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Feature value analysis of delivered dose distribution contributing to individualized radiotherapy

Research Project

Project/Area Number 18K07667
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionThe University of Tokyo

Principal Investigator

Imae Toshikazu  東京大学, 医学部附属病院, 副診療放射線技師長 (80420222)

Co-Investigator(Kenkyū-buntansha) 芳賀 昭弘  徳島大学, 大学院医歯薬学研究部(医学域), 教授 (30448021)
山下 英臣  東京大学, 医学部附属病院, 准教授 (70447407)
高橋 渉  東京大学, 医学部附属病院, 助教 (50755668)
鈴木 雄一  東京大学, 医学部附属病院, 副診療放射線技師長 (70420221)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords放射線治療 / 個別化 / 投与線量分布 / 特徴量 / 形態変化
Outline of Final Research Achievements

This study aimed to reconstruct the dose distribution that reflects the patient's shape and the device movement during treatment, and to clarify the feature value that causes the error between the dose distribution and the treatment plan. We created the delivered dose distribution using non-rigid registration and deep learning approaches. In addition, we extracted feature values for the therapeutic and side effects of stereotactic body radiation therapy using radiomics analysis and clarified that specific feature values indicate clinical usefulness.

Academic Significance and Societal Importance of the Research Achievements

本研究では,非剛体レジストレーションを用いた投与線量分布の作成や深層学習を用いた画質改善法の提案,体幹部定位放射線治療における治療効果と副作用,また,レディオミクス解析を用いて抽出した特徴量の臨床的有用性を示した.治療効果や副作用に直結する投与線量分布の作成や投与線量分布と治療計画の誤差要因の明確化,また,治療後の患者に対する詳細な解析結果は,今後の放射線治療の個別化や最適化に貢献する.

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2022 2021 2020 2019 2018 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (7 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Establishment of a Prediction Model for Overall Survival after Stereotactic Body Radiation Therapy for Primary Non-Small Cell Lung Cancer Using Radiomics Analysis2022

    • Author(s)
      Subaru Sawayanagi, Hideomi Yamashita, Yuki Nozawa, Ryosuke Takenaka, Yosuke Miki, Kosuke Morishima, Hiroyuki Ueno, Takeshi Ohta, Atsuto Katano.
    • Journal Title

      Cancers (Basel)

      Volume: 14 Issue: 16 Pages: 3859-3859

    • DOI

      10.3390/cancers14163859

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement in Image Quality of CBCT during Treatment by Cycle Generative Adversarial Network2020

    • Author(s)
      今江 禄一, 鍛冶 静雄, 木田 智士, 松田 佳奈子, 竹中 重治, 青木 淳, 仲本 宗泰, 尾崎 翔, 名和 要武, 山下 英臣, 中川 恵一, 阿部 修.
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 76 Issue: 11 Pages: 1173-1184

    • DOI

      10.6009/jjrt.2020_JSRT_76.11.1173

    • NAID

      130007941322

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrospective dose reconstruction of prostate stereotactic body radiotherapy using cone-beam CT and a log file during VMAT delivery with flattening-filter-free mode2020

    • Author(s)
      Imae Toshikazu,Haga Akihiro,Watanabe Yuichi,Takenaka Shigeharu,Shiraki Takashi,Nawa Kanabu,Ogita Mami,Takahashi Wataru,Yamashita Hideomi,Nakagawa Keiichi,Abe Osamu.
    • Journal Title

      Radiological Physics and Technology

      Volume: 13 Issue: 3 Pages: 238-248

    • DOI

      10.1007/s12194-020-00574-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visual enhancement of Cone‐beam CT by use of CycleGAN2020

    • Author(s)
      Kida S, Kaji S, Nawa K, Imae T, Nakamoto T, Ozaki S, Ohta T, Nozawa Y, Nakagawa K.
    • Journal Title

      Medical Physics

      Volume: 47(3) Issue: 3 Pages: 998-1010

    • DOI

      10.1002/mp.13963

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salvage stereotactic body radiotherapy for post?operative oligo?recurrence of non?small cell lung cancer: A single?institution analysis of 59?patients2020

    • Author(s)
      Aoki S, Yamashita H, Takahashi W, Nawa K, Ota T, Imae T, Ozaki S, Nozawa Y, Nakajima J, Sato M, Anraku M, Nitadori J, Karasaki T, Abe O, Nakagawa K.
    • Journal Title

      Oncology Letters

      Volume: 19(4) Pages: 2695-2704

    • DOI

      10.3892/ol.2020.11407

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereotactic body radiotherapy for centrally located lung tumors with 56 Gy in seven fractions: A retrospective study2018

    • Author(s)
      Aoki Shuri、Yamashita Hideomi、Haga Akihiro、Ota Takeshi、Takahashi Wataru、Ozaki Sho、Nawa Kanabu、Imae Toshikazu、Abe Osamu、Nakagawa Keiichi
    • Journal Title

      Oncology Letters

      Volume: 16(4) Pages: 4498-4506

    • DOI

      10.3892/ol.2018.9188

    • NAID

      120007099373

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 深層学習により画質改善したCBCT画像を用いた積算線量分布の構築2022

    • Author(s)
      竹中重治,今江禄一,青木淳,松田佳奈子,境紀行,鍛冶静雄,岩永秀幸,山下英臣,阿部修.
    • Organizer
      日本放射線腫瘍学会第35回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 深層学習を用いて画質改善した位置合わせ用CBCT上における線量分布の再構築2021

    • Author(s)
      今江禄一,青木淳,竹中重治,松田佳奈子,三枝茂輝,鍛冶静雄,岩永秀幸,阿部修.
    • Organizer
      第49回日本放射線技術学会秋季学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Cone-beam CT image quality improvement with Cycle-Consistency Generative Adversarial Network.2019

    • Author(s)
      S Kida, S Kaji, K Nawa, T Imae, T Nakamoto, S Ozaki, T Ohta, Y Nozawa and N Keiichi.
    • Organizer
      第117回日本医学物理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Image quality improvement of cone beam CT image reconstruction during treatment.2019

    • Author(s)
      K Mano, T Hashimoto and T Imae.
    • Organizer
      第117回日本医学物理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 班報告:高精度放射線治療における包括的かつ実用的な投与線量保証法に関する研究班.2019

    • Author(s)
      今江禄一,渡邉雄一,辰己大作,藤本隆広,佐々木誠,佐々木幹治,中口裕二,阿部 修.
    • Organizer
      第47回日本放射線技術学会秋季学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Pseudo-CBCT Image Prediction of Head and Neck Cancer Patient Using Principal Component Vector Fields of Early Treatment Fractions.2019

    • Author(s)
      M Nakano, T Imae, T Nakamoto, A Haga, K Nawa, Y Nomura, R Chhatkuli, K Demachi, W Takahashi, K Yamamoto, K Nakagawa, M Hashimoto, Y Yoshioka, M Oguchi,
    • Organizer
      American Association of Physicists in Medicine 61st Annual Meeting and Exhibition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pseudo-CBCT image prediction of head and neck cancer patient using principal component vector fields of early treatment fractions.2019

    • Author(s)
      M Nakano, T Imae, T Nakamoto, K Nawa, A Haga, W Takahashi, K Nakagawa, M Hashimoto, Y Yoshioka and M Oguchi.
    • Organizer
      第117回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Book] 詳説非剛体レジストレーション : 放射線治療領域2020

    • Author(s)
      角谷 倫之,木藤 哲史,黒岡 将彦,武川 英樹,藤田 幸男,宮部 結城.
    • Total Pages
      264
    • Publisher
      中外医学社
    • ISBN
      9784498065284
    • Related Report
      2020 Research-status Report
  • [Remarks] researchmap: 今江禄一

    • URL

      https://researchmap.jp/m035402

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report
  • [Remarks] 東京大学医学部附属病院 放射線科 放射線治療部門 > 研究・業績

    • URL

      http://u-tokyo-rad.jp/works/index.html

    • Related Report
      2021 Research-status Report 2020 Research-status Report 2019 Research-status Report 2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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