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Oxysterol as a biomarker for pediatric acute liver failure

Research Project

Project/Area Number 18K07833
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionKurume University

Principal Investigator

Mizuochi Tatsuki  久留米大学, 医学部, 講師 (20368921)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsオキシステロール / 小児 / 肝臓病 / 急性肝不全 / バイオマーカー / 胆道閉鎖症 / 肝不全
Outline of Final Research Achievements

In this study, we aimed to clarify whether serum and urinary oxysterol is a useful biomarker for pediatric acute live failure.
Unfortunatelly, we could not collect sufficient number of samples to clarify which oxysterol is useful. However, we identified some oxysterols may have a potential for the biomarker. Next step, we would like to collect more samples of pediatric acute liver failure to clarify which oxysterol is the best biomarker for pediatric acute liver failure.

Academic Significance and Societal Importance of the Research Achievements

小児急性肝不全は稀な疾患であるが、予後不良なことが多い。小児急性肝不全の症例から非侵襲的に取得できる検体を用いて、早期診断や予後予測できるバイオマーカーが見つかれば、予後改善に繋がると考えられる。本研究は小児急性肝不全の治療と予後をより良くするために有用な研究と考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2021 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] A Japanese prospective multicenter study of urinary oxysterols in biliary atresia2021

    • Author(s)
      Konishi K, Mizuochi T, Takei H, Yasuda R, Sakaguchi H, Ishihara J, Takaki Y, Kinoshita M, Hashizume N, Fukahori S, Shoji H, Miyano G, Yoshimaru K, Matsuura T, Sanada Y, Tainaka T, Uchida H, Kubo Y, Tanaka H, Sasaki H, Murai T, Fujishiro J, Yamashita Y, Nio M, Nittono H, Kimura A
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 4986-4986

    • DOI

      10.1038/s41598-021-84445-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Urinary and serum oxysterols in children: developmental pattern and potential biomarker for pediatric liver disease.2020

    • Author(s)
      Takaki Y, Mizuochi T, Takei H, Eda K, Konishi KI, Ishihara J, Kinoshita M, Hashizume N, Yamashita Y, Nittono H, Kimura A.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 6752-6752

    • DOI

      10.1038/s41598-020-63758-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 胆道閉鎖症におけるオキシステロールのバイオマーカーとしての可能性2020

    • Author(s)
      水落建輝
    • Organizer
      第47回日本小児栄養消化器肝臓学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Urinary oxysterols in biliary atresia: a prospective multicenter study in Japan2020

    • Author(s)
      Kenichiro Konishi
    • Organizer
      The Liver Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オキシステロールは小児肝疾患のバイオマーカーとして有用か?2019

    • Author(s)
      高木 祐吾
    • Organizer
      第122回日本小児科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 胆道閉鎖症におけるオキシステロール及び胆汁酸分析の有用性~a pilot study~2019

    • Author(s)
      小西 健一郎
    • Organizer
      第36回日本小児肝臓研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 胆道閉鎖症におけるオキシステロール及び胆汁酸分析の有用性~a pilot study~2019

    • Author(s)
      小西 健一郎
    • Organizer
      第46回日本胆道閉鎖症研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] オキシステロールは小児急性肝不全のバイオマーカーとして有用か?~A Pilot Study~2018

    • Author(s)
      水落 建輝
    • Organizer
      第54回日本肝臓学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] オキシステロールは小児急性肝不全のバイオマーカーとなりうるか?: a pilot study2018

    • Author(s)
      小西 健一郎
    • Organizer
      第35回日本小児肝臓研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Oxysterols in pediatric acute liver failure with hepatic encephalopathy: a pilot study2018

    • Author(s)
      Kenichiro Konishi
    • Organizer
      ESPGHAN Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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