Detecting the neural oscillation deficits during abnormal emotional regulation in schizophrenia patients
Project/Area Number |
18K07604
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52030:Psychiatry-related
|
Research Institution | Kyushu University |
Principal Investigator |
Hirano Yoji 九州大学, 大学病院, 講師 (90567497)
|
Project Period (FY) |
2018-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 統合失調症 / 情動制御障害 / ガンマオシレーション / ニューラルオシレーション / 脳波・脳磁図 / ニューロフィードバック / 情動制御 / 社会機能障害 / 脳波 / 脳磁図 / fMRI / ガンマ帯域皮質活動 / ガンマ帯域神経振動 / neurofeedback |
Outline of Final Research Achievements |
This study aimed to elucidate the pathophysiology involved in emotion dysregulation, which is also a cause of social dysfunction in patients with schizophrenia. Specifically, we used electroencephalography (EEG) to measure changes in frontal neural activity indices during emotion regulation in healthy subjects and patients with schizophrenia. The results showed that compared to normal subjects, schizophrenia showed abnormal neural activity in the gamma-band of the frontal cortex during emotion regulation. Based on this finding, we also performed a discrimination task using different frequency stimuli and found that discrimination ability improved and EEG synchronization changed after training. Some of the results were presented at domestic and international conferences and 33 papers were accepted by international journals. We have also applied for a patent for innovative real-time time-frequency analysis, which is indispensable for clinical applications.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究によって、統合失調症の社会機能障害の原因でもある、情動制御障害の神経学的な基盤の一端が明らかになった。情動制御時の前頭部のガンマ帯域神経活動異常をニューロフィードバックにより制御することで、同疾患の情動制御障害の改善が期待できる。今後は、本研究にて同時に開発したリアルタイム時間周波数解析技術を用い、治療へ応用可能なニューロフィードバックシステムの構築を目指す。
|
Report
(5 results)
Research Products
(70 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] Transdiagnostic Comparisons of Intellectual Abilities and Work Outcome in Patients with Mental Disorders: A Multicentre Study2022
Author(s)
Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, et al
-
Journal Title
BJPsych Open
Volume: in press
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Toward Recovery in Schizophrenia: Current Concepts, Findings, and Future Research Directions2022
Author(s)
Toshiaki Onitsuka, Yoji Hirano, Takanobu Nakazawa, Kayo Ichihashi, Kenichiro Miura, Ken Inada, Ryo Mitoma, Norio Yasui_Furukori, Ryota Hashimoto
-
Journal Title
Psychiatry and Clinical Neurosciences
Volume: in press
Issue: 7
Pages: 282-291
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Trends in Big Data Analyses by Multicenter Collaborative Translational Research in Psychiatry2022
Author(s)
Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
-
Journal Title
Psychiatry and Clinical Neurosciences
Volume: 76
Issue: 1
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study2021
Author(s)
Jinya Sato, Yoji Hirano*, Noriaki Hirakawa, Junichi Takahashi, Naoya Oribe, Hironori Kuga, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao, Toshiaki Onitsuka
-
Journal Title
Journal of Personalized Medicine
Volume: 11
Issue: 2
Pages: 121-121
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Effects of age and sex on the eye movement characteristics2021
Author(s)
Takahashi J, Miura K, Morita K, Fujimoto M, Miyata S, Okazaki K, Matsumoto J, Hasegawa N, Hirano Y, Yamamori H, Yasuda Y, Makinodan M, Kasai K, Ozaki N, Onitsuka T, Hashimoto R.
-
Journal Title
Neuropsychopharmacological Reports
Volume: in press
Issue: 2
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Eye Movement Abnormalities in Major Depressive Disorder2021
Author(s)
Junichi Takahashi, Yoji Hirano*, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Ryota Hashimoto, Toshiaki Onitsuka
-
Journal Title
Frontiers in Psychiatry
Volume: 12
Pages: 673443-673443
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
[Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study.2020
Author(s)
Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T.
-
Journal Title
Psychiatry Clin Neurosci
Volume: 74(1)
Issue: 1
Pages: 56-63
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Longitudinal evaluation of visual P300 amplitude in clinical high‐risk subjects: An event‐related potential study2020
Author(s)
Oribe Naoya, Hirano Yoji, Re Elisabetta, Mesholam‐Gately Raquelle I., Woodberry Kristen A., Ueno Takefumi, Kanba Shigenobu, Onitsuka Toshiaki, Shenton Martha E., Spencer Kevin M., Niznikiewicz Margaret A.
-
Journal Title
Psychiatry and Clinical Neurosciences
Volume: 74
Issue: 10
Pages: 527-534
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study2020
Author(s)
Ohara Naotoshi, Hirano Yoji*, Oribe Naoya, Tamura Shunsuke, Nakamura Itta, Hirano Shogo, Tsuchimoto Rikako, Ueno Takefumi, Togao Osamu, Hiwatashi Akio, Nakao Tomohiro, Onitsuka Toshiaki
-
Journal Title
Frontiers in Psychiatry
Volume: 11
Pages: 554844-554844
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
[Journal Article] Abnormalities of eye movement are associated with work hours in schizophrenia.2018
Author(s)
Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
-
Journal Title
Schizophr Res
Volume: 202
Pages: 420-422
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
[Presentation] Cross-diagnostic Comparisons of Intellectual Ability and Work Outcome in Patients with Mental Disorders: A Multi-center Study2021
Author(s)
Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, Uno Y, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Hashimoto N, Makinodan M, Takahashi T, Nemoto N, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R
Organizer
The 2021 Congress of the Schizophrenia International Research Society
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 精神疾患とその治療2020
Author(s)
神庭重信(編集), 平野羊嗣(分担)
Total Pages
280
Publisher
遠見書房
ISBN
9784866160726
Related Report
-
-