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Peptide receptor radionuclide therapy using alpha nuclide labeled RGD for pancreatic cancer

Research Project

Project/Area Number 18K07698
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNational Cancer Center Japan

Principal Investigator

Yoshimoto Mitsuyoshi  国立研究開発法人国立がん研究センター, 研究所, 主任研究員 (00345638)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords核医学治療 / アクチニウム / RGDペプチド / インテグリン / 膵癌 / 膵がん / アルファ線核種 / アルファ線 / アルファ核種 / PRRT
Outline of Final Research Achievements

In this research project, we investigated the usefulness of radionuclide therapy using 225Ac-DOTA-RGD2 for pancreatic cancers with αvβ3 integrin. A biodistribution study of 111In-DOTA-RGD2 revealed high uptake in tumors and kidneys. In a therapeutic experiment, 225Ac-DOTA-RGD2 significantly inhibited tumor growth. However, liver toxicity was found partly.

Academic Significance and Societal Importance of the Research Achievements

膵臓がんは有効な治療方法が確立していない代表的な難治がんであり、その治療方法の開発が熱望されている。本研究では、高い細胞障害性を有するアルファ線核種(225Ac)に着目し、RGDペプチドをキャリヤーとして利用したペプチド受容体放射性核種療法について検討した。ある程度の血液毒性などは観察されたものの、225Ac-DOTA-RGD2は非常に強い増殖抑制効果を示した。本研究成果は、難治がんに対する新しい治療法開発の一助になり、社会的意義の高いものと考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2021 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Radiological protection and biological COVID-19 protection in the nuclear medicine department2021

    • Author(s)
      Ohnuki Kazunobu、Yoshimoto Mitsuyoshi、Fujii Hirofumi
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 48 Issue: 1 Pages: 6-8

    • DOI

      10.1007/s00259-020-05062-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immuno-OpenPET: a novel approach for early diagnosis and image-guided surgery for small resectable pancreatic cancer2020

    • Author(s)
      Yoshii Yukie、Tashima Hideaki、Iwao Yuma、Yoshida Eiji、Wakizaka Hidekatsu、Akamatsu Go、Yamaya Taiga、Matsumoto Hiroki、Yoshimoto Mitsuyoshi、Igarashi Chika、Hihara Fukiko、Tachibana Tomoko、Zhang Ming-Rong、Nagatsu Kotaro、Sugyo Aya、Tsuji Atsushi B.、Higashi Tatsuya
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 4143-4143

    • DOI

      10.1038/s41598-020-61056-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 225Ac-DOTA-E[c(RGDfK)]2を用いた膵臓がんに対するペプチド受容体放射性核種療法2020

    • Author(s)
      吉本光喜、鷲山幸信 、吉井幸恵、大貫和)、藤井博史
    • Organizer
      第60回核医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Preclinical evaluation of 225Ac-DOTA-E[c(RGDfK)] 2 for peptide2020

    • Author(s)
      吉本光喜、藤井博史
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Preclinical evaluation of targeted alpha therapy using 225Ac-DOTA-E[c(RGDfK)]2 for pancreatic cancer2020

    • Author(s)
      M. Yoshimoto, K. Washiyama. Y. Yoshii, K. Ohnuki, H. Fujii
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine (EANM '20)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膜透過性ペプチドMAP(Aib)が111In-DOTA-c(RGDfK)の動態に及ぼす影響2020

    • Author(s)
      吉本光喜,高田晃司,和田俊一,大貫和信,藤井博史
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 神経膠芽腫の新規radiotheranosticプローブの開発2019

    • Author(s)
      高田晃司,吉本光喜,大貫和信,和田俊一,藤井博史
    • Organizer
      第59回日本核医学会総会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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