Detecting the neural oscillation deficits during abnormal emotional regulation in schizophrenia patients

• Project/Area Number: 18K07604
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Kyushu University
• Principal Investigator: Hirano Yoji 九州大学, 大学病院, 講師 (90567497)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 統合失調症 / 情動制御障害 / ガンマオシレーション / ニューラルオシレーション / 脳波・脳磁図 / ニューロフィードバック / 情動制御 / 社会機能障害 / 脳波 / 脳磁図 / fMRI / ガンマ帯域皮質活動 / ガンマ帯域神経振動 / neurofeedback

Outline of Final Research Achievements

This study aimed to elucidate the pathophysiology involved in emotion dysregulation, which is also a cause of social dysfunction in patients with schizophrenia. Specifically, we used electroencephalography (EEG) to measure changes in frontal neural activity indices during emotion regulation in healthy subjects and patients with schizophrenia. The results showed that compared to normal subjects, schizophrenia showed abnormal neural activity in the gamma-band of the frontal cortex during emotion regulation. Based on this finding, we also performed a discrimination task using different frequency stimuli and found that discrimination ability improved and EEG synchronization changed after training. Some of the results were presented at domestic and international conferences and 33 papers were accepted by international journals. We have also applied for a patent for innovative real-time time-frequency analysis, which is indispensable for clinical applications.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、統合失調症の社会機能障害の原因でもある、情動制御障害の神経学的な基盤の一端が明らかになった。情動制御時の前頭部のガンマ帯域神経活動異常をニューロフィードバックにより制御することで、同疾患の情動制御障害の改善が期待できる。今後は、本研究にて同時に開発したリアルタイム時間周波数解析技術を用い、治療へ応用可能なニューロフィードバックシステムの構築を目指す。

Research Products

• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] UNSW Sydney(オーストラリア)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] UNSW Sydney(オーストラリア)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] University of New South Wales(オーストラリア)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] University of New South Wales(オーストラリア)
• [Journal Article] Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, et al
  • Journal Title: Molecular Psychiatry Volume: in press Issue: 7 Pages: 2950-2967
  • DOI: 10.1038/s41380-022-01572-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transdiagnostic Comparisons of Intellectual Abilities and Work Outcome in Patients with Mental Disorders: A Multicentre Study (2022)
  • Author(s): Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, et al
  • Journal Title: BJPsych Open Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools (2022)
  • Author(s): Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 21 Issue: 4 Pages: 539-552
  • DOI: 10.2463/mrms.rev.2021-0050
  • NAID: 130008076114
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Toward Recovery in Schizophrenia: Current Concepts, Findings, and Future Research Directions (2022)
  • Author(s): Toshiaki Onitsuka, Yoji Hirano, Takanobu Nakazawa, Kayo Ichihashi, Kenichiro Miura, Ken Inada, Ryo Mitoma, Norio Yasui_Furukori, Ryota Hashimoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: in press Issue: 7 Pages: 282-291
  • DOI: 10.1111/pcn.13342
  • Peer Reviewed / Open Access
• [Journal Article] Multi-modal imaging of the auditory-larynx motor network for voicing perception (2022)
  • Author(s): Shunsuke Tamura, Nobuyuki Hirose, Takako Mitsudo, Nobuhiko Hoaki, Itta Nakamura, Toshiaki Onitsuka, Yoji Hirano
  • Journal Title: NeuroImage Volume: 251 Pages: 118981-118981
  • Peer Reviewed / Open Access
• [Journal Article] Trends in Big Data Analyses by Multicenter Collaborative Translational Research in Psychiatry (2022)
  • Author(s): Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Issue: 1 Pages: 1-14
  • DOI: 10.1111/pcn.13311
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial (2022)
  • Author(s): Yamasue H, Kojima M, Kuwabara H, ..Hirano Y, Onitsuka T, Kosaka H, Okada T
  • Journal Title: Brain Volume: 145 Issue: 2 Pages: 490-499
  • DOI: 10.1093/brain/awab291
  • Peer Reviewed / Open Access
• [Journal Article] Editorial: Current MEG Research in Psychiatry (2021)
  • Author(s): Hirano Yoji、Uhlhaas Peter J.
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 647085-647085
  • DOI: 10.3389/fpsyt.2021.647085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study (2021)
  • Author(s): Jinya Sato, Yoji Hirano*, Noriaki Hirakawa, Junichi Takahashi, Naoya Oribe, Hironori Kuga, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao, Toshiaki Onitsuka
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 2 Pages: 121-121
  • DOI: 10.3390/jpm11020121
  • Peer Reviewed / Open Access
• [Journal Article] Effects of age and sex on the eye movement characteristics (2021)
  • Author(s): Takahashi J, Miura K, Morita K, Fujimoto M, Miyata S, Okazaki K, Matsumoto J, Hasegawa N, Hirano Y, Yamamori H, Yasuda Y, Makinodan M, Kasai K, Ozaki N, Onitsuka T, Hashimoto R.
  • Journal Title: Neuropsychopharmacological Reports Volume: in press Issue: 2 Pages: 1-7
  • DOI: 10.1002/npr2.12163
  • Peer Reviewed / Open Access
• [Journal Article] Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review (2021)
  • Author(s): Wolf Alexandra、Ueda Kazuo、Hirano Yoji
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Issue: 3 Pages: 82-100
  • DOI: 10.1111/pcn.13188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent Findings on Neurofeedback Training for Auditory Hallucinations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Shunsuke Tamura
  • Journal Title: Current Opinion in Psychiatry Volume: 34 Pages: 245-252
  • Peer Reviewed / Open Access
• [Journal Article] Eye Movement Abnormalities in Major Depressive Disorder (2021)
  • Author(s): Junichi Takahashi, Yoji Hirano*, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Ryota Hashimoto, Toshiaki Onitsuka
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 673443-673443
  • DOI: 10.3389/fpsyt.2021.673443
  • Peer Reviewed / Open Access
• [Journal Article] Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder (2021)
  • Author(s): Ryo Mitoma, Shunsuke Tamura, Hiroshi Tateishi, Takako Mitsudo, Ichiro Tanabe, Akira Monji, Yoji Hirano*
  • Journal Title: Journal of Affective Disorders Reports Volume: 7 Pages: 100277-100277
  • DOI: 10.1016/j.jadr.2021.100277
  • Peer Reviewed / Open Access
• [Journal Article] Current Findings and Perspectives on Aberrant Neural Oscillations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Issue: 12 Pages: 358-368
  • DOI: 10.1111/pcn.13300
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 統合失調症におけるNMDA受容体とガンマオシレーション異常 (2021)
  • Author(s): 平野羊嗣
  • Journal Title: 医学のあゆみ Volume: 277 Pages: 953-959
  • Peer Reviewed
• [Journal Article] 統合失調症の神経活動異常と神経免疫異常 (2021)
  • Author(s): 平野羊嗣, 加藤隆弘
  • Journal Title: 生体の科学（特集：脳とからだ） Volume: 72 Pages: 434-437
  • Peer Reviewed
• [Journal Article] Recent findings on neurofeedback training for auditory hallucinations in schizophrenia (2021)
  • Author(s): Hirano Yoji*, Tamura Shunsuke
  • Journal Title: Current Opinion in Psychiatry Volume: 34 Issue: 3 Pages: 245-252
  • DOI: 10.1097/yco.0000000000000693
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study. (2020)
  • Author(s): Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 74(1) Issue: 1 Pages: 56-63
  • DOI: 10.1111/pcn.12934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Altered P3a Modulations to Emotional Faces in Male Patients With Chronic Schizophrenia (2020)
  • Author(s): Onitsuka Toshiaki、Spencer Kevin M.、Nakamura Itta、Hirano Yoji、Hirano Shogo、McCarley Robert W.、Shenton Martha E.、Niznikiewicz Margaret A.
  • Journal Title: Clinical EEG and Neuroscience Volume: - Issue: 4 Pages: 215-221
  • DOI: 10.1177/1550059419896723
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Longitudinal evaluation of visual P300 amplitude in clinical high‐risk subjects: An event‐related potential study (2020)
  • Author(s): Oribe Naoya, Hirano Yoji, Re Elisabetta, Mesholam‐Gately Raquelle I., Woodberry Kristen A., Ueno Takefumi, Kanba Shigenobu, Onitsuka Toshiaki, Shenton Martha E., Spencer Kevin M., Niznikiewicz Margaret A.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Issue: 10 Pages: 527-534
  • DOI: 10.1111/pcn.13083
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia (2020)
  • Author(s): Hirano Yoji, Oribe Naoya, Onitsuka Toshiaki, Kanba Shigenobu, Nestor Paul G., Hosokawa Taiga, Levin Margaret, Shenton Martha E., McCarley Robert W., Spencer Kevin M
  • Journal Title: Clinical EEG and Neuroscience Volume: 51 Issue: 4 Pages: 244-251
  • DOI: 10.1177/1550059420914201
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-Term Test-Retest Reliability of Auditory Gamma Oscillations Between Different Clinical EEG Systems (2020)
  • Author(s): Hirano Yoji*, Nakamura Itta, Tamura Shunsuke, Onitsuka Toshiaki
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 876-876
  • DOI: 10.3389/fpsyt.2020.00876
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study (2020)
  • Author(s): Ohara Naotoshi, Hirano Yoji*, Oribe Naoya, Tamura Shunsuke, Nakamura Itta, Hirano Shogo, Tsuchimoto Rikako, Ueno Takefumi, Togao Osamu, Hiwatashi Akio, Nakao Tomohiro, Onitsuka Toshiaki
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 554844-554844
  • DOI: 10.3389/fpsyt.2020.554844
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of self‐reported religiosity with the development of major depression in multireligious country Japan (2020)
  • Author(s): Kobayashi Daiki, First Michael B., Shimbo Takuro, Kanba Shigenobu, Hirano Yoji*
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Issue: 10 Pages: 535-541
  • DOI: 10.1111/pcn.13087
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prospects for Future Methodological Development and Application of Magnetoencephalography Devices in Psychiatry (2020)
  • Author(s): Hironaga Naruhito, Takei Yuichi, Mitsudo Takako, Kimura Takahiro, Hirano Yoji
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 863-863
  • DOI: 10.3389/fpsyt.2020.00863
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ニューラルオシレーションを軸にした精神疾患の 橋渡し研究: 脳波国際共同研究に向けて (2020)
  • Author(s): 平野羊嗣
  • Journal Title: Precision Medicine Volume: 3 Pages: 1160-1167
  • Peer Reviewed / Open Access
• [Journal Article] 統合失調症におけるトランスレータブル脳指標としてのガンマ帯域オシレーションとノンレム睡眠スピンドル波 (2020)
  • Author(s): 三輪秀樹, 平野羊嗣
  • Journal Title: 日本生物学的精神医学会誌 Volume: 31 Pages: 190-200
  • NAID: 130007961382
  • Peer Reviewed / Open Access
• [Journal Article] 精神疾患をγ振動で評価する (2020)
  • Author(s): 中西翔一郎, 平野羊嗣, 鬼塚俊明
  • Journal Title: 福岡行動医学誌 Volume: 26 Pages: 28-31
  • Peer Reviewed / Open Access
• [Journal Article] Language-Related Neurophysiological Deficits in Schizophrenia (2019)
  • Author(s): Hirano Shogo、Spencer Kevin M.、Onitsuka Toshiaki、Hirano Yoji
  • Journal Title: Clinical EEG and Neuroscience Volume: - Issue: 4 Pages: 222-233
  • DOI: 10.1177/1550059419886686
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals (2019)
  • Author(s): Oribe Naoya、Hirano Yoji、del Re Elisabetta、Seidman Larry J.、Mesholam-Gately Raquelle I.、Woodberry Kristen A.、Wojcik Joanne D.、Ueno Takefumi、Kanba Shigenobu、Onitsuka Toshiaki、Shenton Martha E.、Goldstein Jill M.、Niznikiewicz Margaret A.、McCarley Robert W.、Spencer Kevin M.
  • Journal Title: Schizophrenia Research Volume: In Press Pages: 145-152
  • DOI: 10.1016/j.schres.2019.03.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study (2019)
  • Author(s): Hirakawa Noriaki、Kuga Hironori、Hirano Yoji、Sato Jinya、Oribe Naoya、Nakamura Itta、Hirano Shogo、Ueno Takefumi、Oda Yuko、Togao Osamu、Hiwatashi Akio、Honda Hiroshi、Kanba Shigenobu、Onitsuka Toshiaki
  • Journal Title: Brain Imaging and Behavior Volume: In Press Issue: 5 Pages: 1382-1387
  • DOI: 10.1007/s11682-019-00044-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 台湾精神医学の発展と日本の関わり- 台大醫院精神部五十年紀要・日治時代精神病學史より - (2019)
  • Author(s): 平野羊嗣, 王百慧, 謝明憲, 黄宗正, 黒木俊秀, 神庭重信
  • Journal Title: 日本精神神経学雑誌 Volume: 121 Pages: 356-365
  • Peer Reviewed / Open Access
• [Journal Article] Abnormalities of eye movement are associated with work hours in schizophrenia. (2018)
  • Author(s): Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
  • Journal Title: Schizophr Res Volume: 202 Pages: 420-422
  • DOI: 10.1016/j.schres.2018.06.064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phase-Amplitude Coupling of the EEG in the Auditory Cortex in Schizophrenia (2018)
  • Author(s): Hirano S, Nakhnikian A, Hirano Y, Oribe N, Kanba S, Onitsuka T, Levin M, Spencer KM
  • Journal Title: Biol Psychiatry Cogn Neurosci Neuroimaging Volume: 3 Issue: 1 Pages: 69-76
  • DOI: 10.1016/j.bpsc.2017.09.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Creativity and arts in psychiatry (2018)
  • Author(s): Hirano Yoji、Hosaka Kenjiro
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 72 Issue: 1 Pages: 1-1
  • DOI: 10.1111/pcn.12617
  • Peer Reviewed
• [Presentation] Spontaneous and Evoked Neural Oscillation Abnormalities in Schizophrenia. (2021)
  • Author(s): Hirano Y
  • Organizer: 9th European Conference on Schizophrenia Research (Symposium Co-chair)
  • Int'l Joint Research / Invited
• [Presentation] Dynamic Neural Activity Changes After Transcranial Magnetic Stimulation Treatment in Patients with Major Depressive Disorder (2021)
  • Author(s): Hirano Y, Mitoma R, Tamura S, Tateishi H, Monji A
  • Organizer: The 2021 Society of Biological Psychiatry Annual Meeting
  • Int'l Joint Research
• [Presentation] Increased Theta/Alpha Source Activity and Default Mode Network Connectivity in Schizophrenia During Eyes-Closed Rest (2021)
  • Author(s): Nakhnikian A, Oribe N, Hirano S, Hirano Y, Levin M, Spencer K
  • Organizer: The 2021 Society of Biological Psychiatry Annual Meeting
  • Int'l Joint Research
• [Presentation] Eye-Movement Abnormalities among Patients with Schizophrenia (2021)
  • Author(s): Wolf A, Hirano Y
  • Organizer: 43rd European Conference on Visual Perception
  • Int'l Joint Research
• [Presentation] Attention to Sound Stimuli Modulates Gamma Oscillation: Towards Neurofeedback Training (2021)
  • Author(s): Hirano Y, Mitsudo T, Tamura S
  • Organizer: The 2021 Congress of The Schizophrenia International Research Society
  • Int'l Joint Research / Invited
• [Presentation] Cross-diagnostic Comparisons of Intellectual Ability and Work Outcome in Patients with Mental Disorders: A Multi-center Study (2021)
  • Author(s): Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Hashimoto N, Makinodan M, Takahashi T, Nemoto N, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R
  • Organizer: The 2021 Congress of the Schizophrenia International Research Society
  • Int'l Joint Research
• [Presentation] Oscillatory Brain Network Changes after TMS in Major Depressive Disorder (2021)
  • Author(s): Ryo Mitoma and Yoji Hirano
  • Organizer: Pharmaco-EEG Society International Joint Meeting 2020
  • Int'l Joint Research
• [Presentation] Attention to Sound Stimuli Modulates Gamma Oscillation: Towards Neurofeedback Training (2021)
  • Author(s): Yoji Hirano
  • Organizer: The 2021 Congress of The Schizophrenia International Research Society
  • Int'l Joint Research
• [Presentation] Oscillatory Neurophysiological Biomarkers in Schizophrenia -Toward Translational Research- (2020)
  • Author(s): Yoji Hirano
  • Organizer: 第43回日本神経科学大会（基礎-臨床連携国際シンポジウム）
  • Invited
• [Presentation] 統合失調症の聴覚皮質体積減少とガンマオシレーション異常 (2020)
  • Author(s): 平野羊嗣
  • Organizer: 第42回日本生物学的精神医学会年会
  • Invited
• [Presentation] 精神現象の可視化：ガンマオシレーションを軸にした統合失調症の病態解明と治療（第7回日本生物学的精神医学会若手研究者育成プログラム最優秀奨励賞） (2020)
  • Author(s): 平野羊嗣
  • Organizer: 第42回日本生物学的精神医学会年会
  • Invited
• [Presentation] 統合失調症の病態と最近の治療および就労について (2020)
  • Author(s): 平野羊嗣
  • Organizer: 勤労者こころの研究会
  • Invited
• [Presentation] Investigation of subcortical volume abnormalities in patients with schizophrenia and bipolar disorder (2019)
  • Author(s): Hirano Y, Sato J, Hirakawa N, Kanba S, Onitsuka T
  • Organizer: The 21st Annual ISBD Conference on Bipolar Disorders and Depression
  • Int'l Joint Research
• [Presentation] Sensory processing dysfunction and abnormal neural oscillation in schizophrenia (2019)
  • Author(s): Hirano Y
  • Organizer: UNSW Sydney Psychiatry Meeting
  • Int'l Joint Research / Invited
• [Presentation] Abnormal Cortical Activities in Schizophrenia -Potential Novel Targets for Clinical Applications- (2019)
  • Author(s): Hirano Y
  • Organizer: Asia Pacific Society for Biology and Medical Sciences 2019 Annual Meeting(Keynote speaker, Outstanding Research Award 2019)
  • Int'l Joint Research / Invited
• [Presentation] Spontaneous Gamma Activity in Schizophrenia (2019)
  • Author(s): Hirano Y
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (Special Symposium)
  • Int'l Joint Research / Invited
• [Presentation] Spontaneous and Evoked Auditory Gamma Abnormalities in First-Episode Schizophrenia: A Longitudinal Study (2019)
  • Author(s): Hirano Y, Oribe N, del Re E, Kanba S, Onitsuka T, Levin M, McCarley RW, Spencer KM
  • Organizer: The ACNP Annual Meeting
  • Int'l Joint Research
• [Presentation] Progressive spontaneous and synchrony gamma-band oscillation deficits in first episode schizophrenia (SIRS Young Investigator Award) (2018)
  • Author(s): Yoji Hirano
  • Organizer: The 2018 Congress of The Schizophrenia International Research Society
  • Int'l Joint Research / Invited
• [Presentation] Abnormal cortical activities in psychosis: toward translational research (2018)
  • Author(s): Yoji Hirano, Kevin Spencer
  • Organizer: 21st International Conference on Biomagnetism (Invited Symphonist & Co-Chair)
  • Int'l Joint Research / Invited
• [Presentation] Neural Oscillation Abnormalities in Psychosis (Cutting-edge translational research in schizophrenia -from neurophysiological perspective-) (2018)
  • Author(s): Yoji Hirano
  • Organizer: The 40th Annual Meeting of JSBP
  • Int'l Joint Research / Invited
• [Presentation] Abnormal Neural Oscillation and Auditory Hallucination in Schizophrenia (2018)
  • Author(s): Yoji Hirano
  • Organizer: The International Consortium on Hallucination Research 2018
  • Int'l Joint Research / Invited
• [Presentation] 統合失調症の神経生理学的研究 -ここまで分かった統合失調症- (2018)
  • Author(s): 平野羊嗣
  • Organizer: 第13回日本統合失調症学会（若手中堅シンポジウム）
  • Invited
• [Presentation] 情動制御とガンマ帯域神経活動 (2018)
  • Author(s): 中西翔一郎、平野羊嗣
  • Organizer: 第70回九州精神神経学会
• [Book] 精神疾患とその治療 (2020)
  • Author(s): 神庭重信（編集）, 平野羊嗣（分担）
  • Total Pages: 280
  • Publisher: 遠見書房
  • ISBN: 9784866160726
• [Book] 精神科のくすりハンドブック 第3版 (2020)
  • Author(s): 樋口輝彦（編集）, 平野羊嗣（分担）
  • Total Pages: 681
  • Publisher: 総合医学社
  • ISBN: 9784883786817
• [Patent(Industrial Property Rights)] 脳活動推定方法、脳活動推定装置および脳活動推定プログラム (2021)
  • Inventor(s): 平野羊嗣、中西翔一郎
  • Industrial Property Rights Holder: 平野羊嗣、中西翔一郎
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021