• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Inhibitory function in ASD

Research Project

Project/Area Number 18K07619
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionInstitute for Developmental Research Aichi Developmental Disability Center

Principal Investigator

Inui Koji  愛知県医療療育総合センター発達障害研究所, 障害システム研究部, 部長 (70262996)

Co-Investigator(Kenkyū-buntansha) 元村 英史  三重大学, 医学部附属病院, 講師 (10324534)
竹内 伸行  愛知医科大学, 医学部, 助教 (20740947)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsinhibition / prepulse / startle / EEG / プレパルス抑制 / ペアパルス抑制 / 変化関連脳活動 / 聴覚誘発脳電位 / 聴覚誘発電位 / 介在細胞 / てんかん / ASD / 脳波 / 脳磁図 / 発達障害 / 自閉症 / 抑制 / 自閉症スペクトラム / GABA
Outline of Final Research Achievements

Responses to a sensory stimulus are inhibited by a preceding stimulus; if the two stimuli are identical, paired-pulse suppression (PPS) occurs; if the preceding stimulus is too weak to reliably elicit the target response, prepulse inhibition (PPI) occurs. PPS and PPI represent excitability changes in neural circuits induced by the first stimulus.In the present study, PPS and PPI of the auditory change-related cortical response were examined to establish normative data in 67 healthy subjects aged 19-71 years. The results obtained showed that sex exerted similar effects on the two measures, with females having stronger test responses and weaker inhibition. Age exerted different effects: aging correlated with stronger test responses and weaker inhibition in the PPS experiment, but had no effects in the PPI experiment. Then, PPI and PPS were compared between normal subjects and patients with epilepsy or ASD. Results showed that both clinical groups had significantly lower inhibition.

Academic Significance and Societal Importance of the Research Achievements

神経回路の出力は、興奮性活動と抑制性活動のバランスで決定しますが、後者は非侵襲的な観察が難しく、研究が進んでいません。統合失調症などの精神疾患、てんかん、発達障害等の疾患や病態で抑制機能の異常が推定されるものの、直接の検査方法がないため異常の有無を含めて詳細な異常の機序は不明のままです。本研究の手法は、通常の検査で使用される強度の音刺激のみを使用し、脳波を記録するだけで抑制性の回路調節を観察できるため、患者さんにも応用可能であり、そのような疾患でどのような調節に障害があるのかを調べる上で有用と考えられます。脳の反応を観察しており、神経伝達の抑制性調節を知ることにも貢献すると期待されます。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (24 results)

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article (24 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 24 results,  Open Access: 18 results)

  • [Journal Article] Age and sex effects on paired-pulse suppression and prepulse inhibition of auditory evoked potentials2024

    • Author(s)
      Inui Koji、Takeuchi Nobuyuki、Borgil Bayasgalan、Shingaki Megumi、Sugiyama Shunsuke、Taniguchi Tomoya、Nishihara Makoto、Watanabe Takayasu、Suzuki Dai、Motomura Eishi、Kida Tetsuo
    • Journal Title

      Frontiers in Neuroscience

      Volume: 18

    • DOI

      10.3389/fnins.2024.1378619

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Auditory sensory suppression and personality traits using Bear-Fedio inventory2023

    • Author(s)
      Takeuchi Nobuyuki、Fujita Kohei、Taniguchi Tomoya、Kinukawa Tomoaki、Sugiyama Shunsuke、Kanemoto Kousuke、Nishihara Makoto、Inui Koji
    • Journal Title

      Current Psychology

      Volume: 43 Issue: 11 Pages: 9598-9601

    • DOI

      10.1007/s12144-023-05082-2

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Target site of prepulse inhibition of the trigeminal blink reflex in humans.2023

    • Author(s)
      Inui K, Itoh Y, Bayasgalan B, Shingaki M, Taniguchi T, Motomura E, Kida T
    • Journal Title

      J Neurosci

      Volume: 43 Issue: 2 Pages: 261-269

    • DOI

      10.1523/jneurosci.1468-22.2022

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of short- and long-latency sensory suppression: magnetoencephalography study2023

    • Author(s)
      4. Takeuchi N, Fujita K, Taniguchi T, Kinukawa T, Sugiyama S, Kanemoto K, Nishihara M, Inui K
    • Journal Title

      Neuroscience

      Volume: - Pages: 92-99

    • DOI

      10.1016/j.neuroscience.2022.11.016

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship of loudness-dependent auditory evoked potentials with change-related cortical responses2022

    • Author(s)
      Fujita Kohei、Takeuchi Nobuyuki、Sugiyama Shunsuke、Inui Koji、Fujita Yuki、Yamaba Ami、Kamiya Taeko、Kanemoto Kousuke、Nishihara Makoto
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 11 Pages: e0277153-e0277153

    • DOI

      10.1371/journal.pone.0277153

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catechol-O-methyltransferase (COMT) Val158Met Polymorphism and Prepulse Inhibition of the Change-related Cerebral Response2022

    • Author(s)
      Motomura E, Tanii H, Kawano Y, Inui K, Okada M.
    • Journal Title

      Psychiatry Res; Neuroimaging

      Volume: 323 Pages: 111484-111484

    • DOI

      10.1016/j.pscychresns.2022.111484

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Review of techniques useful for the assessment of sensory small fiber neuropathies: Report from an IFCN expert group.2022

    • Author(s)
      Inui K, Kakigi R
    • Journal Title

      Clin Neurophysiol

      Volume: . Pages: 13-38

    • DOI

      10.1016/j.clinph.2022.01.002

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural Sources of Vagus Nerve Stimulation?Induced Slow Cortical Potentials2022

    • Author(s)
      Bayasgalan Borgil、Matsuhashi Masao、Fumuro Tomoyuki、Nakano Naoki、Katagiri Masaya、Shimotake Akihiro、Kikuchi Takayuki、Iida Koji、Kunieda Takeharu、Kato Amami、Takahashi Ryosuke、Ikeda Akio、Inui Koji
    • Journal Title

      Neuromodulation: Technology at the Neural Interface

      Volume: 25 Issue: 3 Pages: 407-413

    • DOI

      10.1016/j.neurom.2022.01.009

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanisms of Long-Latency Paired Pulse Suppression: MEG Study2021

    • Author(s)
      Takeuchi Nobuyuki、Fujita Kohei、Taniguchi Tomoya、Kinukawa Tomoaki、Sugiyama Shunsuke、Kanemoto Kousuke、Nishihara Makoto、Inui Koji
    • Journal Title

      Brain Topography

      Volume: 35 Issue: 2 Pages: 241-250

    • DOI

      10.1007/s10548-021-00878-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suppression of Low-Frequency Gamma Oscillations by Activation of 40-Hz Oscillation2021

    • Author(s)
      Sugiyama Shunsuke、Taniguchi Tomoya、Kinukawa Tomoaki、Takeuchi Nobuyuki、Ohi Kazutaka、Shioiri Toshiki、Nishihara Makoto、Inui Koji
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 13 Pages: 2785-2796

    • DOI

      10.1093/cercor/bhab381

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Magnitude of Leading Stimulus on Prepulse Inhibition of Auditory Evoked Cerebral Responses: An Exploratory Study2021

    • Author(s)
      Kawano Yasuhiro、Motomura Eishi、Inui Koji、Okada Motohiro
    • Journal Title

      Life

      Volume: 11 Issue: 10 Pages: 1024-1024

    • DOI

      10.3390/life11101024

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Electrical field distribution of Change-N1 and its prepulse inhibition2021

    • Author(s)
      Watanabe T, Motomura E, Kawano Y, Fujii S, Hakumoto Y, Morimoto M, Nakatani K, Okada M, Inui K.
    • Journal Title

      Neurosci Lett

      Volume: 751 Pages: 135804-135804

    • DOI

      10.1016/j.neulet.2021.135804

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Test-retest reliability of paired pulse suppression paradigm using auditory change-related response2021

    • Author(s)
      Takeuchi Nobuyuki、Fujita Kohei、Kinukawa Tomoaki、Sugiyama Shunsuke、Kanemoto Kousuke、Nishihara Makoto、Inui Koji
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 352 Pages: 109087-109087

    • DOI

      10.1016/j.jneumeth.2021.109087

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Test-retest reliability of prepulse inhibition paradigm using auditory evoked potentials2020

    • Author(s)
      Takeuchi Nobuyuki、Kinukawa Tomoaki、Sugiyama Shunsuke、Inui Koji、Nishihara Makoto
    • Journal Title

      Neuroscience Research

      Volume: . Pages: 187-194

    • DOI

      10.1016/j.neures.2020.08.011

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of haptic memory using somatosensory change‐related cortical responses2020

    • Author(s)
      Sugiyama S, Kinukawa T, Takeuchi N, Nishihara M, Shioiri T, Inui K
    • Journal Title

      Hum Brain Mapp

      Volume: 020 Issue: 17 Pages: 4892-4900

    • DOI

      10.1002/hbm.25165

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Weaker prepulse exerts stronger suppression of a change-detecting neural circuit2020

    • Author(s)
      Fujii S, Motomura E, Inui K, Watanabe T, Hakumoto Y, Higuchi K, Kawano Y, Morimoto M, Nakatani K, Okada M.
    • Journal Title

      Neurosci Res

      Volume: - Pages: 1024-1024

    • DOI

      10.1016/j.neures.2020.07.007

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tactile cross-modal acceleration effects on auditory steady-state response2019

    • Author(s)
      Sugiyama S, Kinukawa T, Takeuchi N, Nishihara M, Shioiri T, Inui K
    • Journal Title

      Front Integr Neurosci

      Volume: 13 Pages: 72-72

    • DOI

      10.3389/fnint.2019.00072

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change-related acceleration effects on auditory steady-state response2019

    • Author(s)
      Sugiyama S, Kinukawa T, Takeuchi N, Nishihara M, Shioiri T, Inui K
    • Journal Title

      Front Syst Neurosci

      Volume: 13 Pages: 53-53

    • DOI

      10.3389/fnsys.2019.00053

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Properties of echoic memory revealed by auditory-evoked magnetic fields2019

    • Author(s)
      Kinukawa T, Takeuchi N, Sugiyama S, Nishihara M, Nishiwaki N, Inui K
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 12260-12260

    • DOI

      10.1038/s41598-019-48796-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of sound-pressure change on the 40 Hz auditory steady-state response and change-related cerebral response2019

    • Author(s)
      Motomura E, Inui K, Kawano Y, Nishihara M, Okada M.
    • Journal Title

      Brain Sciences

      Volume: 9 Issue: 8 Pages: 203-203

    • DOI

      10.3390/brainsci9080203

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli2019

    • Author(s)
      Nobuyuki Takeuchi, Tomoaki Kinukawa, Shunsuke Sugiyama, Koji Inui, Kousuke Kanemoto, Makoto Nishihara
    • Journal Title

      Brain Topography

      Volume: 32 Issue: 5 Pages: 783-793

    • DOI

      10.1007/s10548-019-00721-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of acceleration of auditory inputs on the primary somatosensory cortex in humans2018

    • Author(s)
      Sugiyama S, Takeuchi N, Inui K, Nishihara M, Shioiri T
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 12883-12883

    • DOI

      10.1038/s41598-018-31319-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-latency suppression of auditory and somatosensory change-related cortical responses.2018

    • Author(s)
      Takeuchi N, Sugiyama S, Inui K, Kanemoto K, Nishihara M.
    • Journal Title

      PLoS One

      Volume: 13(6) Issue: 6 Pages: e0199614-e0199614

    • DOI

      10.1371/journal.pone.0199614

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] GABAergic mechanisms involved in the prepulse inhibition of auditory evoked cortical responses in humans2018

    • Author(s)
      Inui Koji、Takeuchi Nobuyuki、Sugiyama Shunsuke、Motomura Eishi、Nishihara Makoto
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: e0190481-e0190481

    • DOI

      10.1371/journal.pone.0190481

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi