Basic research aimed at creating a protocol for boron neutron capture therapy and immunotherapy

• Project/Area Number: 18K07750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: Kinashi Yuko 京都大学, 複合原子力科学研究所, 准教授 (80252534)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 中性子 / アブスコパル効果 / 放射線感受性 / ホウ素中性子捕捉療法

Outline of Final Research Achievements

To investigate the long-term influence of head -neutron irradiation on mice spleens, post-irradiation late effects were examined in three types of mice. The onset of primary splenic malignant lymphoma was recognized in many of the Balb/c mice 18 months after head-neutron irradiation.

Academic Significance and Societal Importance of the Research Achievements

中性子の頭部部分照射後の照射部位ではない脾臓に脾原発性悪性リンパ腫が発症した事実は非常に貴重な発見である。この結果から頭部への部分中性子照射の脾臓への晩発影響は遺伝子背景の違いで非常に異なることが分かった。BNCTプラス免疫療法のプロトコルについて、治療効果向上のためには患者自身の遺伝子情報の違いにより対策を講じる必要があることが示唆された。

Research Products

• [Journal Article] Carcinogenesis Observed in the Spleens of Balb/c Mice After Head-neutron Irradiation (2023)
  • Author(s): Yuko Kinashi, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka
  • Journal Title: ANTICANCER RESEARCH Volume: 43 Issue: 4 Pages: 1455-1462
  • DOI: 10.21873/anticanres.16294
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] BNCT for primary synovial sarcoma (2021)
  • Author(s): Fujimoto T, Suzuki M, Kuratsu S, Morishima M, Sudo T, Nakamatsu Y, Sakurai Y, Takata T, Tamari Y, Tanaka H, Masunaga SI, Kinashi Y, Kondo N, Sakakibara S, Igaki H, Andoh T, Sakamoto S, Kawamoto T, Watanabe T, Hara H, Fukase N, Kawakami Y, Matsumoto T, Akisue T, Ono K, Ichikawa H, Kuroda R, Hirose T.
  • Journal Title: Applied Radiation and Isotopes Volume: 169 Pages: 109407-109407
  • DOI: 10.1016/j.apradiso.2020.109407
  • Peer Reviewed / Open Access
• [Journal Article] The combined effect of neutron irradiation and temozolomide on glioblastoma cell lines with different MGMT and p53 status (2020)
  • Author(s): Yuko Kinashi, Tomoyuki Ikawa, Sentaro Takahashi
  • Journal Title: Applied Radiation and Isotopes Volume: 163 Pages: 109204-109204
  • DOI: 10.1016/j.apradiso.2020.109204
  • Peer Reviewed
• [Journal Article] Characteristic evaluation of the thermal neutron irradiation field using a 30 MeV cyclotron accelerator for basic research on neutron capture therapy (2020)
  • Author(s): Tanaka H, Takata T, Watanabe T, Suzuki M, Mitsumoto T, Kawabata S, Masunaga S, Kinashi Y, Sakurai Y, Maruhashi A, Ono K.
  • Journal Title: Nuclear Inst. And Methods in Physics Research, A Volume: 983 Pages: 164533-164533
  • DOI: 10.1016/j.nima.2020.164533
  • Peer Reviewed / Open Access
• [Presentation] Relationship of the abscopal effect to the survival rate after the head neutron-irradiation between the different types of mice (2021)
  • Author(s): Yuko Kinashi
  • Organizer: 19th International Congress on Neutron Capture Therapy
  • Int'l Joint Research
• [Presentation] p53の発現が異なる神経膠芽腫細胞の中性子照射およびDNAアルキル化剤に対する感受性の差 (2019)
  • Author(s): 木梨友子、井川智之、高橋千太郎
  • Organizer: 第16回日本中性子捕捉療法学会学術大会
• [Presentation] マウス頭部照射で認められた脾臓のアブスコパル効果 (2019)
  • Author(s): 木梨友子、田中浩基
  • Organizer: 第55回日本医学放射線学会秋季臨床大会
• [Presentation] The combination effect of neutron irradiation and exposure to DNA-alkylating agent on glioblastoma cell lines with different MGMT and p53 status (2018)
  • Author(s): Yuko Kinashi, Tomoyuki Ikawa, Sentaro Takahashi
  • Organizer: 18th International Congress on Neutron Capture Therapy
  • Int'l Joint Research
• [Presentation] エックス線感受性の異なるマウスにおける中性子感受性の差 (2018)
  • Author(s): 木梨友子、小野公二
  • Organizer: 日本放射線影響学会 第61回大会
• [Presentation] 絶対生物効果線量の提案-10B(n,α)7Liの効果は核細胞質比または細胞サイズで予測できる (2018)
  • Author(s): 小野公二、田中浩基、玉利勇樹、渡邉翼、鈴木実、木梨友子、増永慎一郎
  • Organizer: 日本放射線影響学会 第61回大会