Analysis of predictive factors for post-transplant recurrence of focal segmental glomerulosclerosis based on comprehensive database
| Project/Area Number |
18K07857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宍戸 清一郎 東邦大学, 医学部, 教授(寄付講座) (00187353)
佐藤 秀則 山形大学, 医学部, 助教 (60326030)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 巣状分節性糸球体硬化症 / 腎移植 / ネフローゼ症候群 / 遺伝子解析 / 腎移植後再発 / 液性因子 / 腎移植後再発予測法 / 再発予測 / データベース |
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| Outline of Final Research Achievements |
Risk factors for posttransplant recurrence of focal segmental glomerulosclerosis (FSGS) have not been established. We examined risk factors for posttransplant recurrence in 36 FSGS patients aged 1-25 years at FSGS onset from seven institutions in Japan, excluding those with secondary FSGS, familial/syndromic FSGS, and genetic FSGS. Our study suggested that treatment responses to initial steroid therapy and/or additional therapies such as immunosuppressive agents, rituximab, plasmapheresis, and/or LDL apheresis may predict posttransplant recurrence of FSGS.
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| Academic Significance and Societal Importance of the Research Achievements |
FSGSはステロイド抵抗性・難治性ネフローゼ症候群を呈しながら末期腎不全に進行し、さらに、腎移植後、高率に再発して移植腎機能廃絶に至る希少難病である。小児では末期腎不全の原因疾患として2番目に多く、また移植腎の生着を妨げる重大な要因であるため、FSGSの腎移植後再発は国際的な最重要課題である。しかしながら、腎移植前のFSGSの再発予測法は確立していない。本研究では、詳細な臨床病理学的検討と網羅的な遺伝子解析を加えた検討で、発症後のステロイド、免疫抑制薬、リツキシマブ、血漿交換、LDL吸着への治療反応性が腎移植後再発を予測するうえで有用な情報となりうることが示された。
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Report
(4 results)
Research Products
(108 results)
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[Journal Article] Rapid progression to end-stage renal disease in a child with IgA-dominant infection-related glomerulonephritis associated with parvovirus B19.2020
Author(s)
Yoko Shirai, Kenichiro Miura, Tomoo Yabuuchi, Takeshi Nagasawa, Kiyonobu Ishizuka, Kazuhiro Takahashi, Sekiko Taneda, Kazuho Honda, Yutaka Yamaguchi, Hitoshi Suzuki, Yusuke Suzuki, Motoshi Hattori
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Journal Title
CEN Case Rep
Volume: 9
Issue: 4
Pages: 423-430
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Renal hypoplasia can be the cause of membranous nephropathy-like lesions.2020
Author(s)
Keiichi Takizawa, Kenichiro Miura, Naoto Kaneko, Tomoo Yabuuchi, Kiyonobu Ishizuka, Shoichiro Kanda, Yutaka Harita, Yuko Akioka, Shigeru Horita, Sekiko Taneda, Kazuho Honda, Motoshi Hattori
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Journal Title
Clin Exp Nephrol
Volume: 24
Issue: 9
Pages: 813-820
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Individualized concept for the treatment of autosomal recessive polycystic kidney disease with end-stage renal disease.2020
Author(s)
Miura K, Sato Y, Yabuuchi T, Kaneko N, Ishizuka K, Chikamoto H, Akioka Y, Nawashiro Y, Hisano M, Imamura H, Miyai T, Sakamoto S, Kasahara M, Fuchinoue S, Okumi M, Ishida H, Tanabe K, Hattori M.
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Journal Title
Pediatr Nephrol
Volume: Mar 3
Issue: 3
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Deletion in the cobalamin synthetase W domain-containing protein 1 gene is associated with congenital anomalies of the kidney and urinary tract.2020
Author(s)
Kanda S, Ohmuraya M, Akagawa H, Horita S, Yoshida Y, Kaneko N, Sugawara N, Ishizuka K, Miura K, Harita Y, Yamamoto T, Oka A, Araki K, Furukawa T, Hattori M.
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Journal Title
J Am Soc Nephrol
Volume: 31
Issue: 1
Pages: 139-147
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] In Vivo Expression of NUP93 and Its Alteration by NUP93 Mutations Causing Focal Segmental Glomerulosclerosis.2019
Author(s)
Hashimoto T, Harita Y, Takizawa K, Urae S, Ishizuka K, Miura K, Horita S, Ogino D, Tamiya G, Ishida H, Mitsui T, Hayasaka K, Hattori M.
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Journal Title
Kidney Int Rep
Volume: 4(9)
Issue: 9
Pages: 1312-1322
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Predicting the risk of recurrence of FSGS in pediatric kidney transplant recipients: A comprehensive approach.2019
Author(s)
Kaneko N, Miura K, Iida T, Taniguchi Y, Ban H, Nagasawa T, Shirai Y, Takagi Y, Yabuuchi T, Hashimoto T, Ishizuka K, Sato H, Harita Y, Yamamoto T, Akioka Y, Hattori M.
Organizer
The 54th Annual Meeting of the Japanese Society for Pediatric Nephrology
Related Report
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[Presentation] ABO-incompatible living kidney transplantation with rituximab induction in children.2018
Author(s)
Miura K, Ishizuka K, Yabuuchi T, Kaneko T, Hisano M, Chikamoto H, Akioka Y, Okumi M, Ishida H, Tanabe K, Hattori M
Organizer
ISN Frontiers Meeting 2018
Related Report
Int'l Joint Research
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[Presentation] Cancer after pediatric kidney transplantation: a long-term single-center experience in Japan.2018
Author(s)
Yabuuchi T, Miura K, Kanda S, Taniguchi Y, Nagasawa T, Hisatomi R, Ban H, Shirai Y, Takagi Y, Kaneko N, Ishizuka K, Chikamoto H, Akioka Y, Hattori M
Organizer
ISN Frontiers Meeting 2018
Related Report
Int'l Joint Research
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[Presentation] Infectious complications in pediatric kidney transplant recipients treated with rituximab: a single-center study.2018
Author(s)
Kaneko N, Miura K, Taniguchi Y, Nagasawa T, Hisatomi R, Ban H, Shirai Y, Yabuuchi T, Takagi Y, Ishizuka K, Akioka Y, Hattori M
Organizer
ISN Frontiers Meeting 2018
Related Report
Int'l Joint Research
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[Presentation] Hyperacute changes of podocytes in posttransplant recurrence of primary focal segmental glomerulosclerosis2018
Author(s)
Ishizuka K, Harita Y, Taniguchi Y, Nagasawa T, Hisatomi R, Ban H, Shirai Y, Kaneko N, Yabuuchi T, Takagi Y, Miura K, Akioka Y, Yamaguchi Y, Oka A, Hattori M.
Organizer
ISN Frontiers Meeting 2018
Related Report
Int'l Joint Research
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[Presentation] Clinicopathological discrimination of primary and genetic focal segmental glomerulosclerosis in children.2018
Author(s)
Ishizuka K, Harita Y, Iida T, Nagasawa T, Ban H, Shirai Y, Yabuuchi T, Kaneko N, Miura K, Hashimoto T, Hattori M
Organizer
American Society of Nephrology Renal Week 2018
Related Report
Int'l Joint Research
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[Presentation] The size of urinary podocyte in focal segmental glomerulosclerosis.2018
Author(s)
Shirai Y, Miura K, Yokoyama T, Horita S, Iida T, Taniguchi Y, Nagasawa T, Ban H, Yabuuchi T, Kaneko N, Takagi Y, Ishizuka K, Hara M, Hattori M.
Organizer
American Society of Nephrology Renal Week 2018
Related Report
Int'l Joint Research
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