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Development of intraoperative heavy particle radiation therapy - Toward expanding adaptation of single beam irradiation of heavy particle beam -

Research Project

Project/Area Number 18K07704
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionYamagata University

Principal Investigator

NEMOTO KENJI  山形大学, 医学部, 理事 (10208291)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords重粒子線治療 / 放射線治療 / 術中放射線療法 / 術中重粒子線療法 / 1回照射 / 重粒子線 / 回転ガントリー / 術中照射 / 重要臓器 / スペース / 重粒子 / 単回照射
Outline of Final Research Achievements

Carbon ion beams have a high RBE with high LET radiation, small OER, and low recovery, making them suitable for single irradiation. However, the use of heavy-ion beams in intraoperative irradiation has not been attempted until now because (1) there is no irradiation room directly connected to the operating room, (2) it takes several days or more to create a bolus and collimator when treatment planning must be done with the wound open, and (3) the irradiation direction is fixed and cannot be adjusted to the surgical position. (3) The East Japan Heavy Ion Center , which is the only facility in the world with a direct connection to a general hospital, scanning irradiation, and a rotating gantry that theoretically allows intraoperative heavy ion beam therapy. In this study, it was confirmed that that the requirements for actual treatment, including patient transport routes, CT imaging time, image transfer time, and treatment planning time, were met.

Academic Significance and Societal Importance of the Research Achievements

理論的に世界で唯一、術中重粒子線療法が可能な山形大学医学部東日本重粒子センターで、実際に術中重粒子線療法を行うための、患者搬送ルートは問題なく、治療時間を左右するCT撮影時間、画像転送時間、治療計画時間なども実用範囲内に収まることが証明され、重粒子線治療を行うための準備が整った。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019 2018

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Open Access: 12 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Dosimetric Analysis for Otitis Media With Effusion Due to Eustachian Tube Dysfunction After Carbon-ion Radiation Therapy for Head and Neck Cancers.2022

    • Author(s)
      Kaneko T, Koto M, Ikawa H, Shinoto M, Takiyama H, Yamada S, Nemoto K, Tsuji H.
    • Journal Title

      Adv Radiat Oncol

      Volume: 23 Pages: 101115-101115

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study.2022

    • Author(s)
      Yano N, Ono T, Suzuki T, Sugai Y, Yamada M, Kawashiro S, Harada M, Akamatsu H, Hagiwara Y, Ichikawa M, Sato H, Takagi M, Kanoto M, Nemoto K.
    • Journal Title

      Oncol Ther.

      Volume: 10 Issue: 2 Pages: 493-501

    • DOI

      10.1007/s40487-022-00204-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implementation rate and effects of multidisciplinary team meetings on decision making about radiotherapy: an observational study at a single Japanese institution2022

    • Author(s)
      Ichikawa M, Uematsu K, Yano N, Yamada M, Ono T, Kawashiro S, Akamatsu H, Hagiwara Y, Sato H, Nemoto K.
    • Journal Title

      BMC Med Inform Decis Mak

      Volume: 27 Issue: 1 Pages: 111-111

    • DOI

      10.1186/s12911-022-01849-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term clinical outcomes after 12-fractionated carbon-ion radiotherapy for localized prostate cancer.2021

    • Author(s)
      Sato H, Kasuya G, Ishikawa H, Nomoto A, Ono T, Nakajima M, Isozaki Y, Yamamoto N, Iwai Y, Nemoto K, Ichikawa T, Tsuji H
    • Journal Title

      Cancer Sci

      Volume: 112 Issue: 9 Pages: 3598-3606

    • DOI

      10.1111/cas.15019

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corrigendum to: Prediction of the minimum spacer thickness required for definitive radiotherapy with carbon ions and photons for pelvic tumors: an in silico planning study using virtual spacers2021

    • Author(s)
      Yamada M, Miyasaka Y, Kanai T, Souda H, Uematsu K, Matsueda R, Yano N, Kawashiro S, Akamatsu H, Harada M, Hagiwara Y, Ichikawa M, Sato H, Nemoto K.
    • Journal Title

      J Radiat Res

      Volume: 62 Issue: 4 Pages: 743-743

    • DOI

      10.1093/jrr/rrab062

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effects of radiotherapy doses of 50.4 Gy and 60 Gy on outcomes of chemoradiotherapy for thoracic esophageal cancer: subgroup analysis based on the Comprehensive Registry of Esophageal Cancer in Japan from 2009 to 2011 by the Japan Esophageal Society2020

    • Author(s)
      Nemoto K, Kawashiro S, Toh Y, Numasaki H, Tachimori Y, Uno T, Jingu K, Matsubara H.
    • Journal Title

      Esophagus

      Volume: 17 Pages: 122-126

    • NAID

      40022193270

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and feasibility of re-irradiation using carbon ions for pancreatic cancer that recurs after carbon-ion radiotherapy2020

    • Author(s)
      Hagiwara Y, Yamada S, Isozaki Y, Takiyama H, Shinoto M, Kawashiro S, Bhattacharyya T, Nemoto K, Tsuji H.
    • Journal Title

      Clin Transl Radiat Oncol .

      Volume: 26 Pages: 24-29

    • DOI

      10.1016/j.ctro.2020.10.007

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] In silico comparison of the dosimetric impacts of a greater omentum spacer for abdominal and pelvic tumors in carbon-ion, proton and photon radiotherapy.2019

    • Author(s)
      Yamada M, Sato H, Ieko Y, Miyasaka Y, Kanai T, Yano N, Ono T, Akamatsu H, Harada M, Ichikawa M, Teranishi Y, Kikuchi Y, Nemoto K.
    • Journal Title

      Radiat Oncol

      Volume: 14 Issue: 3 Pages: 207-207

    • DOI

      10.1007/s10388-020-00725-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity.2019

    • Author(s)
      Ikawa H, Koto M, Demizu Y, Saitoh JI, Suefuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Hayashi K, Nemoto K, Nakano T, Kamada T.
    • Journal Title

      Cancer Med.

      Volume: 8 Issue: 12 Pages: 5482-5491

    • DOI

      10.1002/cam4.2408

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey.2019

    • Author(s)
      Akamatsu H, Nakamura K, Ebara T, Inaba K, Itasaka S, Jingu K, Kosaka Y, Murai T, Nagata K, Soejima T, Takahashi S, Toyoda T, Toyoshima S, Nemoto K, Akimoto T.
    • Journal Title

      J Radiat Res.

      Volume: 60 Issue: 4 Pages: 509-516

    • DOI

      10.1093/jrr/rrz018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proton beam therapy is a safe and feasible treatment for patients with second primary lung cancer after lung resection.2019

    • Author(s)
      Ono T, Nakamura T, Azami Y, Suzuki M, Wada H, Kikuchi Y, Murakami M, Nemoto K.
    • Journal Title

      Thorac Cancer.

      Volume: 10 Issue: 2 Pages: 289-295

    • DOI

      10.1111/1759-7714.12949

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A retrospective multicenter study of carbon-ion radiotherapy for external auditory canal and middle ear carcinomas.2019

    • Author(s)
      Hayashi K, Koto M, Demizu Y, Saitoh JI, Suefuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Ikawa H, Nemoto K, Nakano T, Kamada T.
    • Journal Title

      Cancer Med.

      Volume: 8 Issue: 1 Pages: 51-57

    • DOI

      10.1002/cam4.1830

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carbon-ion radiotherapy for locally recurrent rectal cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1404 Rectum.2019

    • Author(s)
      Shinoto M, Yamada S, Okamoto M, Shioyama Y, Ohno T, Nakano T, Nemoto K, Isozaki Y, Kawashiro S, Tsuji H, Kamada T.
    • Journal Title

      Radiother Oncol.

      Volume: 132 Pages: 236-240

    • DOI

      10.1016/j.radonc.2018.10.007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical results of proton beam therapy for elderly patients with non-small cell lung cancer.2018

    • Author(s)
      Ono T, Nakamura T, Yamaguchi H, Azami Y, Takayama K, Suzuki M, Wada H, Kikuchi Y, Murakami M, Nemoto K.
    • Journal Title

      Radiat Oncol

      Volume: 13 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s13014-018-0967-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carbon-ion radiotherapy for locoregional recurrence after primary surgery for pancreatic cancer.2018

    • Author(s)
      Kawashiro S, Yamada S, Isozaki Y, Nemoto K, Tsuji H, Kamada T.
    • Journal Title

      Radiother Oncol.

      Volume: 129 Issue: 1 Pages: 101-104

    • DOI

      10.1016/j.radonc.2018.02.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of functionally weighted dose-volume parameters for thoracic stereotactic ablative radiotherapy (SABR) using CT ventilation.2018

    • Author(s)
      Kanai T, Kadoya N, Nakajima Y, Miyasaka Y, Ieko Y, Kajikawa T, Ito K, Yamamoto T, Dobashi S, Takeda K, Nemoto K, Jingu K.
    • Journal Title

      Phys Med

      Volume: 49 Pages: 47-51

    • DOI

      10.1016/j.ejmp.2018.05.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multi-institutional Study of Carbon-ion Radiotherapy for Locally Advanced Pancreatic Cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1403 Pancreas.2018

    • Author(s)
      Kawashiro S, Yamada S, Okamoto M, Ohno T, Nakano T, Shinoto M, Shioyama Y, Nemoto K, Isozaki Y, Tsuji H, Kamada T.
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 101 Pages: 1212-1221

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] New CIRT in Yamagata2019

    • Author(s)
      Nemoto K.
    • Organizer
      NIRS-YCC symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

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