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Study on evaluation of treatment irradiation influences on patients using the divided multiple-volume matching technique

Research Project

Project/Area Number 18K07744
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionGunma University

Principal Investigator

TASHIRO Mutsumi  群馬大学, 重粒子線医学推進機構, 教授 (60447274)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords放射線治療 / 重粒子線治療 / 患者位置決め / 動態定量化 / 複数体積同時照合 / 模擬CTボリュームデータ / 線量分布計算 / 分割体積照合法 / 模擬CTボリューム / 粒子線治療 / 2D-3Dマッチング / 複数体積分割照合法 / 関心体積 / 変位 / 関心体積移動
Outline of Final Research Achievements

In radiation (heavy ion) therapy, deviations in the internal anatomy may be observed at the time of treatment compared to the time of treatment planning, which may affect the irradiation accuracy. The divided multiple-volume matching technique developed by the applicant can quantify the three-dimensional (3D) deviation of the volume of interest from the base volume from the orthogonal X-ray images and the treatment planning CT. Since the pseudo-3D CT data obtained by this technique represent the patient's anatomical condition at the time of treatment, we aimed to evaluate the irradiation influence without new CT imaging by calculating the dose distribution for the data. The present method was applied to the data of liver cancer patients, and it was shown that the irradiation influence could generally be simulated in terms of target dose coverage of the heavy-ion beam to the anatomical structural changes.

Academic Significance and Societal Importance of the Research Achievements

放射線治療にて照射時に患者内部の構造が大きくずれていた場合には、室内CTを利用したオンライン/オフラインでのアダプティブの対応が浸透しつつあるが、位置修正や再計画などは非常に手間と時間がかかる工程である。開発した複数体積分割照合法は、母体積の位置決めと同時に関心体積のずれを定量化するものである。この手法により得られる疑似3D-CT画像は、治療位置決め時の患者状態を模擬するものであり、線量分布評価が可能なことが示された。治療時CT撮影なしで照射の影響が評価できることは、より適切な位置決めに向けた効率性や患者低侵襲性、被曝低減の面で、放射線治療分野において画期的な応用可能性を提供するものである。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (27 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 14 results) Presentation (12 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results)

  • [Journal Article] Dose distribution estimation toward CT-less adaptive carbon ion radiotherapy for liver tumors using the divided-volume matching technique2023

    • Author(s)
      Chen Jing-Ni、Ohno Tatsuya、Tashiro Mutsumi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 68 Issue: 20 Pages: 205018-205018

    • DOI

      10.1088/1361-6560/acfc93

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Linear energy transfer-independent calibration of radiochromic film for carbon-ion beams2022

    • Author(s)
      Tashiro Mutsumi、Kawashima Motohiro
    • Journal Title

      Physics and Imaging in Radiation Oncology

      Volume: 23 Pages: 140-143

    • DOI

      10.1016/j.phro.2022.08.001

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] First Human Cell Experiments With FLASH Carbon Ions2022

    • Author(s)
      TASHIRO MUTSUMI、YOSHIDA YUKARI、OIKE TAKAHIRO、NAKAO MASAO、YUSA KEN、HIROTA YUKA、OHNO TATSUYA
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 5 Pages: 2469-2477

    • DOI

      10.21873/anticanres.15725

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An adaptive planning strategy in carbon ion therapy of pancreatic cancer involving beam angle selection2022

    • Author(s)
      Kawashima Motohiro、Tashiro Mutsumi、Varnava Maria、Shiba Shintaro、Matsui Toshiaki、Okazaki Shohei、Li Yang、Komatsu Shuichiro、Kawamura Hidemasa、Okamoto Masahiko、Ohno Tatsuya
    • Journal Title

      Physics and Imaging in Radiation Oncology

      Volume: 21 Pages: 35-41

    • DOI

      10.1016/j.phro.2022.01.005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carbon range verification with 718?keV Compton imaging2021

    • Author(s)
      Parajuli Raj Kumar、Sakai Makoto、Arakawa Kazuo、Kubota Yoshiki、Kubo Nobuteru、Tashiro Mutsumi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-00949-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan, normal tissue complication probability model, and clinical outcomes in prostate cancer2021

    • Author(s)
      Fukata Kyohei、Kawamura Hidemasa、Kubo Nobuteru、Kanai Tatsuaki、Torikoshi Masami、Nakano Takashi、Tashiro Mutsumi、Ohno Tatsuya
    • Journal Title

      Physica Medica

      Volume: 90 Pages: 6-12

    • DOI

      10.1016/j.ejmp.2021.08.013

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adaptive planning based on single beam optimization in passive scattering carbon ion radiotherapy for patients with pancreatic cancer2021

    • Author(s)
      Li Yang、Kubota Yoshiki、Okamoto Masahiko、Shiba Shintaro、Okazaki Shohei、Matsui Toshiaki、Tashiro Mutsumi、Nakano Takashi、Ohno Tatsuya
    • Journal Title

      Radiation Oncology

      Volume: 16 Issue: 1

    • DOI

      10.1186/s13014-021-01841-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calculation of Stopping-Power Ratio from Multiple CT Numbers Using Photon-Counting CT System: Two- and Three-Parameter-Fitting Method2021

    • Author(s)
      Lee Sung Hyun、Sunaguchi Naoki、Nagao Akie、Hirano Yoshiyuki、Sakurai Hiroshi、Kano Yosuke、Torikoshi Masami、Kanai Tatsuaki、Tashiro Mutsumi
    • Journal Title

      Sensors

      Volume: 21 Issue: 4 Pages: 1215-1215

    • DOI

      10.3390/s21041215

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconstruction of dose distributions for fine carbon-ion beams using iterative approximation toward carbon-knife2020

    • Author(s)
      Tashiro Mutsumi、Souda Hikaru、Yoshida Takuya、Sakurai Hiroshi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 65 Issue: 22 Pages: 225023-225023

    • DOI

      10.1088/1361-6560/abc131

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars2020

    • Author(s)
      Takahashi Akihisa、Yamanouchi Sakuya、Takeuchi Kazuomi、Takahashi Shogo、Tashiro Mutsumi、Hidema Jun、Higashitani Atsushi、Adachi Takuya、Zhang Shenke、Guirguis Fady Nagy Lotfy、Yoshida Yukari、Nagamatsu Aiko、Hada Megumi、Takeuchi Kunihito、Takahashi Tohru、Sekitomi Yuji
    • Journal Title

      Life

      Volume: 10 Issue: 11 Pages: 274-274

    • DOI

      10.3390/life10110274

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simultaneous determination of the dose and linear energy transfer (LET) of carbon-ion beams using radiochromic films2020

    • Author(s)
      Kawashima Motohiro、Matsumura Akihiko、Souda Hikaru、Tashiro Mutsumi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 65 Issue: 12 Pages: 125002-125002

    • DOI

      10.1088/1361-6560/ab8bf3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging2020

    • Author(s)
      Sakai Makoto、Parajuli Raj Kumar、Kubota Yoshiki、Kubo Nobuteru、Yamaguchi Mitsutaka、Nagao Yuto、Kawachi Naoki、Kikuchi Mikiko、Arakawa Kazuo、Tashiro Mutsumi
    • Journal Title

      Sensors

      Volume: 20 Issue: 9 Pages: 2453-2453

    • DOI

      10.3390/s20092453

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Divided-volume matching technique for volume displacement estimation of patient positioning in radiation therapy2019

    • Author(s)
      Tashiro Mutsumi、Kubota Yoshiki、Torikoshi Masami、Ohno Tatsuya、Nakano Takashi
    • Journal Title

      Physica Medica

      Volume: 62 Pages: 1-12

    • DOI

      10.1016/j.ejmp.2019.04.028

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer2019

    • Author(s)
      KUBOTA YOSHIKI、OHNO TATSUYA、KAWASHIMA MOTOHIRO、MURATA KAZUTOSHI、OKONOGI NORIYUKI、NODA SHIN-EI、TSUDA KAZUHISA、SAKAI MAKOTO、TASHIRO MUTSUMI、NAKANO TAKASHI
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 4 Pages: 1915-1921

    • DOI

      10.21873/anticanres.13300

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Technical Note: Predicting dose distribution with replacing stopping power ratio for inter‐fractional motion and intra‐fractional motion during carbon ion radiotherapy with passive irradiation method for stage I lung cancer2018

    • Author(s)
      Kubota Yoshiki、Sakai Makoto、Tashiro Mutsumi、Saitoh Jun‐ichi、Abe Takanori、Ohno Tatsuya、Nakano Takashi
    • Journal Title

      Medical Physics

      Volume: 45 Issue: 7 Pages: 3435-3441

    • DOI

      10.1002/mp.12966

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Dose distribution evaluation without additional CT scans toward adaptive carbon ion radiotherapy for liver tumors using the divided-volume matching technique2023

    • Author(s)
      Jing-Ni Chen, Mutsumi Tashiro, and Tatsuya Ohno
    • Organizer
      The 3rd Annual Conference of the Asia-Oceania Particle Therapy Co-Operative Group (PTCOG-AO 2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dosimetry of experimental carbon-ion mini-beams toward ‘Carbon-Knife’ and ‘Carbon-Flash’2021

    • Author(s)
      Mutsumi Tashiro, Masao Nakao, Yukari Yoshida, Ken Yusa, Tatsuya Ohno
    • Organizer
      Flash Radiotherapy & Particle Therapy (FRPT) 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reconstruction of lateral dose distributions with optimized filtering process for fine carbon-ion beams toward ‘carbon-knife’2021

    • Author(s)
      Mutsumi Tashiro, Hikaru Souda, Hiroshi Sakurai
    • Organizer
      59th Annual Conference of the Particle Therapy Co-Operative Group (PTCOG 59)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 群馬大学重粒子線がん治療における医工連携2021

    • Author(s)
      田代 睦
    • Organizer
      第33回「電磁力関連のダイナミクス」シンポジウム(SEAD33)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 重粒子線治療の照射内変動を考慮した積層原体照射の 線量分布評価2021

    • Author(s)
      長谷部有希, 櫻井 浩,田代 睦
    • Organizer
      第58回群馬放射線腫瘍研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Iterative reconstruction of lateral dose distributions for fine carbon-ion beams toward ‘Carbon-Knife’2020

    • Author(s)
      Tashiro M, Souda H, Yoshida T, Sakurai H.
    • Organizer
      The 10th International Society of Radiation Neurobiology Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reconstruction of dose distributions for fine carbon-ion beams toward “Carbon Knife”2019

    • Author(s)
      Tashiro M, Souda H, Yoshida T, Sakurai H
    • Organizer
      International Conference on Mechanical, Electrical and Medical Intelligent System 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Divided-volume matching technique for volume displacement estimation at patient positioning2019

    • Author(s)
      田代睦, 久保田佳樹, 大野達也
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Filtering process examination for dose distribution reconstruction of fine carbon-ion beams using iterative approximation2019

    • Author(s)
      田代睦, 想田光, 吉田拓矢, 櫻井浩
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Dose distribution reconstruction of fine carbon-ion beams for carbon-knife2018

    • Author(s)
      M. Tashiro, H. Souda, M. Torikoshi, T. Ohno, T. Nakano
    • Organizer
      57th Annual Conference of the Particle Therapy Co-operative Group (PTCOG57)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 球標的数値ファントムに対する呼吸性移動積層原体照射の線量 分布評価2018

    • Author(s)
      田代 睦, 横山耕平, 取越正己
    • Organizer
      第116回日本医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 逐次近似法を用いた微小炭素イオンビームの線量分布再構成2018

    • Author(s)
      田代 睦, 想田 光, 取越正己
    • Organizer
      第116回日本医学物理学会学術大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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