Basic research aimed at creating a protocol for boron neutron capture therapy and immunotherapy
| Project/Area Number |
18K07750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Kyoto University |
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Principal Investigator |
Kinashi Yuko 京都大学, 複合原子力科学研究所, 准教授 (80252534)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 中性子 / アブスコパル効果 / 放射線感受性 / ホウ素中性子捕捉療法 |
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| Outline of Final Research Achievements |
To investigate the long-term influence of head -neutron irradiation on mice spleens, post-irradiation late effects were examined in three types of mice. The onset of primary splenic malignant lymphoma was recognized in many of the Balb/c mice 18 months after head-neutron irradiation.
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| Academic Significance and Societal Importance of the Research Achievements |
中性子の頭部部分照射後の照射部位ではない脾臓に脾原発性悪性リンパ腫が発症した事実は非常に貴重な発見である。この結果から頭部への部分中性子照射の脾臓への晩発影響は遺伝子背景の違いで非常に異なることが分かった。BNCTプラス免疫療法のプロトコルについて、治療効果向上のためには患者自身の遺伝子情報の違いにより対策を講じる必要があることが示唆された。
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Report
(6 results)
Research Products
(10 results)
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[Journal Article] BNCT for primary synovial sarcoma2021
Author(s)
Fujimoto T, Suzuki M, Kuratsu S, Morishima M, Sudo T, Nakamatsu Y, Sakurai Y, Takata T, Tamari Y, Tanaka H, Masunaga SI, Kinashi Y, Kondo N, Sakakibara S, Igaki H, Andoh T, Sakamoto S, Kawamoto T, Watanabe T, Hara H, Fukase N, Kawakami Y, Matsumoto T, Akisue T, Ono K, Ichikawa H, Kuroda R, Hirose T.
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Journal Title
Applied Radiation and Isotopes
Volume: 169
Pages: 109407-109407
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characteristic evaluation of the thermal neutron irradiation field using a 30 MeV cyclotron accelerator for basic research on neutron capture therapy2020
Author(s)
Tanaka H, Takata T, Watanabe T, Suzuki M, Mitsumoto T, Kawabata S, Masunaga S, Kinashi Y, Sakurai Y, Maruhashi A, Ono K.
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Journal Title
Nuclear Inst. And Methods in Physics Research, A
Volume: 983
Pages: 164533-164533
DOI
Related Report
Peer Reviewed / Open Access
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