High resolution MR lymphangiography by nanodiamond Gd-DTPA
| Project/Area Number |
18K07647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 哲也 慶應義塾大学, 理工学部(矢上), 教授 (10286635)
長谷部 光泉 東海大学, 医学部, 教授 (20306799)
中村 挙子 国立研究開発法人産業技術総合研究所, エレクトロニクス・製造領域, 研究チーム長 (70357656)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MRリンパ造影 / ナノテクノロジー / ナノダイヤモンド / MRI / 造影剤 / Gd-DTPA-Nd / ガドリニウム / リンパ系 / リンパ造影 |
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| Outline of Final Research Achievements |
In this research, we succeeded in fabricating nanoscale and highly dispersive MRI contrast agents (Gd-DTPA-ND) by oxidizing the surface of nanodiamond (ND) particles. By conducting chemical analysis, it was confirmed that the surface condition was not destroyed by the surface oxidation. Furthermore, by dispersing Gd-DTPA-ND particles in water and conducting MR imaging, we found that Gd-DTPA-ND particles exhibited the same MRI contrast as ordinary agents at a significantly lower Gd concentration.
There was unclear on MR lymphangiography of a rabbit after subcutaneous administration of Gd-DTPA-ND. There was no adverse event a hour after taking MR lymphangiography.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は、本研究においてこれまで問題となっていたGd-DTPA-NDの凝集する性質を解決することに成功しました。これによってGd-DTPA-NDを生体に投与が可能なレベルにすることに成功しました。 実際にMRIでの撮像には、Gd-DTPA-NDの濃度や、撮像タイミングの調整がもう少し必要と考えられましたが、今後の高精細のMRリンパ造影の研究をより進めることが可能となりました。
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] The approach of scratch-imprint cytology: Is it an alternative to frozen section for intraoperative assessment of pulmonary lesions?2020
Author(s)
Sugiyama T, Tajiri T, Fujita H, Hiraiwa S, Toguchi S, Nomura N, Machida T, Natsuyama Y, Aruga N, Matsumoto T, Suga A, Nakagawa T, Hasebe T, Yamada S, Iwazaki M, Nakamura N.
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Journal Title
Pathology International
Volume: 70
Issue: 1
Pages: 31-39
DOI
Related Report
Peer Reviewed
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[Journal Article] Feasibility and Safety of CT-guided Intrathoracic and Bone Re-biopsy for Non-small Cell Lung Cancer.2018
Author(s)
Matsumoto T, Hasebe T, Baba Y, Chosa K, Kondo S, Yamada S, Yoshimatsu R, Kubota T, Fujitaka K, Awai K, Yamagami T.
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Journal Title
Anticancer Res.
Volume: 38
Issue: 6
Pages: 3587-3592
DOI
Related Report
Peer Reviewed
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[Presentation] DAPTとIVR2019
Author(s)
Shunsuke Kamei, Tomohiro Matsumoto, Kazunobu Hashida, Kosuke Tomita, Shota Yamamoto, Satoshi Suda, Yuki Natsuyama, Terumitsu Hasebe
Organizer
インターベンショナルラジオロジー学会，第48回日本IVR学会総会
Related Report
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[Presentation] Development of radiopaque drug-eluting beads on lipiodol/biodegradable-polymer for transarterial chemoembolization2019
Author(s)
T. Hasebe, T. Matsumoto, Y. Okamoto, K. Yano, K. Bito, K. Tomita, S. Maegawa, S. Kamei, E. Matsuoka, Y. Imai, A. Hotta
Organizer
Cardiovascular and Interventional Radiological Society of Europe, CIRSE2019
Related Report
Int'l Joint Research
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[Presentation] Therapeutic lymphangiography2019
Author(s)
Tomohiro Matsumoto Kosuke Tomita, Shunsuke Kamei, Shota Yamamoto, Terumitsu Hasebe
Organizer
The 14th annual scientific meeting of APSCVIR
Related Report
Int'l Joint Research / Invited
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[Presentation] Therapeutic lymphangiography2018
Author(s)
Tomohiro Matsumoto Kosuke Tomita, Terumitsu Hasebe
Organizer
The 47th Annual Meeting of the Japanese Society of Interventional Radiology
Related Report
Int'l Joint Research / Invited
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