Development of a new diagnostic method for pediatric HSPN using urinary biomarkers

• Project/Area Number: 18K07799
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Shima Yuko 和歌山県立医科大学, 医学部, 講師 (60433364)
• Co-Investigator(Kenkyū-buntansha): 吉川 徳茂 社会医療法人愛仁会高槻病院(臨床研究センター), 腎臓疾患研究室, 室長 (10158412) ; 中西 浩一 琉球大学, 医学(系)研究科(研究院), 教授 (50336880)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 尿バイオマーカー / 紫斑病性腎炎 / IgA腎症 / KIM-1 / 疾患活動性 / 蛋白尿 / 非侵襲的診断 / 腎生検組織 / 紫斑病勢腎炎 / 腎生検 / 小児紫斑病性腎炎

Outline of Final Research Achievements

HSPN is the most common pediatric secondary glomerulonephritis and has histological similarity with IgA nephropathy (IgAN). Histological severity in HSPN at the early stage of the disease correlates well with renal prognosis, and at present, renal biopsy is required for diagnosis and understanding of disease severity. Since renal biopsy is an invasive procedure, it would be very useful to make the diagnose and undertanding its severity using the non-invasive urine biomarker
Although some pathological variables can be predicted by urinary biomarker measurements in this study（FABP1、LTP2, Thy1, and CUBN m-RNA expression level), it was not possible to distinguish IgAN from HSPN at this point. As we found a significant positive correlation between proteinuria and KIM-1 expression level, it seemes to be possible to follow up the disease activity using regular measurements of urine biomarkers.

Academic Significance and Societal Importance of the Research Achievements

IgAN、HSPNのようなメサンギウム増殖を示す腎炎では一部の腎由来の蛋白のm-RAN発現レベルの低下を認め、尿バイオマーカーから病理組織を推定できる可能性が示されたが、HSPNにおいて、現時点で尿バイオマーカーの測定は侵襲的検査である腎生検に匹敵する情報量（診断、病理学的重症度）を得ることができなかったが、定期的な測定により、臨床的重症度（蛋白尿）と相関することが分かったため、疾患活動性のモニタリングとして使用できる可能性が高いことが示唆された。
今後、更に様々疾患、バイオマーカーの選定により精度があがり、侵襲的な腎生検を行わずに診断できるようになる可能性も十分に残されていると考えられた。

Research Products

• [Int'l Joint Research] Tronto General Hospital(カナダ)
• [Int'l Joint Research] Regina Margarita Hospital(イタリア)
• [Int'l Joint Research] University of Leicester(英国)
• [Int'l Joint Research] Cedars-Sinai Medical Center(米国)
• [Int'l Joint Research] Peking University First Hospital(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] Toronto General Hospital(カナダ)
• [Int'l Joint Research] Peking University First Hospital(中国)
• [Int'l Joint Research] Regina Margherita Hospital(イタリア)
• [Int'l Joint Research] Cedars-Sinai Medical Center(米国)
• [Int'l Joint Research] University of Leicester(米国)
• [Int'l Joint Research]
• [Int'l Joint Research] Regina Margherita Hospital, Turin(イタリア)
• [Int'l Joint Research] Cedars-Sinai Medical Center(米国)
• [Int'l Joint Research] University of Leicester(英国)
• [Int'l Joint Research] Toronto General Hospital(カナダ)
• [Int'l Joint Research] Peking University First Hospital(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] Regina Margherita Hospital, Turin(イタリア)
• [Int'l Joint Research] University of Leicester(英国)
• [Int'l Joint Research] Cedars-Sinai Medical Center(米国)
• [Int'l Joint Research] Toronto General Hospital(カナダ)
• [Int'l Joint Research] Peking University First Hospital,(中国)
• [Int'l Joint Research]
• [Journal Article] Clinical features of autosomal recessive polycystic kidney disease in the Japanese population and analysis of splicing in PKHD1 gene for determination of phenotypes (2022)
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  • Journal Title: Clin Exp Nephrol . Volume: 26 Issue: 2 Pages: 140-153
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• [Journal Article] Mycophenolate Mofetil after Rituximab for Childhood-Onset Complicated Frequently-Relapsing or Steroid-Dependent Nephrotic Syndrome (2022)
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• [Journal Article] A case of membranous nephropathy secondary to asymptomatic Graves' disease (2022)
  • Author(s): Moniwa N, Shioya Y, Gocho Y, Takahashi S, Tanaka M, Furuhashi M, Kuroda S, Hama T, Shima Y, Ogawa Y, Miura T.
  • Journal Title: CEN Case Rep. Volume: - Issue: 3 Pages: 309-313
  • DOI: 10.1007/s13730-021-00672-0
  • Peer Reviewed / Open Access
• [Journal Article] Use of renin-angiotensin system inhibitors as initial therapy in children with Henoch-Schonlein purpura nephritis of moderate severity (2022)
  • Author(s): Nagai S, Horinouchi T, Ninchoji T, Kondo A, Aoto Y, Ishiko S, Sakakibara N, Nagano C, Yamamura T, Kaito H, Tanaka R, Shima Y, Fujimura J, Kamiyoshi N, Ishimori S, Nakanishi K, Yoshikawa N, Iijima K, Nozu K.
  • Journal Title: Pediatr Nephrol. Volume: - Issue: 8 Pages: 1845-1853
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  • Peer Reviewed
• [Journal Article] Efficacy of combination therapy for childhood complicated focal IgA nephropathy (2022)
  • Author(s): Aoto Y, Ninchoji T, Kaito H, Shima Y, Fujimura J, Kamiyoshi N, Ishimori S, Nakanishi K, Minamikawa S, Ishiko S, Sakakibara N, Nagano C, Horinouchi T, Yamamura T, Nagai S, Kondo A, Inaguma Y, Tanaka R, Yoshikawa N, Iijima K, Nozu K.
  • Journal Title: Clin Exp Nephrol. Volume: - Issue: 6 Pages: 561-570
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  • Peer Reviewed
• [Journal Article] Comprehensive genetic analysis using next-generation sequencing for the diagnosis of nephronophthisis-related ciliopathies in the Japanese population (2022)
  • Author(s): Sakakibara N, Nozu K, Yamamura T, Horinouchi T, Nagano C, Ye MJ, Ishiko S, Aoto Y, Rossanti R, Hamada R, Okamoto N, Shima Y, Nakanishi K, Matsuo M, Iijima K, Morisada N.
  • Journal Title: J Hum Genet. Volume: - Issue: 7 Pages: 427-440
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  • Peer Reviewed
• [Journal Article] Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA nephropathy (2021)
  • Author(s): Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N.
  • Journal Title: Pediatric Nephrology Volume: 36 Issue: 4 Pages: 899-908
  • DOI: 10.1007/s00467-020-04772-4
  • Peer Reviewed
• [Journal Article] Non-immunosuppressive therapies for childhood IgA nephropathy (2021)
  • Author(s): Shima Yuko、Nakanishi Koichi、Yoshikawa Norishige
  • Journal Title: Pediatric Nephrology Volume: - Issue: 10 Pages: 3057-3065
  • DOI: 10.1007/s00467-021-04954-8
  • Peer Reviewed
• [Journal Article] Utility of glomerular Gd-IgA1 staining for indistinguishable cases of IgA nephropathy or Alport syndrome (2021)
  • Author(s): Ishiko Shinya、Tanaka Akihito、Takeda Asami、Hara Masayuki、Hamano Naoto、Koizumi Masahiro、Ueno Toshinori、Hayashi Hiroki、Kondo Atsushi、Nagai Sadayuki、Aoto Yuya、Nozu Kandai
  • Journal Title: Clinical and Experimental Nephrology Volume: Epub Issue: 7 Pages: 779-787
  • DOI: 10.1007/s10157-021-02054-3
  • NAID: 120007125745
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR) (2021)
  • Author(s): Urushihara M, Sato H, Shimizu A, Sugiyama H, Yokoyama H, Hataya H, Matsuoka K, Okamoto T, Ogino D, Miura K, Hamada R, Hibino S, Shima Y, Yamamura T, Kitamoto K, Ishihara M, Konomoto T, Hattori M; the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology.
  • Journal Title: Clin Exp Nephrol. Volume: 25 Issue: 9 Pages: 1018-1026
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  • Peer Reviewed / Open Access
• [Journal Article] Examination of the predicted prevalence of Gitelman syndrome by ethnicity based on genome database (2021)
  • Author(s): Kondo A, Nagano C, Ishiko S, Omori T, Aoto Y, Rossanti R, Sakakibara N, Horinouchi T, Yamamura T, Nagai S, Okada E, Shima Y, Nakanishi K, Ninchoji T, Kaito H, Takeda H, Nagase H, Morisada N, Iijima K, Nozu K.
  • Journal Title: Sci Rep. Volume: 11 Issue: 1 Pages: 16099-16099
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• [Journal Article] Systematic Review of Genotype-Phenotype Correlations in Frasier Syndrome (2021)
  • Author(s): Tsuji Y, Yamamura T, Nagano C, Horinouchi T, Sakakibara N, Ishiko S, Aoto Y, Rossanti R, Okada E, Tanaka E, Tsugawa K, Okamoto T, Sawai T, Araki Y, Shima Y, Nakanishi K, Nagase H, Matsuo M, Iijima K, Nozu K.
  • Journal Title: Kidney Int Rep . Volume: 6 Issue: 10 Pages: 2585-2593
  • DOI: 10.1016/j.ekir.2021.07.010
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  • Peer Reviewed / Open Access
• [Journal Article] Defining renal remission in an international cohort of 248 children and adolescents with lupus nephritis (2021)
  • Author(s): De Mutiis C, Wenderfer SE, Orjuela A, Bagga A, Basu B, Sar T, Aggarwal A, Jain A, Yap HK, Ito S, Ohnishi A, Iwata N, Kasapcopur O, Laurent A, Mastrangelo A, Ogura M, Shima Y, Rianthavorn P, Silva CA, Trindade V, Dormi A, Tullus K.
  • Journal Title: Rheumatology (Oxford) Volume: - Issue: 6 Pages: 2563-2571
  • DOI: 10.1093/rheumatology/keab746
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Last Nucleotide Substitutions of COL4A5 Exons Cause Aberrant Splicing (2021)
  • Author(s): Aoto Y, Horinouchi T, Yamamura T, Kondo A, Nagai S, Ishiko S, Okada E, Rossanti R, Sakakibara N, Nagano C, Awano H, Nagase H, Shima Y, Nakanishi K, Matsuo M, Iijima K, Nozu K.
  • Journal Title: Kidney Int Rep. Volume: 7 Issue: 1 Pages: 108-116
  • DOI: 10.1016/j.ekir.2021.10.012
  • NAID: 120007188929
  • Peer Reviewed / Open Access
• [Journal Article] Glomerular galactose-deficient IgA1 expression analysis in pediatric patients with glomerular diseases (2020)
  • Author(s): Ishiko Shinya、Horinouchi Tomoko、Fujimaru Rika、Shima Yuko et al.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1
  • DOI: 10.1038/s41598-020-71101-y
  • NAID: 120006954852
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genotype-phenotype correlations influence the response to angiotensin-targeting drugs in Japanese patients with male X-linked Alport syndrome (2020)
  • Author(s): Yamamura Tomohiko、Horinouchi Tomoko、Nagano China、Omori Takashi、Sakakibara Nana、Aoto Yuya、Ishiko Shinya、Nakanishi Koichi、Shima Yuko、Nagase Hiroaki、Takeda Hiroki、Rossanti Rini、Ye Ming Juan、Nozu Yoshimi、Ishimori Shingo、Ninchoji Takeshi、Kaito Hiroshi、Morisada Naoya、Iijima Kazumoto、Nozu Kandai
  • Journal Title: Kidney International Volume: 98 Issue: 6 Pages: 1605-1614
  • DOI: 10.1016/j.kint.2020.06.038
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of clinical and genetic characteristics between Dent disease 1 and Dent disease 2 (2020)
  • Author(s): Sakakibara Nana、Nagano China、Ishiko Shinya、Horinouchi Tomoko、Yamamura Tomohiko、Minamikawa Shogo、Shima Yuko、Nakanishi Koichi、Ishimori Shingo、Morisada Naoya、Iijima Kazumoto、Nozu Kandai
  • Journal Title: Pediatric Nephrology Volume: 35 Issue: 12 Pages: 2319-2326
  • DOI: 10.1007/s00467-020-04701-5
  • NAID: 120007052636
  • Peer Reviewed
• [Journal Article] A case with somatic and germline mosaicism in COL4A5 detected by multiplex ligation-dependent probe amplification in X-linked Alport syndrome (2020)
  • Author(s): Aoto Yuya、Kise Tomoo、Nakanishi Koichi、Nagano China、Horinouchi Tomoko、Yamamura Tomohiko、Ishiko Shinya、Sakakibara Nana、Shima Yuko、Morisada Naoya、Iijima Kazumoto、Nozu Kandai
  • Journal Title: CEN Case Reports Volume: 9 Issue: 4 Pages: 431-436
  • DOI: 10.1007/s13730-020-00503-8
  • Peer Reviewed / Open Access
• [Journal Article] Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome (2020)
  • Author(s): Jia Xiaoyuan、Yamamura Tomohiko、et al.
  • Journal Title: Kidney International Volume: 98 Issue: 5 Pages: 1308-1322
  • DOI: 10.1016/j.kint.2020.05.029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathogenic evaluation of synonymous COL4A5 variants in X‐linked Alport syndrome using a minigene assay (2020)
  • Author(s): Horinouchi Tomoko、Yamamura Tomohiko、Minamikawa Shogo、Nagano China、Sakakibara Nana、Nakanishi Koichi、Shima Yuko、Morisada Naoya、Ishiko Shinya、Aoto Yuya、Nagase Hiroaki、Takeda Hiroki、Rossanti Rini、Ishimori Shingo、Kaito Hiroshi、Matsuo Masafumi、Iijima Kazumoto、Nozu Kandai
  • Journal Title: Molecular Genetics & Genomic Medicine Volume: 8 Issue: 8
  • DOI: 10.1002/mgg3.1342
  • NAID: 120006879547
  • Peer Reviewed / Open Access
• [Journal Article] Crescentic IgA nephropathy in children. (2020)
  • Author(s): Shima Y, Nakanishi K, Hama T, Mukaiyama H, Sato M, Tanaka Y, Tanaka R, Kaito H, Nozu K, Sako M, Iijima K, Yoshikawa N.
  • Journal Title: Pediatr Nephrol. Volume: - Issue: 6 Pages: 1005-1014
  • DOI: 10.1007/s00467-020-04483-w
  • Peer Reviewed
• [Journal Article] Molecular mechanisms determining severity in patients with Pierson syndrome (2020)
  • Author(s): Minamikawa Shogo、Miwa Saori、Inagaki Tetsuji、Nishiyama Kei、Kaito Hiroshi、Ninchoji Takeshi、Yamamura Tomohiko、Nagano China、Sakakibara Nana、Ishimori Shingo、Hara Shigeo、Yoshikawa Norishige、Hirano Daishi、Harada Ryoko、Hamada Riku、Matsunoshita Natsuki、Nagata Michio、Shima Yuko、Nozu Kandai
  • Journal Title: Journal of Human Genetics Volume: 65 Issue: 4 Pages: 355-362
  • DOI: 10.1038/s10038-019-0715-0
  • NAID: 120006811107
  • Peer Reviewed
• [Journal Article] Comprehensive genetic diagnosis of Japanese patients with severe proteinuria. (2020)
  • Author(s): Nagano C, Yamamura T, Horinouchi T, Aoto Y, Ishiko S, Sakakibara N, Shima Y, Nakanishi K, Nagase H, Iijima K, Nozu K.
  • Journal Title: Sci Rep. Volume: 10(1) Issue: 1 Pages: 428-437
  • DOI: 10.1038/s41598-019-57149-5
  • NAID: 120006884200
  • Peer Reviewed / Open Access
• [Journal Article] Neonatal diabetes caused by the heterozygous Pro1198Leu mutation in the ABCC8 gene in a male infant: 6-year clinical course. (2020)
  • Author(s): Uraki S, Furuta H, Miyawaki M, Matsutani N, Shima Y, Iwamoto M, Matsuno S, Morita S, Furuta M, Doi A, Iwakura H, Ariyasu H, Nishi M, Suzuki H, Akamizu T.
  • Journal Title: J Diabetes Investig. Volume: 11(2) Issue: 2 Pages: 502-505
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• [Journal Article] Determination of the pathogenicity of known COL4A5 intronic variants by in vitro splicing assay. (2019)
  • Author(s): Horinouchi T, Nozu K, Yamamura T, Minamikawa S, Nagano C, Sakakibara N, Nakanishi K, Shima Y, Morisada N, Ishiko S, Aoto Y, Nagase H, Takeda H, Rossanti R, Kaito H, Matsuo M, Iijima K.
  • Journal Title: Sci Rep. Volume: 9(1) Issue: 1 Pages: 12696-12696
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• [Journal Article] Comparison between conventional and comprehensive sequencing approaches for genetic diagnosis of Alport syndrome. (2019)
  • Author(s): Yamamura T, Nozu K, Minamikawa S, Horinouchi T, Sakakibara N, Nagano C, Aoto Y, Ishiko S, Nakanishi K, Shima Y, Nagase H, Rossanti R, Ye MJ, Nozu Y, Ishimori S, Morisada N, Kaito H, Iijima K.
  • Journal Title: Mol Genet Genomic Med. Volume: 7(9) Issue: 9
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  • NAID: 120006733124
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• [Journal Article] Clinical spectrum of male patients with OFD1 mutations. (2019)
  • Author(s): Sakakibara N, Morisada N, Nozu K, Nagatani K, Ohta T, Shimizu J, Wada T, Shima Y, Yamamura T, Minamikawa S, Fujimura J, Horinouchi T, Nagano C, Shono A, Ye MJ, Nozu Y, Nakanishi K, Iijima K.
  • Journal Title: J Hum Genet. Volume: 64 Issue: 1 Pages: 3-9
  • DOI: 10.1038/s10038-018-0532-x
  • NAID: 120006888530
  • Peer Reviewed
• [Journal Article] Lisinopril versus lisinopril and losartan for mild childhood IgA nephropathy: a randomized controlled trial (JSKDC01 study). (2019)
  • Author(s): Shima Y, Nakanishi K, Sako M, Saito-Oba M, Hamasaki Y, Hataya H, Honda M, Kamei K, Ishikura K, Ito S, Kaito H, Tanaka R, Nozu K, Nakamura H, Ohashi Y, Iijima K, Yoshikawa N; Japanese Study Group of Kidney Disease in Children (JSKDC).
  • Journal Title: Pediatr Nephrol. Volume: 34 Issue: 5 Pages: 837-846
  • DOI: 10.1007/s00467-018-4099-8
  • Peer Reviewed
• [Journal Article] Clinical and Genetic Characteristics in Patients With Gitelman Syndrome. (2018)
  • Author(s): Fujimura J, Nozu K, Yamamura T, Minamikawa S, Nakanishi K, Horinouchi T, Nagano C, Sakakibara N, Nakanishi K, Shima Y, Miyako K, Nozu Y, Morisada N, Nagase H, Ninchoji T, Kaito H, Iijima K.
  • Journal Title: Kidney Int Rep. Volume: ４ Issue: 1 Pages: 119-125
  • DOI: 10.1016/j.ekir.2018.09.015
  • NAID: 120006847258
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological characteristics and renal outcomes of childhood-onset lupus nephritis with acute kidney injury: A multicenter study. (2018)
  • Author(s): Ishimori S, Kaito H, Shima Y, Kamioka I, Hamahira K, Nozu K, Nakanishi K, Tanaka R, Yoshikawa N, Iijima K.
  • Journal Title: Mod Rheumatol. Volume: 印刷中 Issue: 6 Pages: 970-976
  • DOI: 10.1080/14397595.2018.1532861
  • Peer Reviewed
• [Journal Article] Study protocol: high-dose mizoribine with prednisolone therapy in short-term relapsing steroid-sensitive nephrotic syndrome to prevent frequent relapse (JSKDC05 trial). (2018)
  • Author(s): Hama T, Nakanishi K, Ishikura K, Ito S, Nakamura H, Sako M, Saito-Oba M, Nozu K, Shima Y, Iijima K, Yoshikawa N; Japanese Study Group of Kidney Disease in Children (JSKDC).
  • Journal Title: BMC Nephrol. Volume: 19 Issue: 1 Pages: 223-223
  • DOI: 10.1186/s12882-018-1033-z
  • NAID: 120006523804
  • Peer Reviewed / Open Access
• [Journal Article] Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population. (2018)
  • Author(s): Jia X, Horinouchi T, Hitomi Y, Shono A, Khor SS, Omae Y, Kojima K, Kawai Y, Nagasaki M, Kaku Y, Okamoto T, Ohwada Y, Ohta K, Okuda Y, Fujimaru R, Hatae K, Kumagai N, Sawanobori E, Nakazato H, Ohtsuka Y, Nakanishi K, Shima Y, Tanaka R, Ashida A, Kamei K, Ishikura K, Nozu K, Tokunaga K, Iijima K
  • Journal Title: J Am Soc Nephrol. Volume: 29 Issue: 8 Pages: 2189-2199
  • DOI: 10.1681/asn.2017080859
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combination therapy with or without warfarin and dipyridamole for severe childhood IgA nephropathy: an RCT. (2018)
  • Author(s): Shima Y, Nakanishi K, Kaku Y, Ishikura K, Hataya H, Matsuyama T, Honda M, Sako M, Nozu K, Tanaka R, Iijima K, Yoshikawa N; Japanese Pediatric IgA Nephropathy Treatment Study Group.
  • Journal Title: Pediatr Nephrol. Volume: 33 Issue: 11 Pages: 2103-2112
  • DOI: 10.1007/s00467-018-4011-6
  • Peer Reviewed
• [Journal Article] Detection of Splicing Abnormalities and Genotype-Phenotype Correlation in X-linked Alport Syndrome. (2018)
  • Author(s): Horinouchi T, Nozu K, Yamamura T, Minamikawa S, Omori T, Nakanishi K, Fujimura J, Ashida A, Kitamura M, Kawano M, Shimabukuro W, Kitabayashi C, Imafuku A, Tamagaki K, Kamei K, Okamoto K, Fujinaga S, Oka M, Igarashi T, Miyazono A, Sawanobori E, Fujimaru R, Nakanishi K, Shima Y et al
  • Journal Title: J Am Soc Nephrol. Volume: 29 Issue: 8 Pages: 2244-2254
  • DOI: 10.1681/asn.2018030228
  • Peer Reviewed / Open Access
• [Journal Article] Serine Protease Inhibitor Kazal Type I (SPINK1) Mutation: A Risk Factor for Early-onset Chronic Pancreatitis? (2018)
  • Author(s): Hama T, Nakanishi N, Suzuki M, Shima Y, Suzuki H.
  • Journal Title: J Pediatr Gastroenterol Nutr. Volume: 67 Issue: 2
  • DOI: 10.1097/mpg.0000000000002024
  • Peer Reviewed
• [Journal Article] Development of ultra-deep targeted RNA sequencing for analyzing X-chromosome inactivation in female Dent disease (2018)
  • Author(s): Minamikawa S, Nozu K, Nozu Y, Yamamura T, Taniguchi-Ikeda M, Nakanishi K, Fujimura J, Horinouchi T, Shima Y, Nakanishi K, Hattori M, Kanda K, Tanaka R, Morisada N, Nagano C, Sakakibara N, Nagase H, Morioka I, Kaito H, Iijima K.
  • Journal Title: Journal of Human Genetics Volume: 63 Issue: 5 Pages: 589-595
  • DOI: 10.1038/s10038-018-0415-1
  • Peer Reviewed
• [Presentation] 重度の小児IgA腎症に対するプレドニゾロン、ミゾリビン、リシノプリルを用いた3剤併用治療法の有効性の検討 (2022)
  • Author(s): 島友子、向山弘展、田中侑、和田卓三、貝藤裕史、田中亮二郎、野津寛大、飯島一誠、吉川徳茂、中西浩一
  • Organizer: 第45回IgA 腎症研究会学術集会
• [Presentation] 遺伝子解析で診断しえた軽症常染色体劣性多発性嚢胞腎の長期経過 (2022)
  • Author(s): 島友子、向山弘展、田中侑、和田卓三、中西浩一
  • Organizer: 第35回近畿小児科学会
• [Presentation] Efficacy of New Combination Therapy with Prednisolone, Mizoribine, and Lisinopril for Severe Childhood IgA Nephropathy. (2021)
  • Author(s): Shima Y, Mukaiyama H, Tanaka Y, Wada T, Kaito H, R, Tanaka R, Nozu K, Iijima K, Yoshikawa N, Nakanishi K.
  • Organizer: The 54th Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Two male relatives with OFD1 mutations. (2021)
  • Author(s): Wada T, Shima Y, Tanaka Y, Mukaiyama H, Morisada N, Nozu K, Iijima K, Nakanishi K.
  • Organizer: The 18th Japan-Korea-China Pediatric Nephrology Seminar
  • Int'l Joint Research
• [Presentation] Pediatric IgA Nephropathy. (2021)
  • Author(s): Shima Y
  • Organizer: The 16th congress of Asian Society for Pediatric Reserch
  • Int'l Joint Research / Invited
• [Presentation] Oxford分類を用いた小児IgA腎症、紫斑病性腎炎の臨床病理学的所見の比較 (2021)
  • Author(s): 島友子、中西浩一、田中侑、向山弘展、和田卓三、浜武継、佐藤匡、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、鈴木啓之、吉川徳茂
  • Organizer: 第124回日本小児科学会学術集会
• [Presentation] Oxford 分類による小児 IgA 腎症（IgAN），紫斑病性腎炎（IgAVN）の臨床病理学的検討 (2021)
  • Author(s): 島友子、浜武継、向山弘展、田中侑、野津寛大、田中亮二郎、飯島一誠、吉川徳茂、中西浩一
  • Organizer: 第50回日本腎臓学会学術総会
• [Presentation] IgA腎症Oxford分類を用いた病理学的重症度スコアリングの開発と検証 (2021)
  • Author(s): 島友子、向山弘展、田中侑、和田卓三、野津寛大、田中亮二郎、飯島一誠、吉川徳茂、中西浩一
  • Organizer: 第56回日本小児腎臓病学会
• [Presentation] 遺伝子解析で診断しえた軽症常染色体劣性多発性嚢胞腎の長期経過 (2021)
  • Author(s): 島友子、島袋渡、向山弘展、田中侑、和田卓三、森貞直哉、野津寛大、飯島一誠、中西浩一
  • Organizer: 第29回発達腎研究会
• [Presentation] Comparison of clinicopathological findings between childhood IgA nephropathy and IgA vasculitis nephritis using Oxford classification (2021)
  • Author(s): Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Nozu K, Tanaka R, Iijima K, Yoshikawa N
  • Organizer: The 14th Asian Congress of Pediatric Nephrology
  • Int'l Joint Research
• [Presentation] The combination therapy for pathologically mild childhood IgA nephropathy. (2021)
  • Author(s): Aoto Y, Iijima K, Nozu K, Kaito H, Inaguma Y, Yoshikawa N, Kondo A, Nagai S, Yamamura T, Horinouchi T, Nagano C, Sakakibara N, Ishiko S, Minamikawa S, Nakanishi K, Shima Y, Ishimori S, Kamiyoshi N, Fujimura J, Ninchoji T
  • Organizer: The 14th Asian Congress of Pediatric Nephrology
  • Int'l Joint Research
• [Presentation] Evaluation of synonymous variants of COL4A3 and COL4A4 in suspected autosomal Alport Syndrome patients using an in vitro splicing assay. (2021)
  • Author(s): Rossanti R, Horinouchi T, Yamamura T, Nagano C, Sakakibara N, Ishiko S, Aoto Y, Kondo A, Nagai S, Okada E, Ishimori S, Nagase H, Matsui S, Tamagaki K, Ubara Y, Nagahama M, Shima Y, Nakanishi K, Matsuo M, Ninchoji T, Nozu K, Iijima K.
  • Organizer: The 14th Asian Congress of Pediatric Nephrology
  • Int'l Joint Research
• [Presentation] Oxford分類を用いた小児IgA腎症・紫斑病性腎炎の臨床病理学的所見の比較 (2021)
  • Author(s): 島友子、中西浩一、浜武継、向山弘展、佐藤匡、田中侑、和田卓三、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、鈴木啓之、吉川徳茂
  • Organizer: 第55回日本小児腎臓病学会
• [Presentation] 小児慢性腎炎における糖鎖不全IgA1（Gd-IgA1）免疫染色の有用性の検討 (2021)
  • Author(s): 石河慎也、野津寛大、近藤淳、永井貞之、青砥悠哉、榊原菜々、長野智那、堀之内智子、山村智彦、島 友子、中西浩一、吉川徳茂、飯島一誠
  • Organizer: 第55回日本小児腎臓病学会
• [Presentation] びまん性メサンギウム細胞増殖を呈する特発性ネフローゼ症候群の臨床病理学的検討 (2021)
  • Author(s): 永井貞之、山村智彦、近藤淳、青砥悠哉、石河慎也、榊原菜々、長野智那、堀之内智子、忍頂寺毅史、島友子、中西浩一、吉川徳茂、野津寛大、飯島一誠
  • Organizer: 第55回日本小児腎臓病学会
• [Presentation] IgA腎症Oxford分類を用いた病理学的重症度スコアリングの開発と検証 (2021)
  • Author(s): 島友子、向山弘展、田中侑、和田卓三、野津寛大、田中亮二郎、飯島一誠、吉川徳茂、中西浩一
  • Organizer: 第44回IgA腎症研究会
• [Presentation] Comparison of clinicopathological findings between childhood IgA nephropathy and IgA vasculitis nephritis using Oxford classification (2020)
  • Author(s): Shima Y, Nakanishi K, Mukaiyama H, Tanaka Y, Wada T, Nozu K, Tanaka R, Iijima, K, Yoshikawa N
  • Organizer: The 53rd Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] NPHS1 Variants Can Cause Persistent Asymptomatic Proteinuria: Genetic and Clinical Characteristics of Patients with NPHS1 Variants in Japan (2020)
  • Author(s): Yamamura T,Horinouchi T, Ishiko S, Aoto Y, Sakakibara N, Nagano C, Ninchoji T, Shima Y, Nakanishi K, Nozu K, Iijima K
  • Organizer: The 53rd Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] A Case with Somatic and Germline Mosaicism in COL4A5 Detected by Multiplex Ligation-Dependent Probe Amplification in X-Linked Alport Syndrome (2020)
  • Author(s): Aoto Y, Nakanishi K, Nagano C, Horinouchi T, Yamamura T, Ishiko S, Sakakibara N, Shima Y, Iijima K, Nozu K
  • Organizer: The 53rd Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] Glomerular Galactose-Deficient IgA1 Expression Analysis in Pediatric Patients with Glomerular Diseases (2020)
  • Author(s): Ishiko S, Nozu K,Fujimaru R,Shima Y, Kaito H, Tanaka R, Ishimori S, Aoto Y, Sakakibara N, Nagano C, Horinouchi T, Yamamura T, Ninchoji T, Nakanishi K, Yoshikawa N, Iijima K
  • Organizer: The 53rd Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] 小児IgA 腎症におけるプレドニゾロン（PSL）＋ミゾリビン＋RA系阻害薬3 剤治療の有用性の検討 (2020)
  • Author(s): 島友子、中西浩一、浜武継、向山弘展、田中侑、吉川徳茂
  • Organizer: 第63回日本腎臓学会学術総会
• [Presentation] OFD1変異を持つ男性親族の2例 (2020)
  • Author(s): 島友子、中西浩一、田中侑、向山弘展、森貞直哉、野津寛大、飯島一誠、吉川徳茂
  • Organizer: 第50回日本腎臓学会西部学術大会
• [Presentation] Galactose-deficient IgA1 expression analysis is a useful tool for the diagnosis of IgA nephropathy: Two pediatric cases with pathological diagnosis of IgA nephroapthy. (2019)
  • Author(s): Ishiko S, Nozu K, Shima Y, Hara S, Aoto Y, Sakakibara N, Nagano C, Minamikawa S, Yamamura T, Yoshikawa N, Nakanishi K, Iijima K
  • Organizer: The 17th Japan-Korea-China Pediatric nephrology Seminar
  • Int'l Joint Research
• [Presentation] Two siblings of familial hematuria with thin basement membrane and family history of end stage kidney disease. (2019)
  • Author(s): Shima Y, Nakanishi K, Nozu K, Yamamura T, Hama T, Mukaiyama H, Suzuki H, Iijima K, Yoshikawa N
  • Organizer: The 17th Japan-Korea-China Pediatric nephrology Seminar
  • Int'l Joint Research
• [Presentation] Factord related to proteinuria relapse in childhood IgA nephropathy. (2019)
  • Author(s): Shima Y, Nakanishi K, Hama T, Tanaka Y, Wada T, Mukaiyama H, Sato M, Nozu K, Kaito H, Tanaka R, Suzuki H, Iijima K, Yoshikawa N
  • Organizer: 18th Congress of International Pediateic Nephrology Association
  • Int'l Joint Research
• [Presentation] Two male relatives with OFD1 mutation. (2019)
  • Author(s): Wada T, Shima Y, Hama T, Tanaka Y, Mukaiyama H, Sato M, Morisada N, Nozu K, Yoshikawa N, Iijima K, Nakanishi K, Suzuki H.
  • Organizer: 18th Congress of International Pediateic Nephrology Association
  • Int'l Joint Research
• [Presentation] Treatment with ACE-I/ARBs in Childhood Mild IgA Nephropathy. Long-Term Treatment with ACE-I/ARBs in Childhood Mild IgA Nephropathy. (2019)
  • Author(s): Shima Y, Nakanishi K, Hama T, Tanaka Y, Mukaiyama H, Sato M, Wada T, Nozu K, Iijima, K, Yoshikawa N.
  • Organizer: 52nd Annual Meeting of the American Society of Nephrology,
  • Int'l Joint Research
• [Presentation] Epidemiology of IgA Nephropathy in children (IgA Nephropathy) (2019)
  • Author(s): Shima Y
  • Organizer: 18th Congress of International Pediateic Nephrology Association
  • Int'l Joint Research / Invited
• [Presentation] Forty years of studies in IgAN: what we have learned? (IgA Nephropathy and Henocho Schonlein Purpura Nephropathy) (2019)
  • Author(s): Yoshikawa N, Shima Y
  • Organizer: 18th Congress of International Pediateic Nephrology Association
  • Int'l Joint Research / Invited
• [Presentation] 小児IgA腎症のEBM＜シンポジウム 小児腎疾患のEBMの進歩と移行医療＞ (2019)
  • Author(s): 島 友子
  • Organizer: 第62回日本腎臓学会学術総会
• [Presentation] 小児IgA腎症における蛋白尿再燃因子の検討 (2018)
  • Author(s): 島友子、中西浩一、浜武継、田中侑、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、吉川徳茂、鈴木啓之
  • Organizer: 日本小児科学会学術集会
• [Presentation] 小児Silent lupus nephritisに関する臨床病理学的検討 (2018)
  • Author(s): 島友子、中西浩一、浜武継、田中侑、佐藤匡、向山弘展、戸川寛子、貝藤裕史、野津寛大、田中亮二郎、鈴木啓之、飯島一誠、吉川徳茂
  • Organizer: 日本小児腎臓病学会
• [Presentation] 小児IgA腎症における蛋白尿再燃因子の検討 (2018)
  • Author(s): 島友子、中西浩一、浜武継、田中侑、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、吉川徳茂、鈴木啓之
  • Organizer: 日本小児腎不全学会
• [Presentation] Clinicopathological significance in juvenile-onset silent lupus nephritis (2018)
  • Author(s): Yuko Shima, Koichi Nakanishi, Taketsugu Hama, Masashi Sato, Yu Tanaka, Hironobu Mukaiyama, Hiroshi Kaito, Kandai Nozu, Ryojiro Tanaka, Hiroyuki Suzuki, Kazumoto Iijima, Norishige Yoshikawa
  • Organizer: American Society of Nephrology
  • Int'l Joint Research
• [Book] CKD・AKI診療ガイドラインの内側と外側 こんなときどう考える？どうする？ (2020)
  • Author(s): 島 友子
  • Total Pages: 304
  • Publisher: 日本医事新報社
  • ISBN: 9784784957699
• [Book] 小児の診療手技 (2019)
  • Author(s): 島 友子
  • Total Pages: 444
  • Publisher: 診断と治療社
• [Book] IgA腎症の病態と治療 (2019)
  • Author(s): 島 友子
  • Total Pages: 317
  • Publisher: 中外医学者
  • ISBN: 9784498224469
• [Book] IgA腎症の臨床 (2018)
  • Author(s): 編集： 湯村 和子
  • Total Pages: 333
  • Publisher: 東京医学社
  • ISBN: 9784885632976