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Database of effect of different radiation on cancer metastatic potential

Research Project

Project/Area Number 18K07632
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionOsaka University

Principal Investigator

Koizumi Masahiko  大阪大学, 医学系研究科, 教授 (90186594)

Co-Investigator(Kenkyū-buntansha) 沖本 智昭  神戸大学, 医学研究科, 客員教授 (20295067)
山本 浩文  大阪大学, 医学系研究科, 教授 (30322184)
出水 祐介  神戸大学, 医学研究科, 客員准教授 (50452496)
皆巳 和賢  大阪大学, 医学系研究科, 助教 (90634593)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsγ線 / 炭素イオン線 / 陽子線 / 細胞浸潤能 / 転移能 / がん転移 / Rac1 / cdc42 / 転移 / 浸潤能 / 医学物理 / 医学物理学 / がん細胞 / 光子線 / 粒子線
Outline of Final Research Achievements

The mechanisms of cancer metastases induced by irradiation (photon, proton, and carbon ion beams) were elucidated from a molecular biological perspective. The indices such as line dose, irradiation type, genotype with pronounced effect, and cell condition were determined for each cancer type and compiled into a database.The effects of γ-ray, proton, and carbon-ion irradiation on the invasive potential of lung, breast, and pancreatic cancer cell lines were investigated, and it was suggested that carbon-ion irradiation had an inhibitory effect on invasive potential compared to γ-ray, regardless of cancer type. The lung metastasis was examined by inoculating breast, pancreatic, and lung cancer cells from the tail vein of mice after 72 hours of γ-ray and carbon-ion irradiation, and the lung metastatic potential was significantly suppressed in mice inoculated with carbon-ion irradiated cells.
We provided a molecular biological suggestion for the radiotherapy methods to prevent metastases.

Academic Significance and Societal Importance of the Research Achievements

近年、光子線は局所制御を高め、隣接正常臓器への過照射を避けるため、強度変調放射線治療(IMRT)や低位放射線照射が急速に普及してきている。更に、炭素イオン線や陽子線といった粒子線を用いた放射線治療により、今まで治療成績が不良であった腫瘍に対しても、良好な治療成績が得られている。外科、化学療法を含む集学的な局所療法の進歩で、良好な局所制御がなされるようになっている現在においても、今なおがんの遠隔転移は最大の課題であり、がん転移の有無は生存率に大きく影響し、がん患者の予後に関わる。
初期治療からの放射線治療において転移予防を視野に入れた放射線治療法の開発として、本課題は分子生物学的示唆を与えた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (5 results) (of which Int'l Joint Research: 5 results) Book (1 results)

  • [Int'l Joint Research] Purdue University Indianapolis(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Local hyperthermia combined with CTLA-4 blockade induces both local and abscopal effects in a murine breast cancer model2021

    • Author(s)
      Ibuki Y, Takahashi Y, Tamari K, Minami K, Seo Y, Isohashi F, Koizumi M, Ogawa K.
    • Journal Title

      Int J Hyperthermia

      Volume: 38 Issue: 1 Pages: 363-371

    • DOI

      10.1080/02656736.2021.1875059

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells2021

    • Author(s)
      Adachi Takanori、Zhao Wantong、Minami Kazumasa、Yokoyama Yuhki、Okuzaki Daisuke、Kondo Rika、Takahashi Yutaka、Tamari Keisuke、Seo Yuji、Isohashi Fumiaki、Yamamoto Hirofumi、Koizumi Masahiko、Ogawa Kazuhiko
    • Journal Title

      Journal of Radiation Research

      Volume: 62 Issue: 5 Pages: 764-772

    • DOI

      10.1093/jrr/rrab049

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN42021

    • Author(s)
      Fan Yao、Zha Rongrong、Sano Tomohiko、Zhao Xinyu、Liu Shengzhi、Woollam Mark D.、Wu Di、Sun Xun、Li Kexin、Egi Motoki、Li Fangjia、Minami Kazumasa、Siegel Amanda P.、Horiuchi Takashi、Liu Jing、Agarwal Mangilal、Sudo Akihiro、Nakshatri Harikrishna、Li Bai-Yan、Yokota Hiroki
    • Journal Title

      Bone Research

      Volume: 9 Issue: 1 Pages: 26-26

    • DOI

      10.1038/s41413-021-00144-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Elimination of residual undifferentiated induced pluripotent stem cells (iPSCs) using irradiation for safe clinical applications of iPSC-derived cardiomyocytes2021

    • Author(s)
      Takeda Maki、Ito Emiko、Minami Kazumasa、Harada Akima、Mochizuki-Oda Noriko、Sawa Yoshiki、Miyagawa Shigeru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 574 Pages: 91-96

    • DOI

      10.1016/j.bbrc.2021.08.065

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method2021

    • Author(s)
      Wu Xin、Yokoyama Yuhki、Takahashi Hidekazu、Kouda Shihori、Yamamoto Hiroyuki、Wang Jiaqi、Morimoto Yoshihiro、Minami Kazumasa、Hata Tsuyoshi、Shamma Awad、Inoue Akira、Ohtsuka Masahisa、Shibata Satoshi、Kobayashi Shogo、Akai Shuji、Yamamoto Hirofumi
    • Journal Title

      Journal of Personalized Medicine

      Volume: 11 Issue: 11 Pages: 1160-1160

    • DOI

      10.3390/jpm11111160

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation2019

    • Author(s)
      TAMARI KEISUKE、SANO KEISUKE、LI ZHIHAO、SEO YUJI、OTANI KEISUKE、TATEKAWA SHOTARO、TORATANI MASAYASU、TAKAOKA YUJI、TAKAHASHI YUTAKA、MINAMI KAZUMASA、ISOHASHI FUMIAKI、KOIZUMI MASAHIKO、OGAWA KAZUHIKO
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 9 Pages: 4805-4810

    • DOI

      10.21873/anticanres.13665

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pitavastatin slows tumor progression and alters urine-derived volatile organic compounds through the mevalonate pathway2019

    • Author(s)
      Wang Luqi、Wang Yue、Chen Andy、Teli Meghana、Kondo Rika、Jalali Aydin、Fan Yao、Liu Shengzhi、Zhao Xinyu、Siegel Amanda、Minami Kazumasa、Agarwal Mangilal、Li Bai-Yan、Yokota Hiroki
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 12 Pages: 13710-13721

    • DOI

      10.1096/fj.201901388r

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Radiobiological effects of flattening filter?free photon beams on A549 non-small-cell lung cancer cells2018

    • Author(s)
      Nakano Hisashi、Minami Kazumasa、Yagi Masashi、Imaizumi Hiromasa、Otani Yuki、Inoue Shinichi、Takashina Masaaki、Seo Yuji、Takahashi Yutaka、Sumida Iori、Ogawa Kazuhiko、Koizumi Masahiko
    • Journal Title

      Journal of Radiation Research

      Volume: 59 Issue: 4 Pages: 442-445

    • DOI

      10.1093/jrr/rry041

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma2018

    • Author(s)
      Takahashi Yutaka、Yasui Tomohiro、Minami Kazumasa、Tamari Keisuke、Hayashi Kazuhiko、Otani Keisuke、Seo Yuji、Isohashi Fumiaki、Koizumi Masahiko、Ogawa Kazuhiko
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 6 Pages: 9364-9378

    • DOI

      10.18632/oncotarget.26551

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] X-ray-enhanced cancer cell migration requires the linker of nucleoskeleton and cytoskeleton complex2018

    • Author(s)
      Imaizumi, H., Sato, S., Nishihara, A., Minami, K., Koizumi, M., Matsuura, N., Hieda, M
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 4 Pages: 1158-1165

    • DOI

      10.1111/cas.13545

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparision of the effect of X-ray, carbon ion beam and proton beam on metastatic potential.2019

    • Author(s)
      Kondo R, Minami K, Koizumi M
    • Organizer
      PTCOG 58th
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Combination of carbon ion irradiation with dual immune checkpoint blockade therapy enhances local and distant antitumor efficacy.2019

    • Author(s)
      Minami K, Kondo R, Koizumi M, Ogawa K
    • Organizer
      58th AnnualConference of the Particle Therapy Co-Operative Group
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dosimetric effect of rotational setup errors in stereotactic radiosurgery with HyperArc for single and multiple brain metastases.2019

    • Author(s)
      Sagawa T, Ohira S, Ueda Y, Akino Y, Mizuno H, Matsumoto M, Miyazaki M, Koizumi M, Teshima T
    • Organizer
      7大学連携個別化がん医療実践者養成プラン, 第2回国際がん研究シンポジウム
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparision of the effect of X-ray, carbon ion beam and proton beam on metastatic potential.2018

    • Author(s)
      Kondo R, Adachi T, Minami K, Koizumi M
    • Organizer
      PTCOG 57th
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Combination of carbon ion irradiation with dual immune checkpoint blockade therapy enhances local and distant antitumor efficacy2018

    • Author(s)
      Masahiko Koizumi, Yutaka Takahashi, Tomohiro Yasui, Kazumasa Minami, Keisuke Tamari, Kazuhiko Hayashi, Keisuke Otani, Yuji Seo, Fumiaki Isohashi, Kazuhiko Ogawa
    • Organizer
      The 6th Taiwan Japan Radiation Oncology Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] 新・医用放射線科学講座 放射線腫瘍学2020

    • Author(s)
      松本 光弘, 小泉 雅彦, 川守田 龍
    • Total Pages
      186
    • Publisher
      医歯薬出版
    • ISBN
      9784263206492
    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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