Enhancement of radiation cancer therapy by gold nanorods
| Project/Area Number |
18K07668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | University of Toyama |
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Principal Investigator |
KONDO Takashi 富山大学, 学術研究部医学系, 特別研究教授 (40143937)
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| Co-Investigator(Kenkyū-buntansha) |
野口 京 富山大学, 学術研究部医学系, 教授 (10242497)
齋藤 淳一 富山大学, 学術研究部医学系, 教授 (70572816)
趙 慶利 富山大学, 学術研究部医学系, 助教 (90313593)
REHMAN MATIUR 富山大学, 学術研究部医学系, 特命助教 (10810921)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナノメディシン / 金ナノロッド / 放射線増感 / 放射線 / アポトーシス / 金ナノ粒子 / 大気圧プラズマ / 細胞死 / 癌治療 |
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| Outline of Final Research Achievements |
Although radio-sensitization using gold-nanoparticles is well known, less information is available on gold-nanorods. In this study, combined effects of gold-nanorods and ionizing radiation on apoptosis were investigated. Enhancement of radiation-induced apoptosis in the presence of gold-nanorods was observed under some proper condition. Gold-nanorods reduced intracellular GSH concentration and induced increase in intracellular oxidative stress. DNA damage, Fas expression and ER stress related molecules were enhanced by the combination.
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| Academic Significance and Societal Importance of the Research Achievements |
金ナノロッドによる放射線がん治療効果の増強を目的とし、アポトーシスを指標として、その増強効果および分子機序について検討した。本成果はナノ粒子の医学応用を目指す、ナノメディシンの発展に寄与するとともに、放射線がん治療に関する増感剤開発についても有用な情報を提供する。
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Report
(5 results)
Research Products
(37 results)
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[Journal Article] Combination of 5-aminosalicylic acid and hyperthermia synergistically enhances apoptotic cell death in HSC-3 cells due to intracellular nitric oxide/peroxynitrite generation2019
Author(s)
Moniruzzaman R, Rehman MU, Zhao QL, Jawaid P, Mitsuhashi Y, Sakurai K, Heshiki W, Ogawa R, Tomihara K, Saitoh J, Noguchi K, Kondo T, Noguchi M
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Journal Title
Cancer Lett
Volume: 451
Pages: 58-67
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Anti-psychotic drugs scavenge radiation-induced hydroxyl radicals and intracellular ROS formation, and protect apoptosis in human lymphoma U937 cells2019
Author(s)
Zhao QL, Ito H, Kondo T, Uehara T, Ikeda M, Abe H, Saitoh JI, Noguchi K, Suzuki M, Kurachi M
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Journal Title
Free Radic Res
Volume: 53
Issue: 3
Pages: 304-312
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Roles of intracellular and extracellular ROS formation in apoptosis induced by cold atmospheric helium plasma and X-irradiation in the presence of sulfasalazine2018
Author(s)
Moniruzzaman R, Rehman MU, Zhao QL, Jawaid P, Mitsuhashi Y, Imaue S, Fujiwara K, Ogawa R, Tomihara K, Saitoh J-I, Noguchi K, Kondo T, Noguchi M
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Journal Title
Free Radic Biol Med
Volume: 129
Pages: 537-547
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Free radical generation by non-equilibrium atmospheric pressure plasma in alcohol-water mixtures: an EPR-spin trapping study2018
Author(s)
Uchiyama H, Ishikawa K, Zhao QL, Andocs G, Nojima N, Takeda K, Krishna MC, Ishijima T, Matsuya Y, Hori M, Noguchi K, Kondo T
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Journal Title
J Phys D: Applied Phys
Volume: 51
Pages: 095202-095202
Related Report
Peer Reviewed / Open Access
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[Book] Plasma Medical Science2018
Author(s)
Kondo T, Rehman MU,Jawaid P, Tabuchi Y, Uchiyama H, Noguchi K
Total Pages
7
Publisher
Academic Press
ISBN
9780128150047
Related Report
