Diagnosis of inherited arrhythmias and prediction of life-threatening arrhythmias in children using newly developed high resolution electrocardiography
Project/Area Number |
18K07813
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 先天性QT延長症候群 / 再分極過程 / T波 / 独立成分分析 / 主成分分析 / 幾何学的形態測定 / 遺伝性不整脈 / 遺伝子変異 / 心電図 / 心筋再分極過程 |
Outline of Final Research Achievements |
High frequency electrocardiographic data were obtained from patients with congenital long QT syndrome (LQTS) and multivariate analyses were applied to the repolarization process of electrocardiograms (T wave area), and the results were compared with the genotype. Independent component analysis (ICA) revealed that T waves in all normal control subjects were composed of 4 independent components (ICs), and that T waves in LQTS (type 1-3) were 5-7 ICs, including additional abnormal ICs. Principal component analysis (PCA) revealed that the PCA ratios (second/first eigenvector ratios) in LQTS (type 1-3, 7) were higher than those in normal subjects. These results may imply dispersion of repolarization process and resultant inducibility of arrhythmias in LQTS. Furthermore, T waves in LQTS type 3 could be differentiated from those in normal subjects based only on morphology itself, independent of QT intervals, by geometrics morphometrics.
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Academic Significance and Societal Importance of the Research Achievements |
遺伝性不整脈の代表である先天性QT延長症候群(LQTS)の心電図のT波には重要な電気生理学的情報が含まれている。そこで高精度心電図を記録し、T波部分(再分極過程)のデータに多変量解析法を応用した結果、同法はLQTSの遺伝子型診断に有用であることが判明した。また、再分極過程の不均一性の評価から不整脈発生基質を検出でき、致死的不整脈の予防に役立つ可能性があることが示された。
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Report
(4 results)
Research Products
(109 results)
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[Journal Article] Diagnostic value of P-waves in children with idiopathic restrictive cardiomyopathy2021
Author(s)
Muraji S, Sumitomo N, Imamura T, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Yoshinaga M, Nakano S
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Journal Title
Heart and Vessels
Volume: ―
Pages: 1141-1150
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genetic Background of Catecholaminergic Polymorphic Ventricular Tachycardia in Japan2020
Author(s)
Kawamura M, Ohno S, Naiki N, Nagaoka I, Dochi K, Wang Q, Hasegawa K, Kimura H, Miyamoto A, Mizusawa Y, Itoh H, Makiyama T, Sumitomo N, Ushinohama H, Oyama K, Murakoshi N, Aonuma K, Horigome H, Honda T, Yoshinaga M, Ito M, Horie M
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Journal Title
Circulation Journal
Volume: 84
Issue: 11
Pages: 2124-2126
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2020-10-23
Related Report
Open Access
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[Journal Article] Co-Phenotype of Left Ventricular Non-Compaction Cardiomyopathy and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia in Association With R169Q, a <i>Ryanodine Receptor Type 2</i> Missense Mutation2020
Author(s)
Nozaki Y, Kato Y, Uike K, Yamamura K, Kikuchi M, Yasuda M, Ohno S, Horie M, Murayama T, Kurebayashi N, Horigome H
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Journal Title
Circulation Journal
Volume: 84
Issue: 2
Pages: 226-234
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2020-01-24
Related Report
Peer Reviewed / Open Access
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[Journal Article] Direct oral anticoagulant use and outcomes in adult patients with Fontan circulation: A multicenter retrospective cohort study2020
Author(s)
Kawamatsu N, Ishizu T, Machino-Ohtsuka T, Masuda K, Horigome H, Takechi F, Tateno S, Fukuda T, Kijima Y, Shiina Y, Komiyama N, Niwa K, Hiramatsu Y, Ieda M
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Journal Title
International Journal of Cardiology
Volume: ―
Pages: 74-79
DOI
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Peer Reviewed
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[Journal Article] Genotype predicts outcomes in fetuses and neonates with severe congenital long QT syndrome2020
Author(s)
Moore JP, Gallotti RG, Shannon KM, Bos JM, Sadeghi E, Strasburger JF, Wakai RT, Horigome H, Clur SA, Hill AC, Shah MJ, Behere S, Sarquella-Brugada G, Czosek R, Etheridge SP, Fischbach P, Kannankeril PJ, Motonaga K, Landstrom AP, Williams M, Patel A, Dagradi F, Tan RB, Stephenson E, Krishna MR, Miyake CY, Lee ME, et al.
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Journal Title
JACC. Clinical Electrophysiology
Volume: 6
Issue: 12
Pages: 1561-1570
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Promoting physical activity through walking to treat childhood obesity, mainly for mild to moderate obesity.2020
Author(s)
Masao Yoshinaga , Ayumi Miyazaki , Machiko Aoki , Hiromitsu Ogata , Yoshiya Ito , Takashi Hamajima , Masakuni Tokuda , Lisheng Lin , Hitoshi Horigome , Hideto Takahashi , Masami Nagashima
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Journal Title
Pediatrics international
Volume: 0
Issue: 8
Pages: 0-0
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The impact of right bundle branch block on right ventricular size and function assessed by three-dimensional speckle-tracking echocardiography2020
Author(s)
Nakazawa N, Ishizu T, Seo Y, Kawamatsu N, Sato K, Yamamoto M, Machino-Ohtsuka T, Horigome H, Hiramatsu Y, Ieda M, Kawakami Y
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Journal Title
Heart and Vessels
Volume: 35
Issue: 4
Pages: 576-585
DOI
Related Report
Peer Reviewed
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[Journal Article] Mothers with long QT syndrome are at increased risk for fetal death: findings from a multicenter international study2020
Author(s)
Cuneo BF, Kaizer AM, Clur SA, Swan H, Herberg U, Winbo A, Rydberg A, Haugaa K, Etheridge S, Ackerman MJ, Dagradi F, Killen SAS, Wacker-Gussmann A, Benson DW, Wilde AAM, Pan Z, Lam A, Spazzolini C, Horigome H, Schwartz PJ.
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Journal Title
American Journal of Obstetrics and Gynecology
Volume: 222
Issue: 3
Pages: 263.e1-263.e11
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Multivariate analysis of TU wave complex on electrocardiogram in Andersen-Tawil syndrome with KCNJ2 mutations2019
Author(s)
Horigome H, Ishikawa Y, Kokubun N, Yoshinaga M, Sumitomo N, Lin L, Kato Y, Tanabe‐Kameda Y, Ohno S, Nagashima M, Horie M
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Journal Title
Annals of Noninvasive Electrocardiology
Volume: Epub
Issue: 3
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antenatal Therapy for Fetal Supraventricular Tachyarrhythmias2019
Author(s)
Miyoshi T, Maeno Y, Hamasaki T, Inamura N, Yasukochi S, Kawataki M, Horigome H, Yoda H, Taketazu M, Nii M, Hagiwara A, Kato H, Shimizu W, Shiraishi I, Sakaguchi H, Ueda K, Katsuragi S, Yamamoto H, Sago H, Ikeda T
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Journal Title
Journal of the American College of Cardiology
Volume: 74
Issue: 7
Pages: 874-885
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Noninvasive Mapping of Premature Ventricular Contractions by Merging Magnetocardiography and Computed Tomography2019
Author(s)
Aita S, Ogata K, Yoshida K, Inaba T, Kosuge H, Machino T, Tsumagari Y, Hattori A, Ito Y, Komatsu Y, Sekihara K, Horigome H, Aonuma K, Nogami A, Kandori A, Ieda M
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Journal Title
JACC: Clinical Electrophysiology
Volume: 5
Issue: 10
Pages: 1144-1157
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Structural relation between the superior vena cava and pulmonary veins in patients with atrial fibrillation2019
Author(s)
Yoshida K, Baba M, Hasebe H, Shinoda Y, Harunari T, Ebine M, Uehara Y, Watabe H, Takeyasu N, Horigome H, Nogami A, Ieda M
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Journal Title
Heart and Vessels
Volume: 34
Issue: 12
Pages: 2052-2058
DOI
Related Report
Peer Reviewed
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[Journal Article] Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia2019
Author(s)
Lieve KVV, Verhagen JMA, Wei J, Bos JM, van der Werf C, Roses I Noguer F, Mancini GMS, Guo W, Wang R, van den Heuvel F, Frohn-Mulder IME, Shimizu W, Nogami A, Horigome H, Roberts JD, Leenhardt A, Crijns HJG, Blank AC, Aiba T, Wiesfeld ACP, Blom NA, Sumitomo N, Till J, Ackerman MJ, Chen SRW, van de Laar IMBH, Wilde AAM
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Journal Title
Heart Rhythm
Volume: 16(2)
Issue: 2
Pages: 220-228
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) ― Digest Version ―2018
Author(s)
umitomo N, Baba R, Doi S, Higaki T, Horie M, Nagashima M, Niwa K, Ogawa S, Okumura K, Tsutsui H (et al. )
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Journal Title
Circulation Journal
Volume: 82
Issue: 9
Pages: 2385-2444
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2018-08-24
Related Report
Peer Reviewed / Open Access
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[Presentation] Characterization of the TU-wave complex of Andersen-Tawil syndrome with KCNJ2 mutations using high-frequency ECG data2019
Author(s)
Horigome H, Ishikawa Y, Kokubun N, Yoshinaga M, Sumitomo N, Lin L, Kato Y, Tanabe-Kameda Y, Ohno S, Nagashima M, Horie M
Organizer
APHRS 2019: 12th Asia Pacific Heart Rhythm Society Scientific Session
Related Report
Int'l Joint Research
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[Presentation] Management of high-risk congenital long QT syndrome with atrioventricular block in fetal and neonatal life2019
Author(s)
Lin L, Horigome H, Shiono J, Iwamoto M, Ohashi N, Goto H, Suzuki T, Takahashi K, Miura M, Yoshinaga M, Sumitomo N
Organizer
APHRS 2019: 12th Asia Pacific Heart Rhythm Society Scientific Session
Related Report
Int'l Joint Research
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[Presentation] Electrocardiographic Screening of 1-Month-Old Infants to Prevent Sudden Infant Death2018
Author(s)
Yoshinaga M, Ushinohama H, Sato S, Horigome H, Hata T, Tauchi N, Nishihara E, Sumitomo N, Ozawa A, Ichida F, Shiraishi H, Nomura Y, Kucho Y, Takahashi H, Ohno S, Nagashima M
Organizer
Heart Rhythm Scientific Sessions 2018
Related Report
Int'l Joint Research
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