Development of PET tracer for neurogenesin in the brain based on DNA synthesis imaging

• Project/Area Number: 18K07658
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: Toyohara Jun 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50425659)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経新生 / PET / DNA合成

Outline of Final Research Achievements

In this study, we aimed to establish a method for non-invasive imaging of neurogenesis in the adult human brain. Therefore, we attempted to develop a tracer for positron emission tomography (PET) based on the same biochemistry as the currently established cell labeling method using bromo-deoxyuridine.
The candidate compound 4DST showed accumulation in the subventricular zone and hippocampus with high cell proliferation activity, and autoradiographic analysis revealed that accumulation of 4DST in these sites was about twice that in the low cell proliferating cerebral cortex. In small animal PET study, we successfully imaged the subventricular zone, but the sensitivity was low. Attempts were made to develop a prodrug to improve the uptake of 4DST to the brain, but the target compound was not isolated within the research period.

Academic Significance and Societal Importance of the Research Achievements

ヒトにおける神経新生の客観的な評価法は確立されておらず、研究の進展が妨げられている。神経新生による再生医療が大きな注目を集める中、その評価法の確立は急務である。この技術が確立されれば、神経再生治療や運動刺激などの介入の効果や精神神経疾患の神経新生仮説の検証に客観的な指標を与えるものと考えられる。
本研究では、4DSTがプロベネシドなどの薬剤負荷を伴わず神経新生を画像化できる可能性を示した点で画期的である。今後、4DSTを基本骨格としてさらに脳移行性を高めた化合物を開発することにより、ヒトにおける非侵襲的な神経新生の評価方法が可能になるものと期待される。

Research Products

• [Journal Article] Head-to-head comparison of the two MAO-B radioligands, 18F-THK5351 and 11C-L-Deprenyl, to visualize astrogliosis in patients with neurological disorders (2021)
  • Author(s): Kenji Ishibashi, Masashi Kameyama, Yoshiharu Miura, Jun Toyohara, Kenji Ishii
  • Journal Title: Clinical Nuclear Medicine Volume: 46 Issue: 1 Pages: e31-e33
  • DOI: 10.1097/rlu.0000000000003197
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Automated production of [18F]MK-6240 on CFN-MPS200 (2021)
  • Author(s): Toyohara Jun、Nishino Kosuke、Sakai Masanari、Tago Tetsuro、Oda Takashi
  • Journal Title: Applied Radiation and Isotopes Volume: 168 Pages: 109468-109468
  • DOI: 10.1016/j.apradiso.2020.109468
  • Peer Reviewed
• [Journal Article] Efficacy of cell proliferation imaging with 4DST PET/CT for predicting the prognosis of patients with esophageal cancer: a comparison study with FDG PET/CT (2021)
  • Author(s): Hotta Masatoshi、Minamimoto Ryogo、Toyohara Jun、Nohara Kyoko、Nakajima Kazuhiko、Takase Kei、Yamada Kazuhiko
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 48 Issue: 8 Pages: 2615-2623
  • DOI: 10.1007/s00259-020-05179-x
  • Peer Reviewed / Open Access
• [Journal Article] Effects of 18F-fluorinated neopentyl glycol side-chain on the biological characteristics of stilbene amyloid-β PET ligands (2021)
  • Author(s): Tago Tetsuro、Toyohara Jun、Fujimaki Ryo、Tatsuta Maho、Song Ruichong、Hirano Keiichi、Iwai Kumiko、Tanaka Hiroshi
  • Journal Title: Nuclear Medicine and Biology Volume: 94-95 Pages: 38-45
  • DOI: 10.1016/j.nucmedbio.2020.12.008
  • Peer Reviewed
• [Journal Article] Preclinical Evaluation of an 18F-Labeled SW-100 Derivative for PET Imaging of Histone Deacetylase 6 in the Brain (2021)
  • Author(s): Tago Tetsuro、Toyohara Jun、Ishii Kenji
  • Journal Title: ACS Chemical Neuroscience Volume: 12 Issue: 4 Pages: 746-755
  • DOI: 10.1021/acschemneuro.0c00774
  • Peer Reviewed
• [Journal Article] Highlight selection of radiochemistry and radiopharmacy developments by editorial board (January-June 2020) (2021)
  • Author(s): Al-Qahtani Mohammed、Behe Martin、Bormans Guy、Carlucci Giuseppe、Dasilva Jean、Decristoforo Clemens、Elsinga Philip H.、Kopka Klaus、Li Xiang-Guo、Mach Robert、Middel Oskar、Passchier Jan、Patt Marianne、Penuelas Ivan、Rey Ana、Scott Peter J. H.、Todde Sergio、Toyohara Jun、Vugts Danielle
  • Journal Title: EJNMMI Radiopharmacy and Chemistry Volume: 6 Issue: 1
  • DOI: 10.1186/s41181-020-00118-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interim 4′-[methyl-11C]-thiothymidine PET for predicting the chemoradiotherapeutic response in head and neck squamous cell carcinoma: comparison with [18F]FDG PET (2021)
  • Author(s): Mitamura Katsuya、Norikane Takashi、Yamamoto Yuka、Fujimoto Kengo、Takami Yasukage、Hoshikawa Hiroshi、Toyohara Jun、Nishiyama Yoshihiro
  • Journal Title: EJNMMI Research Volume: 11 Issue: 1
  • DOI: 10.1186/s13550-021-00749-y
  • Peer Reviewed / Open Access
• [Journal Article] Highlight selection of radiochemistry and radiopharmacy developments by editorial board (2021)
  • Author(s): Aime S.、Al-Qahtani M.、Behe M.、Bormans G.、Carlucci G.、DaSilva J. N.、Decristoforo C.、Duatti A.、Elsinga P. H.、Kopka K.、Li X.-G.、Liu Z.、Mach R. H.、Middel O.、Passchier J.、Patt M.、Penuelas I.、Rey A.、Scott P. J. H.、Todde S.、Toyohara J.、Vugts D.、Yang Z.
  • Journal Title: EJNMMI Radiopharmacy and Chemistry Volume: 6 Issue: 1
  • DOI: 10.1186/s41181-021-00128-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlation of 4′-[methyl-11C]-thiothymidine PET with Gd-enhanced and FLAIR MRI in patients with newly diagnosed glioma (2021)
  • Author(s): Norikane Takashi、Mitamura Katsuya、Yamamoto Yuka、Maeda Yukito、Tanaka Kenichi、Hatakeyama Tetsuhiro、Miyake Keisuke、Toyohara Jun、Nishiyama Yoshihiro
  • Journal Title: EJNMMI Research Volume: 11 Issue: 1 Pages: 42-42
  • DOI: 10.1186/s13550-021-00785-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] N-Alkyl 3‐aminobut‐2‐enenitrile as a Non‐radioactive Side Product in Nucleophilic 18F‐Fluorination (2021)
  • Author(s): Song Ruichong、Tago Tetsuro、Tatsuta Maho、Shiraishi Nana、Iwai Kumiko、Hirano Keiichi、Toyohara Jun、Tanaka Hiroshi
  • Journal Title: ChemistrySelect Volume: 6 Issue: 12 Pages: 2826-2831
  • DOI: 10.1002/slct.202100723
  • Peer Reviewed
• [Journal Article] Relationship between the temporal course of astrogliosis and symptom improvement in cerebral infarction: report of a case monitored using 18 F-THK5351 positron emission tomography (2020)
  • Author(s): Kenji Ishibashi, Yoshiharu Miura, Kosei Hirata, Jun Toyohara, Kenji Ishii
  • Journal Title: BMC Medical Imaging Volume: 20 Issue: 1 Pages: 81-81
  • DOI: 10.1186/s12880-020-00481-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Automated synthesis, preclinical toxicity, and radiation dosimetry of [18F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier (2020)
  • Author(s): Toyohara Jun、Sakata Muneyuki、Tago Tetsuro、Colabufo Nicola A.、Luurtsema Gert
  • Journal Title: EJNMMI Research Volume: 10 Issue: 1
  • DOI: 10.1186/s13550-020-00674-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pharmacokinetic Modeling of [18F]MC225 for Quantification of the P-Glycoprotein Function at the Blood-Brain Barrier in Non-Human Primates with PET (2020)
  • Author(s): Garcia-Varela Lara、Arif Wejdan M.、Vallez Garcia David、Kakiuchi Takeharu、Ohba Hiroyuki、Harada Norihiro、Tago Tetsuro、Elsinga Philip H.、Tsukada Hideo、Colabufo Nicola Antonio、Dierckx Rudi A. J. O.、van Waarde Aren、Toyohara Jun、Boellaard Ronald、Luurtsema Gert
  • Journal Title: Molecular Pharmaceutics Volume: 17 Issue: 9 Pages: 3477-3486
  • DOI: 10.1021/acs.molpharmaceut.0c00514
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis and evaluation of N-isopropyl-p-[11C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography (2020)
  • Author(s): Toyohara Jun、Harada Norihiro、Kakiuchi Takeharu、Ohba Hiroyuki、Kanazawa Masakatsu、Tago Tetsuro、Sakata Muneyuki、Ishiwata Kiichi
  • Journal Title: EJNMMI Research Volume: 10 Issue: 1
  • DOI: 10.1186/s13550-020-00702-5
  • Peer Reviewed / Open Access
• [Journal Article] Voxel-based morphometry focusing on medial temporal lobe structures has a limited capability to detect amyloid β, an Alzheimer’s disease pathology (2020)
  • Author(s): Kameyama Masashi、Ishibashi Kenji、Toyohara Jun、Wagatsuma Kei、Umeda-Kameyama Yumi,、Shimoji Keigo、Kanemaru Kazutomi、Murayama Shigeo、Ogawa Sumito、Tokumaru Aya M.、Ishii Kenji
  • Journal Title: Aging Volume: 12 Issue: 19 Pages: 19701-19710
  • DOI: 10.18632/aging.104012
  • Peer Reviewed / Open Access
• [Journal Article] Adenosine A2A Receptor Occupancy by Long‐Term Istradefylline Administration in Parkinson's Disease (2020)
  • Author(s): Ishibashi Kenji、Miura Yoshiharu、Wagatsuma Kei、Toyohara Jun、Ishiwata Kiichi、Ishii Kenji
  • Journal Title: Movement Disorders Volume: 36 Issue: 1 Pages: 268-269
  • DOI: 10.1002/mds.28378
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates (2020)
  • Author(s): Garcia-Varela Lara、Garcia David Vallez、Kakiuchi Takeharu、Ohba Hiroyuki、Nishiyama Shingo、Tago Tetsuro、Elsinga Philip H.、Tsukada Hideo、Colabufo Nicola A.、Dierckx Rudi A.J.O.、van Waarde Aren、Toyohara Jun、Boellaard Ronald、Luurtsema Gert
  • Journal Title: Molecular Pharmaceutics Volume: 18 Issue: 1 Pages: 416-428
  • DOI: 10.1021/acs.molpharmaceut.0c01014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Texture indices of 4′-[methyl-11C]-thiothymidine uptake predict p16 status in patients with newly diagnosed oropharyngeal squamous cell carcinoma: comparison with 18F-FDG uptake (2020)
  • Author(s): Ihara-Nishishita Ayumi、Norikane Takashi、Mitamura Katsuya、Yamamoto Yuka、Fujimoto Kengo、Takami Yasukage、Ibuki Emi、Kudomi Nobuyuki、Hoshikawa Hiroshi、Toyohara Jun、Nishiyama Yoshihiro
  • Journal Title: European Journal of Hybrid Imaging Volume: 4 Issue: 1
  • DOI: 10.1186/s41824-020-00090-y
  • Peer Reviewed / Open Access
• [Journal Article] Development of PET radiopharmaceuticals at the Tokyo Metropolitan Institute of Gerontology (2020)
  • Author(s): Jun Toyohara
  • Journal Title: Annals of Nuclear Medicine and Molecular Imaging Volume: 33 Pages: 137-150
  • Peer Reviewed / Open Access
• [Journal Article] パーキンソン病におけるアデノシンA2A受容体の病態解析 (2020)
  • Author(s): 石橋賢士、多胡哲郎、我妻慧、坂田宗之、豊原潤、石井賢二
  • Journal Title: 臨床薬理の進歩 Volume: 41 Pages: 15-23
• [Journal Article] Metabolic network topology of Alzheimer’s disease and dementia with Lewy bodies generated using fluorodeoxyglucose positron emission tomography. (2020)
  • Author(s): Imai M, Tanaka M, SakataM, Wagatsuma K, Tago T, Toyohara J, Sengoku R, Nishina Y, Kanemaru K, Ishibashi K, Murayama S, Ishii K.
  • Journal Title: J Alzheimers Dis Volume: 73 Issue: 1 Pages: 197-207
  • DOI: 10.3233/jad-190843
  • Peer Reviewed / Open Access
• [Journal Article] Radiosynthesis and preliminary evaluation of an 18F-labeled tubastatin A analog for PET imaging of histone deacetylase 6 (2020)
  • Author(s): Tago Tetsuro、Toyohara Jun、Ishii Kenji
  • Journal Title: Journal of Labelled Compounds and Radiopharmaceuticals Volume: 63 Issue: 2 Pages: 85-95
  • DOI: 10.1002/jlcr.3823
  • Peer Reviewed
• [Journal Article] Mechanical regulation underlies effects of exercise on serotonin-induced signaling in the prefrontal cortex neurons. (2020)
  • Author(s): Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Fujita N, Sawada K, Murase S, Watanave M, Sakai T, Yoshikawa Y, Ogata T, Shinohara M, Nagao M, Sawada Y
  • Journal Title: iScience Volume: 23 Issue: 2 Pages: 100874-100874
  • DOI: 10.1016/j.isci.2020.100874
  • Peer Reviewed / Open Access
• [Journal Article] 18F-THK5351 PET Can Identify Astrogliosis in Multiple Sclerosis Plaques (2020)
  • Author(s): Ishibashi Kenji、Miura Yoshiharu、Hirata Kosei、Toyohara Jun、Ishii Kenji
  • Journal Title: Clinical Nuclear Medicine Volume: 45 Issue: 2 Pages: e98-e100
  • DOI: 10.1097/rlu.0000000000002751
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site (2019)
  • Author(s): Tago Tetsuro、Toyohara Jun、Harada Ryuichi、Furumoto Shozo、Okamura Nubuyuki、Kudo Yukitsuka、Takahashi-Fujigasaki Junko、Murayama Shigeo、Ishii Kenji
  • Journal Title: Annals of Nuclear Medicine Volume: 33 Issue: 6 Pages: 1-8
  • DOI: 10.1007/s12149-019-01344-x
  • Peer Reviewed / Open Access
• [Journal Article] Monoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis (2019)
  • Author(s): Tago Tetsuro、Toyohara Jun、Sengoku Renpei、Murayama Shigeo、Ishii Kenji
  • Journal Title: Clinical Nuclear Medicine Volume: 44 Issue: 6 Pages: 507-509
  • DOI: 10.1097/rlu.0000000000002564
  • Peer Reviewed / Open Access
• [Journal Article] Pre‐discard estimation of radioactivated materials in positron emission tomography cyclotron systems and concrete walls of a cyclotron vault (2019)
  • Author(s): Wagatsuma Kei、Ishiwata Kiichi、Nobuhara Fumiyoshi、Koumura Iwane、Kunugi Masayuki、Oda Keiichi、Miwa Kenta、Toyohara Jun、Ishii Kenji
  • Journal Title: Medical Physics Volume: 46 Issue: 5 Pages: 2457-2467
  • DOI: 10.1002/mp.13492
  • Peer Reviewed
• [Journal Article] A pitfall of white matter reference regions used in [18F] florbetapir PET: a consideration of kinetics (2019)
  • Author(s): Kameyama M, Ishibash K, Wagatsuma K, Toyohara J, Ishii K
  • Journal Title: Ann Nucl Med Volume: 33 Issue: 11 Pages: 848-854
  • DOI: 10.1007/s12149-019-01397-y
  • Peer Reviewed
• [Journal Article] Searching for diagnostic properties of novel fluorine-18-labeled d-allose (2019)
  • Author(s): Toyohara Jun、Yamamoto Hiroyuki、Tago Tetsuro
  • Journal Title: Annals of Nuclear Medicine Volume: 33 Issue: 11 Pages: 855-865
  • DOI: 10.1007/s12149-019-01398-x
  • Peer Reviewed / Open Access
• [Journal Article] Radiosynthesis of 18F-labeled d-allose (2019)
  • Author(s): Yamamoto Hiroyuki、Wada Kenji、Toyohara Jun、Tago Tetsuro、Ibaraki Masanobu、Kinoshita Toshibumi、Yamamoto Yuka、Nishiyama Yoshihiro、Kudomi Nobuyuki
  • Journal Title: Carbohydrate Research Volume: 486 Pages: 107827-107827
  • DOI: 10.1016/j.carres.2019.107827
  • Peer Reviewed
• [Journal Article] 4′-[methyl-11C]-thiothymidine as a proliferation imaging tracer for detection of colorectal cancer: comparison with 18F-FDG (2019)
  • Author(s): Fukuda Yuko、Yamamoto Yuka、Mitamura Katsuya、Ishikawa Ryo、Asano Eisuke、Toyohara Jun、Norikane Takashi、Nishiyama Yoshihiro
  • Journal Title: Annals of Nuclear Medicine Volume: 33 Issue: 11 Pages: 822-827
  • DOI: 10.1007/s12149-019-01393-2
  • Peer Reviewed
• [Journal Article] 18F-FDG and 11C-4DST PET/CT for evaluating response to platinum-based doublet chemotherapy in advanced non-small cell lung cancer: a prospective study (2019)
  • Author(s): Minamimoto Ryogo、Takeda Yuichiro、Hotta Masatoshi、Toyohara Jun、Nakajima Kazuhiko、Naka Go、Sugiyama Haruhito
  • Journal Title: EJNMMI Research Volume: 9 Issue: 1 Pages: 4-4
  • DOI: 10.1186/s13550-019-0472-2
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of 4′-[methyl-11C] thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer: a pilot study (2019)
  • Author(s): Hotta Masatoshi、Minamimoto Ryogo、Yamada Kazuhiko、Nohara Kyoko、Soma Daisuke、Nakajima Kazuhiko、Toyohara Jun、Takase Kei
  • Journal Title: EJNMMI Research Volume: 9 Issue: 1 Pages: 10-10
  • DOI: 10.1186/s13550-019-0478-9
  • Peer Reviewed / Open Access
• [Journal Article] Unchanged type 1 metabotropic glutamate receptor availability in patients with Alzheimer's disease: A study using 11C-ITMM positron emission tomography (2019)
  • Author(s): Ishibashi Kenji、Miura Yoshiharu、Toyohara Jun、Ishiwata Kiichi、Ishii Kenji
  • Journal Title: NeuroImage: Clinical Volume: 22 Pages: 101783-101783
  • DOI: 10.1016/j.nicl.2019.101783
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Usefulness of ¹¹C-Methionine Positron Emission Tomography for Monitoring of Treatment Response and Recurrence in a Glioblastoma Patient on Bevacizumab Therapy: A Case Report (2018)
  • Author(s): Nakano Tomoyuki、Tamura Kaoru、Tanaka Yoji、Inaji Motoki、Hayashi Shihori、Kobayashi Daisuke、Nariai Tadashi、Toyohara Jun、Ishii Kenji、Maehara Taketoshi
  • Journal Title: Case Reports in Oncology Volume: 11 Issue: 2 Pages: 442-449
  • DOI: 10.1159/000490457
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic Exercise Elicits Dissociated Changes Between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study Using NIRS and PET. (2018)
  • Author(s): (12).Hiura, M., Nariai, T., Takahashi, K., Muta, A., Sakata, M., Ishibashi, K., Toyohara, J., Wagatsuma, K., Tago, T., Ishii, K., Maehara, T.
  • Journal Title: Adv Exp Med Biol. 2018 Aug 30;1072:269-274. Volume: 1072 Pages: 269-274
  • DOI: 10.1007/978-3-319-91287-5_43
  • ISBN: 9783319912851, 9783319912875
  • Peer Reviewed
• [Journal Article] Reliable radiosynthesis of 4-[10B]borono-2-[18F]fluoro-l-phenylalanine with quality assurance for boron neutron capture therapy-oriented diagnosis (2018)
  • Author(s): Ishiwata Kiichi、Ebinuma Ryoichi、Watanabe Chuichi、Hayashi Kunpei、Toyohara Jun
  • Journal Title: Annals of Nuclear Medicine Volume: 32 Issue: 7 Pages: 463-473
  • DOI: 10.1007/s12149-018-1268-6
  • Peer Reviewed / Open Access
• [Journal Article] Validation of scatter limitation correction to eliminate scatter correction error in oxygen-15 gas-inhalation positron emission tomography images (2018)
  • Author(s): Wagatsuma Kei、Oda Keiichi、Sakata Muneyuki、Inaji Motoki、Miwa Kenta、Sasaki Masayuki、Toyohara Jun、Ishii Kenji
  • Journal Title: Nuclear Medicine Communications Volume: 39 Issue: 10 Pages: 936-944
  • DOI: 10.1097/mnm.0000000000000882
  • Peer Reviewed
• [Journal Article] Correlation of 4′-[methyl-11C]-thiothymidine uptake with human equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in patients with newly diagnosed gliomas (2018)
  • Author(s): Takami Yasukage、Yamamoto Yuka、Ueno Masaki、Chiba Yoichi、Norikane Takashi、Hatakeyama Tetsuhiro、Miyake Keisuke、Toyohara Jun、Nishiyama Yoshihiro
  • Journal Title: Annals of Nuclear Medicine Volume: 32 Issue: 9 Pages: 634-641
  • DOI: 10.1007/s12149-018-1285-5
  • Peer Reviewed
• [Journal Article] Occupancy of adenosine A2A receptors by istradefylline in patients with Parkinson's disease using 11C-preladenant PET (2018)
  • Author(s): Ishibashi Kenji、Miura Yoshiharu、Wagatsuma Kei、Toyohara Jun、Ishiwata Kiichi、Ishii Kenji
  • Journal Title: Neuropharmacology Volume: 143 Pages: 106-112
  • DOI: 10.1016/j.neuropharm.2018.09.036
  • Peer Reviewed
• [Presentation] Head to head comparison of [15O]H2O and [11C]MMP in non-human primates; tracers for measuring regional cerebral blood flow. (2020)
  • Author(s): Toyohara, J., Kakiuchi, T., Ohba, H., Kanazawa, M., Tago, T., Sakata, M., Harada, N.
  • Organizer: EANM'20 Virtual Event
  • Int'l Joint Research
• [Presentation] Potential use of 18F-THK5351 PET to identify astrogliosis in neurological disease. (2020)
  • Author(s): Ishibashi, K., Tago, T., Wagatsuma, K., Sakata, M., Toyohara, J., Ishii, K.
  • Organizer: American Society of Neurology Annual Meeting 2000 Virtual Event
  • Int'l Joint Research
• [Presentation] Efficacy of 4DST-PET/CT for predicting the prognosis in patients with esophageal cancer: a comparison study with FDG-PET/CT. (2020)
  • Author(s): Hotta, M., Minamimoto, R., Yamada, K., Toyohara, J.
  • Organizer: SNMMI 2020 Annual Meeting Virtual Events
  • Int'l Joint Research
• [Presentation] Adenosine A2A receptor occupancy by istradefylline in Parkinson's disease, using 11C-preladenant PET. (2020)
  • Author(s): 石橋賢士、三浦義治、多胡哲郎、我妻慧、坂田宗之、豊原潤、石井賢二
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] 脳内HDAC6 PETイメージングのための18F-標識テトラヒドロキノリン誘導体の開発 (2020)
  • Author(s): 多胡哲郎、豊原潤、石井賢二
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] 18F-標識ネオペンチルスチリルピリジンアミロイド-β PETプローブの生物学的評価 (2020)
  • Author(s): 多胡哲郎、豊原潤、ソウエイソウ、龍田真帆、新崎智子、柳井修一、遠藤昌吾、斉藤貴志、西道隆臣、田中浩士
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] ネオペンチル側鎖を利用した18F-標識合成における副生成物の評価 (2020)
  • Author(s): 多胡哲郎、豊原潤、ソウエイソウ、龍田真帆、平野圭市、岩井久美子、田中浩士
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] 新規脳血流PETイメージング剤[11C]MMP：覚醒サルにおける[15O]H2Oとの直接比較 (2020)
  • Author(s): 豊原潤、垣内岳春、大庭弘行、金澤将勝、多胡哲郎、坂田宗之、原田典弘
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] 施設認証の必須項目の詳細(1)PET薬剤の製造および試験検査の基礎 (2020)
  • Author(s): 豊原潤
  • Organizer: 第20回日本核医学会春季大会
  • Invited
• [Presentation] Occupancy of adenosine A2A receptors after ustradefylline administration (2020)
  • Author(s): 石橋賢士、多胡哲郎、我妻慧、坂田宗之、豊原潤、石井賢二
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] COX-2イメージング剤を目的とした二メスリド[11C]Me/[18F]OFEt誘導体の開発 (2020)
  • Author(s): 山本由美、多胡哲郎、豊原潤、斎藤陽平、山本文彦
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] FDG画像の機械学習を用いた認知症鑑別診断支援における特徴量増加による精度向上の検討 (2020)
  • Author(s): 坂田宗之、我妻慧、多胡哲郎、石橋賢士、豊原潤、石井賢二
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] 虚血性脳血管障害における運動中の脳血流量の特徴：PET研究 (2020)
  • Author(s): 日浦幹夫、成相直、坂田宗之、石橋賢士、我妻慧、多胡哲郎、豊原潤、石井賢二、片山容一
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] [18F]MC225特定臨床研究への道 (2020)
  • Author(s): 豊原潤
  • Organizer: PET化学ワークショップ2020
• [Presentation] 18F-標識ネオペンチルスチルベンアミロイドPETプローブの固相抽出精製による合成 (2020)
  • Author(s): 多胡哲郎、豊原潤、龍田真帆、ソウエイソウ、平野圭一、岩井久美子、石橋賢士、田中浩士
  • Organizer: 日本薬学会第140年会（web開催）
• [Presentation] フッ化物イオンの求核置換反応を用いる18F-標識化において生じる副生成物に関する研究 (2020)
  • Author(s): ソウエイソウ、多胡哲郎、豊原潤、田中浩士
  • Organizer: 日本化学会第100春季大会（web開催）
• [Presentation] A simple SPE purification method for 18F-radiolabeling: Proof-of-concept study in stilbene amyloid-β ligands with a noepentyl labeling group. (2019)
  • Author(s): Tago T, Toyohara J, Fujimaki R, Hirano K, Iwai K, Ishibashi K, Tanaka H.
  • Organizer: The 23rd International Symposium on Radiopharmaceutical Sciences 2019
  • Int'l Joint Research
• [Presentation] Dosimetry and toxicology of [18F]MC225 for measuring P-glycoprotein function at the blood-brain barrier in humans. (2019)
  • Author(s): Toyohara J, Sakata M, Tago T, Colabufo N, Luurtsema G.
  • Organizer: The 23rd I nternational Symposium on Radiopharmaceutical Sciences 2019
  • Int'l Joint Research
• [Presentation] Edge artifacts attributable to point spread function correction included in reconstruction for brain PET imaging. (2019)
  • Author(s): Sakata M, Wagatsuma K, Hirayama A, Kawakami H, Toyohara J, Ishii K.
  • Organizer: Brain & Brain PET 2019
  • Int'l Joint Research
• [Presentation] Alterations in cerebral blood flow evoked by dynamic exercise in post-stroke patients implies a mechanism for cerebral autoregulation: a PET study. (2019)
  • Author(s): Hiura M, Nariai T, Sakata M, Muta A, Ishibashi K, Wagatsuma K, Tago T, Toyohara J, Ishii K, Katayama Y.
  • Organizer: Brain & Brain PET 2019
  • Int'l Joint Research
• [Presentation] Biological evaluations of fluorine-18 labeled D-allose. (2019)
  • Author(s): Toyohara J, Yamamoto H, Tago T, Ibaraki M, Kinoshita T, Ishii K.
  • Organizer: World Molecular Imaging Congress
  • Int'l Joint Research
• [Presentation] Relationship between symptoms and regional density of metabotropic glutamate receptor subtype 1 measured with 11C-ITMM PET in de novo Parkinson's disease. (2019)
  • Author(s): Mishina M, Suzuki M, Ishii K, Sakata M, Wagastuma K, Ishibashi K, Toyohara J, Zhang MR, Kimura K, Ishiwata K.
  • Organizer: The MDS International Congress of Parkinson's Disease and Movement Disorders 2019
  • Int'l Joint Research
• [Presentation] Fully automated radiosynthesis of [18F]MK-6240 for clinical use. (2019)
  • Author(s): Toyohara J, Tago T, Nishino K, Sakai M, Ishii K.
  • Organizer: EANM'19
  • Int'l Joint Research
• [Presentation] Test-retest reliability of adenosine A2A binding in the human brain with 11C-preladenent PET. (2019)
  • Author(s): Sakata M, Wagatsuma K, Tago T, Ishibashi K, Ishii K, Ishiwata K, Toyohara J.
  • Organizer: EANM'19
  • Int'l Joint Research
• [Presentation] Pharmacokinetics modeling of P-glycoprotein function at the blood-brain brrier with [18F]MC225 in non-human primates. (2019)
  • Author(s): Garcia Varle L, Arif WM, Gardia Vallez D, Kakiuchi T, Ohba H, NIshiyama S, Tago T, Elsinga PH, Tsukada H, Colabufo NA, Dierckx RAJO, van Waarde A, Toyohara J, Boellaard R, Luurtsema G.
  • Organizer: EANM'19
  • Int'l Joint Research
• [Presentation] Cerebral type 1 metabotropic glutamate receptor availability in early Alzheimer's disease. (2019)
  • Author(s): Ishibashi K, Tago T, Wagatsuma K, Sakata M, Toyohara J, Ishii K.
  • Organizer: Neuroscience 2019. Society for Neuroscience.
  • Int'l Joint Research
• [Presentation] PET薬剤の製造および試験検査の基礎 (2019)
  • Author(s): 豊原潤
  • Organizer: 第18回日本核医学会春季大会
  • Invited
• [Presentation] 医学・医療研究を支えるPET薬剤の開発 (2019)
  • Author(s): 豊原潤
  • Organizer: TOBIRA第８回研究交流フォーラム
  • Invited
• [Presentation] 18F-標識PETプローブ合成のための簡便な固相抽出精製法の開発 (2019)
  • Author(s): 多胡哲郎、豊原潤、藤牧諒、平野圭一、岩井久美子、田中浩士
  • Organizer: TOBIRA第８回研究フォーラム
• [Presentation] ネオペンチル標識基を用いるスチリルピリジン型AβPETトレーサーの合成研究 (2019)
  • Author(s): ソウエイソウ、多胡哲郎、藤牧諒、龍田真帆、豊原潤、平野圭一、岩井久美子、田中浩士
  • Organizer: 第77回有機合成化学協会関東支部シンポジウム
• [Presentation] 18F-THK5351 PET can identify Wallerian degeneration of the pyramidal tract in a post-stroke patient (2019)
  • Author(s): 石橋賢士、三浦義治、亀山征史、多胡哲郎、豊原潤、石井賢二
  • Organizer: 第60回日本神経学会学術大会
• [Presentation] 放射性フッ素-18標識希少糖の生物学的評価 (2019)
  • Author(s): 豊原潤、山本浩之、多胡哲郎、茨木正信、木下俊文
  • Organizer: 第14回日本分子イメージング学会総会・学術集会
• [Presentation] HDAC6イメージングを目的とした18F-標識ツバスタチンA類縁体の標識合成と生物学的評価 (2019)
  • Author(s): 多胡哲郎、豊原潤、石井賢二
  • Organizer: 第14回日本分子イメージング学会総会・学術集会
• [Presentation] ネオペンチル標識基を用いるスチリルピリジン型AβPETトレーサーの合成研究 (2019)
  • Author(s): ソウエイソウ、多胡哲郎、藤牧諒、龍田真帆、岩井久美子、平野圭一、石橋賢士、豊原潤、田中浩士
  • Organizer: 第９回CSJ化学フェスタ2019
• [Presentation] 臨床使用を目的とした[18F]MK-6240の自動合成とバリデーション (2019)
  • Author(s): 豊原潤、多胡哲郎、西野浩輔、酒井昌成、石井賢二
  • Organizer: 第59回日本核医学会学術総会
• [Presentation] 早期アルツハイマー病における代謝型グルタミン酸受容体１型 (2019)
  • Author(s): 石橋賢士、多胡哲郎、我妻慧、坂田宗之、豊原潤、石井賢二
  • Organizer: 第59回日本核医学会学術総会
• [Presentation] 11C-Preladenantを用いたアデノシンA2A受容体定量測定の再現性検討 (2019)
  • Author(s): 坂田宗之、我妻慧、多胡哲郎、石橋賢士、石井賢二、石渡喜一、豊原潤
  • Organizer: 第59回日本核医学会学術総会
• [Presentation] 高悪性度神経膠腫再発における4DSTの取り込み：治療誘発性壊死との比較 (2019)
  • Author(s): 安賀文俊、山本由佳、三田村克哉、豊原潤、西山佳宏
  • Organizer: 第59回日本核医学会学術総会
• [Presentation] Off-target bindingを有するアミロイド・タウPETトレーサーのための特異的集積量推定法 (2019)
  • Author(s): 徳田明日香、田中美香、多胡哲郎、石橋賢士、我妻慧、坂田宗之、井上一雄、福士政広、豊原潤、石井賢二
  • Organizer: 第59回日本核医学会学術総会
• [Presentation] [18F]Florbetapir PETにおける白質参照領域の優位性の源泉 (2019)
  • Author(s): 亀山征史、石橋賢士、豊原潤、石井賢二
  • Organizer: 第59回日本核医学会学術総会
• [Presentation] アミロイド陽電子断層撮像（PET）の臨床使用へ向けた撮像条件の検討 (2019)
  • Author(s): 我妻慧、石橋賢士、坂田宗之、多胡哲郎、豊原潤、石井賢二
  • Organizer: 首都大学バイオコンファレンス2019
• [Presentation] 18F-THK5351 PET Imaging of Wallerian Degeneration of the Pyramidal Tract in a Post-Stroke Patient: A Longitudinal Case Study (2019)
  • Author(s): Ishibashi, K., Tago, T., Toyohara, J., Ishii, K.
  • Organizer: American Heart/Stroke Association International Stroke Conference 2019
  • Int'l Joint Research
• [Presentation] ネオペンチル標識基を有するスチリルピリジン型Aβ[18F]PETトレーサーの合成研究 (2019)
  • Author(s): Song Ruichong、多胡哲郎、藤牧諒、龍田真帆、豊原潤、平野圭市、岩井久美子、石橋賢士、田中浩士
  • Organizer: 日本化学会第99春季年会
• [Presentation] Optimization of reconstruction conditions for tau PET imaging using [18F]THK5351 (2018)
  • Author(s): Wagatsuma, K., Miwa, K., Sakata, M., Ishibashi, K., Oda, K., Tago, T., Toyohara, J., Ishii, K.
  • Organizer: WFNMB 2018
  • Int'l Joint Research
• [Presentation] Automated radiosynthesis and biodistribuion of fluorine-18 labelled D-allose (2018)
  • Author(s): Yamamoto, H., Toyohara, J., Tago, T., Ibaraki, M., Kinoshita, T.
  • Organizer: WFNMB 2018
  • Int'l Joint Research
• [Presentation] Metabotropic glutamate receptor subtype 1 PET imaging in medial temporal lobe epilepsy patients with hippocampal sclerosis (2018)
  • Author(s): Inaji, M., Nariai, T., Hayashi, S., Wagatsuma, K., Toyohara, J., Ishii, K., Maehara, T.
  • Organizer: WFNMB 2018
  • Int'l Joint Research
• [Presentation] Efficacy of 4’-[methyl-11C]thiothymidine PET/CT before and after neoadjuvant therapy for predicting therapeutic responses in patients with esophageal cancer (2018)
  • Author(s): Hotta, M., Minamimoto, R., Yamada, K., Souma, D., Yokoyama, K., Toyohara, J., Takase, K.
  • Organizer: 64th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
  • Int'l Joint Research
• [Presentation] Volume estimation of radio-activated material in inner concrete walls of a cyclotron room at a PET research facility (2018)
  • Author(s): Wagatsuma, K., Kunugi, M., Miwa, K., Oda, K., Toyohara, J., Ishii, K.
  • Organizer: 64th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
  • Int'l Joint Research
• [Presentation] Type 1 metabotropic glutamate receptors measured with a novel PET ligand, 11C-ITMM, in patients with cerebellar ataxia (2018)
  • Author(s): Ishibashi, K., Tago, T., Wagatsuma, K., Sakata, M., Toyohara, J., Ishii, K.
  • Organizer: 64th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
  • Int'l Joint Research
• [Presentation] Origin of the superiority of white matter reference region (2018)
  • Author(s): Kameyama, M., Ishibashi, K., Toyohara, J., Tokumaru, Aya M. Ishii, K.
  • Organizer: Alzheimer Imaging Consortium 2018
  • Int'l Joint Research
• [Presentation] Glia imaging with 18F-THK5351 as a potential marker for neurodegeneration (2018)
  • Author(s): Ishii, K., Tago, T., Ishibashi, K., Wagatsuma, K., Sakata, M., Toyohara, J., Sengoku, R., Kanemaru, K., Murayama, S.
  • Organizer: Alzheimer Imaging Consortium 2018
  • Int'l Joint Research
• [Presentation] Biological Evaluation Of Novel 18F-labeled Beta-amyloid Probes With A Neopentyl Labeling Group (2018)
  • Author(s): Toyohara, J., Tago, T., Fujimaki, R., Hirano, K., Iwai, K., Tanaka, H.
  • Organizer: EANM’18
  • Int'l Joint Research
• [Presentation] Preliminary biological evaluation of radioligands for PET imaging of histone deacetylase 6 (2018)
  • Author(s): Tago, T., Toyohara, J., Ishii, K.
  • Organizer: EANM’18
  • Int'l Joint Research
• [Presentation] Radiosynthesis and preliminary biological evaluation of a 18F-labeled probe for histone deacetylase 6 PET imaging (2018)
  • Author(s): Tago, T., Toyohara, J., Ishii, K.
  • Organizer: The 10th China-Japan-Korea Symposium on Radiopharmaceutical Sciences
  • Int'l Joint Research
• [Presentation] Fully automated radiosynthesis and preclinical toxicity studies of [18F]MC225 for clinical use (2018)
  • Author(s): Toyohara, J,, Tago, T., Colabufo, N.A., Luurtsema, G.
  • Organizer: The 10th China-Japan-Korea Symposium on Radiopharmaceutical Sciences
  • Int'l Joint Research
• [Presentation] Imaging Cellular Proliferation by Using [Methyl-11C]-4’-Thiothymidine: Great Idea but Tough Reality. (2018)
  • Author(s): Toyohara, J.
  • Organizer: 2018 Annual Meeting, Taiwanese Society of Medical Cyclotron
  • Int'l Joint Research / Invited
• [Presentation] Short-term follow-up of type 1 metabotropic glutamate receptor availability in patients with spinocerebellar ataxia type 6 (2018)
  • Author(s): Ishibashi, K., Miura, Y., Wagatsuma, K., Toyohara, J., Ishii, K.
  • Organizer: Society for Neuroscience Annual Meeting 2018
  • Int'l Joint Research
• [Presentation] Correlation of 11C-4DST uptake with isocitrate dehydrogenase 1 mutation in patients with glioma in comparison with 18F-FLT uptake. (2018)
  • Author(s): Yamamoto, Y., Takami, Y., Norikane, T., Toyohara, J., Nishiyama, Y.
  • Organizer: RSNA2018
  • Int'l Joint Research
• [Presentation] 施設認証の必要項目の詳細(1)PET薬剤の製造の基礎 (2018)
  • Author(s): 豊原潤
  • Organizer: 第18回日本核医学会春季大会
  • Invited
• [Presentation] ネオペンチル標識基を有する18F-標識アミロイド-βプローブの性能評価 (2018)
  • Author(s): 多胡哲郎、豊原潤、藤牧諒、田中浩士、石井賢二
  • Organizer: 第13回日本分子イメージング学会学術集会
• [Presentation] Recovery from spatial memory deficits and increase of cerebral glucose uptake in cilostazol-administered aged mice (2018)
  • Author(s): 柳井修一、多胡哲郎、豊原潤、新崎智子、遠藤昌吾
  • Organizer: 第41回日本基礎老化学会大会
• [Presentation] 未治療パーキンソン病における脳内代謝型グルタミン酸受容体1型密度－[C-11]ITMM PET研究－ (2018)
  • Author(s): 三品雅洋、鈴木正彦、石井賢二、石橋賢士、坂田宗之、我妻慧、豊原潤、張明栄、石渡喜一、木村和美
  • Organizer: 第12回パーキンソン病・運動障害疾患コングレス
• [Presentation] PDE3阻害剤シロスタゾールの投与が老齢マウスの記憶機能改善と糖代謝亢進に及ぼす効果 (2018)
  • Author(s): 柳井修一、多胡哲郎、豊原潤、新崎智子、遠藤昌吾
  • Organizer: 第41回日本神経科学大会
• [Presentation] Pre-discard estimation of radio-activated materials in the PET cyclotron systems of TMIG (2018)
  • Author(s): Wagatsuma, K., Kunugi, M., Oda, K., Miwa, K., Toyohara, J., Ishii, K.
  • Organizer: 第58回日本核医学回学術総会
• [Presentation] Isomeric [11C]methoxy analogs of nimesulide: radiosynthesis and in/ex vivo evaluation (2018)
  • Author(s): 山本由美、多胡哲郎、豊原潤、齋藤陽平、山本文彦
  • Organizer: 第58回日本核医学会学術総会
• [Presentation] Development of amyloid-β imaging ligands with a 18F-labeled neopentyl side-chain (2018)
  • Author(s): 多胡哲郎、藤牧諒、豊原潤、平野圭市、岩井久美子、石橋賢士、田中浩士
  • Organizer: 第58回日本核医学会学術総会
• [Presentation] SCA6における代謝型グルタミン酸受容体1型の経時的変化 (2018)
  • Author(s): 石橋賢士、三浦義治、我妻慧、豊原潤、石井賢二
  • Organizer: 第58回日本核医学回学術総会
• [Presentation] Fully automated radiosynthesis of [18F]MC225 for clinical use (2018)
  • Author(s): Toyohara, J., Tago, T., Colabufo, N.A., Luurtsema, G.
  • Organizer: 第58回日本核医学回学術総会
• [Book] PET and SPECT of Neurobiological Systems (2020)
  • Author(s): Dierckx R. A., Otte A., de Vries E. F., van Waarde A., Lammertsma A. A. (eds)
  • Total Pages: 1132
  • Publisher: Springer, Cham
• [Book] 新核医学技術総論 臨床編 (2020)
  • Author(s): 日本核医学技術学会編集委員会
  • Total Pages: 630
  • Publisher: 山代印刷株式会社