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Analysis of epigenetic regulation in the diversity of hepatocellular carcinoma

Research Project

Project/Area Number 18K07900
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Minami Tatsuya  東京大学, 医学部附属病院, 助教 (60459401)

Co-Investigator(Kenkyū-buntansha) 立石 敬介  東京大学, 医学部附属病院, 講師 (20396948)
中塚 拓馬  東京大学, 医学部附属病院, 助教 (50772042)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肝癌 / 肝がん / 肝臓がん
Outline of Final Research Achievements

The mechanisms of tumor herterogeneity remain to be elucidated. Hepatocellular carcinoma sometimes represent mixed subtype including cholangiocarcinoma tissues. This research project aims to address the significance of IDH mutation in the development of heterogeneity in liver cancers.

Academic Significance and Societal Importance of the Research Achievements

本研究では肝がんの発生や進展における分化異常に対するIDH変異の影響について、遺伝子改変マウスおよび肝がん幹細胞の解析、さらには臨床検体を用いた検討を行い、臨床的マーカーとしての可能性も検証する。IDH変異が肝がん幹細胞のレベルにおける分化制御に及ぼす影響を解析できる点で学術的意義が高い。さらにIDH遺伝子変異については、すでに変異特異的な阻害化合物の開発もなされていることも併せ、将来的には特異的分子標的治療および診断法の開発に直結する創造性も有している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results)

  • [Journal Article] Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis2021

    • Author(s)
      Sapena V, Enea M, Torres F, Celsa C, Rios J, Rizzo GEM, Nahon P, Marino Z, Tateishi R, Minami T, Sangiovanni A, Forns X, Toyoda H, Brillanti S, Conti F, Degasperi E, Yu ML, Tsai PC, Jean K, El Kassas M, Shousha HI, Omar A, Zavaglia C, Nagata H, Nakagawa M, Asahina Y, et al
    • Journal Title

      Gut

      Volume: in press Issue: 3 Pages: 323663-323663

    • DOI

      10.1136/gutjnl-2020-323663

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021

    • Author(s)
      Nakatsuka T、Nakagawa H、Hayata Y、Wake T、Yamada T、Nishibatake Kinoshita M、Nakagmi R、Sato M、Minami T、Uchino K、Enooku K、Kudo Y、Tanaka Y、Kishikawa T、Otsuka M、Tateishi R、Koike K
    • Journal Title

      Journal of Gastroenterology

      Volume: - Issue: 5 Pages: 01773-4

    • DOI

      10.1007/s00535-021-01773-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronological change in alpha‐fetoprotein levels in hepatocellular carcinoma after eradication of hepatitis C virus2020

    • Author(s)
      Fukumoto Tsuyoshi、Minami Tatsuya、Tateishi Ryosuke、Koike Kazuhiko
    • Journal Title

      Liver International

      Volume: 40 Issue: 9 Pages: 2305-2306

    • DOI

      10.1111/liv.14544

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation2019

    • Author(s)
      Fujiwara H、Tateishi K、Misumi K、Hayashi A、Igarashi K、Kato H、Nakatsuka T、Suzuki N、Yamamoto K、Kudo Y、Hayakawa Y、Nakagawa 、Tanaka Y、Ijichi H、Kogure H、Nakai Y、Isayama H、Hasegawa K、Fukayama M、Soga T、Koike K
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 18859-18859

    • DOI

      10.1038/s41598-019-55211-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2022-12-28  

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