| Project/Area Number |
18K07848
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Fukuda Ken 山口大学, 医学部附属病院, 医師(時間給) (80566646)
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| Co-Investigator(Kenkyū-buntansha) |
長谷川 俊史 山口大学, 大学院医学系研究科, 教授 (90314806)
脇口 宏之 山口大学, 大学院医学系研究科, 助教 (00716590)
安戸 裕貴 山口大学, 大学院医学系研究科, 講師 (70422285)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | IL-2 / 新生児・乳幼児消化管アレルギー / 新生児・乳児消化管アレルギー / IL-10 / サイトカインプロファイル / バイオマーカー / 新生児、乳児消化管アレルギー |
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| Outline of Final Research Achievements |
We analyzed the cytokine profiles of neonatal and infant gastrointestinal allergy and differential diseases (viral enteritis, bacterial enteritis, and type 1 allergy). Serum IL-2 and IL-10 concentrations were significantly increased in patients with neonatal and infantile gastrointestinal allergy in the symptomatic state compared to the asymptomatic state. There were no significant differences in IL-4, IL-6, INF-γ, and TNF-α between the symptomatic and asymptomatic states.
In comparison with the differential diseases (viral enteritis, bacterial enteritis, and type 1 allergy), the serum IL-2 concentration in the neonates and infants with gastrointestinal allergy group was significantly increased compared with the differential disease group. There were no significant differences in IL-4, IL-6, INF-γ, and TNF-α compared with the differential disease group.
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| Academic Significance and Societal Importance of the Research Achievements |
消化器症状を呈する急性期の新生児・乳幼児消化管アレルギーにおいて他疾患と比して有意に血清IL-2濃度が上昇することを確認した.この結果は新生児・乳幼児消化管アレルギーの診断、病性判定のバイオマーカーとしてIL-2が有効である可能性を示唆する.
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