someya T,Hashimoto R,Yoshikawa T,Kubo M,Iwata N
    • Journal Title

      Schizophrenia Bulletin

      Volume: 印刷中 Issue: 4 Pages: 824-834

    • DOI

      10.1093/schbul/sby140

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rare loss of function mutations in N-methyl-d-aspartate glutamate receptors and their contributions to schizophrenia susceptibility2018

    • Author(s)
      Yu Yanjie、Lin Yingni、Takasaki Yuto、Wang Chenyao、Kimura Hiroki、Xing Jingrui、Ishizuka Kanako、Toyama Miho、Kushima Itaru、Mori Daisuke、Arioka Yuko、Uno Yota、Shiino Tomoko、Nakamura Yukako、Okada Takashi、Morikawa Mako、Ikeda Masashi、Iwata Nakao、Okahisa Yuko、Takaki Manabu、Sakamoto Shinji、et al.
    • Journal Title

      Translational Psychiatry

      Volume: 8 Issue: 1 Pages: 12-20

    • DOI

      10.1038/s41398-017-0061-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia.2018

    • Author(s)
      Ishizuka K, Kimura H, Kushima I, Inada T, Okahisa Y, Ikeda M, Iwata N, Mori D, Aleksic B, Ozaki N.
    • Journal Title

      Psychiatr Genet.

      Volume: 5 Issue: 5 Pages: 90-93

    • DOI

      10.1097/ypg.0000000000000204

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine.2018

    • Author(s)
      Takaki M, Kodama M, Mizuki Y, Kawai H, Yoshimura B, Kishimoto M, Sakamoto S, Okahisa Y, Yamada N.
    • Journal Title

      Eur Neuropsychopharmacol.

      Volume: 28(5) Issue: 5 Pages: 610-619

    • DOI

      10.1016/j.euroneuro.2018.03.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.2017

    • Author(s)
      Ikeda M, Shimasaki A, Takahashi A,et al.
    • Journal Title

      Mol Psychiatry

      Volume: in press Issue: 3 Pages: 1-9

    • DOI

      10.1038/mp.2016.259

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The relationship of N-methyl-D-aspartate receptor antibody and psychiatric disorders2018

    • Author(s)
      Kawai H, Sakamoto S, Kishimoto M, Okahisa Y, Takaki M, Yamada N.
    • Organizer
      CINP 31st World Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine2018

    • Author(s)
      Takaki M, Kodama M, Mizuki Y, Kawai H, Yoshimura B, Kishimoto M, Sakamoto S, Okahisa Y, Yamada N.
    • Organizer
      CINP 31st World Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2025-01-30  

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