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Study on dose-increasing effect of iodine enhancement in contrast-enhanced CT

Research Project

Project/Area Number 18K07719
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKumamoto University

Principal Investigator

Funama Yoshinori  熊本大学, 大学院生命科学研究部(保), 教授 (30380992)

Co-Investigator(Kenkyū-buntansha) 宇都宮 大輔  横浜市立大学, 医学研究科, 教授 (30571046)
中浦 猛  熊本大学, 病院, 准教授 (90437913)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCT線量 / 造影剤ヨード / 造影CT / シミュレーション / 管電圧 / 小児 / 造影前CT / CT / 線量
Outline of Final Research Achievements

Contrast-enhanced CT is widely used for improving tissue contrast in the CT images at clinical situation. The purpose of our study was to investigate the effect of increasing iodine contrast on radiation dose in a contrast-enhanced CT using Monte-Carlo simulation tool compared to the radiation dose in a non-contrast-enhanced CT. Based on the phantom and the clinical results, our study relieved that the effect of increase in radiation dose was dependent on the tube voltage and amount of iodinated contrast dosage. Besides, the dual-energy CT was also useful technique from the perspective of reducing radiation dose on iodinated contrast dose.

Academic Significance and Societal Importance of the Research Achievements

医療の検査で使用するCTはX線を用いるが、他のモダリティーに比べて比較的線量が高く社会的な関心も高い。そのため、正確なX線量を把握し、線量低減の手法を検討することは重要である。一般的に造影剤を用いない非造影CTに比較して造影CTは、ヨードを用いるために人体へのX線吸収が高く、造影剤による線量増加が懸念される。また、この線量増加は造影剤ヨードの使用量や、CTで使用するエネルギーによっても異なることが予想され、CT線量を正確に把握するためには、ヨード造影剤の線量増加分を加味して検討することが重要である。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2022 2020 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Comparison of the effects of varying tube voltage and iodinated concentration on increasing the iodinated radiation dose in computed tomography2022

    • Author(s)
      Hoshika Minori、Nakaura Takeshi、Oda Seitaro、Kidoh Masafumi、Nagayama Yasunori、Sakabe Daisuke、Hirai Toshinori、Funama Yoshinori
    • Journal Title

      Physica Medica

      Volume: 95 Pages: 57-63

    • DOI

      10.1016/j.ejmp.2022.01.007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decreasing the radiation dose for contrast-enhanced abdominal spectral CT with a half contrast dose: a matched-pair comparison with a 120 kVp protocol2020

    • Author(s)
      Daisuke Sakabe, Takeshi Nakaura, Seitaro Oda, Masafumi Kidoh, Daisuke Utsunomiya, Masahiro Hatemura, Yoshinori Funama
    • Journal Title

      British Journal Open

      Volume: 11 Issue: 1 Pages: 1-7

    • DOI

      10.1259/bjro.20200006

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effect of iodinated contrast medium on organ dose at coronary CT angiography using 100 kVp and 120 kVp scans2018

    • Author(s)
      坂部大介
    • Organizer
      北米放射線学会(RSNA)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2024-01-30  

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