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The study of pathophysiology and a novel regulation mechanism of innate and acquired allergy in virus-induced bronchial asthma

Research Project

Project/Area Number 18K07856
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionTokai University

Principal Investigator

KATO Masahiko  東海大学, 医学部, 教授 (30292593)

Co-Investigator(Kenkyū-buntansha) 大坪 慶輔  東海大学, 医学部, 講師 (10401837)
林 泰秀  群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
望月 博之  東海大学, 医学部, 教授 (50270856)
山田 佳之  群馬県衛生環境研究所, 研究企画係, 研究員 (80309252)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsウイルス感染 / 気管支喘息 / 好酸球 / RSウイルス / サイトカイン / マウス / 自然リンパ球 / ライノウイルス / 自然型アレルギー
Outline of Final Research Achievements

To elucidate the pathogenesis of acute exacerbations of bronchial asthma induced by viral infection, we investigated bronchial resistance, peripheral blood and bronchial alveolar fluid (BALF) cells analyses, and 23 types of cytokines/chemokines using an experimental asthma model mice infected with respiratory syncytial virus (RSV). The levels of BALF and tissue eosinophils showed significant increase in both ovalbumin (OVA) and OVA/RSV groups compared with control groups. MIP-1α in BALF was significantly increased in OVA/RSV groups compared with RSV groups, OVA groups, and controls. Serum IL-5 in OVA groups and serum IL-17 in OVA/RSV groups were also higher than in controls. These results suggest that eosinophilic inflammation via MIP-1α, IL-5, and IL-17 may play an important role in acute exacerbations of asthma model induced by RSV.

Academic Significance and Societal Importance of the Research Achievements

呼吸器ウイルス感染は、気管支喘息 (喘息) の発症と増悪を引き起こし、この病態には、慢性の好酸球性気道炎症が関与しているが、これらの詳細な機序については、よく分かっていない。本研究では、マウスの喘息モデルにRSウイルスを感染させることにより、喘息の増悪にどのような因子が鍵となるのかを明らかにし、新たな喘息治療に寄与することを目的とした。結果として、RSウイルス感染させた喘息マウスでは、気道過敏性の亢進とMIP-1αなどを介して好酸球性炎症が惹起されること、またIL-10は、RSウイルス感染喘息の病態に抑制性に働いていた。今後、これらの因子は、新たなウイルス感染喘息の治療候補になると考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Differences in virus detection and cytokine profiles between first wheeze and childhood asthma2020

    • Author(s)
      Shinichi Matsuda, Masahiko Kato, Takashi Koike, Yuichi Kama, Kazuo Suzuki, Mayumi Enseki, Hideyuki Tabata, Kota Hirai, Yoshiyuki Yamada, Hiroyuki Mochizuki
    • Journal Title

      The Tokai Journal of Experimental and Clinical Medicine

      Volume: 45 Pages: 10-17

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Suppressive Role of Streptococcus pneumoniae Colonization in Acute Exacerbations of Childhood Bronchial Asthma2019

    • Author(s)
      Kama Yuichi, Kato Masahiko, Yamada Yoshiyuki, Koike Takashi, Suzuki Kazuo, Enseki Mayumi, Tabata Hideyuki, Hirai Kota, Mochizuki Hiroyuki
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: 181 Issue: 3 Pages: 191-199

    • DOI

      10.1159/000504541

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肥満と喘息の関係を教えてください2018

    • Author(s)
      加藤政彦
    • Journal Title

      周産期医学

      Volume: 48 (増刊) Pages: 362-362

    • Related Report
      2018 Research-status Report
  • [Journal Article] NO (一酸化窒素 ) が喘息と関係あると聞きました。教えてください2018

    • Author(s)
      加藤政彦
    • Journal Title

      周産期医学

      Volume: 48 (増刊) Pages: 363-363

    • Related Report
      2018 Research-status Report
  • [Journal Article] 小児気管支喘息の急性増悪3例の肺音に関する検討2018

    • Author(s)
      坂間 隆, 額賀真理子, 兵頭裕美, 煙石真弓, 田端秀之, 平井康太, 加藤政彦, 望月博之
    • Journal Title

      日本小児科学会雑誌

      Volume: 122 Pages: 767-773

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Pharyngeal Streptococcus pneumoniae colonization in acute exacerbations of childhood bronchial asthma is associated with shorter duration of wheezing and lower levels of serum TNF-α2020

    • Author(s)
      Yuichi Kama, Masahiko Kato, Yoshiyuki Yamada, Takashi Koike, Kazuo Suzuki, Mayumi Enseki, Hideyuki Tabata, Kota Hirai, Hiroyuki Mochizuki
    • Organizer
      JSA/WAO Joint Congress 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of airway pathogenic bacteria on development and exacerbation of childhood bronchial asthma2020

    • Author(s)
      Yuichi Kama, Masahiko Kato
    • Organizer
      第57回日本小児アレルギー学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Pharyngeal Streptococcus pneumoniae colonization in acute exacerbations of childhood bronchial asthma is associated with shorter duration of wheezing2020

    • Author(s)
      Yuichi Kama, Masahiko Kato, Yoshiyuki Yamada, Takashi Koike, Kazuo Suzuki, Mayumi Enseki, Hideyuki Tabata, Kota Hirai, Hiroyuki Mochizuki
    • Organizer
      第57回日本小児アレルギー学会学術大会 (I-PAS)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 小児気管支喘息の急性増悪時における細菌感染の関与-続報2019

    • Author(s)
      鎌 裕一, 加藤政彦, 山田佳之, 額賀真理子, 煙石真弓, 田端秀之, 平井康太 , 望月博之
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 小児気管支喘息の急性増悪時における細胞感染の関与2018

    • Author(s)
      鎌 裕一, 加藤政彦, 山田佳之, 額賀真理子, 煙石真弓, 田端秀之, 平井康太, 望月博之
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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