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Development of a liver cancer treatment simulation system and establishment of a remote treatment system

Research Project

Project/Area Number 18K07634
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionEhime University

Principal Investigator

Hirooka Masashi  愛媛大学, 医学部附属病院, 准教授 (30432785)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords肝腫瘍 / シミュレーションシステム / fusion system / 肝細胞癌 / ラジオ波焼灼術 / 肝がん / 治療支援システム
Outline of Final Research Achievements

We developed the 3D sim-Navigator with E-field for malignant liver tumors, and developed a locoregional therapy technique using this function. The aim of this study was to establish a foundation for remote treatment by the conferences with other hospitals member through the VPN. First, we confirmed that the ablation area was correlated with low density area of CT accurately. Although it was extremely difficult to establish a network in the midst of the COVID-19 pandemic, we were able to use ICT through VPN connections with 30 hospitals. As a result, we were able to establish a foundation for remote medical care. In the future, we plan to use this system to build a treatment system in which many doctors can participate.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したE-fieldをはじめとした治療システムにより主観的な超音波画像システムにおいても客観的な治療シミュレーション、治療効果判定が可能になった。特に2次元断面でしか評価できなかった治療範囲が3次元的に容易に評価可能になったことは意義が大きい。さらにVPNによりネットワーク接続を行い学習効果やコロナ感染対策を行えたことも大きいと考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Development of a method for measuring spleen stiffness by transient elastography using a new device and ultrasound-fusion method2021

    • Author(s)
      Tanaka Takaaki、Hirooka Masashi、Koizumi Yohei、Watanabe Takao、Yoshida Osamu、Tokumoto Yoshio、Nakamura Yoshiko、Sunago Koutarou、Yukimoto Atsushi、Abe Masanori、Hiasa Yoichi
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 2 Pages: e0246315-e0246315

    • DOI

      10.1371/journal.pone.0246315

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dilatation of lymphatic vessels increases liver stiffness on transient elastography irrespective of fibrosis2021

    • Author(s)
      Hirooka Masashi、Koizumi Yohei、Tanaka Takaaki、Sunago Kotarou、Nakamura Yoshiko、Yukimoto Atsushi、Watanabe Takao、Yoshida Osamu、Tokumoto Yoshio、Abe Masanori、Hiasa Yoichi
    • Journal Title

      Hepatology Research

      Volume: 51 Issue: 3 Pages: 284-293

    • DOI

      10.1111/hepr.13610

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment on the spleen prevents the progression of secondary sarcopenia in patients with liver cirrhosis2020

    • Author(s)
      Hirooka M, Koizumi Y, Tanaka T, Nakamura Y, Sunago K, Yukimoto A, Watanabe T, Yoshida O, Miyake T, Tokumoto Y, Matsuura B, Abe M, Hiasa Y
    • Journal Title

      Hepatol Commun

      Volume: 4 Issue: 12 Pages: 1812-1823

    • DOI

      10.1002/hep4.1604

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of combining electric‐field and coronal‐plane imaging to obtain ultrasound?ultrasound fusion images in monopolar radiofrequency ablation for patients with liver cancer2020

    • Author(s)
      Hirooka Masashi、Koizumi Yohei、Tanaka Takaaki、Nakamura Yoshiko、Tokumoto Yoshio、Abe Masanori、Hiasa Yoichi
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 8 Pages: 985-995

    • DOI

      10.1111/hepr.13527

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factor of lenvatinib for unresectable hepatocellular carcinoma in real‐world conditions?Multicenter analysis2019

    • Author(s)
      Hiraoka Atsushi、Hirooka Masashi、et al.
    • Journal Title

      Cancer Medicine

      Volume: 8 Issue: 8 Pages: 3719-3728

    • DOI

      10.1002/cam4.2241

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early Relative Change in Hepatic Function with Lenvatinib for Unresectable Hepatocellular Carcinoma2019

    • Author(s)
      Hiraoka Atsushi、Hirooka Masashi、et al.
    • Journal Title

      Oncology

      Volume: 97 Issue: 6 Pages: 334-340

    • DOI

      10.1159/000502095

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Important Clinical Factors in Sequential Therapy Including Lenvatinib against Unresectable Hepatocellular Carcinoma2019

    • Author(s)
      Hiraoka Atsushi、Hirooka Masashi、et al.
    • Journal Title

      Oncology

      Volume: 97 Issue: 5 Pages: 277-285

    • DOI

      10.1159/000501281

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lenvatinib-induced thyroid abnormalities in unresectable hepatocellular carcinoma2019

    • Author(s)
      Koizumi Yohei、Hirooka Masashi、Hiraoka Atsushi、Ochi Hironori、Tanaka Takaaki、Yukimoto Atsushi、Imai Yuusuke、Watanabe Takao、Yoshida Osamu、Miyake Teruki、Matsuura Bunzo、Michitaka Kojiro、Joko Kouji、Abe Masanori、Hiasa Yoichi
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 9 Pages: 787-792

    • DOI

      10.1507/endocrj.EJ19-0140

    • NAID

      130007719421

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] New diagnostic technique to evaluate hepatic steatosis using the attenuation coefficient on ultrasound B mode2019

    • Author(s)
      Koizumi Yohei、Hirooka Masashi、Tamaki Nobuharu、Yada Norihisa、Nakashima Osamu、Izumi Namiki、Kudo Masatoshi、Hiasa Yoichi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 8 Pages: 0221548-0221548

    • DOI

      10.1371/journal.pone.0221548

    • Related Report
      2019 Research-status Report
  • [Journal Article] Validation trial for efficacy of ultrasonographic measurement method to predict ascitic volume using virtual ultrasonography2018

    • Author(s)
      Hirooka Masashi、Koizumi Yohei、Imai Yusuke、Yukimoto Atsushi、Watanabe Takao、Yoshida Osamu、Abe Masanori、Hiasa Yoichi
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 45 Issue: 4 Pages: 555-564

    • DOI

      10.1007/s10396-018-0879-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transcatheter Arterial Chemoembolization With or Without Radiofrequency Ablation: Outcomes in Patients With Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma.2018

    • Author(s)
      Hirooka M, Hiraoka A, Ochi H, Kisaka Y, Joko K, Michitaka K, Hiasa Y.
    • Journal Title

      AJR Am J Roentgenol.

      Volume: 210 Issue: 4 Pages: 891-898

    • DOI

      10.2214/ajr.17.18177

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 門脈圧亢進症の診断と治療 新規アタッチメントを用いた肝脾臓硬度測定による門脈圧亢進症の評価2020

    • Author(s)
      廣岡 昌史 , 田中 孝明 , 日浅 陽一
    • Organizer
      日本肝臓学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肝画像診断の新潮流 集団健診におけるFAST score高値例の病態背景の検討2020

    • Author(s)
      廣岡 昌史 , 小泉 洋平 , 日浅 陽一
    • Organizer
      日本肝臓学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Splenic stiffness measurement using the ultrasound fusion method2019

    • Author(s)
      Masashi Hirooka, Yohei Koizumi, Takaaki Tanaka, Kotarou Sunago, Atsushi Yukimoto, Yusuke Imai, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa
    • Organizer
      EASL The International Liver Congress 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical utility of multipolar ablation with a three-dimensional simulator system for patients with hepatocellular carcinoma2019

    • Author(s)
      Masashi Hirooka, Yohei Koizumi, Takaaki Tanaka, Kotarou Sunago, Atsushi Yukimoto, Yusuke Imai, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa
    • Organizer
      WFUMB (World Federation for Ultrasound in Medicine) congress 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] US‐fusion法とE‐fieldを活用したラジオ波焼灼術2019

    • Author(s)
      広岡昌史, 小泉洋平, 日浅陽一
    • Organizer
      第92回日本超音波医学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Long-term outcomes of health-checkup patients with NAFLD in intermediate advanced fibrosis risk group2018

    • Author(s)
      Masashi Hirooka, Yohei Koizumi, Takaaki Tanaka, Kotarou Sunago, Atsushi Yukimoto, Yusuke Imai, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa
    • Organizer
      AASLD The Liver Meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] US LI-RADSとCT/MRI LI-RADSによる肝悪性腫瘍診断能の検討2018

    • Author(s)
      廣岡昌史、平岡淳、日浅陽一
    • Organizer
      JDDW2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 新しい肝画像診断・報告システムLI-RADSを用いた超音波診療2018

    • Author(s)
      廣岡昌史
    • Organizer
      第91回日本超音波医学会総会
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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