Utility of NaF PET/MR for radionuclide therapy with radium-223 of metastatic castration-resistant prostate cancer
Project/Area Number |
18K07714
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Kobe University |
Principal Investigator |
Nogami Munenobu 神戸大学, 医学部附属病院, 特命准教授 (30464267)
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Project Period (FY) |
2018-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | PET/MRI / 高速撮像法 / 定量解析 / BPL / ZTE / 深層学習 / 拡散強調画像 / PET/MR / NaF / Ra-223内用療法 / 去勢抵抗性前立腺癌 |
Outline of Final Research Achievements |
Through a five-year investigation, a protocol for high-speed imaging using whole-body PET/MRI has been established. This study successfully determined the imaging method for whole-body NaF PET/MRI in patients with castration-resistant prostate cancer and bone metastases, which is the focus of this research project. PET phantom tests were conducted on a PET/MRI device to examine fundamental image reconstruction. Multiple image reconstruction approaches under clinical conditions were explored to validate the optimal parameter (β-value) for the Bayesian Penalized Likelihood (BPL) method used for high-speed PET imaging. It was demonstrated that the previously determined optimal β-value remains optimal in the phantom tests. The findings were presented at the 2022 American Society of Nuclear Medicine and published in the journal "Diagnostics."
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Academic Significance and Societal Importance of the Research Achievements |
本研究の対象となる骨転移巣を有する去勢抵抗性前立腺癌をはじめ、長い時間安静を保つ事が難しい症例において、PET/MRI撮像の高速化は患者にとって有益となりうるとともに、検査の完遂率を向上させると考えられる。今回単純に高速化を狙うのではなく、従来法と比して定量値の精度や診断能を損なう事なく高速化を達成することが出来たため、今後のPET/MRIを用いた臨床検査において広く応用可能と考える。
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Report
(6 results)
Research Products
(28 results)
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[Presentation] Detecting and differentiating capability of quick whole-body scan for FDG PET/MRI in oncology: Utility of combination of the Bayesian penalized likelihood PET reconstruction and abbreviated whole-body MRI2021
Author(s)
Junko Inukai, M.D.1), Munenobu Nogami, M.D., Ph.D., FANMB2), Feibi Zeng, M.D.1), Atsushi K. Kono, M.D., Ph.D. 1), Kazuhiro Kubo, RT2), Takamichi Murakami, M.D., Ph.D.1)
Organizer
Society of Nuclear Medicine and Molecular Imaging 2021
Related Report
Int'l Joint Research
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[Presentation] Zero-TE vs 2-point Dixon MRI-based Attenuation Correction for Chest FDG PET/MRI with Deep Learning: Comparison of Quantitative Values on Pseudo CT and Reconstructed PET data2021
Author(s)
Munenobu Nogami, M.D., Ph.D., FANMB1), Hidetoshi Matsuo1), Mizuho Nishio1), Miho Tachibana1), Junko Inukai1), Feibi Zeng1), Takako Kurimoto2), Kazuhiro Kubo1) and Takamichi Murakami1)
Organizer
European Association of Nuclear Medicine and Molecular Imaging 2021
Related Report
Int'l Joint Research
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[Presentation] 深層学習を用いたZTE MRIによる胸部PET/MRIの吸収補正に関する定量的検証2021
Author(s)
Munenobu Nogami, M.D., Ph.D., FANMB1), Hidetoshi Matsuo1), Mizuho Nishio1), Feibi Zeng1), Junko Inukai1), Miho Tachibana1), Takako Kurimoto3), Kazuhiro Kubo1) and Takamichi Murakami1)
Organizer
第61回日本核医学会総会
Related Report
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[Presentation] Physiological FDG uptake of the human skin: Quantitative and regional assessment of repeatability, gender difference, and age-dependency on SiPM PET/MRI2020
Author(s)
Munenobu Nogami, Feibi Zeng, Junko Inukai, Yoshiaki Watanabe, Mizuho Nishio, Tomonori Kanda, Keitaro Sofue, Atsushi K. Kono, Kazuhiro Kubo, Takako Kurimoto, and Takamichi Murakami
Organizer
Society of Nuclear Medicine 2020
Related Report
Int'l Joint Research
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[Presentation] Physiological FDG uptake of the human skin: Quantitative and regional assessment of repeatability, gender difference, and age-dependency on SiPM PET/MRI2020
Author(s)
Munenobu Nogami, Feibi Zeng, Junko Inukai, Yoshiaki Watanabe, Mizuho Nishio, Tomonori Kanda, Keitaro Sofue, Atsushi K. Kono, Kazuhiro Kubo, Takako Kurimoto, Takamichi Murakami
Organizer
Society of Nuclear Medicine 2020
Related Report
Int'l Joint Research
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