Development of a novel radiosensitizer with inorganic nanoparticles
| Project/Area Number |
18K07752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐々木 良平 神戸大学, 医学部附属病院, 教授 (30346267)
赤坂 浩亮 神戸大学, 医学研究科, 医学研究員 (20707161)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ナノ粒子 / 過酸化チタン / 放射線増感 / 表面修飾技術 / 活性酸素種 / 活性酸素 / 放射線治療 / がん治療 |
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| Outline of Final Research Achievements |
The development of potentially safe radiosensitizing agents is essential to enhance the treatment outcomes of radioresistant cancers. The titanium peroxide nanoparticle (TiOxNP) was originally produced using the titanium dioxide nanoparticle, and it showed excellent reactive oxygen species (ROS) generation in response to ionizing radiation. Surface coating the TiOxNPs with polyacrylic acid (PAA) showed low toxicity to the living body and excellent radiosensitizing effect on cancer cells. Herein, we evaluated the mechanism of radiosensitization by PAA-TiOxNPs in comparison with gold nanoparticles (AuNPs). PAA-TiOxNPs showed a significantly more radiosensitizing effect than that of AuNPs. A comparison of the types and amounts of ROS generated showed that hydrogen peroxide generation by PAA-TiOxNPs was the major factor that contributed to the nanoparticle radiosensitization.
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| Academic Significance and Societal Importance of the Research Achievements |
今日の臨床のがん治療の現場において、有機的な化合物で放射線増感剤として認識され、広く臨床使用されているものはない。そのため、その現状を打破する画期的なアイデアとして無機ナノ粒子に着目し、開発を進めてきた。これまで世界的にも金ナノ粒子の効果が期待されてきたが、我々が開発した過酸化チタンナノ粒子は金ナノ粒子よりも過酸化水素の産生が協力であり、より強い放射線増感効果を示すことを世界で初めて実証した。今後は臨床応用を目指して、毒性の評価や有効性の非臨床試験などを一歩一歩進めていく。
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique.2018
Author(s)
Nishikawa R, Yoshida K, Ebina Y, Omoteda M, Miyawaki D, Ishihara T, Ejima Y, Akasaka H, Satoh H, Kyotani K, Takahashi S, Sasaki R.
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Journal Title
Journal of Radiation Research
Volume: 印刷中
Issue: 3
Pages: 316-326
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 限局性肝細胞癌に対するサイバーナイフ動体追尾定位放射線治療の長期成績2019
Author(s)
馬屋原 博, 橋本 直樹, 原田 文,西村 英輝, 北谷 圭司, 岩下 和真, 薮内 伴憲, 川口 弘毅, 石原 武明, 妹尾 悟史, 溝延 数房, 上原 和之, 石田 淳，藤井 正彦, 佐々木 良平
Organizer
第28回日本定位放射線治療学会
Related Report
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