Development of intraoperative heavy particle radiation therapy - Toward expanding adaptation of single beam irradiation of heavy particle beam -
Project/Area Number |
18K07704
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Yamagata University |
Principal Investigator |
NEMOTO KENJI 山形大学, 医学部, 理事 (10208291)
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Project Period (FY) |
2018-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 重粒子線治療 / 放射線治療 / 術中放射線療法 / 術中重粒子線療法 / 1回照射 / 重粒子線 / 回転ガントリー / 術中照射 / 重要臓器 / スペース / 重粒子 / 単回照射 |
Outline of Final Research Achievements |
Carbon ion beams have a high RBE with high LET radiation, small OER, and low recovery, making them suitable for single irradiation. However, the use of heavy-ion beams in intraoperative irradiation has not been attempted until now because (1) there is no irradiation room directly connected to the operating room, (2) it takes several days or more to create a bolus and collimator when treatment planning must be done with the wound open, and (3) the irradiation direction is fixed and cannot be adjusted to the surgical position. (3) The East Japan Heavy Ion Center , which is the only facility in the world with a direct connection to a general hospital, scanning irradiation, and a rotating gantry that theoretically allows intraoperative heavy ion beam therapy. In this study, it was confirmed that that the requirements for actual treatment, including patient transport routes, CT imaging time, image transfer time, and treatment planning time, were met.
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Academic Significance and Societal Importance of the Research Achievements |
理論的に世界で唯一、術中重粒子線療法が可能な山形大学医学部東日本重粒子センターで、実際に術中重粒子線療法を行うための、患者搬送ルートは問題なく、治療時間を左右するCT撮影時間、画像転送時間、治療計画時間なども実用範囲内に収まることが証明され、重粒子線治療を行うための準備が整った。
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Report
(6 results)
Research Products
(18 results)
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[Journal Article] MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study.2022
Author(s)
Yano N, Ono T, Suzuki T, Sugai Y, Yamada M, Kawashiro S, Harada M, Akamatsu H, Hagiwara Y, Ichikawa M, Sato H, Takagi M, Kanoto M, Nemoto K.
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Journal Title
Oncol Ther.
Volume: 10
Issue: 2
Pages: 493-501
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term clinical outcomes after 12-fractionated carbon-ion radiotherapy for localized prostate cancer.2021
Author(s)
Sato H, Kasuya G, Ishikawa H, Nomoto A, Ono T, Nakajima M, Isozaki Y, Yamamoto N, Iwai Y, Nemoto K, Ichikawa T, Tsuji H
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Journal Title
Cancer Sci
Volume: 112
Issue: 9
Pages: 3598-3606
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Corrigendum to: Prediction of the minimum spacer thickness required for definitive radiotherapy with carbon ions and photons for pelvic tumors: an in silico planning study using virtual spacers2021
Author(s)
Yamada M, Miyasaka Y, Kanai T, Souda H, Uematsu K, Matsueda R, Yano N, Kawashiro S, Akamatsu H, Harada M, Hagiwara Y, Ichikawa M, Sato H, Nemoto K.
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Journal Title
J Radiat Res
Volume: 62
Issue: 4
Pages: 743-743
DOI
Related Report
Peer Reviewed
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[Journal Article] In silico comparison of the dosimetric impacts of a greater omentum spacer for abdominal and pelvic tumors in carbon-ion, proton and photon radiotherapy.2019
Author(s)
Yamada M, Sato H, Ieko Y, Miyasaka Y, Kanai T, Yano N, Ono T, Akamatsu H, Harada M, Ichikawa M, Teranishi Y, Kikuchi Y, Nemoto K.
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Journal Title
Radiat Oncol
Volume: 14
Issue: 3
Pages: 207-207
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity.2019
Author(s)
Ikawa H, Koto M, Demizu Y, Saitoh JI, Suefuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Hayashi K, Nemoto K, Nakano T, Kamada T.
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Journal Title
Cancer Med.
Volume: 8
Issue: 12
Pages: 5482-5491
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey.2019
Author(s)
Akamatsu H, Nakamura K, Ebara T, Inaba K, Itasaka S, Jingu K, Kosaka Y, Murai T, Nagata K, Soejima T, Takahashi S, Toyoda T, Toyoshima S, Nemoto K, Akimoto T.
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Journal Title
J Radiat Res.
Volume: 60
Issue: 4
Pages: 509-516
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A retrospective multicenter study of carbon-ion radiotherapy for external auditory canal and middle ear carcinomas.2019
Author(s)
Hayashi K, Koto M, Demizu Y, Saitoh JI, Suefuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Ikawa H, Nemoto K, Nakano T, Kamada T.
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Journal Title
Cancer Med.
Volume: 8
Issue: 1
Pages: 51-57
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Carbon-ion radiotherapy for locally recurrent rectal cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1404 Rectum.2019
Author(s)
Shinoto M, Yamada S, Okamoto M, Shioyama Y, Ohno T, Nakano T, Nemoto K, Isozaki Y, Kawashiro S, Tsuji H, Kamada T.
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Journal Title
Radiother Oncol.
Volume: 132
Pages: 236-240
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation of functionally weighted dose-volume parameters for thoracic stereotactic ablative radiotherapy (SABR) using CT ventilation.2018
Author(s)
Kanai T, Kadoya N, Nakajima Y, Miyasaka Y, Ieko Y, Kajikawa T, Ito K, Yamamoto T, Dobashi S, Takeda K, Nemoto K, Jingu K.
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Journal Title
Phys Med
Volume: 49
Pages: 47-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Multi-institutional Study of Carbon-ion Radiotherapy for Locally Advanced Pancreatic Cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1403 Pancreas.2018
Author(s)
Kawashiro S, Yamada S, Okamoto M, Ohno T, Nakano T, Shinoto M, Shioyama Y, Nemoto K, Isozaki Y, Tsuji H, Kamada T.
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 101
Pages: 1212-1221
Related Report
Peer Reviewed
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