Tumor vascularity and tumor-related vessels using ultrafast DCE MRI of the Breast
Project/Area Number |
18K07673
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
飯間 麻美 京都大学, 医学研究科, 助教 (60748797)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | MRI / 乳癌 / 血流 / 画像診断 / 高速撮像法 / 血管新生 / 圧縮センシング / 灌流 / 拡散強調画像 / Breast / 高速撮像 |
Outline of Final Research Achievements |
We aimed to improve the image quality of ultrafast contrast-enhanced dynamic MRI of the breast, to establish imaging and analysis methods, and to establish methods for diagnosis and prediction of therapeutic effects based on evaluation of blood flow and blood vessels in breast tumors. We optimized the imaging method using compressed sensing, demonstrated the usefulness of new parameters such as Maximum Slope, and improved the diagnostic performance by analyzing the images together with diffusion-weighted images. In addition, this method is less sensitive to the background parenchymal enhancement, which we described in our paper. We also presented the relationship between tumor blood vessels and proliferation, developing the method of automatic segmentation of tumor blood vessels using machine-learning.
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Academic Significance and Societal Importance of the Research Achievements |
従来の乳房造影MRIでは、造影のみでも約8分を要するため、時間や費用面でスクリーニング検査としての乳房MRI導入の障壁となっていた。また、腫瘍血管は癌の悪性度や治療効果を評価する手がかりと考えられていたが、標準的な乳房MRIでは腫瘍血管の描出は困難であった。 本研究で得られた成果は、これらの問題点を克服するものであり、時間短縮により乳房MRIのスクリーニング検査としての実用への一歩を示した点での社会的意義とともに、腫瘍血管からのアプローチという新たな手法を見出したという点で学術的意義も大きいと考えられる。
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] A multiparametric approach to diagnosing breast lesions using diffusion-weighted imaging and ultrafast dynamic contrast-enhanced MRI2020
Author(s)
Akane Ohashi, Masako Kataoka, Mami Iima, Shotaro Kanao, Maya Honda, Yuta Urushibata, Marcel Dominik Nickel, Ayami Ohno Kishimoto, Rie Ota, Masakazu Toi, Kaori Togashi
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Journal Title
MAGNETIC RESONANCE IMAGING
Volume: 71
Pages: 154-160
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The comparison of high-resolution diffusion weighted imaging (DWI) with high-resolution contrast-enhanced MRI in the evaluation of breast cancers2020
Author(s)
Ayami Ohno Kishimoto, Masako Kataoka, Mami Iima, Maya Honda, Kanae Kawai Miyake, Akane Ohashi, Rie Ota, Tatsuki Kataoka, Takaki Sakurai, Masakazu Toi, Kaori Togashi
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Journal Title
MAGNETIC RESONANCE IMAGING
Volume: 71
Pages: 161-169
DOI
Related Report
Peer Reviewed
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[Presentation] Post-NAC evaluation using ultrafast breast dynamic contrast-enhanced MRI2020
Author(s)
Honda M, Kataoka M, Iima M, Miyake KK, Ohashi A, Kishimoto AO, Ota R, Nickel MD, Kataoka T, Toi M, Togashi K
Organizer
ISMRM & SMRT Virtual Conference & Exhibition
Related Report
Int'l Joint Research
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[Presentation] Quantitative Evaluation of Tumor-related Vessels on Ultrafast Dynamic Contrast-Enhanced MRI: Image Biomarker of Breast Cancer Proliferation2020
Author(s)
Kawase K, Kataoka M, Takemura T, Fukutome T, Yano K, Honda M, Iima M, Nickel MD, Kataoka TR, Toi M, Togashi K
Organizer
ISMRM & SMRT Virtual Conference & Exhibition
Related Report
Int'l Joint Research
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[Presentation] Multiparametric approach of diagnosing breast lesions using DWI and ultrafast DCE MRI: compared with conventional DCE MRI2020
Author(s)
Ohashi A, Kataoka M, Iima M, Honda M, Urushibata Y, Nickel DM, Weiland E, Kishimoto AO , Ota R , Toi M, and Togashi K
Organizer
ISMRM & SMRT Virtual Conference & Exhibition
Related Report
Int'l Joint Research
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[Presentation] MR findings of pure DCIS2020
Author(s)
Makiko Kawai, Masako Kataoka, Shotaro Kanao, Maya Honda, Mami Iima, Ayami Ohno-Kishimoto, Akane Ohashi, Masakazu Toi, Kaori Togashi
Organizer
第79回日本医学放射線学会
Related Report
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[Presentation] Novel parameters of ultrafast DCE MRI of the breast using a compressed sensing technique2018
Author(s)
Honda M, Kataoka M, Onishi N, Kanao S, Sagawa H, Iima M, Miyake KK, Toi M, Nickel MD, Togashi K
Organizer
Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France, 16-21 June, 2018
Related Report
Int'l Joint Research
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[Presentation] Added ADC value in diagnostic performance of Maximum Slope in Ultrafast Dynamic Contrast Enhance Breast MRI2018
Author(s)
Akane Ohashi, Masako Kataoka, Mami Iima, Shotaro Kanao, Maya Honda, Ayami Kishimoto Ohno, Rie Oota, Katsutoshi Murata, Elisabeth Weiland, Masakazu Toi, and Kaori Togashi
Organizer
ISMRM Workshop on Breast MRI
Related Report
Int'l Joint Research
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[Presentation] Maximum slope as a kinetic parameter based on ultrafast dynamic contrast-enhanced MRI of the breast using k-space weighted imaging contrast2018
Author(s)
Akane Ohashi, Masako Kataoka, Shotaro Kanao, Mami Iima, Makiko Kawai, Natsuko Onishi, Yuta Urushibata, Katsutoshi Murata, Elisabeth Weiland, Masakazu Toi, and Kaori Togashi
Organizer
104th RSNA Scientific Assembly and Annual Meeting
Related Report
Int'l Joint Research
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