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Utility of NaF PET/MR for radionuclide therapy with radium-223 of metastatic castration-resistant prostate cancer

Research Project

Project/Area Number 18K07714
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKobe University

Principal Investigator

Nogami Munenobu  神戸大学, 医学部附属病院, 特命准教授 (30464267)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsPET/MRI / 高速撮像法 / 定量解析 / BPL / ZTE / 深層学習 / 拡散強調画像 / PET/MR / NaF / Ra-223内用療法 / 去勢抵抗性前立腺癌
Outline of Final Research Achievements

Through a five-year investigation, a protocol for high-speed imaging using whole-body PET/MRI has been established. This study successfully determined the imaging method for whole-body NaF PET/MRI in patients with castration-resistant prostate cancer and bone metastases, which is the focus of this research project. PET phantom tests were conducted on a PET/MRI device to examine fundamental image reconstruction. Multiple image reconstruction approaches under clinical conditions were explored to validate the optimal parameter (β-value) for the Bayesian Penalized Likelihood (BPL) method used for high-speed PET imaging. It was demonstrated that the previously determined optimal β-value remains optimal in the phantom tests. The findings were presented at the 2022 American Society of Nuclear Medicine and published in the journal "Diagnostics."

Academic Significance and Societal Importance of the Research Achievements

本研究の対象となる骨転移巣を有する去勢抵抗性前立腺癌をはじめ、長い時間安静を保つ事が難しい症例において、PET/MRI撮像の高速化は患者にとって有益となりうるとともに、検査の完遂率を向上させると考えられる。今回単純に高速化を狙うのではなく、従来法と比して定量値の精度や診断能を損なう事なく高速化を達成することが出来たため、今後のPET/MRIを用いた臨床検査において広く応用可能と考える。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (28 results)

All 2022 2021 2020 2019 2018

All Journal Article (11 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 13 results)

  • [Journal Article] FDG PET/MRI in Synchronous Uterine Adenocarcinoma and Leiomyosarcoma2022

    • Author(s)
      Yokoo Shiho、Zeng Feibi、Nogami Munenobu、Ueno Yoshiko R.、Murakami Takamichi
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 47 Issue: 6 Pages: e452-e454

    • DOI

      10.1097/rlu.0000000000004144

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metformin action in the gut―insight provided by [18F]FDG PET imaging2021

    • Author(s)
      Tsuchida Hitomi、Morita Yasuko、Nogami Munenobu、Ogawa Wataru
    • Journal Title

      Diabetology International

      Volume: 13 Issue: 1 Pages: 35-40

    • DOI

      10.1007/s13340-021-00545-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] PET/MRI is useful for early detection of pelvic insufficiency fractures after radiotherapy for cervical cancer2021

    • Author(s)
      Azumi Maho、Matsumoto Masuyo、Suzuki Kaho、Sasaki Ryohei、Ueno Yoshiko、Nogami Munenobu、Terai Yoshito
    • Journal Title

      Oncology Letters

      Volume: 22 Issue: 5 Pages: 776-776

    • DOI

      10.3892/ol.2021.13037

    • NAID

      120007153052

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI2021

    • Author(s)
      Nogami Munenobu、Zeng Feibi、Inukai Junko、Watanabe Yoshiaki、Nishio Mizuho、Kanda Tomonori、Ueno Yoshiko R.、Sofue Keitaro、Kono Atsushi K.、Hori Masatoshi、Ohnishi Akihito、Kubo Kazuhiro、Kurimoto Takako、Murakami Takamichi
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 3 Pages: e0249304-e0249304

    • DOI

      10.1371/journal.pone.0249304

    • NAID

      120007035659

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Editorial for “Application of Simultaneous <scp>18F‐FDG PET</scp> With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted <scp>MR</scp> Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma”2021

    • Author(s)
      Nogami Munenobu
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: - Issue: 1 Pages: 75-76

    • DOI

      10.1002/jmri.28026

    • Related Report
      2021 Research-status Report
  • [Journal Article] Dose‐dependent accumulation of glucose in the intestinal wall and lumen induced by metformin as revealed by 18 F‐labelled fluorodeoxyglucose positron emission tomography‐ MRI2020

    • Author(s)
      Ito Jun、Nogami Munenobu、Morita Yasuko、Sakaguchi Kazuhiko、Komada Hisako、Hirota Yushi、Sugawara Kenji、Tamori Yoshikazu、Zeng Feibi、Murakami Takamichi、Ogawa Wataru
    • Journal Title

      Diabetes, Obesity and Metabolism

      Volume: 23 Issue: 3 Pages: 692-699

    • DOI

      10.1111/dom.14262

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced Release of Glucose Into the Intraluminal Space of the Intestine Associated With Metformin Treatment as Revealed by [18F]Fluorodeoxyglucose PET-MRI2020

    • Author(s)
      Morita Yasuko、Nogami Munenobu、Sakaguchi Kazuhiko、Okada Yuko、Hirota Yushi、Sugawara Kenji、Tamori Yoshikazu、Zeng Feibi、Murakami Takamichi、Ogawa Wataru
    • Journal Title

      Diabetes Care

      Volume: 43 Issue: 8 Pages: 1796-1802

    • DOI

      10.2337/dc20-0093

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic performance of zero-TE lung MR imaging in FDG PET/MRI for pulmonary malignancies2020

    • Author(s)
      Zeng Feibi、Nogami Munenobu、Ueno Yoshiko R.、Kanda Tomonori、Sofue Keitaro、Kubo Kazuhiro、Kurimoto Takako、Murakami Takamichi
    • Journal Title

      European Radiology

      Volume: 30 Issue: 9 Pages: 4995-5003

    • DOI

      10.1007/s00330-020-06848-z

    • NAID

      120006882471

    • Related Report
      2020 Research-status Report 2019 Research-status Report
  • [Journal Article] Diffusion-Weighted Imaging Shows a False-Negative Finding for Bone Marrow Involvement on 18F-FDG PET/MRI in a Patient With Malignant Lymphoma After Blood Transfusion2018

    • Author(s)
      Zeng Feibi、Nogami Munenobu、Shirai Taiichiro、Zen Yoh、Murakami Takamichi
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 5 Issue: 5 Pages: 361-362

    • DOI

      10.1097/rlu.0000000000002052

    • Related Report
      2018 Research-status Report
  • [Journal Article] Mechanisms of metformin action: In and out of the gut2018

    • Author(s)
      Minamii Takahiro、Nogami Munenobu、Ogawa Wataru
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 9 Issue: 4 Pages: 701-703

    • DOI

      10.1111/jdi.12864

    • NAID

      120006599092

    • Related Report
      2018 Research-status Report
  • [Journal Article] Computed Diffusion-Weighted Imaging in Prostate Cancer: Basics, Advantages, Cautions, and Future Prospects2018

    • Author(s)
      Ueno Yoshiko R.、Tamada Tsutomu、Takahashi Satoru、Tanaka Utaru、Sofue Keitaro、Kanda Tomonori、Nogami Munenobu、Ohno Yoshiharu、Hinata Nobuyuki、Fujisawa Masato、Murakami Takamichi
    • Journal Title

      Korean Journal of Radiology

      Volume: 19 Issue: 5 Pages: 832-832

    • DOI

      10.3348/kjr.2018.19.5.832

    • Related Report
      2018 Research-status Report
  • [Presentation] Utility of abbreviated MRI combined with Bayesian penalized likelihood PET reconstruction during rapid whole-body FDG PET/MRI in oncology patients: Assessment of the detection and differentiation capabilities in different regions of the body2022

    • Author(s)
      Junko Inukai, Munenobu Nogami, Miho Tachibana, Feibi Zeng, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      Society of Nuclear Medicine Annual Meeting 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Zero-TE MR-based Attenuation Correction with a Deep Learning Approach:Impact of bone components on Attenuation Correction for Chest FDG PET/MRI2022

    • Author(s)
      Miho Tachibana, Munenobu Nogami, Hidetoshi Matsuo, Mizuho Nishio, Junko Inukai, FeibeZeng, Takako Kurimoto, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      European Association of Nuclear Medicine Annual Meeting 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of region-based detection and differentiation capability of rapid whole-body FDG PET/MRI scans using a combination of Bayesian penalized likelihood PET reconstruction and abbreviated whole-body MRI in oncology patients2022

    • Author(s)
      Junko Inukai, Munenobu Nogami, Miho Tachibana, Feibi Zeng, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      13th Congress of the World Feferation of Nuclear Medicine and Biology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detecting and differentiating capability of quick whole-body scan for FDG PET/MRI in oncology: Utility of combination of the Bayesian penalized likelihood PET reconstruction and abbreviated whole-body MRI2021

    • Author(s)
      Junko Inukai, M.D.1), Munenobu Nogami, M.D., Ph.D., FANMB2), Feibi Zeng, M.D.1), Atsushi K. Kono, M.D., Ph.D. 1), Kazuhiro Kubo, RT2), Takamichi Murakami, M.D., Ph.D.1)
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Zero-TE MRI-based attenuation correction for chest FDG PET/MRI with deep learning using unpaired PET/CT data: Quantitative analysis for difference in values of normal organ and malignant lesions2021

    • Author(s)
      Munenobu Nogami, M.D., Ph.D., FANMB1), Hidetoshi Matsuo1), Mizuho Nishio1), Feibi Zeng1), Junko Inukai1), Takako Kurimoto3), Kazuhiro Kubo1) and Takamichi Murakami1)
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Assessment of the detection and differentiation capability of lung metastasis and the precision in fused images: Comparison between FDG PET/CT and PET/MRI with Zero-echo time (ZTE)2021

    • Author(s)
      J. Inukai1, M. Nogami1, F. Zeng1, M. Tachibana1, T. Kurimoto2, K. Kubo1, T. Murakami1
    • Organizer
      European Association of Nuclear Medicine and Molecular Imaging 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Zero-TE vs 2-point Dixon MRI-based Attenuation Correction for Chest FDG PET/MRI with Deep Learning: Comparison of Quantitative Values on Pseudo CT and Reconstructed PET data2021

    • Author(s)
      Munenobu Nogami, M.D., Ph.D., FANMB1), Hidetoshi Matsuo1), Mizuho Nishio1), Miho Tachibana1), Junko Inukai1), Feibi Zeng1), Takako Kurimoto2), Kazuhiro Kubo1) and Takamichi Murakami1)
    • Organizer
      European Association of Nuclear Medicine and Molecular Imaging 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 深層学習を用いたZTE MRIによる胸部PET/MRIの吸収補正に関する定量的検証2021

    • Author(s)
      Munenobu Nogami, M.D., Ph.D., FANMB1), Hidetoshi Matsuo1), Mizuho Nishio1), Feibi Zeng1), Junko Inukai1), Miho Tachibana1), Takako Kurimoto3), Kazuhiro Kubo1) and Takamichi Murakami1)
    • Organizer
      第61回日本核医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Zero-TE MRI-based attenuation correction for chest FDG PET/MRI: A feasibility study of deep learning approach using unpaired PET/CT data2020

    • Author(s)
      Munenobu Nogami, Hidetoshi Matsuo, Mizuho Nishio, Feibi Zeng, Junko Inukai, Florian Wiesinger, Sandeep Kaushik, Takako Kurimoto, Kazuhiro Kubo and Takamichi Murakami
    • Organizer
      European Association of Nuclear Medicine 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Physiological FDG uptake of the human skin: Quantitative and regional assessment of repeatability, gender difference, and age-dependency on SiPM PET/MRI2020

    • Author(s)
      Munenobu Nogami, Feibi Zeng, Junko Inukai, Yoshiaki Watanabe, Mizuho Nishio, Tomonori Kanda, Keitaro Sofue, Atsushi K. Kono, Kazuhiro Kubo, Takako Kurimoto, and Takamichi Murakami
    • Organizer
      Society of Nuclear Medicine 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 胸部PET/MRIの吸収補正:別症例のCTを用いてZTEから偽CTを深層学習により作成する検討2020

    • Author(s)
      Munenobu Nogami, Hidetoshi Matsuo, Mizuho Nishio, Feibi Zeng, Junko Inukai, Florian Wiesinger, Sandeep Kaushik Takako Kurimoto, Kazuhiro Kubo and Takamichi Murakami
    • Organizer
      第60回日本核医学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Physiological FDG uptake of the human skin: Quantitative and regional assessment of repeatability, gender difference, and age-dependency on SiPM PET/MRI2020

    • Author(s)
      Munenobu Nogami, Feibi Zeng, Junko Inukai, Yoshiaki Watanabe, Mizuho Nishio, Tomonori Kanda, Keitaro Sofue, Atsushi K. Kono, Kazuhiro Kubo, Takako Kurimoto, Takamichi Murakami
    • Organizer
      Society of Nuclear Medicine 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diagnostic performance of rapid whole-body FDG PET/MRI in oncology patients: Assessment of optimal beta-value for block sequential regularized expectation maximization (BSREM) reconstruction and combination of whole-body MR sequences2020

    • Author(s)
      Junko Inukai, Munenobu Nogami, Feibi Zeng, Yoshiaki Watanabe, Mizuho Nishio, Tomonori Kanda, Keitaro Sofue, Atsushi K. Kono, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      Society of Nuclear Medicine 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] High-speed whole-body scan for FDG PET/MRI: optimized beta-value of BSREM reconstruction2019

    • Author(s)
      Munenobu Nogami, Feibi Zeng, Yoshiko R. Ueno, Tomonori Kanda, Keitaro Sofue, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      第59回日本核医学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Optimized beta-value of block sequential regularized expectation maximization (BSREM) reconstruction for rapid whole-body scan on FDG PET/MRI2019

    • Author(s)
      Munenobu Nogami, Feibi Zeng, Yoshiko R. Ueno, Tomonori Kanda, Keitaro Sofue, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      Society of Nuclear Medicine 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reproducibility of texture features with block sequential regularized expectation maximization (BSREM) reconstruction on FDG PET/MR2018

    • Author(s)
      Munenobu Nogami, Feibi Zeng, Yuichi Wakabayashi , Yoshiko Ueno, Tomonori Kanda, Keitaro Sofue, Takako Kurimoto, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      Society of Nuclear Medicine 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of respiratory-gated MR attenuation correction and PET reconstruction algorithm on FDG PET/MR2018

    • Author(s)
      Munenobu Nogami, Feibi Zeng, Yuichi Wakabayashi, Yoshiko R. Ueno, Tomonori Kanda, Keitaro Sofue, Takako Kurimoto, Kazuhiro Kubo, Takamichi Murakami
    • Organizer
      第58回日本核医学会総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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