The role of monocyte and Macrophage in Kawasaki disease(KD), the role of lncRNA in KD inflammation.

• Project/Area Number: 18K07785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: International University of Health and Welfare (2019-2022); University of Toyama (2018)
• Principal Investigator: Ichida Fukiko 国際医療福祉大学, 臨床医学研究センター, 特任教授 (30223100)
• Co-Investigator(Kenkyū-buntansha): 廣野 恵一 富山大学, 学術研究部医学系, 講師 (80456384) ; 小澤 綾佳 富山大学, 学術研究部医学系, 助教 (40596540) ; 齋藤 和由 富山大学, 附属病院, 助教 (30566097)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 川崎病 / 血管炎 / 血管微小粒子 / micro RNA / 単球 / microRNA / 単球・マクロファージ / non coding RNA / バイオマーカー / 発症機序

Outline of Final Research Achievements

Kawasaki disease (KD) is a systemic vasculitis that is currently the most common cause of acquired heart disease in children. However, its etiology remains unknown. Long non-coding RNAs (lncRNAs) contribute to the pathophysiology of various diseases. Few studies have reported the role of lncRNAs in KD inflammation; thus, we investigated the role of lncRNA in KD inflammation.This study revealed the whole aspect of the gene expression profile of monocytes of patients with Kawasaki disease (KD) using cap analysis gene expression sequencing and identified KD-specific molecules: G0/G1 switch gene 2 (G0S2) and long non-coding RNA (lncRNA) HSD11B1-AS1. We demonstrated that G0S2 and its antisense HSD11B1-AS1 were associated with inflammation of innate immunity in KD.This study uncovered the crucial role of lncRNAs in innate immunity in acute KD. lncRNA may be a novel key target for the diagnosis of patients with KD.

Academic Significance and Societal Importance of the Research Achievements

川崎病は未だ原因不明であり、川崎病の治療戦略を立てる上で原因究明および新たなバイオマーカーの確立が喫緊の課題である。本研究を行うことで、川崎病の原因が単球・マクロファージであることを実証でき、川崎病の診断・治療のパラダイムシフトを起こすことが期待できる。川崎病急性期血管炎において血管微小粒子は血管内皮障害のバイオマーカーとなり、 血管微小粒子に含まれるmicroRNAは炎症の調節に関与している可能性を報告した。血管微小粒子は血管内皮障害や血管炎の重症度を反映し、冠動脈病変を予測する鋭敏なバイオマーカーであり、血管微小粒子内のIncRNAは、川崎病診断の新たなターゲットとなりうることを解明した。

Research Products

• [Journal Article] Analysis of Coronary Arterial Aneurysm Regression in Patients With Kawasaki Disease by Aneurysm Severity: Factors Associated With Regression (2023)
  • Author(s): Kato Taichi、Hirono Keiichi、et al
  • Journal Title: Journal of the American Heart Association Volume: 12 Issue: 3
  • DOI: 10.1161/jaha.121.022417
  • Peer Reviewed / Open Access
• [Journal Article] Pathological and Comprehensive Genetic Investigation of Autopsy Cases of Idiopathic Bradyarrhythmia (2022)
  • Author(s): Hata Yukiko、Ichimata Shojiro、Hirono Keiichi、Yamaguchi Yoshiaki、Oku Yuko、Ichida Fukiko、Nishida Naoki
  • Journal Title: Circulation Journal Volume: 87 Issue: 1 Pages: 111-119
  • DOI: 10.1253/circj.CJ-22-0397
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2022-12-23
  • Peer Reviewed / Open Access
• [Journal Article] Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity?a narrative review (2022)
  • Author(s): Hirono Keiichi、Ichida Fukiko
  • Journal Title: Cardiovascular Diagnosis and Therapy Volume: 12 Issue: 4 Pages: 495-515
  • DOI: 10.21037/cdt-22-198
  • Peer Reviewed / Open Access
• [Journal Article] G0S2 regulates innate immunity in Kawasaki disease via lncRNA HSD11B1-AS1 (2022)
  • Author(s): Okabe Mako、Takarada Shinya、Miyao Nariaki、Nakaoka Hideyuki、Ibuki Keijiro、Ozawa Sayaka、Watanabe Kazuhiro、Tsuji Harue、Hashimoto Ikuo、Hatasaki Kiyoshi、Hayakawa Shotaro、Hamaguchi Yu、Hamada Michiaki、Ichida Fukiko、Hirono Keiichi
  • Journal Title: Pediatric Research Volume: 15 Issue: 2 Pages: 378-387
  • DOI: 10.1038/s41390-022-01999-9
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Characteristics and Prognosis of Fetal Left Ventricular Noncompaction in Japan (2021)
  • Author(s): Ozawa SW, Takarada S, Okabe M, Miyao N, Nakaoka H, Ibuki K, Ichida F, Hirono K; Fetal CM Study Collaborators.
  • Journal Title: Circulation Journal Volume: 86 Issue: 1 Pages: 98-105
  • DOI: 10.1253/circj.CJ-20-1148
  • NAID: 130008132661
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-12-24
  • Peer Reviewed / Open Access
• [Journal Article] Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- and Post-Diagnostic Phases in Children and Adolescents (2021)
  • Author(s): Yoshinaga M, Horigome H, Yasuda K, Kogaki S, Tateno S, Ohta K, Hirono K, Hosokawa S, Takechi F, Ishikawa Y, Hata T, Ichida F, Ohno S, Makita N, Horie M, Takahashi H, Nagashima M.
  • Journal Title: Circulation Journal Volume: 86 Issue: 1 Pages: 118-127
  • DOI: 10.1253/circj.CJ-21-0376
  • NAID: 130008132672
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-12-24
  • Peer Reviewed / Open Access
• [Journal Article] Outcomes of hypertrophic cardiomyopathy in Japanese children: a retrospective cohort study. (2021)
  • Author(s): Mori H, Yoshikawa T, Kimura H, Ono H, Kato H, Ono Y, Nii M, Shindo T, Inuzuka R, Horigome H, Miura M, Hirono K, Kobayashi T, Kogaki S, Furutani Y, Nakanishi T
  • Journal Title: Heart Vessels. Volume: - Issue: 6 Pages: 109-11
  • DOI: 10.1007/s00380-021-01989-7
  • Peer Reviewed / Open Access
• [Journal Article] Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children (2021)
  • Author(s): Imamura Tomohiko、Sumitomo Naokata、Muraji Shota、Yasuda Kazushi、Nishihara Eiki、Iwamoto Mari、Tateno Shigeru、Doi Shozaburo、Hata Tadayoshi、Kogaki Shigetoyo、Horigome Hitoshi、Ohno Seiko、Ichida Fukiko、Nagashima Masami、Makiyama Takeru、Yoshinaga Masao
  • Journal Title: International Journal of Cardiology Volume: 323 Pages: 168-174
  • DOI: 10.1016/j.ijcard.2020.08.088
  • Peer Reviewed / Open Access
• [Journal Article] A burden of sarcomere gene variants in fetal-onset patients with left ventricular noncompaction (2021)
  • Author(s): Hirono Keiichi、Hata Yukiko、Ozawa Sayaka Watanabe、Toda Takako、Momoi Nobuo、Fukuda Yutaka、Inuzuka Ryo、Nagamine Hiroki、Sakaguchi Heima、Kurosaki Kenichi、Okabe Mako、Takarada Shinya、Miyao Nariaki、Nakaoka Hideyuki、Ibuki Keijiro、Origasa Hideki、Bowles Neil E.、Nishida Naoki、Ichida Fukiko
  • Journal Title: International Journal of Cardiology Volume: 328 Pages: 122-129
  • DOI: 10.1016/j.ijcard.2020.12.013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reversible left ventricular noncompaction caused by hypertensive hydrocephalus: a pediatric case report. (2021)
  • Author(s): ato R, Taneichi H, Takarada S, Okabe M, Miyao N, Nakaoka H, Ibuki K, Ozawa S, Adachi Y, Yoshimura N, Saito K, Ichida F, Hirono K.
  • Journal Title: BMC Pediatr. Volume: 21 Issue: 1 Pages: 205-205
  • DOI: 10.1186/s12887-021-02680-6
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic value of P-waves in children with idiopathic restrictive cardiomyopathy (2021)
  • Author(s): Muraji S, Sumitomo N, Imamura T, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Yoshinaga M, Nakano S
  • Journal Title: Heart and Vessels Volume: ― Pages: 1141-1150
  • DOI: 10.1007/s00380-021-01784-4
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of chronic myocarditis: systematic review and meta-analysis. (2021)
  • Author(s): Hirono K, Takarada S, Okabe M, Miyao N, Nakaoka H, Ibuki K, Ozawa S, Origasa H, Ichida F, Imanaka-Yoshida K.
  • Journal Title: Heart Vessels. Volume: 37 Issue: 2 Pages: 300-314
  • DOI: 10.1007/s00380-021-01914-y
  • Peer Reviewed / Open Access
• [Journal Article] Anatomical Classification and Posttreatment Remodeling Characteristics to Guide Management and Follow-Up of Neonates and Infants With Coronary Artery Fistula: A Multicenter Study From the Coronary Artery Fistula Registry. (2021)
  • Author(s): Gowda ST, Latson L, Sivakumar K, Hiremath G, Crystal M, Law M, Shahanavaz S, Asnes J, Veeram Reddy S, Kobayashi D, Alwi M, Ichida F, Hirono K, Tahara M, Takeda A, Minami T, Kutty S, Nugent AW, Forbes T, Prieto LR, Qureshi AM.
  • Journal Title: Circ Cardiovasc Interv. Volume: 14 Issue: 12
  • DOI: 10.1161/circinterventions.120.009750
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Pharmacokinetics of Sildenafil May Be Affected by Intestinal Absorption Rate in Children Admitted to the Intensive Care Unit (2020)
  • Author(s): Yukino Oya, Daisuke Watahiki, Mitsuki Matsunaga, Keiichi Hirono, Fukiko Ichida, Masaya Aoki, Naoki Yoshimura, Masato Taguchi
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 43 Issue: 12 Pages: 1917-1923
  • DOI: 10.1248/bpb.b20-00614
  • NAID: 130007948744
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2020-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Left ventricular noncompaction ? Risk stratification and genetic consideration ? (2020)
  • Author(s): Ichida Fukiko
  • Journal Title: Journal of Cardiology Volume: 75 Issue: 1 Pages: 1-9
  • DOI: 10.1016/j.jjcc.2019.09.011
  • Peer Reviewed / Open Access
• [Journal Article] Neurodevelopmental outcomes at three years for infants with CHD and VLBW (2020)
  • Author(s): Yoshida Taketoshi、Hiraiwa Akiko、Ibuki Keijiro、Makimoto Masami、Inomata Satomi、Tamura Kentaro、Kawasaki Yukako、Ozawa Sayaka、Hirono Keiichi、Ichida Fukiko
  • Journal Title: Pediatrics International Volume: - Issue: 7 Pages: 797-803
  • DOI: 10.1111/ped.14160
  • Peer Reviewed / Open Access
• [Journal Article] A significance of school screening electrocardiogram in the patients with ventricular noncompaction. (2020)
  • Author(s): Hirono K, Miyao N, Yoshinaga M, Nishihara E, Hata T, et al.
  • Journal Title: Heart Vessels Volume: 11 Issue: 7 Pages: 985-995
  • DOI: 10.1007/s00380-020-01571-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Left Ventricular Noncompaction and Congenital Heart Disease Increases the Risk of Congestive Heart Failure. (2020)
  • Author(s): Hirono K, Hata Y, Miyao N, Okabe M, Takarada S, Nakaoka H, Ibuki K, Ozawa S, Yoshimura N, Nishida N, Ichida F, Lvnc Study Collaborators.
  • Journal Title: J Clin Med. Volume: 9 Issue: 3 Pages: 785-785
  • DOI: 10.3390/jcm9030785
  • Peer Reviewed / Open Access
• [Journal Article] The Bayley-III scale may underestimate neurodevelopmental disability after cardiac surgery in infants (2020)
  • Author(s): Goldstone Andrew B、 Ichida Fukiko、et al
  • Journal Title: European Journal of Cardio-Thoracic Surgery Volume: 57 Issue: 1 Pages: 63-71
  • DOI: 10.1093/ejcts/ezz123
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway (2020)
  • Author(s): Miyao N., Hata Y., Izumi H., Nagaoka R., Oku Y., Takasaki I., Ishikawa T., Takarada S., Okabe M., Nakaoka H., Ibuki K., Ozawa S., Yoshida T., Hasegawa H., Makita N., Nishida N., Mori H., Ichida F., Hirono K.
  • Journal Title: PLOS ONE Volume: 15 Issue: 4 Pages: 0227393-0227393
  • DOI: 10.1371/journal.pone.0227393
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac Emerinopathy (2020)
  • Author(s): Ishikawa Taisuke、Ichida Fukiko、Makita Naomasa et al
  • Journal Title: Circulation: Arrhythmia and Electrophysiology Volume: 13 Issue: 10 Pages: 1165-1174
  • DOI: 10.1161/circep.120.008712
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased Burden of Ion Channel Gene Variants Is Related to Distinct Phenotypes in Pediatric Patients With Left Ventricular Noncompaction (2020)
  • Author(s): Hirono Keiichi、Hata Yukiko、Ichida Fukiko、et al
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 13 Issue: 4
  • DOI: 10.1161/circgen.119.002940
  • Peer Reviewed / Open Access
• [Journal Article] Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10 (2019)
  • Author(s): Hirono Keiichi、Saito Kazuyoshi、Munkhsaikhan Undral、Xu Fuyi、Wang Ce、Lu Lu、Ichida Fukiko、Towbin Jeffrey A.、Purevjav Enkhsaikhan
  • Journal Title: Circulation Journal Volume: 83 Issue: 8 Pages: 1737-1746
  • DOI: 10.1253/circj.CJ-19-0116
  • NAID: 130007683001
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-07-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Determination of the Serum Unbound Fraction of Tadalafil in Children with Protein-Losing Enteropathy and Its Specific Binding to Human Serum Proteins <i>in Vitro</i> (2019)
  • Author(s): Shigetomi N, Kamiya K, Takamori T, Yoshimura N, Ozawa S, Hirono K, Ichida F, and Taguchi M.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 42 Issue: 1 Pages: 110-115
  • DOI: 10.1248/bpb.b18-00652
  • NAID: 130007542233
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2019-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Brain Development of Children with Single Ventricle Physiology or Transposition of the Great Arteries: A Longitudinal Observation Study. (2019)
  • Author(s): Hiraiwa A, Kawasaki Y, Ibuki K, Hirono K, Matsui M, Yoshimura N, Origasa H, Oishi K, Ichida F.
  • Journal Title: Semin Thorac Cardiovasc Surg Volume: - Issue: 4 Pages: 936-944
  • DOI: 10.1053/j.semtcvs.2019.06.013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Toddler Neurodevelopmental Outcomes Are Associated with School-Age IQ in Children With Single Ventricle Physiology. (2019)
  • Author(s): Hiraiwa A, Ibuki K, Tanaka T, Hirono K, Miya K, Yoshimura N, Ichida F.
  • Journal Title: Semin Thorac Cardiovasc Surg Volume: - Issue: 2 Pages: 302-310
  • DOI: 10.1053/j.semtcvs.2019.10.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial (2019)
  • Author(s): Hamada H, Suzuki H, Onouchi Y, Ebata R, Terai M, Fuse S, Okajima Y, Kurotobi S, Hirai K, Soga T, Ishiguchi Y, et al.
  • Journal Title: Lancet. Volume: 393(10176): Issue: 10176 Pages: 1128-1137
  • DOI: 10.1016/s0140-6736(18)32003-8
  • Peer Reviewed / Open Access
• [Journal Article] Reply (2019)
  • Author(s): Wilfong Erin M.、Bayram Kevin W.、Crofford Leslie J.
  • Journal Title: Arthritis & Rheumatology Volume: 71 Issue: 4 Pages: 652-653
  • DOI: 10.1002/art.40782
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of the effects of ontogenetic or maturation functions and chronic heart failure on the model analysis for the dose-response relationship of warfarin in Japanese children (2019)
  • Author(s): Tamura R, Watanabe N, Nakamura S, Yoshimura N, Ozawa S, Hirono K, Ichida F, Taguchi M.
  • Journal Title: Eur J Clin Pharmacol. Volume: 75 Pages: 913-920
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial complex deficiency by novel compound heterozygous TMEM70 variants and correlation with developmental delay, undescended testicle, and left ventricular noncompaction in a Japanese patient: A case report (2019)
  • Author(s): Hirono Keiichi、Ichida Fukiko、Nishio Natsuhito、Ogawa-Tominaga Minako、Fushimi Takuya、Feichtinger Rene′ G.、Mayr Johannes A.、Kohda Masakazu、Kishita Yoshihito、Okazaki Yasushi、Ohtake Akira、Murayama Kei
  • Journal Title: Clinical Case Reports Volume: 7 Issue: 3 Pages: 553-557
  • DOI: 10.1002/ccr3.2050
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinicopathological and Genetic Profiles of Cases with Myocytes Disarray?Investigation for Establishing the Autopsy Diagnostic Criteria for Hypertrophic Cardiomyopathy (2019)
  • Author(s): Hata Yukiko、Ichimata Shojiro、Yamaguchi Yoshiaki、Hirono Keiichi、Oku Yuko、Ichida Fukiko、Nishida Naoki
  • Journal Title: Journal of Clinical Medicine Volume: 8 Issue: 4 Pages: 463-463
  • DOI: 10.3390/jcm8040463
  • Peer Reviewed / Open Access
• [Journal Article] Novel compound heterozygous TBX5 variants may induce hypoplastic left heart syndrome (2019)
  • Author(s): Miyao Nariaki、Hirono Keiichi、Hata Yukiko、Yoshimura Naoki、Ichida Fukiko
  • Journal Title: Pediatrics International Volume: 61 Issue: 6 Pages: 607-609
  • DOI: 10.1111/ped.13854
  • Peer Reviewed / Open Access
• [Journal Article] Emergence and Characterization of Acute Coronary Syndrome in Adults After Confirmed or Missed History of Kawasaki Disease in Japan: A Japanese Nationwide Survey (2019)
  • Author(s): Mitani Yoshihide、Tsuda Etsuko、Kato Hitoshi、Higaki Takashi、Fujiwara Masako、Ogawa Shunichi、Satoh Fumiko、Nakamura Yoshikazu、Takahashi Kei、Ayusawa Mamoru、Kobayashi Tohru、Ichida Fukiko、et al.
  • Journal Title: Frontiers in Pediatrics Volume: 7 Pages: 275-275
  • DOI: 10.3389/fped.2019.00275
  • Peer Reviewed / Open Access
• [Journal Article] Monocyte‐Derived Interleukin‐1β As the Driver of S100A12‐Induced Sterile Inflammatory Activation of Human Coronary Artery Endothelial Cells: Implications for the Pathogenesis of Kawasaki Disease (2019)
  • Author(s): Armaroli Giulia、Verweyen Emely、Pretzer Carolin、Kessel Katharina、Hirono Keiichi、Ichida Fukiko、Okabe Mako、Cabral David A.、Foell Dirk、Brown Kelly L.、Kessel Christoph
  • Journal Title: Arthritis & Rheumatology Volume: 71 Issue: 5 Pages: 792-804
  • DOI: 10.1002/art.40784
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy (2018)
  • Author(s): Hirono K、Hata Y、Nakazawa M、Momoi N、Tsuji T、Matsuoka T、Ayusawa M、Abe Y、Hayashi T、Tsujii N、Abe T、Sakaguchi H、Wang C、Takasaki A、Takarada S、Okabe M、Miyao N、Nakaoka H、Ibuki K、Saito K、Ozawa S、Nishida N、Bowles N E.、Ichida F
  • Journal Title: Circulation Journal Volume: 82 Issue: 10 Pages: 2609-2618
  • DOI: 10.1253/circj.CJ-18-0470
  • NAID: 130007487877
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-09-25
  • Peer Reviewed / Open Access
• [Journal Article] Detection of Pediatric Pulmonary Arterial Hypertension by School Electrocardiography Mass Screening (2018)
  • Author(s): Sawada Hirofumi、Mitani Yoshihide、Nakayama Tomotaka、Fukushima Hiroyuki、Kogaki Shigetoyo、Igarashi Takehiro、Ichida Fukiko、Ono Yasuo、Nakanishi Toshio、Doi Shozaburo、Ishikawa Shiro、Matsushima Masaki、Yamada Osamu、Saji Tsutomu
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 印刷中 Issue: 11 Pages: 1397-1406
  • DOI: 10.1164/rccm.201802-0375oc
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease. (2018)
  • Author(s): Nakaoka H, Hirono K, Yamamoto S, Takasaki I, Takahashi K, Kinoshita K, Takasaki A, Nishida N, Okabe M, Ce W, Miyao N, Saito K, Ibuki K, Ozawa S, Adachi Y, Ichida F.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 1016-1023
  • DOI: 10.1038/s41598-018-19310-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events. (2018)
  • Author(s): Miura M, Kobayashi T, Fukaza R et al
  • Journal Title: JAMA Pediatr Volume: 5 Issue: 5 Pages: 180030-180030
  • DOI: 10.1001/jamapediatrics.2018.0030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Barth syndrome: Different approaches to diagnosis (2018)
  • Author(s): Imai-Okazaki A, Kishita Y, Kohda M, Yatsuka Y, Hirata T, Mizuno Y, Harashima H, Hirono K, Ichida F, Noguchi A, Yoshida M, Tokorodani C, Nishiuchi R, Takeda A, Nakaya A, Sakata Y, Murayama K, Ohtake A, & Okazaki Y
  • Journal Title: Journal of Pediatrics Volume: 193 Pages: 256-260
  • DOI: 10.1016/j.jpeds.2017.09.075
  • Peer Reviewed / Open Access
• [Journal Article] Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction (2018)
  • Author(s): Takasaki Asami、Hirono Keiichi、Hata Yukiko、Wang Ce、Takeda Masafumi、Yamashita Jun K、Chang Bo、Nakaoka Hideyuki、Okabe Mako、Miyao Nariaki、Saito Kazuyoshi、Ibuki Keijiro、Ozawa Sayaka、Sekine Michikazu、Yoshimura Naoki、Nishida Naoki、Bowles Neil E.、Ichida Fukiko
  • Journal Title: Pediatric Research Volume: 84 Issue: 5 Pages: 733-742
  • DOI: 10.1038/s41390-018-0162-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reactive peripheral blood plasmacytosis in Kawasaki disease (2018)
  • Author(s): Okabe Mako、Hirono Keiichi、Tamura Kentaro、Ichida Fukiko、Kanegane Hirokazu
  • Journal Title: Pediatrics International Volume: 60 Issue: 9 Pages: 884-885
  • DOI: 10.1111/ped.13600
  • Peer Reviewed / Open Access
• [Journal Article] 5.Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan. (2017)
  • Author(s): Masuda H, Kobayashi T, Hachiya A, Nakashima Y, Shimizu H, Nozawa T, Ogihara Y, Ito S, Takatsuki S, Katsumata N, Suzuki Y, Takenaka S, Hirono K, Kobayashi T, Suzuki H, Suganuma E, Takahashi K, Saji T
  • Journal Title: J Pediatr. Volume: - Pages: 115-120.e3
  • DOI: 10.1016/j.jpeds.2017.10.013
  • Peer Reviewed / Open Access
• [Presentation] microRNAに着目した川崎病観動脈瘤における血管微小粒子の役割解明と新薬開発 (2022)
  • Author(s): 仲岡英幸
  • Organizer: 第58回日本小児循環器学会
• [Presentation] 難治性川崎病をバイオマーカーで予測する (2022)
  • Author(s): 吉兼由香子、廣野恵一他
  • Organizer: 第125回小児科学会
• [Presentation] G0S2はLncRNA HSD11B1-AS1を介して川崎病における自然免疫を調節する (2022)
  • Author(s): 岡部真子、廣野恵一、市田蕗子
  • Organizer: 第58回日本小児循環器学会
• [Presentation] CAWSマウスモデルを用いた川崎病血管炎における血管微小粒子の役割の解明 (2022)
  • Author(s): 廣野恵一
  • Organizer: 川崎病勉強会
• [Presentation] 川崎病におけるlong noncoding RNAとの関連の解析 (2022)
  • Author(s): 岡部真子、廣野恵一
  • Organizer: 第15回北陸川崎病研究会
• [Presentation] 移行期医療と脳卒中・循環器病対策基本法 (2022)
  • Author(s): 市田蕗子
  • Organizer: 第53回若年者心疾患・生活習慣病対策協議会総会
  • Invited
• [Presentation] 先天性心疾患児の精神運動発達 (2021)
  • Author(s): 市田蕗子
  • Organizer: 日本麻酔科学会第68回学術集会
  • Invited
• [Presentation] Functional analysis of the specific microRNA encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease using in silico (2020)
  • Author(s): 仲岡英幸、寳田真也、岡部真子、伊吹圭二郎、小澤綾佳、廣野恵一、市田蕗子
  • Organizer: 第40回日本川崎病学会学術集会
• [Presentation] microRNAに着目した川崎病冠動脈瘤における血管微小粒子の役割解明と新薬開発 (2020)
  • Author(s): 仲岡英幸
  • Organizer: 第56回日本小児循環期学会総会・学術集会
• [Presentation] ACHD Management & Education System In Japan. (2019)
  • Author(s): Fukiko Ichida
  • Organizer: The 1st Asia Pacific Society for ACHD Symposium.
  • Int'l Joint Research / Invited
• [Presentation] 専門医制度（内科系）成人先天性心疾患専門医制度解説セッション (2019)
  • Author(s): 市田蕗子
  • Organizer: 第21回成人先天性心疾患学会
  • Invited
• [Presentation] 成人先天性心疾患ガイドライン「ガイドラインに学ぶ」 (2019)
  • Author(s): 市田蕗子
  • Organizer: 第49回日本心臓血管外科学会学術総会
  • Invited
• [Presentation] シンポジウム「成人先天性心疾患専門医の誕生」GUCH専門医制度の今・これから (2019)
  • Author(s): 市田蕗子
  • Organizer: 第20回成人先天性心疾患セミナー
  • Invited
• [Presentation] 「先天性心疾患と精神神経発達」 (2019)
  • Author(s): 市田蕗子
  • Organizer: 日本心臓血管麻酔学会第24回学術大会
  • Invited
• [Presentation] 「動き出したACHD専門医制度の現状」 (2019)
  • Author(s): 市田蕗子
  • Organizer: ACHD-PAH講演会
  • Invited
• [Presentation] 9.Kawasaki disease-specific molecules are associated with the degree of inflammation, IVIG-resistance and the formation of coronary artery lesions in Kawasaki disease (2018)
  • Author(s): Yasutaka Nakashima, Yumi Mizuno, Kenji Furuno, Hisanori Nishio, Keiichi Hirono, Shinichi Takatsuki, Hiroyuki Suzuki, Yoshihiro Onouchi, Tohru Kobayashi, Toshiro Hara
  • Organizer: The 12th International Kawasaki Disease Symposium
  • Int'l Joint Research
• [Presentation] Kawasaki disease: vasculitis and endothelial microparticles (2018)
  • Author(s): Keiichi Hirono
  • Organizer: The 9th Asian Congress of Pediatric Infectious Diseases (ACPID)
  • Int'l Joint Research
• [Presentation] 内径のZscoreによる冠動脈瘤退縮の解析;ZSP2studyサブ解析 (2018)
  • Author(s): 加藤太一、小林徹、鮎澤衛、深澤隆治、布施茂登、廣野恵一、三谷義英、須田憲治、前田潤、三浦大
  • Organizer: 第38回日本川崎病学会学術集会
• [Presentation] 31.免疫グロブリン大量療法に不応リスクの高い川崎病児に対してシクロスポリンを併用した初期強化療法の効果と安全性 (2018)
  • Author(s): 濱田洋通、鈴木啓之、尾内善広、江畑亮太、寺井勝、布施茂登、岡嶋良知、黒飛俊二、平井克樹、曽我恭司、石口由希子、大熊喜彰、高田展行、柳井雅明、佐藤純一、中矢代真美、鮎澤衛、山本栄一、野村裕一、橋村裕也、尾内一信、益田博史、高月晋一、廣野恵一
  • Organizer: 第38回日本川崎病学会学術集会
• [Presentation] バイオマーカーによる川崎病初回治療不応予測;川崎病バイオマーカー小委員会報告 (2018)
  • Author(s): 勝部康弘、今中恭子、武田充人、阿部淳、小林徹、益田博司、大熊喜彰、深澤隆治、高月晋一、加藤太一、三谷義英、廣野恵一、池田和幸、吉兼由佳子、須田憲治、永田弾
  • Organizer: 第38回日本川崎病学会学術集会
• [Book] 診断と治療 一般内科医が知っておきたい最新の心筋症治療 (2021)
  • Author(s): 市田蕗子
  • Total Pages: 5
  • Publisher: 診断と治療社
• [Book] 麻酔70巻増刊号 先天性心疾患児の精神神経発達 (2021)
  • Author(s): 市田蕗子
  • Total Pages: 10
  • Publisher: 日本麻酔学会
• [Book] 心筋症診療のフロントラインー概念から最新の治療まで (2021)
  • Author(s): 3)廣野恵一、市田蕗子
  • Total Pages: 7
  • Publisher: 循環器ジャーナル
• [Book] 代謝異常と二次性心筋症 (2021)
  • Author(s): 市田蕗子
  • Total Pages: 2
  • Publisher: 心臓
• [Book] 一般内科医が知っておきたい最新の心筋症治療 (2021)
  • Author(s): 市田蕗子
  • Total Pages: 5
  • Publisher: 診断と治療社
• [Book] 循環器ジャーナル (2021)
  • Author(s): 廣野恵一、市田蕗子
  • Total Pages: 7
  • Publisher: 医学書院
• [Book] 心疾患と妊娠・出産ベスト・プラクテイス (2020)
  • Author(s): 市田蕗子
  • Total Pages: 7
  • Publisher: 南江堂
• [Book] 今日の治療指針 2019年版―私はこう治療している (2019)
  • Author(s): 市田蕗子
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] 実は知らない循環器希少疾患 (2019)
  • Author(s): 市田蕗子
  • Total Pages: 7
  • Publisher: 南江堂
• [Book] 診療ガイドラインUP-TO-DATE 2018-2019 (2019)
  • Author(s): 市田蕗子
  • Total Pages: 4
  • Publisher: メデイカルビュー
• [Book] 小児科 (2019)
  • Author(s): 市田蕗子
  • Total Pages: 8
  • Publisher: 金原出版
• [Book] 循環器内科 (2019)
  • Author(s): 市田蕗子
  • Total Pages: 8
  • Publisher: 科学評論社
• [Book] 心不全（第2版）最新の基礎・臨床研究の進歩 (2019)
  • Author(s): 市田蕗子
  • Total Pages: 6
  • Publisher: 日本臨床
• [Book] 循環器症候群（第3版） (2019)
  • Author(s): 市田蕗子
  • Total Pages: 5
  • Publisher: 日本臨床
• [Book] 小児科診療増刊号（81巻増刊号）「特集：小児の治療指針」 (2018)
  • Author(s): 廣野恵一、市田蕗子
  • Total Pages: 2
  • Publisher: 診断と治療社
• [Book] 小児・成育循環器学 (2018)
  • Author(s): 廣野恵一、市田蕗子
  • Total Pages: 4
  • Publisher: 診断と治療社
• [Book] 週刊日本医事新報 (2018)
  • Author(s): 廣野恵一、市田蕗子
  • Total Pages: 8
  • Publisher: 日本医事新報社