Development of Dosimetry and Personalized Treatment in Radionuclide Therapy with Novel Nuclides

• Project/Area Number: 18K07651
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kindai University
• Principal Investigator: Hosono Makoto 近畿大学, 医学部, 教授 (00281303)
• Co-Investigator(Kenkyū-buntansha): 若林 源一郎 近畿大学, 原子力研究所, 教授 (90311852)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 核医学治療 / RI内用療法 / 線量評価 / アルファ核種 / ペプチド受容体放射性核種療法 / ベータ核種 / 個別化医療 / 標的アイソトープ治療 / アルファ線放出核種 / α核種 / β核種

Outline of Final Research Achievements

The purpose of this study was to evaluate the absorbed dose in normal organs and lesions in Nuclear Medicine Therapy (Radionuclide Therapy) and to optimize the treatment method. Nuclear Medicine Therapy has made remarkable progress in both basic research and clinical application. Against this background, in this study, we introduced dose calculation software and established a patient dose calculation method in Nuclear Medicine Therapy based on biodistribution data. We also accumulated data on castration-resistant prostate cancer bone metastases treated with radium-223 and analyzed factors that lead to the development of personalized treatment. In the development of new Nuclear Medicine Therapy methods in the future, it is important to develop a method for acquiring biodistribution data and to construct a method for performing dose evaluation based on it.

Academic Significance and Societal Importance of the Research Achievements

核医学治療（RI内用療法）が基礎研究としても臨床手法としても発展する中で、正常組織と腫瘍の線量評価の手法を開発し、線量評価を核医学治療の実施に役立てていくことは極めて重要である。実臨床において多数の核医学治療を行う本研究者らが、その中で線量評価に取り組み、その手法を開発して実際のデータを用いて検証した意義は大きい。

Research Products

• [Journal Article] Escalated Maximum Dose in the Planning Target Volume Improves Local Control in Stereotactic Body Radiation Therapy for T1-2 Lung Cancer (2022)
  • Author(s): Inagaki Takaya、Doi Hiroshi、Ishida Naoko、Ri Aritoshi、Tatsuno Saori、Wada Yutaro、Uehara Takuya、Inada Masahiro、Nakamatsu Kiyoshi、Hosono Makoto、Nishimura Yasumasa
  • Journal Title: Cancers Volume: 14 Issue: 4 Pages: 933-933
  • DOI: 10.3390/cancers14040933
  • Peer Reviewed / Open Access
• [Journal Article] Safety and response after peptide receptor radionuclide therapy with 177Lu-DOTATATE for neuroendocrine tumors in phase 1/2 prospective Japanese trial (2021)
  • Author(s): Kudo Atsushi、Tateishi Ukihide、Yoshimura Ryoichi、Tsuchiya Junichi、Yokoyama Kota、Takano Shoko、Kobayashi Noritoshi、Utsunomiya Daisuke、Hata Masaharu、Ichikawa Yasushi、Tanabe Minoru、Hosono Makoto、Kinuya Seigo
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences Volume: - Issue: 4 Pages: 487-499
  • DOI: 10.1002/jhbp.1101
  • Peer Reviewed
• [Journal Article] Safety and efficacy of peptide receptor radionuclide therapy with 177Lu-DOTA0-Tyr3-octreotate in combination with amino acid solution infusion in Japanese patients with somatostatin receptor-positive, progressive neuroendocrine tumors (2021)
  • Author(s): Kobayashi Noritoshi、Takano Shoko、Ito Kenichi、Sugiura Madoka、Ogawa Matsuyoshi、Takeda Yuma、Okubo Naoki、Suzuki Akihiro、Tokuhisa Motohiko、Kaneta Tomohiro、Utsunomiya Daisuke、Hata Masaharu、Inoue Tomio、Hosono Makoto、Kinuya Seigo、Ichikawa Yasushi
  • Journal Title: Annals of Nuclear Medicine Volume: 35 Issue: 12 Pages: 1332-1341
  • DOI: 10.1007/s12149-021-01674-9
  • Peer Reviewed / Open Access
• [Journal Article] Inverted papilloma originating from the lacrimal sac and the nasolacrimal duct with marked FDG accumulation (2021)
  • Author(s): Ito Shuichi、Hosono Makoto、Kawabata Kazuna、Kawamura Hitomi、Ishikawa Masaaki、Kanagaki Mitsunori
  • Journal Title: Radiology Case Reports Volume: 16 Issue: 11 Pages: 3577-3580
  • DOI: 10.1016/j.radcr.2021.08.039
  • Peer Reviewed
• [Journal Article] Activities to support individual dosimetry of children in Kawamata Town (2021)
  • Author(s): Yamanishi Hirokuni、Ito Tetsuo、Hosono Makoto
  • Journal Title: Annals of the ICRP Volume: 50 Issue: 1_suppl Pages: 95-101
  • DOI: 10.1177/01466453211010918
  • Peer Reviewed
• [Journal Article] The radiation doses and radiation protection on the endoscopic retrograde cholangiopancreatography procedures (2021)
  • Author(s): Takenaka Mamoru、Hosono Makoto、Hayashi Shiro、Nishida Tsutomu、Kudo Masatoshi
  • Journal Title: The British Journal of Radiology Volume: 94 Issue: 1126 Pages: 1-8
  • DOI: 10.1259/bjr.20210399
  • Peer Reviewed
• [Journal Article] FDG-Avid Tracheal Mass and Cartilage Involvements in ANCA-Negative Granulomatosis With Polyangiitis (2021)
  • Author(s): Tanaka Hiroki、Hosono Makoto、Kawabata Kazuna、Kageyama Goichi、Yamashita Mai
  • Journal Title: Clinical Nuclear Medicine Volume: 47 Issue: 1 Pages: 83-85
  • DOI: 10.1097/rlu.0000000000003848
  • Peer Reviewed
• [Journal Article] Cumulative radiation doses from recurrent PET/CT examinations (2021)
  • Author(s): Hosono Makoto、Takenaka Mamoru、Monzen Hajime、Tamura Mikoto、Kudo Masatoshi、Nishimura Yasumasa
  • Journal Title: The British Journal of Radiology Volume: 94 Issue: 1126 Pages: 1-5
  • DOI: 10.1259/bjr.20210388
  • Peer Reviewed / Open Access
• [Journal Article] Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition) (2021)
  • Author(s): Watabe Tadashi、Hosono Makoto、Kinuya Seigo、Yamada Takahiro、Yanagida Sachiko、Namba Masao、Nakamura Yoshihide
  • Journal Title: Annals of Nuclear Medicine Volume: 35 Issue: 7 Pages: 753-766
  • DOI: 10.1007/s12149-021-01619-2
  • Peer Reviewed / Open Access
• [Journal Article] Developing diagnostic reference levels in Japan (2021)
  • Author(s): Kanda Reiko、Akahane Masaaki、Koba Yusuke、Chang Weishan、Akahane Keiichi、Okuda Yasuo、Hosono Makoto
  • Journal Title: Japanese Journal of Radiology Volume: 39 Issue: 4 Pages: 307-314
  • DOI: 10.1007/s11604-020-01066-5
  • NAID: 210000172974
  • Peer Reviewed
• [Journal Article] Real-world safety and effectiveness of radium-223 in Japanese patients with castration-resistant prostate cancer (CRPC) and bone metastasis: exploratory analysis, based on the results of post-marketing surveillance, according to prior chemotherapy status and in patients without concomitant use of second-generation androgen-receptor axis-targeted agents (2021)
  • Author(s): Uemura Hirotsugu、Masumori Naoya、Takahashi Shunji、Hosono Makoto、Kinuya Seigo、Sunaya Toshiyuki、Horio Tomoyo、Okayama Yutaka、Kakehi Yoshiyuki
  • Journal Title: International Journal of Clinical Oncology Volume: 26 Issue: 4 Pages: 753-763
  • DOI: 10.1007/s10147-020-01850-3
  • Peer Reviewed
• [Journal Article] G-CSF administration at 1 hour before F-18 FDG-PET does not increase bone marrow FDG accumulation (2021)
  • Author(s): Kawabata K, Hosono M, Tanaka H, Hyuga M, Kanagaki M
  • Journal Title: Clin Nucl Med Volume: in press
  • Peer Reviewed
• [Journal Article] Clinical practice guidelines for high-resolution breast PET, 2019 edition (2021)
  • Author(s): Satoh Y, Kawamoto M, Kubota K, Murakami K, Hosono M
  • Journal Title: Annals of Nuclear Medicine Volume: 35 Issue: 3 Pages: 406-414
  • DOI: 10.1007/s12149-021-01582-y
  • Peer Reviewed / Open Access
• [Journal Article] The 2020 national diagnostic reference levels for nuclear medicine in Japan (2020)
  • Author(s): Abe Koichiro、Hosono Makoto、Igarashi Takayuki、Iimori Takashi、Ishiguro Masanobu、Ito Teruo、Nagahata Tomomasa、Tsushima Hiroyuki、Watanabe Hiroshi
  • Journal Title: Annals of Nuclear Medicine Volume: 34 Issue: 11 Pages: 799-806
  • DOI: 10.1007/s12149-020-01512-4
  • Peer Reviewed / Open Access
• [Journal Article] Multicentre prospective observational study protocol for radiation exposure from gastrointestinal fluoroscopic procedures (REX-GI study) (2020)
  • Author(s): Nishida T, Hayashi S, Takenaka M, Hosono M, Kogure H, Hasatani K, Yamaguchi S, Maruyama H, Doyama H, Ihara H, Yoshio T, Nagaike K, Yamada T, Yakushijin T, Takagi T, Tsumura H, Kurita A, Asai S, Ito Y, Kuwai T, Hori Y, Maetan I, Ikezawa K, Iwashita T, Matsumoto K, Inada M
  • Journal Title: BMJ Open Volume: 10 Issue: 2 Pages: e033604-e033604
  • DOI: 10.1136/bmjopen-2019-033604
  • Peer Reviewed / Open Access
• [Journal Article] A randomized, double-blind, comparison of radium-223 and placebo, in combination with abiraterone acetate and prednisolone, in castration-resistant metastatic prostate cancer: subgroup analysis of Japanese patients in the ERA 223 study (2020)
  • Author(s): Matsubara N, Kimura G, Uemura H, Uemura H, Nakamura M, Nagamori S, Mizokami A, Kikukawa H, Hosono M, Kinuya S, Krissel H, Siegel J, Yoshiyuki Kakehi Y
  • Journal Title: Int J Clin Oncol Volume: 25 Issue: 4 Pages: 720-731
  • DOI: 10.1007/s10147-019-01589-6
  • Peer Reviewed
• [Journal Article] Manual on the proper use of yttrium-90-labeled anti-P-cadherin antibody injection for radionuclide therapy in clinical trials (Second Edition) (2019)
  • Author(s): Hosono M, Ikebuchi H, Kinuya S, Yanagida S, Nakamura Y, Yamada T, Sakaguchi K, Sugano H, Kojima K, Hatazawa J
  • Journal Title: Ann Nucl Med Volume: 33 Issue: 11 Pages: 787-805
  • DOI: 10.1007/s12149-019-01409-x
  • Peer Reviewed / Open Access
• [Journal Article] Radiation protection in therapy with radiopharmaceuticals (2019)
  • Author(s): Hosono M
  • Journal Title: International Journal of Radiation Biology Volume: 95 Issue: 10 Pages: 1427-1430
  • DOI: 10.1080/09553002.2018.1516910
  • Peer Reviewed
• [Journal Article] ICRP Publication 140: Radiological Protection in Therapy with Radiopharmaceuticals (2019)
  • Author(s): Yonekura Y, Mattsson S, Flux G, Bolch WE, Dauer LT, Fisher DR, Lassmann M, Palm S, Hosono M, Doruff M, Divgi C, Zanzonico P
  • Journal Title: Annals of the ICRP Volume: 48 Issue: 1 Pages: 5-95
  • DOI: 10.1177/0146645319838665
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative measurement of 219Rn radioactivity in exhaled breath from patients with bone metastasis of castration-resistant prostate cancer treated with 223RaCl2 (2019)
  • Author(s): Ooe K, Watabe T, Kamiya T, Yoshimura T, Hosono M, Shinohara A, Hatazawa J
  • Journal Title: EJNMMI Physics Volume: 6 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s40658-019-0249-8
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation and Optimization of a New PET Reconstruction Algorithm, Bayesian Penalized Likelihood Reconstruction, for Lung Cancer Assessment According to Lesion Size (2019)
  • Author(s): Otani T, Hosono M, Kanagaki M, Oka S, Fukumoto G, Onishi Y, Matsubara N, Kawabata K, Kimura H
  • Journal Title: American Journal of Roentgenology Volume: 213 Issue: 2 Pages: W50-W56
  • DOI: 10.2214/ajr.18.20478
  • Peer Reviewed
• [Journal Article] Perspectives for concepts of individualized radionuclide therapy, molecular radiotherapy, and theranostic approaches (2019)
  • Author(s): Hosono M
  • Journal Title: Nuclear Medicine and Molecular Imaging Volume: 53 Issue: 3 Pages: 167-171
  • DOI: 10.1007/s13139-019-00586-x
  • Peer Reviewed
• [Journal Article] Three-year follow-up of a phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer and bone metastases (2019)
  • Author(s): Uemura Hirotsugu、Uemura Hiroji、Nagamori Satsohi、Wakumoto Yoshiaki、Kimura Go、Kikukawa Hiroaki、Yokomizo Akira、Mizokami Atsushi、Kosaka Takeo、Masumori Naoya、Kawasaki Yoshihide、Yonese Junji、Nasu Yasutomo、Fukasawa Satoshi、Sugiyama Takayuki、Kinuya Seigo、et al
  • Journal Title: International Journal of Clinical Oncology Volume: 24 Issue: 5 Pages: 557-566
  • DOI: 10.1007/s10147-018-01389-4
  • Peer Reviewed / Open Access
• [Journal Article] Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation (2019)
  • Author(s): Hosono M, Ikebuchi H, Nakamura Y, Yanagida S, Kinuya S.
  • Journal Title: Ann Nucl Med Volume: 33 Issue: 3 Pages: 211-221
  • DOI: 10.1007/s12149-018-1317-1
  • Peer Reviewed / Open Access
• [Journal Article] Perspectives for concepts of individualized radionuclide therapy, molecular radiotherapy, and theranostic approaches (2019)
  • Author(s): Hosono M.
  • Journal Title: Nuclear Medicine and Molecular Imaging Volume: in press
  • Peer Reviewed
• [Journal Article] Manual on the proper use of lutetium-177-labeled somatostatin analogue (Lu-177-DOTA-TATE) injectable in radionuclide therapy (2nd ed.) (2018)
  • Author(s): Hosono M, Ikebuchi H, Nakamura Y, Nakamura N, Yamada T, Yanagida S, Kitaoka A, Kojima K, Sugano H, Kinuya S, Inoue T, Hatazawa J.
  • Journal Title: Ann Nucl Med Volume: 32 Issue: 3 Pages: 217-235
  • DOI: 10.1007/s12149-018-1230-7
  • Peer Reviewed / Open Access
• [Journal Article] Tumor hypoxia detected by 18F-fluoromisonidazole positron emission tomography (FMISO PET) as a prognostic indicator of radiotherapy (RT). (2018)
  • Author(s): Tachibana I , Nishimura Y, Hanaoka K, Inada M, Fukuda K, Tatebe H, Ishikawa K, Nakamatsu K, Kanamori S, Hosono M.
  • Journal Title: Anticancer Res Volume: 38 Issue: 3 Pages: 1775-1781
  • DOI: 10.21873/anticanres.12415
  • Peer Reviewed / Open Access
• [Journal Article] Radiation exposure during image-guided endoscopic procedures: The next quality indicator for endoscopic retrograde cholangiopancreatography (2018)
  • Author(s): Hayashi S, Takenaka M, Hosono M, Nishida T.
  • Journal Title: World J Clin Cases Volume: 6 Pages: 1087-1093
  • Peer Reviewed
• [Presentation] G 36: The Revision of Dose Coefficients in Diagnostic Nuclear Medicine (2021)
  • Author(s): Giussani A, Mattsson S Nosske D, Hosono M, Andersson M
  • Organizer: Future of Radiological Protection Digital Workshop ICRP
  • Int'l Joint Research
• [Presentation] Serum Lactate Dehydrogenase is a Predictive Biomarker in Oropharyngeal Cancer Patients Undergoing Radiotherapy (2021)
  • Author(s): Uehara T, Doi H, Ishikawa K, Tatsuno S, Wada Y, Oguma Y, Inada M, Nakamatsu K, Hosono M, Nishimura Y
  • Organizer: 2021 ASTRO Annual Meeting
  • Int'l Joint Research
• [Presentation] Previous pneumectomy is a risk factor of severe radiation pneumonitis after IMRT for lung cancer (2021)
  • Author(s): Tatsuno S, Doi H, Okada W, noue E, Nakamura K, Sano K, Wada Y, Uehara T, Inada M, Nakamatsu K, Monzen K, Hosono M, Matsumoto K, Tanooka M, Tanaka M, Nishimura Y
  • Organizer: ESTRO 2021
  • Int'l Joint Research
• [Presentation] Coping with low dose radiation effects and health risk by evident dose evaluation among residents (2021)
  • Author(s): Hosono M, Yamanishi H, Kanai K, Hanada K, Ito T
  • Organizer: 5th International Symposium, Research Center for Radiation Disaster Medical Science
  • Int'l Joint Research / Invited
• [Presentation] National survey and research on actual circumstances of radiation exposure and reduction of staff members working in nuclear medicine and other radiological procedures in Japan, Grant research of Ministry of Health, Labour and Welfare (2020)
  • Author(s): Hosono M, Mikami Y, Watanabe H, Takenaka M, Koba Y, Kanda R, Akahane K, Torisu K, Sakamoto H, Yamamoto K
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Int'l Joint Research
• [Presentation] National survey on actual conditions of radiation exposure and reduction for radiological staff members in Japan, Research group of Ministry of Health, Labour and Welfare (2020)
  • Author(s): Hosono M, Mikami Y, Watanabe H, Takenaka M, Koba Y, Kanda R, Akahane K, Torisu K, Yamada T, Sakaguchi K, Sakamoto H, Yamamoto K
  • Organizer: Annual Meeting of Radiological Society of North America 2020
  • Int'l Joint Research
• [Presentation] High Exposure Patients in Nuclear Medicine Imaging. (2020)
  • Author(s): Hosono M, Yoshida S, Sakaguchi K, Matano K, Yamada K, Nishimura Y, Kudo M
  • Organizer: IAEA Technical Meeting on the Justification and Optimization of Protection of Patients Requiring Multiple Imaging Procedures
  • Int'l Joint Research / Invited
• [Presentation] Radiation protection of patients in nuclear imaging: What, Why and How? (2020)
  • Author(s): Hosono M
  • Organizer: Mongolian National Workshop on Diagnostic Reference Levels sponsored by IAEA
  • Int'l Joint Research / Invited
• [Presentation] Construction of safety standards for short-half-life alpha emitters by grant of nuclear regulatory agency of Japan (2019)
  • Author(s): Hosono M, Yamada T, Oriuchi N, Ukon N, Nagatsu K, Ito T, Yamanishi H, Matsuda T, Hachisuka A, Nakamura Y
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Int'l Joint Research
• [Presentation] Radiation exposure of nurses including eye lens in PET facility in association with performance status of patients (2019)
  • Author(s): Hosono M, Takahara N, Yakushiji Y, Sakaguchi K, Yamada Y, H. Kaida H, Ishii K, Nishimura Y
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Int'l Joint Research
• [Presentation] Optimization of respiratory gated 18F-FDG PET/CT scan protocol for cardiac sarcoidosis (2019)
  • Author(s): Hanaoka K, Watanabe S, Kaida H, Hosono M, Ishii K
  • Organizer: Annual Meeting of Society of Nuclear Medicine Molecular Imaging
  • Int'l Joint Research
• [Presentation] Comparison among 18F-FDG uptake parameters for assessing the prognosis of esophageal squamous cell carcinoma (2019)
  • Author(s): Kaida H, Shiraishi O, Iwama M, Kimura Y, Kitajima K, Hosono M, Yasuda T, Ishii K
  • Organizer: Annual Meeting of Society of Nuclear Medicine Molecular Imaging
  • Int'l Joint Research
• [Presentation] Evaluation of respiratory motion-corrected PET/CT in oncological patients (2019)
  • Author(s): Otani T, Hosono M, Nakamoto Y, Kidera K, Kitaguchi K, Watanabe M, Miyake K
  • Organizer: Annual Meeting of Society of Nuclear Medicine Molecular Imaging
  • Int'l Joint Research
• [Presentation] Examination of actual radiation exposure dose of the patients who performed EUS-guided drainage (EUS-BD/EUS-PD/EUS-CD) (2019)
  • Author(s): Takenaka M, Hayashi S, Nishida T, Hosono M, Yoshikawa T, Ishikawa Rei, Okamoto A, Yamazaki T, Nakai A, Omoto S, Minaga K, Kamata K, Yamao K, Kudo M
  • Organizer: DDW 2019
  • Int'l Joint Research
• [Presentation] Radiation protection standards in novel radionuclide therapy. Invited lecture in Session; Radiation Safety. The 13th Asia Oceania Congress of Nuclear Medicine and Biology (2019)
  • Author(s): Hosono M
  • Organizer: The 13th Asia Oceania Congress of Nuclear Medicine and Biology
  • Int'l Joint Research / Invited
• [Presentation] ICRP perspectives for individualized radionuclide therapy (2019)
  • Author(s): Hosono M
  • Organizer: Theranostics World Congress 2019
  • Int'l Joint Research / Invited
• [Presentation] ICRP perspectives for individualized radionuclide therapy (2019)
  • Author(s): Hosono M.
  • Organizer: Theranostics World Congress 2019
  • Int'l Joint Research / Invited
• [Presentation] Radiological protection for innovative targeted therapy (2018)
  • Author(s): Hosono M.
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Int'l Joint Research / Invited
• [Presentation] Evidence-based safety management for short-lived alpha emitters by grant of Nuclear Regulatory Agency of Japan (2018)
  • Author(s): Hosono M, Oriuchi N, Ukon N, Nagatsu K, Ito T, Yamanishi H, Matsuda T, Yamada T, Hachisuka A, Nakamura Y.
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Int'l Joint Research
• [Presentation] Evaluation of iterative reconstruction compensated by Monte Carlo simulation for quantitative radium-223 SPECT (2018)
  • Author(s): Sakaguchi K, Yoshida S, Watanabe S, Hanaoka K, Matano K, Okumura M, Hosono M, Ishii K.
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Int'l Joint Research
• [Presentation] The risk factors for occult lymph node metastasis and recurrence by F-18 FDG uptake in clinical N0 esophageal squamous cell carcinoma patients (2018)
  • Author(s): Kaida H, Shiraishi O, Iwama M, Kato H, Kimura Y, Kitajima K, Hosono M, Yasuda T, Ishii K.
  • Organizer: Annual Congress of European Association of Nuclear Medicine
  • Int'l Joint Research
• [Book] 新核医学技術総論［臨床編］ (2020)
  • Author(s): 細野 眞
  • Total Pages: 630
  • Publisher: 山代印刷株式会社
  • ISBN: 9784991020131
• [Book] Features of ibritumomab as radionuclide therapy. Pages 59-66. Resistance to ibritumomab in lymphoma (2018)
  • Author(s): Hosono M.
  • Total Pages: 158
  • Publisher: Springer
  • ISBN: 9783319782386
• [Book] Resistance and heterogeneity of intratumoral antibody distribution. Pages 99-104.Resistance to ibritumomab in lymphoma. (2018)
  • Author(s): Hanaoka K, Hosono M.
  • Total Pages: 158
  • Publisher: Springer
  • ISBN: 9783319782386
• [Remarks] 近畿大学教員一覧
  • URL: https://research.kindai.ac.jp/profile/ja.33c1b4a23deb02c8.html
• [Remarks] 近畿大学教員一覧
  • URL: http://research.kindai.ac.jp/profile/ja.33c1b4a23deb02c8.html