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The relation between breast tissue density and breast cancer and expression method of breast tissue density in the mammography

Research Project

Project/Area Number 18K07734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Yamada Takyuki  聖マリアンナ医科大学, 医学部, 教授 (30302144)

Co-Investigator(Kenkyū-buntansha) 印牧 義英  聖マリアンナ医科大学, 医学部, 講師 (40318944)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords乳癌 / 乳腺組織 / 濃度 / CT / 乳腺濃度 / 乳腺
Outline of Final Research Achievements

150 patients with breast cancer and 100 patients with non-breast cancer were included in this study. Regarding the density of breast tissue, the mean CT attenuation numbers were not significantly different between them. However, the breast density after the surgery was only obtained for the patients with breast cancer because precontrast CT was conducted as preoperative examination. Then the breast density may have been affected by the postoperative hormonal therapy.
The occupation of breast tissue in the breast was difficult to measure because the CT scanning was performed in the supine position that made it difficult to extract the breast owing to the various breast positions.

Academic Significance and Societal Importance of the Research Achievements

乳癌患者と非乳癌患者において、乳腺CT値に特に有意差は認められなかった。ただし、乳癌患者に対する術後ホルモン療法の乳腺濃度に対する影響を完全には排除できなかった。乳腺組織自体の密度(濃度)が乳癌のリスクになっているという結果は得られなかった。マンモグラフィで行われている乳房に占める乳腺組織の体積比がパラメータとして、重要かもしれないが、CTを用いてその全スライスから体積比を求めることは、撮像ポジションを考えると難しい。簡便な計測法の検討が必要と考えられた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (20 results)

All 2022 2021 2020 2019 2018

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 7 results) Presentation (9 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] A collision between vascular adrenal cyst and adrenocortical adenoma2021

    • Author(s)
      Tagawa H, Yamada T, Miyakawa T, Aida Y, Sekiguchi Z
    • Journal Title

      Radiol Case Rep

      Volume: 16 Issue: 6 Pages: 1294-1299

    • DOI

      10.1016/j.radcr.2021.02.067

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional computed tomography is effective in diagnosing uterine arterial pseudoaneurysm, a cause of secondary postpartum hemorrhage: A case report2021

    • Author(s)
      Iwahata Y, Tamura M, Yamada T, Harada S, Kotoku A, Suzuki N
    • Journal Title

      SAGE Open Medical Case Reports

      Volume: 9 Pages: 1-4

    • DOI

      10.1177/2050313x211046742

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualizing high-intensity thrombosis with plaque imaging of coronary aneurysm in Kawasaki disease2021

    • Author(s)
      Kotoku A, Aso K, Yamada T, Shimizu N, Mimura H
    • Journal Title

      Pediatrics International

      Volume: 63 Issue: 11 Pages: 1405-1407

    • DOI

      10.1111/ped.14847

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulmonary Artery Occlusion Due to Abrupt Pinhole Rupture of Aortic Arch Aneurysm2021

    • Author(s)
      Warisawa T, Kotoku A, Miyauchi R, Kobayashi T, Yamada T, Matsuda H, Akashi Y
    • Journal Title

      JACC Cardiovasc Interv

      Volume: 14 Issue: 2 Pages: e15-e16

    • DOI

      10.1016/j.jcin.2020.11.028

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endovascular retrieval of a Gunther-tulip vena cava filter migrated into the right atrium2020

    • Author(s)
      Yamada T, Shinjo Y, Yagihashi K, Hashimoto K, Hamaguchi S
    • Journal Title

      Radiol Case Rep

      Volume: 15 Issue: 7 Pages: 1002-1005

    • DOI

      10.1016/j.radcr.2020.04.056

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent hyperparathyroidism due to parathyroid and pulmonary tumors showing features of parathyroid adenoma2020

    • Author(s)
      Miyauchi R, Yamada T, Kumano R, Aida Y, Takagi M
    • Journal Title

      Radiol Case Rep

      Volume: 15 Issue: 8 Pages: 1289-1294

    • DOI

      10.1016/j.radcr.2020.05.024

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary ovarian leiomyoma with predominant cystic change.2019

    • Author(s)
      Asada Tatsunori, Yamada Takayuki, Kumano Reiko
    • Journal Title

      Radiology Case Reports

      Volume: 14 Issue: 11 Pages: 1315-1319

    • DOI

      10.1016/j.radcr.2019.08.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of detectability of breast cancer by abbreviated breast MRI based on diffusion-weighted images and postcontrast MRI2018

    • Author(s)
      Yamada Takayuki、Kanemaki Yoshihide、Okamoto Satoko、Nakajima Yasuo
    • Journal Title

      Japanese Journal of Radiology

      Volume: 36 Issue: 5 Pages: 331-339

    • DOI

      10.1007/s11604-018-0731-6

    • NAID

      50012894414

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Grading System to Categorize Breast MRI in BI-RADS 5th Edition: A Multivariate Study of Breast Mass Descriptors in Terms of Probability of Malignancy2018

    • Author(s)
      Fujiwara Keishi、Yamada Takayuki、Kanemaki Yoshihide、Okamoto Satoko、Kojima Yasuyuki、Tsugawa Koichiro、Nakajima Yasuo
    • Journal Title

      American Journal of Roentgenology

      Volume: 210 Issue: 3 Pages: W118-W127

    • DOI

      10.2214/ajr.17.17926

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 肝炎症性偽腫瘍と肝膿瘍を異時性に来し、S状結腸慢性炎症が由来と考えられた1例2020

    • Author(s)
      宮川天志, 大島隆一, 相田芳夫, 山田隆之
    • Organizer
      第457回日本医学放射線学会関東地方会定期大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Philips社製Ingeniaを用いたGd造影MRIによる内リンパ水腫可視化の試み2020

    • Author(s)
      中村 学, 岩武桜子, 久保佑介, 笹野恭之, 荒井光太郎, 四戸達也, 佐藤卓夫, 瀬尾 徹, 山田隆之, 肥塚 泉
    • Organizer
      第79回日本めまい平衡医学会総会・学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 識別困難だったカテコラミン軽度高値、サブクリニカクッシング症候群(SCS)を伴った血管嚢胞合併副腎腺腫の1例2020

    • Author(s)
      常見真吾, 方波見卓行, 月山秀一, 松葉 怜, 川名部新, 久保ゆい, 蜂巣賀智, 北島和樹, 山田隆之, 山崎有人, 笹野公伸, 曽根正勝
    • Organizer
      第31回間脳・下垂体・副腎系研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 大動脈弓部瘤破裂穿破による肺動脈解離を経右室と経静脈的に造影したCTで診断しえた1例2019

    • Author(s)
      宮内亮輔, 小徳暁生, 宮川天志, 原口貴史, 熊野玲子, 山田隆之, 柳澤信之, 相田芳夫
    • Organizer
      第90回日本心臓血管放射線研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 2度にわたる副甲状腺腺腫切除後に原発性副甲状腺機能亢進症が持続した孤立性肺結節を示した1例2019

    • Author(s)
      宮内亮輔, 小徳暁生, 宮川天志, 原口貴史, 熊野玲子, 山田隆之, 相田芳夫, 田島信哉, 高木正之
    • Organizer
      第456回日本医学放射線学会関東地方会定期大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 2度にわたる副甲状腺腺腫切除後に原発性副甲状腺機能亢進症が持続した孤立性肺結節を示した1例2019

    • Author(s)
      宮内亮輔, 小徳暁生, 宮川天志, 原口貴史, 熊野玲子, 山田隆之, 相田芳夫, 田島信哉, 高木正之
    • Organizer
      第60回神奈川県放射線医会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 当院でのバゼドウ病に対するヨード内服療法の現況2019

    • Author(s)
      山田隆之, 宮内亮輔, 宮川天志, 小徳暁生, 原口貴史, 熊野玲子, 方波見卓行
    • Organizer
      第60回神奈川県放射線医会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] ECPR 下の出血病態に対する止血戦略 A case of endovascular hemostatic management in a patient with ECPR.2019

    • Author(s)
      昆祐理, 島望, 大熊正剛, 熊野玲子, 松本純一, 山田隆之, 三村秀文
    • Organizer
      第48回日本IVR学会総会 福岡国際会議
    • Related Report
      2019 Research-status Report
  • [Presentation] Comparison of detectability of breast cancer by abbreviated breast MRI based on diffusion-weighted images and postcontrast MRI2018

    • Author(s)
      Yamada Takayuki
    • Organizer
      European Society of Radiology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] Diagnosis and Management of Endocrine Disorders in Interventional Radiology2022

    • Author(s)
      Yamada T, Kotoku A
    • Total Pages
      345
    • Publisher
      Springer Nature
    • ISBN
      9783030871888
    • Related Report
      2021 Annual Research Report
  • [Book] 知っておきたい泌尿器のCT・MRI2019

    • Author(s)
      山田隆之
    • Total Pages
      624
    • Publisher
      秀潤社
    • ISBN
      4780909732
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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