Establishment of evaluation for the response after proton beam therapy for hepatocellular carcinoma

• Project/Area Number: 18K07761
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Nagoya City University
• Principal Investigator: Ogino Hiroyuki 名古屋市立大学, 医薬学総合研究院(医学), 高度医療教育研究センター教授 (60315885)
• Co-Investigator(Kenkyū-buntansha): 原 眞咲 名古屋市立大学, 医薬学総合研究院(医学), 高度医療教育研究センター教授 (50244562)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 陽子線治療 / 肝細胞癌 / 効果判定法 / 効果判定

Outline of Final Research Achievements

Proton therapy for hepatocellular carcinoma is becoming widespread worldwide, and its high local control rate is drawing attention. On the other hand, the problem is that it is difficult to evaluate whether or not a tumor that can recur remains.
In this study, the MRI image after irradiation was examined in detail in order to accurately perform the therapeutic effect after proton therapy. In addition, as a result of analyzing the movement of widely used tumor markers, we believe that it is possible to accurately determine the effect of recurrence after proton therapy.

Academic Significance and Societal Importance of the Research Achievements

肝細胞癌に対する陽子線治療後の効果を正しく判定し、本来であれば再発しないのに再発と誤認されて本来必要のない追加治療が行われたり、逆に再発しているのに照射後の変化と考えて腫瘍を増大させてしまうことを防ぐためのMRIと腫瘍マーカーの評価方法を提案できた。

Research Products

• [Journal Article] A Phase II Study of Image-guided Proton Therapy for Operable or Ablation-treatable Primary Hepatocellular Carcinoma (2021)
  • Author(s): Iwata Hiromitsu、Ogino Hiroyuki、Hattori Yukiko、Nakajima Koichiro、Nomura Kento、Hashimoto Shingo、Hayashi Kensuke、Toshito Toshiyuki、Sasaki Shigeru、Mizoe Jun-etsu、Shibamoto Yuta
  • Journal Title: International Journal of Radiation Oncology*Biology*Physics Volume: 30 Issue: 1 Pages: 360-360
  • DOI: 10.1016/j.ijrobp.2021.03.049
  • Peer Reviewed
• [Journal Article] Image-Guided Proton Therapy for Elderly Patients with Hepatocellular Carcinoma: High Local Control and Quality of Life Preservation (2021)
  • Author(s): Iwata Hiromitsu、Ogino Hiroyuki、Hattori Yukiko、Nakajima Koichiro、Nomura Kento、Hashimoto Shingo、Hayashi Kensuke、Toshito Toshiyuki、Sasaki Shigeru、Mizoe Jun-etsu、Shibamoto Yuta
  • Journal Title: Cancers Volume: 13 Issue: 2 Pages: 219-219
  • DOI: 10.3390/cancers13020219
  • Peer Reviewed / Open Access
• [Journal Article] Biological effects of passive scattering and spot scanning proton beams at the distal end of the spread-out Bragg peak in single cells and multicell spheroids (2021)
  • Author(s): Nomura Kento、Iwata Hiromitsu、Toshito Toshiyuki、Omachi Chihiro、Nagayoshi Junpei、Nakajima Koichiro、Ogino Hiroyuki、Shibamoto Yuta
  • Journal Title: International Journal of Radiation Biology Volume: 97 Issue: 5 Pages: 695-703
  • DOI: 10.1080/09553002.2021.1889704
  • Peer Reviewed / Open Access
• [Journal Article] Transient increases in serum α fetoprotein and protein induced by vitamin K antagonist II levels following proton therapy does not necessarily indicate progression of hepatocellular carcinoma (2019)
  • Author(s): Yoshida M, Ogino H, Iwata H, Hattori Y, Hashimoto S, Nakajima K, Sasaki S, Hara M, Sekido Y, Mizoe JE, Shibamoto Y
  • Journal Title: Oncol Lett Volume: 17 Pages: 3026-3034
  • DOI: 10.3892/ol.2019.9922
  • Peer Reviewed / Open Access
• [Journal Article] Dosimetric verification of IMPT using a commercial heterogeneous phantom. (2019)
  • Author(s): Yasui K, Toshito T, Omachi C, Hayashi K, Kinou H, Katsurada M, Hayashi N, Ogino H.
  • Journal Title: J Appl Clin Med Phys. Volume: 20 Issue: 2 Pages: 114-120
  • DOI: 10.1002/acm2.12535
  • Peer Reviewed
• [Journal Article] A quality assurance for respiratory gated proton irradiation with range modulation wheel. (2019)
  • Author(s): Yasui K, Shimomura A, Toshito T, Tanaka K, Ueki K, Muramatsu R, Katsurada M, Hayashi N, Ogino H.
  • Journal Title: J Appl Clin Med Phys. Volume: 20 Issue: 1 Pages: 258-264
  • DOI: 10.1002/acm2.12526
• [Presentation] Image-guided proton therapy for elderly patients with hepatocellular carcinoma: high local control and quality of life (2020)
  • Author(s): Iwata H, Ogino H, Hattori Y, Nakajima K, Nomura K, Hayashi K, Toshito T, Sasaki S, Hashimoto S, Mizoe J, Shibamoto Y
  • Organizer: the 62nd American Society for Therapeutic Radiology and Oncology Annual Meeting
• [Presentation] Hydrogel Spacer Injections for Prostate Cancer Patients Undergoing Proton Beam Therapy (2019)
  • Author(s): Ogino H, Iwata H, Hashimoto H, Nakajima K, Hattori Y, Nomura K, Shibamoto Y.
  • Organizer: 58th Annual Conference of the Particle Therapy Co-Operative Group