• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Genetic effects on brain network in drug-naive patients with depressive disorder: a DTI study of 17 candidate genetic loci

Research Project

Project/Area Number 18K07654
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionHirosaki University (2019-2020)
University of Occupational and Environmental Health, Japan (2018)

Principal Investigator

Kakeda Shingo  弘前大学, 医学研究科, 教授 (30352313)

Co-Investigator(Kenkyū-buntansha) 興梠 征典  産業医科大学, 医学部, 教授 (60195691)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords画像診断 / 脳画像解析 / ボクセルベーズ解析 / うつ病 / MRI / 遺伝子 / テンソル画像 / 脳容積 / 脳内ネットワーク / 拡散テンソル画像 / ミエリンマップ / 血液バイオロジカルマーカ / 大うつ病 / 脳MRI / 拡散テンソル
Outline of Final Research Achievements

A genome-wide association study using mega-data identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). We investigated the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and healthy subjects underwent diffusion tensor imaging scans and genotyping. For the various WM tract, the genotype effect significantly differed between diagnosis groups in only one SNP, rs301806, in the arginine-glutamic acid dipeptide (RE) repeats (RERE) gene. The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD.

Academic Significance and Societal Importance of the Research Achievements

今回の研究成果は、関連遺伝子と17種類の遺伝子は、うつ病との関連が証明された数少ない候補遺伝子であり、今後、診断、治療、予防など様々な観点より、これらの遺伝子変異についての研究が進められるための有用なデータになると考える。以前より我々は、うつ病患者の遺伝子多型(BDNF遺伝子など)が関連する脳領域を特定し、これらの脳領域と臨床特性との関係を証明してきた。よって、我々が用いてきた形態的脳内ネットワークの画像的手法が、遺伝子が脳内ネットワークなど脳変容に与える影響を証明することに有用であるとことを証明したものと考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (1 results)

  • [Journal Article] Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder2020

    • Author(s)
      Katsuki Asuka、Watanabe Keita、Nguyen LeHoa、Otsuka Yuka、Igata Ryohei、Ikenouchi Atsuko、Kakeda Shingo、Korogi Yukunori、Yoshimura Reiji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 9 Pages: 3032-3032

    • DOI

      10.3390/ijms21093032

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-brain structural covariance network abnormality in first-episode and drug-naïve major depressive disorder2020

    • Author(s)
      Watanabe K, Kakeda S, Katsuki A, Ueda I, Ikenouchi A, Yoshimura R, Korogi Y
    • Journal Title

      Psychiatry research: neuroimaging

      Volume: 300 Pages: 111083-111083

    • DOI

      10.1016/j.pscychresns.2020.111083

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An independent component analysis reveals brain structural networks related to TNF-α in drug-na?ve, first-episode major depressive disorder: a source-based morphometric study2020

    • Author(s)
      Kakeda Shingo、Watanabe Keita、Nguyen Hoa、Katsuki Asuka、Sugimoto Koichiro、Igata Natsuki、Abe Osamu、Yoshimura Reiji、Korogi Yukunori
    • Journal Title

      Translational Psychiatry

      Volume: 10 Issue: 1 Pages: 1-5

    • DOI

      10.1038/s41398-020-00873-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder2019

    • Author(s)
      Otsuka Yuka、Kakeda Shingo、Sugimoto Koichiro、Katsuki Asuka、Nguyen Le Hoa、Igata Ryohei、Watanabe Keita、Ueda Issei、Kishi Taro、Iwata Nakao、Korogi Yukunori、Yoshimura Reiji
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 15 Pages: 1537-1545

    • DOI

      10.2147/ndt.s199598

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms2019

    • Author(s)
      Kakeda Shingo、Watanabe Keita、Katsuki Asuka、Sugimoto Koichiro、Ueda Issei、Igata Natsuki、Kishi Taro、Iwata Nakao、Abe Osamu、Yoshimura Reiji、Korogi Yukunori
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 15 Pages: 375-383

    • DOI

      10.2147/ndt.s190268

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A single-nucleotide polymorphism influences brain morphology in drug-naive patients with major depressive disorder2019

    • Author(s)
      Katsuki Asuka、Kakeda Shingo、Watanabe Keita、Igata Ryohei、Otsuka Yuka、Kishi Taro、Nguyen LeHoa、Ueda Issei、Iwata Nakao、Korogi Yukunori、Yoshimura Reiji
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 15 Pages: 2425-2432

    • DOI

      10.2147/ndt.s204461

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics2018

    • Author(s)
      Sugimoto Koichiro、Kakeda Shingo、Watanabe Keita、Katsuki Asuka、Ueda Issei、Igata Natsuki、Igata Ryohei、Abe Osamu、Yoshimura Reiji、Korogi Yukunori
    • Journal Title

      Translational Psychiatry

      Volume: 8 Issue: 1 Pages: 141-141

    • DOI

      10.1038/s41398-018-0174-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between interleukin (IL)-6 and brain morphology in drug-na?ve, first-episode major depressive disorder using surface-based morphometry2018

    • Author(s)
      Kakeda Shingo、Watanabe Keita、Katsuki Asuka、Sugimoto Koichiro、Igata Natsuki、Ueda Issei、Igata Ryohei、Abe Osamu、Yoshimura Reiji、Korogi Yukunori
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 10054-10054

    • DOI

      10.1038/s41598-018-28300-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Relationship between interleukin (IL)-6 and brain morphology in drug-na?ve, first-episode major depressive disorder using surface-based morphometry2018

    • Author(s)
      掛田伸吾
    • Organizer
      日本放射線学会総会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi