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Development of a computer-aided device for ultra-low-dose CT screening for lung cancer and differential diagnosis of lung nodules using AI

Research Project

Project/Area Number 18K07675
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKobe University

Principal Investigator

Takenaka Daisuke  神戸大学, 医学研究科, 非常勤講師 (60258233)

Co-Investigator(Kenkyū-buntansha) 大野 良治  藤田医科大学, 医学部, 教授 (30324924)
吉川 武  神戸大学, 医学研究科, 特命講師 (40332788)
関 紳一郎  神戸大学, 医学研究科, 特命助教 (30773519)
西村 善博  神戸大学, 医学研究科, 名誉教授 (20291453)
眞庭 謙昌  神戸大学, 医学研究科, 教授 (50362778)
岸田 雄治  神戸大学, 医学部附属病院, 特命助教 (90792250)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords放射線医学 / CT / 人工知能 / 被曝線量低減 / 画像診断支援 / 肺癌検診 / 低線量CT / AI / Deep Learning
Outline of Final Research Achievements

In this research project, we developed computer-aided volumetry software with atrificial intelligence and compared it's capability with that without artificial intelligence. In addition, we tested CT value accuracy of standard-, rduced- and ultra-low-dose CTs reconstructed with different reconstruction methods with artificial intelligence.
These results were presented at international and domestic society meetings and published in international journals.

Academic Significance and Societal Importance of the Research Achievements

1990年代の後半より臨床応用されてきたMDCTにおいて、近年臨床応用が進められている逐次近似再構成および逐次再構成などの新たな再構成法により低線量CTや超低線量CTの臨床応用が進められている。あわせて、NLSTによるCT肺癌検診の有用性及び日本肺癌学会による肺癌取扱い規約第8版における肺癌内のすりガラス濃度部分および充実部分の成分分析による病期分類や予後の差などが指摘されている。
本研究では人工知能を併用した新たなCAD装置の臨床応用を可能にするとともに新たな低線量CT検査を可能にした。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (25 results)

All 2022 2021 2020 2019

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 2 results) Presentation (16 results) (of which Int'l Joint Research: 10 results,  Invited: 2 results)

  • [Journal Article] Newly developed artificial intelligence algorithm for COVID-19 pneumonia: utility of quantitative CT texture analysis for prediction of favipiravir treatment effect2022

    • Author(s)
      Ohno Yoshiharu、Aoyagi Kota、Arakita Kazumasa、et al.
    • Journal Title

      Japanese Journal of Radiology

      Volume: - Issue: 8 Pages: 800-813

    • DOI

      10.1007/s11604-022-01270-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Machine learning for lung CT texture analysis: Improvement of inter-observer agreement for radiological finding classification in patients with pulmonary diseases.2021

    • Author(s)
      Ohno Y, Aoyagi K, Takenaka D, Yoshikawa T, Ikezaki A, Fujisawa Y, Murayama K, Hattori H, Toyama H.
    • Journal Title

      Eur J Radiol.

      Volume: 134 Pages: 109410-109410

    • DOI

      10.1016/j.ejrad.2020.109410

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Machine learning for lung texture analysis on thin-section CT: Capability for assessments of disease severity and therapeutic effect for connective tissue disease patients in comparison with expert panel evaluations2021

    • Author(s)
      Ohno Yoshiharu、Aoyagi Kota、Takenaka Daisuke、Yoshikawa Takeshi、Fujisawa Yasuko、Sugihara Naoki、Hamabuchi Nayu、Hanamatsu Satomu、Obama Yuki、Ueda Takahiro、Hattori Hidekazu、Murayama Kazuhiro、Toyama Hiroshi
    • Journal Title

      Acta Radiologica

      Volume: - Issue: 10 Pages: 1363-1373

    • DOI

      10.1177/02841851211044973

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of Benign from Malignant Pulmonary Nodules by Using a Convolutional Neural Network to Determine Volume Change at Chest CT2020

    • Author(s)
      Ohno Yoshiharu、Aoyagi Kota、Yaguchi Atsushi、Seki Shinichiro、Ueno Yoshiko、Kishida Yuji、Takenaka Daisuke、Yoshikawa Takeshi
    • Journal Title

      Radiology

      Volume: 296 Issue: 2 Pages: 432-443

    • DOI

      10.1148/radiol.2020191740

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differentiation of Benign from Malignant Pulmonary Nodules by Using a Convolutional Neural Network to Determine Volume Change at Chest CT2020

    • Author(s)
      Ohno Y, Aoyagi K, Yaguchi A, Seki S, Ueno Y, Kishida Y, Takenaka D, Yoshikawa T.
    • Journal Title

      Radiology

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Variability and Standardization of Quantitative Imaging: Monoparametric to Multiparametric Quantification, Radiomics, and Artificial Intelligence.2020

    • Author(s)
      Hagiwara A, Fujita S, Ohno Y, Aoki S.
    • Journal Title

      Investigative Radiology

      Volume: - Issue: 9 Pages: 601-616

    • DOI

      10.1097/rli.0000000000000666

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of acquisition method and reconstruction algorithm for CT number measurement on standard-dose CT and reduced-dose CT: a QIBA phantom study2019

    • Author(s)
      Ohno Yoshiharu、Fujisawa Yasuko、Fujii Kenji、Sugihara Naoki、Kishida Yuji、Seki Shinichiro、Yoshikawa Takeshi
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 5 Pages: 399-411

    • DOI

      10.1007/s11604-019-00823-5

    • NAID

      50014127806

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiation dose reduction techniques for chest CT: Principles and clinical results2019

    • Author(s)
      Ohno Yoshiharu、Koyama Hisanobu、Seki Shinichiro、Kishida Yuji、Yoshikawa Takeshi
    • Journal Title

      European Journal of Radiology

      Volume: 111 Pages: 93-103

    • DOI

      10.1016/j.ejrad.2018.12.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Reconstruction Parameters on the Quantitative Analysis of Chest Computed Tomography2019

    • Author(s)
      Kim Hyungjin、Goo Jin Mo、Ohno Yoshiharu、Kauczor Hans-Ulrich、Hoffman Eric A.、Gee James C.、van Beek Edwin J.R.
    • Journal Title

      Journal of Thoracic Imaging

      Volume: 34 Issue: 2 Pages: 92-102

    • DOI

      10.1097/rti.0000000000000389

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Ultra-high Resolution CT と Area-Detector CTにおける低線量下CT値測定の検討2022

    • Author(s)
      大島夕佳,濱渕菜邑,秋野成臣,伊藤雄也,木全洋奈,藤井健二,藤澤恭子,服部秀計,大野良治,外山 宏
    • Organizer
      第13回呼吸機能イメージング研究会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 超高精細CTにおけるCOPDに対するCT検診用撮像法の被曝低減に関する基礎的検討:撮像モード及び再構成法に関する検討2022

    • Author(s)
      大野良治,大島夕佳,濱渕菜邑,秋野成臣,木全洋奈,藤井健二,藤澤恭子,村山和宏,外山 宏
    • Organizer
      第41回日本CT検診学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Deep Learning Reconstruction vs. Hybrid-Type and Model-Based Iterative Reconstructions: Radiation Dose Reduction of Lung Density Evaluation on Ultra-High Resolution and Area-Detector CTs as QIBA Study2022

    • Author(s)
      Ohno Y, Akino N, Ito Y, Kimata H, Fujii K, Fujisawa Y, Murayama K, Toyama H
    • Organizer
      28th European Congress of Radiology (ECR2022)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Machine Learning for Lung CT Texture Analysis in Connective Tissue Disease: Capability for Disease Severity and Therapeutic Effect Evaluations.2021

    • Author(s)
      Ohno Y, Aoyagi K, Takenaka D, Yoshikawa T, Fujisawa Y, Sugihara N, Hattori H, Murayama K, Toyama H
    • Organizer
      CARS 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultra-High-Resolution and Area-Detector CTs for Lung Density Assessment: Comparison of Radiation Dose Reduction Capability among Hybrid-Type and Model-Based Iterative Reconstructions and Deep Learning Reconstruction at QIBA Recommended Phantom Study2021

    • Author(s)
      Shigamura C. Ohno Y, Hamabuchi N, Watanabe A, Kataoka Y, Ida Y, Akino N, Ito Y, Kimata H, Fujii K, Nakanishi S, Murayama K, Katada K, Toyama H
    • Organizer
      107th Scientific Assembly and Annual Meeting of Radiological Society of North America (RSNA 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 3D CADv System with and without CNN: Comparison of Nodule Component Measurement Accuracy and Differentiation in Routine Clinical Practice Data2020

    • Author(s)
      Ohno Y, Aoyagi K, Kishida Y, Seki S, Ueno Y, Yaguchi A, Takenaka D, Yoshikawa T
    • Organizer
      CARS 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] CT を用いた肺癌の最新診療2020

    • Author(s)
      大野良治
    • Organizer
      第61回日本肺癌学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 人工知能を用いた3D Computer-Aided Volumetry (CADv) の肺結節経過観察CT における有用性に関する検討2020

    • Author(s)
      大野良治,青柳康太,谷口敦司,竹中大祐,吉川 武
    • Organizer
      第27回日本CT検診学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 低線量CT肺がん検診における至適撮像法の確立とCADおよび人工知能の活用2020

    • Author(s)
      大野良治
    • Organizer
      第27回日本CT検診学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 3D Computer-Aided Volumetry (CADv) System with AI System: Comparison of Quantitative Nodule Component Measurement Accuracy and Pulmonary Nodule Differentiation Capability on Repeated CT Examination2020

    • Author(s)
      Yoshiharu Ohno, Kota Aoyagi, Yuji Kishida, Shinichiro Seki, Yoshiko Ueno, Atsushi Yaguchi, Takeshi Yoshikawa
    • Organizer
      European Congress of Radiology (ECR) 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3D CADv System with and without CNN: Comparison of Nodule Component Measurement Accuracy and Differentiation in Routine Clinical Practice Data2020

    • Author(s)
      Yoshiharu Ohno, Kota Aoyagi, Yuji Kishida, Shinichiro Seki, Yoshiko Ueno, Atsushi Yaguchi, Takeshi Yoshikawa
    • Organizer
      Computer Assisted Radiology and Surgery(CARS)2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Capability of Quantitative Assessment of Subsegmental Bronchi on Thin-Section CT to Evaluate the Therapeutic Effects in Patients with Pulmonary Lymphangitis Carcinomatosa2019

    • Author(s)
      Daisuke Takenaka, Yoshiharu Ohno, Chika Tanaka, Erika Matsushiro, Ayumi Higashida, Tomohisa Hashimoto, Hiroaki Maeda, Setsu Sakamoto, Miyako Satouchi
    • Organizer
      2019 World Conference on Lung Cancer
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肺結節自動容積測定(Computer-Aided Volumetry)によるConvolutional Neural Networkの有用性に関する検討2019

    • Author(s)
      大野良治, 谷口敦司, 青柳康太, 岸田雄治, 関 紳一郎, 上野嘉子, 吉川 武
    • Organizer
      第26回日本CT検診学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 3D fully convolutional network-based segmentation of lung nodules in CT images with a clinically inspired data synthesis method2019

    • Author(s)
      Atsushi Yaguchi, Kota Aoyagi, Akiyuki Tanizawa, Yoshiharu Ohno
    • Organizer
      SPIE Medical Imaging 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of Capability for Nodule Component Measurement and Management on Follow-Up CT Examinations between 3D CADv Systems with and without CNN2019

    • Author(s)
      Yoshiharu Ohno, Atsushi Yaguchi, Kota Aoyagi, Yuji Kishida, Shinichiro Seki, Yoshiko Ueno, Takeshi Yoshikawa, akamichi Murakami
    • Organizer
      European Congress of Radiology (ECR) 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The utility of the ultra-high-resolution CT to evaluate the detailed bronchial tree for COPD2019

    • Author(s)
      Daisuke Takenaka, Ayumi Higashida, Yasuhide Kono, Tomohisa Hashimoto, Hiroaki Maeda, Setsu Sakamoto
    • Organizer
      European Congress of Radiology (ECR) 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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